Endocrine

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Major Trials

Endocrine

Sections

Insulin | Vitamin D | Vitamin C | Vitamin B1

Insulin

Insulin infusion in the ICU

Image: Shutterstock | Komsan Loonprom

General

Gunst. Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU. N Engl J Med 2023;389:1180-1190
NICE-SUGAR Study Investigators. Intensive versus Conventional Glucose Control in Critically Ill Patients. N Engl J Med 2009;360:1283-97.
Van den Berghe. Intensive Insulin Therapy in Critically Ill Patients. N Engl J Med 2001;345:1359-67

Medical ICU

Van den Berghe. Intensive Insulin Therapy in the Medical ICU. N Engl J Med 2006;354:449-61.

Sepsis

Vitamin D

Vitamin D plus a facemask

Image: Shutterstock | Komsan Loonprom

General

Vitamin C

Vitamin D plus a facemask

Image: Shutterstock | Komsan Loonprom

Sepsis

See also Sepsis Trials

ARDS

Fowler. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure. The CITRIS-ALI Randomized Clinical Trial. JAMA 2019;322(13):1261-1270

Vitamin B1 (Thiamine)

Vitamin D plus a facemask

Image: Shutterstock | CLUSTERX

Sepsis

Donnino. Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study. Crit Care Med 2016;44:360–367