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Hot Trials

Hot Trials 2025

The best critical care trials published in 2024

Other Years: 2021 | 2022 | 2023 | 2024

Jabaudon. Inhaled Sedation in Acute Respiratory Distress SyndromeThe SESAR Randomized Clinical Trial. JAMA 2025;epublished March 18th

Monti. Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial. Br J Anaesth 2024;epublished January 2nd

Wu. The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial. BMJ 2025;388:e082583

Spence. Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial. JAMA Surg 2025;160(3):286-294

End-of-Life

Grudzen. Palliative Care Initiated in the Emergency Department: A Cluster Randomized Clinical Trial. JAMA 2025;epublished January 15th

Epidemiology

The African Critical Illness Outcomes Study (ACIOS) Investigators. The African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa. Lancet 2025;405(10480):715-724

Last updated March 27th, 2025