Hot Trials 2022

1. Writing Committee for the REMAP-CAP Investigators. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA 2022;epublished December 16th
2. Frat. Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19. The SOHO-COVID Randomized Clinical Trial. JAMA 2022;328(12):1212-1222
3. Arabi. Effect of Helmet Noninvasive Ventilation vs Usual Respiratory Support on Mortality Among Patients With Acute Hypoxemic Respiratory Failure Due to COVID-19. The HELMET-COVID Randomized Clinical Trial. JAMA 2022;328(11):1063-1072
4. Bowdish. A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe ARDS From COVID-19. Am J Respir Crit Care Med 2022;epublished September 13th
5. Vlaar. Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Respir Med 2022;epublished September 7th
6. Bouadma. High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial. JAMA Intern Med 2022;182(9):906-916
7. Gaughan. An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial. Am J Respir Crit Care Med 2022;epublished August 16th
8. Salvarani. Intravenous methylprednisolone pulses in hospitalized patients with severe Covid-19 pneumonia, A double-blind, randomized, placebo-controlled trial. Eur Respir J 2022;2200025
9. Labro. Nicotine patches in patients on mechanical ventilation for severe COVID‑19: a randomized, double‑blind, placebo‑controlled, multicentre trial. Intensive Care Med 2022;epublished June 9th
10. Wolfe. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial. Lancet Respir Med 2022;epublished May 23rd
11. Alhazzani. Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory FailureA Randomized Clinical Trial. JAMA 2022;epublished May 15th
12. Crimi. High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial. Thorax 2022;epublished May 17th
13. Monsel. Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial. Crit Care 2022;26:48
14. REMAP-CAP Writing Committee for the REMAP-CAP Investigators. Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19. A Randomized Clinical Trial. JAMA 2022;epublished March 22nd
15. Criner. Anti-GM-CSF Monoclonal Antibody Gimsilumab for COVID-19 Pneumonia: A Randomized, Double-Blind, Placebo-Controlled Trial. Am J Respir Crit Care Med 2022;epublished March 15th
16. RECOVERY Collaborative Group. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet 2022;399(10325):665-676
17. Perkins. Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19The RECOVERY-RS Randomized Clinical Trial. JAMA 2022;epublished January 24th
18. Ely. Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trial. Lancet Respir Med 2022;epublished February 3rd
19. Hermine. Effect of Interleukin-6 Receptor Antagonists in Critically Ill Adult Patients with COVID-19 Pneumonia: two Randomised Controlled Trials of the CORIMUNO-19 Collaborative Group. Eur Respir J 2022;epublished February 3rd
20. INSPIRATION-S Investigators. Atorvastatin versus placebo in patients with covid-19 in intensive care: randomized controlled trial. BMJ 2022;376:e068407

Observational Study

1. Azoulay. Association of COVID-19 Acute Respiratory Distress Syndrome With Symptoms of Posttraumatic Stress Disorder in Family Members After ICU Discharge. JAMA 2022;epublished February 18th

1. Yang. Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial. Lancet 2022;400(10363):1585-1596
2. Andersen-Ranberg. Haloperidol for the Treatment of Delirium in ICU Patients. N Engl J Med 2022;epublished October 26th
3. The TEAM Study Investigators and the ANZICS Clinical Trials Group. Early Active Mobilization during Mechanical Ventilation in the ICU. N Engl J Med 2022;epublished October 26th
4. Chen. Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke. The RICAMIS Randomized Clinical Trial. JAMA 2022;328(7):627-636
5. Bösel. Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation The SETPOINT2 Randomized Clinical Trial. JAMA 2022;epublished May 4th
6. Yoshimura. Endovascular Therapy for Acute Stroke with a Large Ischemic Region. N Engl J Med 2022;386:1303-1313
7. Ruijter. Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest. N Engl J Med 2022;386(8):724-734
8. Renú. Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke: The CHOICE Randomized Clinical Trial. JAMA 2022;epublished February 10th
9. Yoshimura. Endovascular Therapy for Acute Stroke with a Large Ischemic Region. N Engl J Med 2022;epublished February 9th

1. Ostadal. Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial. Circulation 2022;epublished November 6th
2. Mullens. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. N Engl J Med 2022;epublished August 27th
3. Diab. Cytokine Hemoadsorption During Cardiac Surgery versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results from a Multicenter, Randomized, Controlled Trial. Circulation 2022;epublished February 25th
4. Levy. Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation. A Randomized Clinical Trial. JAMA 2022;327(5):442-453
5. Finfer. Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. N Engl J Med 2022;epublished January 18th

1. Cheskes. Defibrillation Strategies for Refractory  Ventricular Fibrillation. N Engl J Med 2022;epublished November 6th
2. Hassager. Duration of Device-Based Fever Prevention after Cardiac Arrest. N Engl J Med 2022;epublished November 6th
3. Bernard. Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest. The EXACT Randomized Clinical Trial. JAMA 2022;epublished October 26th
4. Wolfrum. Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial. Circulation 2022;epublished September 28th
5. Kjaergaard. Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest. N Engl J Med 2022;epublished August 27th
6. Schmidt. Oxygen Targets in Comatose Survivors of Cardiac Arrest. N Engl J Med 2022;epublished August 27th
7. Hauw-Berlemont. Emergency vs Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac Arrest: Results of the Randomized, Multicentric EMERGE Trial. JAMA Cardiol 2022;7(7):700-707
8. Ruijter. Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest. N Engl J Med 2022;386(8):724-734
9. Belohlavek. Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest. A Randomized Clinical Trial. JAMA 2022;327(8):737-747
10. Supady. Cytokine adsorption in patients with post-cardiac arrest syndrome after extracorporeal cardiopulmonary resuscitation (CYTER) – A single-centre, open-label, randomised, controlled trial. Resuscitation 2022;epublished February 7th

1. Russell. Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation (PREPARE II). A Randomized Clinical Trial. JAMA 2022;epublished June 16th
2. Hodgson. Nasal High-Flow Therapy during Neonatal Endotracheal Intubation. N Engl J Med 2022;386(17):1627-1637
3. Lee. Effect of Placement of a Supraglottic Airway Device vs Endotracheal Intubation on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest in Taipei, Taiwan. A Cluster Randomized Clinical Trial. JAMA Netw Open 2022;5(2):e2148871
4. Ferguson. Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: the FAKT study - a randomized clinical trial. Acad Emerg Med. 2022 January 22nd

1. Hernández. Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial. Intensive Care Med 2022;epublished November 18th
2. The SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group. Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation. A Randomized Clinical Trial. JAMA 2022;epublished October 26th
3. Thille. Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece. N Engl J Med 2022;epublished October 26th
4. Semler. Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation. N Engl J Med 2022;epublished October 24th
5. Schmidt. Oxygen Targets in Comatose Survivors of Cardiac Arrest. N Engl J Med 2022;epublished August 27th
6. Mullens. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. N Engl J Med 2022;epublished August 27thFernando. Association of Extracorporeal Membrane Oxygenation With New Mental Health Diagnoses in Adult Survivors of Critical Illness. JAMA 2022;epublished October 26th
7. Meduri. Low‑dose methylprednisolone treatment in critically ill patients with severe community‑acquired pneumonia. Intensive Care Med 2022;epublished May 13th
8. Dat. Effectiveness of Continuous Endotracheal Cuff Pressure Control for the Prevention of Ventilator-Associated Respiratory Infections: An Open-Label Randomized, Controlled Trial. Clin Infect Dis. 2022 May 30;74(10):1795-1803
9. Dres. Randomized Clinical Study of Temporary Transvenous Phrenic Nerve Stimulation in Difficult-to-Wean Patients. Am J Respir Crit Care Med 2022;205(10):1169–1178
10. Coudroy. High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial. Lancet Respir Med 2022;epublished March 21st
11. Ibarra-Estrada. Use of Airway Pressure Release Ventilation in Patients With Acute Respiratory Failure Due to COVID-19: Results of a Single-Center Randomized Controlled Trial. Crit Care Med. 2022;50(4):586–594
12. Lewis. Cuff Leak Test and Airway Obstruction in Mechanically Ventilated Intensive Care Unit Patients: A Pilot Randomized Controlled Clinical Trial. Ann Am Thorac Soc 2022;19(2):238–244
13. de Vries. Lung- and Diaphragm-Protective Ventilation by Titrating Inspiratory Support to Diaphragm Effort: A Randomized Clinical Trial. Crit Care Med 2022;50(2):192-203
14. Fitzgerald. The Steroid Therapy and Outcome of Parapneumonic Pleural Effusions (STOPPE): A Pilot Randomized Trial. Am J Respir Crit Care Med 2022;epublished January 24th
15. Damas. Prevention of ventilator-associated pneumonia by noble metal coating of endotracheal tubes: a multi-center, randomized, double-blind study. Ann Intensive Care 2022;12:1

Observational

1. Fernando. Association of Extracorporeal Membrane Oxygenation With New Mental Health Diagnoses in Adult Survivors of Critical Illness. JAMA 2022;epublished October 26th

1. de-Madaria. Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis. N Engl J Med 2022;387:989-1000
2. Ke. Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double‑blind randomised controlled trial. Intensive Care Med 2022;epublished June 17th
3. He. Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis. Crit Care 2022;26:52

1. Ke. Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial. Intensive Care Med 2022;48:899–909
2. Ke. Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial. Crit Care 2022;26:46
3. Lee. Continuous versus Intermittent Enteral Tube Feeding for Critically Ill Patients: A Prospective, Randomized Controlled Trial. Nutrients 2022;14(3):664

1. James. Effect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial. JAMA 2022;328(9):839-849
2. Osterholt. Preoperative Short‐Term Restriction of Sulfur‐Containing Amino Acid Intake for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Double‐Blind, Translational Trial. J Am Heart Assoc 2022;0:e025229

1. Poole. The Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial. Am J Respir Crit Care Med 2022;epublished May 20th

1. Thompson. Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial. Lancet 2022;epublished November 25th
2. Cour. Remote ischemic conditioning in septic shock: the RECO-Sepsis randomized clinical trial. Intensive Care Med 2022;epublished September 14th
3. Poole. Molecular point-of-care testing for lower respiratory tract pathogens improves safe antibiotic de-escalation in patients with pneumonia in the ICU: results of a randomised controlled trial. J Infect 2022;epublished September 9th
4. Meyhoff. Restriction of Intravenous Fluid in ICU Patients with Septic Shock (CLASSIC). N Engl J Med 2022;epublished June 17th
5. Lamontagne. Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit (LOVIT). N Engl J Med 2022;epublished June 15th
6. Bloos. (1 → 3)‑β‑d‑Glucan‑guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial. Intensive Care Med 2022;epublished June 16th
7. Bouglé. Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Intensive Care Med 2022;epublished May 13th
8. Yoshimura. Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia. The GRACE-VAP Randomized Clinical Trial. JAMA Netw Open 2022;5(4):e226136
9. Hagel. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial. Intensive Care Med 2022;epublished February 1st
10. Cocchi. Esmolol TO Treat The Hemodynamic Effects of Septic Shock: A Randomized Controlled Trial. Shock 2021;epublished December 27th

1. Dehghan. Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries. A Randomized Clinical Trial. JAMA Surg 2022;epublished September 21st
2. Jost. Prehospital Lyophilized Plasma Transfusion for Trauma-Induced Coagulopathy in Patients at Risk for Hemorrhagic Shock: A Randomized Clinical Trial. JAMA Netw Open 2022;5(7):e2223619
3. Crombie. Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Haematology 2022;epublished March 7th

1. Hill. Methylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial. N Engl J Med 2022;epublished November 6th
2. Schlapbach. Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery. The NITRIC Randomized Clinical Trial. JAMA 2022;328(1):38-47
3. Wu. Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns. N Engl J Med 2022;387:148-159
4. Ramnarayan. Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units (FIRST-ABC). A Randomized Clinical Trial. JAMA 2022;epublished June 16th
5. Ramnarayan. Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill Children: A Randomized Clinical Trial. JAMA 2022;epublished April 7th
6. Watterberg. Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia. N Engl J Med 2022;386(12):1121-1131
7. Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups. Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs. A Randomized Clinical Trial. JAMA 2022;327(10):934-945

1. Pallesen. The effects of preoperative focused cardiac ultrasound in high-risk patients: A randomised controlled trial (PREOPFOCUS). Acta Anaesthesiol Scand 2022;epublished August 18th
2. Pesonen. Effect of 4% Albumin Solution vs Ringer Acetate on Major Adverse Events in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass. A Randomized Clinical Trial. JAMA 2022;328(3):251-258
3. Shi. Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac SurgeryThe OPTIMAL Randomized Clinical Trial. JAMA 2022;328(4):336-347
4. Jost. Prehospital Lyophilized Plasma Transfusion for Trauma-Induced Coagulopathy in Patients at Risk for Hemorrhagic Shock: A Randomized Clinical Trial. JAMA Netw Open 2022;5(7):e2223619
5. Smith. Prothrombin Complex Concentrate vs Plasma for Post-Cardiopulmonary Bypass Coagulopathy and Bleeding: A Randomized Clinical Trial. JAMA Surg 2022;epublished June 29th
6. Meersch. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial. JAMA 2022;epublished June 4th
7. Sessler. Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial. Lancet 2022;399(10337):1799-1808
8. Devereaux. Tranexamic Acid in Patients Undergoing Noncardiac Surgery. N Engl J Med 2022;epublished April 2nd
9. Gao. Effect of Early vs Late Supplemental Parenteral Nutrition in Patients Undergoing Abdominal Surgery: A Randomized Clinical Trial. JAMA Surg 2022;epublished March 16th

Burns

1. Heyland. A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries. N Engl J Med 2022;epublished September 9th

General

1. Greenberg. Daily Written Care Summaries for Families of Critically Ill Patients: A Randomized Controlled Trial. Crit Care Med 2022;epublished May 23rd

2. Kentish-Barnes. A three-step support strategy for relatives of patients dying in the intensive care unit: a cluster randomised trial. Lancet 2022;epublished January 19th

Perioperative

1. Park. Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery: a multicentre randomised clinical trial. Br J Anaesth 2022;epublished August 20th
2. Abrard. Postoperative prophylactic intermittent noninvasive ventilation versus usual postoperative care for patients at high risk of pulmonary complications: a multicentre randomised trial. Br J Anaesth 2022;epublished January 5th

Rehabilitation

1. Campos. Early Neuromuscular Electrical Stimulation in Addition to Early Mobilization Improves Functional Status and Decreases Hospitalization Days of Critically Ill Patients. Crit Care Med 2022;50(7):1116-1126