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CCR-Newsletter-BannerNewsletter 457  |  September 19th 2020

Journal Watch  |  Newsletters  |  CCR Meeting 2021  |  CCR18 BookPodcast  |  Hot Articles  |  Topic of the Week  |  Reviews  |  Top 100 Studies  |  Guidelines  |  Journals

 

Welcome to the 457th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature last week.

The highlights of this edition are randomised controlled trials on out-of-hospital tranexamic acid for traumatic brain injury, high-flow oxygen with capping or suctioning for tracheostomy decannulation & recombinant human granulocyte colony–stimulating factor for patients with COVID-19 and lymphopenia; systematic reviews and meta analyses on prediction of poor neurological outcome in comatose survivors of cardiac arrest & the effect of delayed appropriate antibiotic treatment on the outcomes of patients with severe bacterial infections; and observational studies on Inappropriate empirical antibiotic therapy for bloodstream infections & the prevalence and course of frailty in survivors of critical illness.

There are also guidelines on management of intravascular catheters & adult ICU triage during the COVID-19 pandemic; narrative reviews on nasal high flow oxygen during acute respiratory failure & allergy and anaesthesia; an editorial on reassuring the public and clinical community about a COVID-19 vaccine; and commentaries on bacterial and fungal superinfections in critically ill patients with COVID-19 & COVID-19 and the path to immunity; as well as correspondence on the interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest & MSC-derived exosomes for ECMO-supported ARDS.

If you only have time to read one review article from this newsletter, try this one on chest trauma: current recommendations for rib fractures.

 

Research

Review Articles

COVID-19

Neurological

Circulatory

Respiratory

Sepsis

Trauma

Immunology

Perioperative

Miscellaneous

I hope you find these links useful.


Until next week

Rob

Supported by the Health Research Board

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Prof Kathryn Maitland (Kalifi, Kenya)

John Hinds Lecture

 Hot Articles

The following articles have been chosen as the most noteworthy publications in critical care since December 2011.

 

2020

Randomised Controlled Trials

Systematic Reviews & Meta Analysis

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Guidelines & Position Statements

{slider=July}

Randomised Controlled Trials

Press Release

  1. Update on the phase III COVACTA trial of Actemra/RoActemra in hospitalised patients with severe COVID-19 associated pneumonia. Roche 2020;epublished July 29th

Systematic Reviews & Meta Analyses

  1. Turner. Association of checklist use in endotracheal intubation with clinically important outcomes: a systematic review and meta-analysis. JAMA Netw Open 2020;3(7):e209278
  2. Parhar. Standardized Management for Hypoxemic Respiratory Failure and ARDS: Systematic Review & Meta-analysis. Chest 2020;epublished July 3rd

Observational Studies

  1. Folegatti. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet 2020;epublished July 20th
  2. Zhu. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet 2020;epublished July 20th
  3. Jackson. An mRNA Vaccine against SARS-CoV-2 — Preliminary Report. N Engl J Med 2020;epublished July 14th
  4. Carfì. Persistent Symptoms in Patients After Acute COVID-19. JAMA 2020;epublished July 9th
  5. Paterson. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain 2020;epublished July 8th
  6. Pollán. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet 2020;epublished July 6th
  7. Foster. The Association Between Discharge Delay from Intensive Care and Patient Outcomes. Am J Respir Crit Care Med 2020;epublished July 10th
  8. Dufort. Multisystem Inflammatory Syndrome in Children in New York State. N Engl J Med 2020;epublished June 29th
  9. Feldstein. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med 2020;epublished June 29th

Guidelines & Position Statements

  1. Rochwerg. Remdesivir for severe covid-19: a clinical practice guideline. BMJ 2020;370:m2924
  2. Recommendations of the Working Groups from the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) for the management of adult critically ill patients in the coronavirus disease (COVID-19). Medicina Intensiva 2020;epublished July 7th
  3. Guimarães. Position Statement: Cardiopulmonary Resuscitation of Patients with Confirmed or Suspected COVID-19 - 2020. Arq Bras Cardiol 2020 ;114(6):1078-1087
  4. Triage of Scarce Critical Care Resources in COVID-19 An Implementation Guide for Regional Allocation. An Expert Panel Report of the Task Force for Mass Critical Care and the American College of Chest Physicians. Chest 2020;158(1):212–225
  5. Prevention, Diagnosis, and Treatment of VTE in Patients With COVID-19. CHEST Guideline and Expert Panel Report. Chest 2020;epublished June 2nd

Randomised Controlled Trials

  1. The HALT-IT Trial Collaborators. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. Lancet 2020;395(10241):1927-1936
  2. Pfortmueller. Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial. Intensive Care Med 2020;epublished June 9th
  3. Li. Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19A Randomized Clinical Trial. JAMA 2020;epublished June 3rd
  4. Boulware. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med 2020;epublished June 3rd
  5. Borges. Duration of antibiotic therapy in critically ill patients: a randomized controlled trial of a clinical and C-reactive protein-based protocol versus an evidence-based best practice strategy without biomarkers. Crit Care 2020;24:281

Press Releases

  1. No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY. Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on lopinavir-ritonavir, 29 June 2020
  2. RECOVERY Trial Investigators. Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19. Press Release June 16th
  3. Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on hydroxychloroquine

Retractions

Pilot Randomised Controlled Trials

  1. Zampieri. Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit: CRITIC Pilot Randomized Controlled Trial. Annals ATS 2020;epublished June 11thAnnals ATS 2020;epublished June 11th

Systematic Review & meta Analysis

  1. Ferreyro. Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory FailureA Systematic Review and Meta-analysis. JAMA 2020;epublished June 4th
  2. Chu. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 2020;epublished June 1st

Observational Studies

Guidelines & Position Statements

  1. European Resuscitation Council COVID-19 Guidelines Executive Summary. Resuscitation 2020;epublished June 8th
  2. Aziz. Managing ICU surge during the COVID‑19 crisis: rapid guidelines. Intensive Care Med 2020;epublished June 8th
  3. Shang. Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China. Annals Intensive Care 2020;10:73
  4. Critical Care for COVID-19 Affected Patients: Position Statement of the Indian Society of Critical Care Medicine. Indian J Crit Care Med 2020;24(4):222–241
  5. Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report. Chest 2020;epublished June 2nd
  6. The Use of Bronchoscopy During the COVID-19 Pandemic. CHEST/AABIP Guideline and Expert Panel Report. Chest 2020;epublished April 30th
  7. Use of Tracheostomy During the COVID-19 Pandemic: CHEST/AABIP/AIPPD: Expert Panel Report. Chest 2020;epublished June 5th

Randomised Controlled Trials

  1. Beigel. Remdesivir for the Treatment of Covid-19 — Preliminary Report. N Engl J Med 2020;epublished May 22nd
  2. Goldman. Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. N Engl J Med 2020;epublished May 27th
  3. Cao. Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial, J Allergy Clin Immunol 2020;epublished May 26th
  4. Cao. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med 2020;382:1787-1799
  5. Hung. Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet 2020;epublished May 8th
  6. Francois. Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial. Intensive Care Med 2020;epublished May 28th
  7. Hung. Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet 2020;395(10238):1695-1704
  8. Tang. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. BMJ 2020;369:m1849
  9. Yang. Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke. N Engl J Med 2020;epublished May 6th
  10. Sadan. Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage–related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial. J Intensive Care 2020;8:32

Pilot Randomised Controlled Trials

  1. Deng. A pilot randomised controlled trial of the management of systolic blood pressure during endovascular thrombectomy for acute ischaemic stroke. Anaesthesia 2020;75(6):739-746
  2. Van Dyck. Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study. Crit Care 2020;24:249
  3. Hadfield. Neurally adjusted ventilatory assist versus pressure support ventilation: a randomized controlled feasibility trial performed in patients at risk of prolonged mechanical ventilation. Critical Care 2020;24:220

Observational Studies

  1. COVIDSurg Collaborative. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. Lancet 2020;epublished May 29th
  2. Elharrar. Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure. JAMA 2020;epublished May 15th
  3. Geleris. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl J Med 2020;epublished May 7th
  4. Mahévas. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ 2020;369:m1844 
  5. Rosenberg. Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State. JAMA 2020;epublished May 11th
  6. Sartini. Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit. JAMA 2020;epublished May 15th
  7. Elharrar. Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure. JAMA 2020;epublished May 15th
  8. Geleris. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl J Med 2020;epublished May 7th
  9. Mahévas. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ 2020;369:m1844 

Guidelines & Position Statements

  1. Consensus guidelines for managing the airway in patients with COVID ‐19. Anaesthesia 2020;75(6):785-799
  2. Cook. Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients. Neurocrit Care 2020;32:647–666
  3. Coccolini. Liver trauma: WSES 2020 guidelines. World J Emerg Surg 2020;15:24
  4. Takhar. Recommendation of a practical guideline for safe tracheostomy during the COVID-19 pandemic. Eur Arch Otorhinolaryngol 2020;epublished April 21st
  5. Making Medical Treatment Decisions for Unrepresented Patients in the ICU. An Official American Thoracic Society/American Geriatrics Society Policy Statement. Am J Respir Crit Care Med 2020;201(10):1182–1192
  6. Harhay. Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop. Intensive Care Med 2020;46:930–942
  7. Advanced Pulmonary and Cardiac Support of COVID-19 Patients. Emerging Recommendations From ASAIO—a Living Working Document. Heart Failure. 2020;13:e007175
  8. Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. Revista Española de Anestesiología y Reanimación 2020;epublished May 7th
  9. Abdul-Aziz. Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper. Intensive Care Med 2020;epublished May 7th
  10. Recommendations from the Sociedade Portuguesa de Cuidados Intensivos and Infection & Sepsis Group for intensive care approach to COVID-19. Rev Bras Ter Intensiva. 2020;32(1):2-10
  11. Legrand. Management of severe thermal burns in the acute phase in adults and children. Anaesth Crit Care Pain Med 2020;39(2):253-267
  12. Bouzat. Early management of severe abdominal trauma. Anaesth Crit Care Pain Med 2020;39(2):269-277
  13. French recommendations for the management of patients with spinal cord injury or at risk of spinal cord injury. Anaesth Crit Care Pain Med 2020;39(2):279-289
  14. Gruel. Diagnosis and management of heparin-induced thrombocytopenia. Anaesth Crit Care Pain Med 2020;39(2):291-310

Randomised Controlled Trials

  1. Wang. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2020;epublished April 29th
  2. Lau. Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. N Engl J Med 2020;382:1299-1308
  3. Deane. Outcomes Six Months after Delivering 100% or 70% of Enteral Calorie Requirements during Critical Illness (TARGET). A Randomized Controlled Trial. Am J Respir Crit Care Med 2020;814–822
  4. Lertwattanachai. Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: a randomized controlled trial. J Intensive Care 2020;8:26
  5. McNelly. Effect of intermittent or continuous feed on muscle wasting in critical illness: A phase II clinical trial. Chest 2020;epublished April 2nd

Pilot Randomised Controlled Trials

  1. Kakihana. Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial. Lancet Respir Med 2020;epublished March 31st
  2. Schomer. Effect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study. Crit Care Expl 2020;2:e0085

Systematic Review & meta Anaysis

  1. Gaudry. Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet 2020;epublished April 23rd
  2. Fernando. Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Med 2020;epublished April 18th

Observational Studies

  1. Jernigan. Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017. N Engl J Med 2020;382:1309-1319
  2. Du. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study. Am J Respir Crit Care 2020;epublished April 3rd
  3. Zhou. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054-1062
  4. Bhatraju. Covid-19 in Critically Ill Patients in the Seattle Region — Case Series. N Engl J Med 2020;epublished March 30th
  5. Wang. The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China. Annals of Intensive Care 2020;10:37
  6. Grasselli. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020;epublished April 6th

Guidelines & Position Statements

  1. Yang. Expert recommendations on blood purification treatment protocol for patients with severe COVID-19: Recommendation and consensus. Chronic Dis Transl Med 2020;epublished April 28th
  2. Yang. Imaging of coronavirus disease 2019: A Chinese expert consensus statement. Eur J Radiol 2020;127:109008
  3. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. Clinical Infectious Diseases 2020;epublished April 27th
  4. Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association. Circulation 2020;141:e654–e685
  5. Bartlett. Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure. ASAIO 2020;epublished March 30th
  6. Martin. Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance. Perioper Med 2020;9:12.
  7. Cinesi Gómez. Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. Arch Bronconeumol 2020;epublished March 30th
  8. Rascado Sedes. Contingency plan for the intensive care services for the COVID-19 pandemic. Med Intensiva 2020;epublished April 23rd
  9. Guidelines for the management of glucocorticoids during the peri‐operative period for patients with adrenal insufficiency. Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK. Anaesthesia 2020;75(5):654-663
  10. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 2020;epublished March 25th
  11. Management of SARS-CoV-2 infection: recommendations of the Polish Association of Epidemiologists and Infectiologists. Pol Arch Intern Med 2020;130:352-357
  12. Foust. International Expert Consensus Statement on Chest Imaging in Pediatric COVID-19 Patient Management: Imaging Findings, Imaging Study Reporting and Imaging Study Recommendations. Radiology: Cardiothoracic Imaging 2020;epublished April 23rd
  13. Kim. Interim Guidelines on Antiviral Therapy for COVID-19. Infect Chemother 2020;epublished April 23rd
  14. Triage of scarce critical care resources in COVID-19: an implementation guide for regional allocation An expert panel report of the Task Force for Mass Critical Care and the American College of Chest Physicians. Chest 2020;epublished April 11th
  15. Leisman. Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Crit Care Med 2020;48(5):623-633
  16. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection. IDSA 2020;epublished April 11th
  17. Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with lots of other groups. Circulation 2020;epublished April 9th
  18. Shanthanna. Caring for patients with pain during the COVID‐19 pandemic: Consensus recommendations from an international expert panel. Anaesthesia 2020;epublished April 7th
  19. Harhay. Methodologic Guidance and Expectations for the Development and Reporting of Prediction Models and Causal Inference Studies. Ann Thor Med 2020;epublished April 10th
  20. The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. Radiology 2020;epublished April 7th
  21. Song. Recommendations on cardiopulmonary resuscitation strategy and procedure for novel coronavirus pneumonia. Resuscitation 2020;epublished April 7th
  22. Ball. Management of the neurologically deceased organ donor: A Canadian clinical practice guideline. CMAJ 2020;192:E361­9

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

2019

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

Pilot Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials

American Thoracic Society Meeting

Pilot RCTs

Observational Studies

American Thoracic Society Meeting

Guidelines & Position Statements

Randomised Controlled Trials

Pilot RCTs

Guidelines & Position Statements

Randomised Controlled Trials

American College of Cardiology Meeting

Pilot RCTs

Guidelines & Position Statements

Randomised Controlled Trials

Society of Critical Care Medicine Congress 2019

Observational Studies

Guidelines & Position Statements

2018

Randomised Controlled Trials

Pilot RCTs

Observational Studies

Guidelines & Position Statements

Chinese Combat Injury Guidelines

American Society of Haematology Venous Thromboembolism Guideline

Randomised Controlled Trials

ESICM Trials

Non-ESICM Trials

Guidelines & Position Statements

Randomised Controlled Trials

Guidelines & Position Statements

Randomised Controlled Trials

Observational Studies

Guidelines & Position Statements

Randomised Controlled Trials


Guidelines & Position Statements

2017

Randomised Controlled Trials

Guidelines & Position Statements

Laptook. Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy. A Randomized Clinical Trial. JAMA 2017;318(16):1550-1560

Stöckl. Continuous versus intermittent neuromuscular blockade in patients during targeted temperature management after resuscitation from cardiac arrest—A randomized, double blinded, double dummy clinical trial. Resuscitation 2017;120:14-19

Koster. Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. European Heart Journal 2017;38(40):3006–3013

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society. Neurocrit Care 2017;epublished October 16th

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2017;epublished October 16th

Koch. A Randomized Clinical Trial of Red Blood Cell Transfusion Triggers in Cardiac Surgery. Ann Thorac Surg 2017;104(4):1243-1250

Jaillette. Impact of tapered-cuff tracheal tube on microaspiration of gastric contents in intubated critically ill patients: a multicenter cluster-randomized cross-over controlled trial. Intensive Care Med 2017;43(11):1562–1571

Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intnsive Care Med 2017;epublished October 31st

Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association / American Stroke Association. Stroke 2017;epublished November 2nd

Thiele. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock (CULPRIT-SHOCK). N Engl J Med 2017;epublished October 30th

van Brunschot. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2017;epublished November 3rd

European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology. Eur J Neurol 2017;24:1203–1213

30th Annual ESICM Congress (LIVES2017, Vienna) 

New Engl J Med - Age of Transfused Red Cells

JAMA - Alveolar Recruitment in ARDS

JAMA - Intra-Operative Blood Pressure Management

JAMA - Systematic ICU Admission for Elderly Sick Patients

JAMA - Early Goal-Directed Sepsis Care in Zambia

Intensive Care Medicine - Early Goal-Directed Nutrition

Intensive Care Medicine - Airway Pressure Release Ventilation

Intensive Care Medicine - Spontaneous Breathing Trials

Intensive Care Medicine - Biomarker-Guided Strategy for Discontinuing Antifungal Therapy

Kneyber. Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC). Intensive Care Med 2017;epublished September 22nd


Intensive Care Medicine - Positioning for VAP


Intensive Care Medicine - Adrenal Insufficiency Guideline


Circulation - Cardiogenic Shock Guideline


Lancet Respiratory Medicine - Sedation Interruption


Chest - Checklists for ICU Intubation


Critical Care Medicine - Nebulized Versus IV Amikacin in VAP


European Respiratory Journal - HAP / VAP Guideline


Annals of Surgery - Transfusion Thresholds in Burns


Critical Care - Loxapine for Agitation


Critical Care - Recombinant ACE 2 in ARDS


J Crit Care - Enteral Nutrition as Stress Prophylaxis


Am J Respir Crit Care Med - Coping Skills in ICU Survivors


European Respiratory Journal - NIV Guideline

NEJM - Oxygen in Acute Myocardial Infarction


Crit Care Resusc - Earplugs for Sleep Quality


Resuscitation - Intermittent vs Continuous Neuromuscular Blockade during Temperature Management post Cardiac Arrest


JAMA - Ganciclovir in CMV-Positive Critically Ill Patients


Critical Care - Serlipressin in Septic Shock


Critical Care Medicine - Simulation for ECMO Emergencies


Critical Care Medicine - Exposure Keratopathy


Critical Care - Software-Guided Glycaemic Control


Thorax - Rehabilitation in the ICU

JAMA - 24 vs 48 Hours of Hypothermia post Cardiac Arrest


JPEN - Paediatric Nutritional Support Guideline


Journal of Intensive Care - Japanese ARDS Guideline


Chinese Medical Journal - EEG Monitoring Guideline


Lancet respiratory Medicine - Simvastatin for Prevention & Treatment of ICU Delirium


Journal of Critical Care - Furosemide in Early Acute Kidney Injury


Lancet - Procalcitonin-Guided Antibiotics in Early Sepsis


Minerva Pneumologica - NIV vs IMV in Hypoxaemic Respiratory Failure


JAMA Cardiology - Spironolactone in Acute Heart Failure


Anaesth Crit Care Pain - French TTM Guideline


World Jounal of Emergency Surgery - Intra-Abdominal Infections Guideline


Critical Care Medicine - Blood flow & CRRT Circuit Lifespan


European Heart Journal - Safety of Mechanical Chest Compression Devices


Journal of Korean medical Science - Mild Hypothermia for Poor Grade Subarachnoid Haemorrhage


Critical Care Medicine - Shenfu Injection post Cardiac Arrest


JAMA - Cooling post Neonatal Hypoxic-Ischaemic Encephalopathy

Circulation - N-Acetylcysteine & Nitrate Therapy in STEMI


Thorax - Post ICU Rehabilitation

McDowell. Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial) Thorax 2017;72:594-595


JAMA - FAST Scan in Paediatric Trauma


J Allergy Clin Immunol Pract - Icatibant for ACE Inhibitor-Induced Angioedema


Ann Emerg Med - High Flow Nasal Oxygen in Cardiogenic Pulmonary Oedema


Critical Care - Supplementary Parenteral Nutrition


JAMA Surgery - Intraoperative Dexmedetomidine & Post-Op Cognitive Dysfunction


Intensive Care Med - AKI Guideline