Miscellaneous Trials

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Major Trials

Miscellaneous

Sections

Perioperative | Toxicology | End-of-Life | Quality Improvement

Perioperative

Blood Pressure

Saugel. Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery. The IMPROVE-multi Randomized Clinical Trial. JAMA 2025;epublished October 12th
Kant. Proactive vs Reactive Treatment of Hypotension During Surgery. The PRETREAT Randomized Clinical Trial. JAMA 2025;epublished October 12th

Toxicology

Airway

Freund. Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning. A Randomized Clinical Trial. JAMA 2023;epublished November 29th

End-of-Life

Post ICU Survivorship

Cox. Effects of a Telephone- and Web-based Coping Skills Training Program Compared to an Education Program for Survivors of Critical Illness and Their Family Members: A Randomized Clinical Trial. Am J Respir Crit Care Med 2017;epublished September 5th

End-of-Life

Curtis. Effect of a quality-improvement intervention on end-of-life care in the intensive care unit: a randomized trial. Am J Respir Crit Care Med 2011;183(3):348-55

Palliative Care

Carson. Effect of Palliative Care–Led Meetings for Families of Patients With Chronic Critical Illness. A Randomized Clinical Trial. JAMA 2016;316(1):51-62

Organ Donation

Organ Optimisation

Dhar. Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors. N Engl J Med 2023;389:2029-2038

Quality Improvement

Tele-ICU

Pereira. Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients. The TELESCOPE Randomized Clinical Trial. JAMA 2024;epublished October 9th

Checklists

BRICNet. Effect of a Quality Improvement Intervention With Daily Round Checklists, Goal Setting, and Clinician Prompting on Mortality of Critically Ill Patients. A Randomized Clinical Trial (CHECKLIST-ICU). JAMA 2016;315(14):1480-1490

Rehabilitation

Remote Rehabilitation

Rosa. Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults. A Randomized Clinical Trial. JAMA 2026;epublished June 10th
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Last updated August 31st, 2026