Critical Care Reviews Newsletter

Welcome to the 688th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on early hydrocortisone versus placebo in neonatal shock & intravenous nerinetide for acute cerebral ischaemia; systematic reviews and meta analyses on antibiotic prophylaxis in polytrauma patients & high-flow nasal oxygen therapy in patients with hypercapnic respiratory failure; and observational studies on serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride & acute pulmonary embolism in children and adolescents in the USA.

There are also guidelines on red blood cell transfusion in critically ill adults & diagnosis and management of candidiasis; narrative reviews on traumatic brain injury & noninvasive respiratory supports in the management of severe asthma exacerbations; editorials on AI in neurocritical care & venovenous ECMO in patients with shock; and commentaries on the overreliance on p-values in critical care research & a checklist for environmentally responsible research within the ICU. 

If you only have time to read one review article this week, try this one on the etiology and management of critical acute right heart failure.

Critical Care Reviews Meeting 2025

There's now less than 4 months to go until CCR25. If you haven't booked yet, don't leave it too long! 1, 2 and 3-day registrations are available.