Major Trials
Trauma
Blood Product & Fluid Transfusion
Image: Shutterstock | Matej Kastelic
Red Cells, Platelets & Plasma
Plasma
- Sperry. Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock (PAMPer). N Engl J Med 2018; 379:315-326
- Moore. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial (COMBAT). Lancet 2018;epublished July 19th
- Jost. Prehospital Lyophilized Plasma Transfusion for Trauma-Induced Coagulopathy in Patients at Risk for Hemorrhagic Shock: A Randomized Clinical Trial. JAMA Netw Open 2022;5(7):e2223619
Drug Therapy
Image: Shutterstock | Komsan Loonprom
Corticosteroids
Antifibrinolytics
- Guyette. Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury. A Double-blind, Placebo-Controlled, Randomized Clinical Trial. JAMA Surg 2021;156(1):11-20
- CRASH-3 Trial Collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet 2019;394(10210):1713-1723
- Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet 2017;389:2105-2116
- CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23-32
Imaging
Image: Shutterstock | Yok_onepiece
