Major Trials
Endocrine
Insulin
Image: Shutterstock | Komsan Loonprom
General
Medical ICU
Vitamin D
Image: Shutterstock | Komsan Loonprom
General
- The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients (VIOLET). N Engl J Med 2019; 381:2529-2540
- Amrein. Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D DeficiencyThe VITdAL-ICU Randomized Clinical Trial. JAMA 2014;312(15):1520-1530
Vitamin C
Image: Shutterstock | Komsan Loonprom
Sepsis
- Sevransky. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis. The VICTAS Randomized Clinical Trial. JAMA 2021;325(8):742-750
- Moskowitz. Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial. JAMA 2020;324(7):642-650
- Hwang. Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study. Intensive Care Med 2020;epublished August 11th
- Chang. Combined Treatment With Hydrocortisone, Vitamin C, and Thiamine for Sepsis and Septic Shock. A Randomized Controlled Trial. Chest 2020;158(1):174–182
- Iglesias. Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis. The ORANGES Trial. Chest 2020;158(1):164–173
- Fujii. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock. The VITAMINS Randomized Clinical Trial. JAMA 2020;323(5):423-431
See also Sepsis Trials
Vitamin B1 (Thiamine)
Image: Shutterstock | CLUSTERX
