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Major Trials

Haematology

Sections

Red Cells |  Haemorrhage |  Thrombosis

Red Cells

Red Cell Transfusion Thresholds

General Critical Care

  1. Hebert. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999;340:409-17

Sepsis
  1. Holst. Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock. TRISS Trial Group and the Scandinavian Critical Care Trials Group. New Engl J Med 2014;epublished October 1st
Acute Myocardial Infarction
  1. Ducrocq. Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and AnemiaThe REALITY Randomized Clinical Trial. JAMA 2021;325(6):552-560
Cardiac Surgery
  1. Mazer. Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery (TRICS3). N Engl J Med 2017;epublished November 12th
  2. Murphy. Liberal or Restrictive Transfusion after Cardiac Surgery (TITRe2 Trial). N Engl J Med 2015;372:997-1008
  3. Hajjar. Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial. JAMA. 2010; 304:1559-1567
Gastrointestinal Bleeding
  1. Villanueva.  Transfusion strategies for acute upper gastrointestinal bleeding.   N Engl J Med 2013;368(1):11-21
Trauma
  1. Carson. Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery. N Engl J Med 2011; 365:2453-2462

Age of Transfused Red Cells

General Critical Care
  1. Lacroix. Age of Transfused Blood in Critically Ill Adults (ABLE Study). N Engl J Med 2015;epublished March 17th
Cardiac Surgery
  1. Steiner. Effects of Red-Cell Storage Duration on Patients Undergoing Cardiac Surgery (RECESS study). N Engl J Med 2015;372:1419-1429

Erythropoietin

General Critical Care
  1. Corwin. Efficacy and Safety of Epoetin Alfa in Critically Ill Patients. N Engl J Med 2007; 357:965-976
  2. Corwin. Efficacy of Recombinant Human Erythropoietin in Critically Ill Patients: A Randomized Controlled Trial. JAMA. 2002;288(22):2827-2835
Traumatic Brain Injury
  1. Nichol. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet 2015;epublished October 7th 
  2. Robertson. Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury:  A Randomized Clinical Trial. JAMA 2014;312(1):36
Post Cardiac Arrest
  1. Cariou. Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial. J Am Coll Cardiol 2016;68(1):40

Iron Transfusion

  1. Litton. Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial. Intensive Care Med 2016;42:1715-1722

Haemorrhage

Transfusion

Transfusion Ratios

  1. Holcomb. Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma:  The PROPPR Randomized Clinical Trial. JAMA 2015;313(5):471

Prehospital Plasma

  1. Sperry. Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock. N Engl J Med 2018; 379:315-326
  2. Moore. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial (COMBAT). Lancet 2018;epublished July 19th

Prehospital Red Cells & Plasma

  1. Crombie. Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Haematology 2022;epublished March 7th

Invasive Procedures

  1. A British Society for Haematology guideline on the assessment and management of bleeding risk prior to invasive procedures. Br J Haematol 2024;epublished March 22nd

Pharmacotherapy

Tranexamic Acid

Trauma
  1. Shakur. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376(9734):23–32
Traumatic Brain Injury
  1. The CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet 2019;394(10210):1713-1723
Obstetrics
  1. Shakur. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet 2017;389(10084):2105–16
Upper GI Bleed
  1. Kumar. Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis - a randomized controlled trial. Hepatology 2024;epublished March 5th