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Hot Trials

Hot Trials

The best critical care trials published in 2024

Other Years: 2025 | 2024 | 2023 | 2022 | 2021

Neuro

Ma. Tenecteplase for acute non–large vessel occlusion 4.5 to 24 hours after ischemic stroke: the OPTION randomized clinical trial. JAMA 2026;epublished February 5th 🔴 CCR summary
Broderick. Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet 2026;epublished February 4th 🔴 CCR Summary
Xiong Y, Alemseged F, Cao Z, et al. Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial. Lancet. 2026;epublished February 5th 🔴 CCR Summary
Lu. Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial. Lancet 2026;epublished January 30th

Last updated February 9th, 2026