Major Trials
Metabolic
Sodium Bicarbonate
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Metabolic Acidosis
- Jaber. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet 2018;epublished June 14th
- Cooper. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis: a prospective, controlled clinical study. Ann Intern Med 1990;112:492-498
- Mathieu. Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: a prospective, controlled clinical study. Crit Care Med 1991;19:1352-1356
Induced Hypothermia
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Traumatic Brain Injury
- Andrews. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury (Eurotherm3235 Trial). N Engl J Med 2015;epublished October 7th
- Clifton. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol 2011;10:131-39
- Clifton. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001;344:556-63