Traumatic Brain Injury
Decompressive Craniectomy
Induced Hypothermia
Pharmacotherapy
Hypertonic Saline
Erythropoietin
Progesterone
- Wright. Very Early Administration of Progesterone for Acute Traumatic Brain Injury (PROTECT III Trial) Investigators. N Engl J Med 2014;371:2457-2466
- Skolnick. A Clinical Trial of Progesterone for Severe Traumatic Brain Injury (SYNAPSE Trial). N Engl J Med 2014; 371:2467-2476
Citicoline
Amantadine
Corticosteroids
Stroke
Blood Pressure Control
- He. Effects of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke. The CATIS Randomized Clinical Trial. JAMA 2014;311(5):479-489
- Anderson. Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage (INTERACT 2). N Eng J Med 2013;368:2355-2365
Surgery
Clot Evacuation
Decompressive Craniectomy
- Jüttler. Hemicraniectomy in Older Patients with Extensive Middle-Cerebral-Artery Stroke (Destiny II). N Engl J Med 2014;370:1091-1100
- Vahedi. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 2007;6(3):215–22.
- Jüttler. Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY). A Randomized, Controlled Trial. Stroke 2007;38:2518
- Vahedi. Sequential-Design, Multicenter, Randomized, Controlled Trial of Early Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction (DECIMAL Trial). Stroke. 2007;38:2506
Aneurysmal Subarachnoid Haemorrhage
Pharmacotherapy
Nimodipine
Magnesium Sulphate
Statins
Sedation
Sedation Breaks
- Mehta. Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol. A Randomized Controlled Trial (SLEAP study). JAMA 2012; epublished ahead of print
- Girard.Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial). Lancet 2008;371(9607):126-134 (abstract)
- Kress. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-7
Dexmedetomidine
- Shehabi. Early Sedation with Dexmedetomidine in Critically Ill Patients (SPICE III trial). N Engl J Med 2019;epublished May 19th
- Reade. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated DeliriumA Randomized Clinical Trial (DahLIA Trial). JAMA 2016;epublished March 15th
- Jakob. Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation: Two Randomized Controlled Trials. JAMA 2012;307(11):1151-1160
- Pandharipande. Effect of sedation with dexmedetomidine versus lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 2007;298:2644-53
Delirium
Pharmacotherapy
- Reade. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated DeliriumA Randomized Clinical Trial (DahLIA Trial). JAMA 2016;epublished March 15th
- Page. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respiratory Medicine 2013;epublished August 21st
- Shehabi. Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). Anesthesiology 2009;111(5):1075-1084
Epilepsy
Meningitis
Corticosteroids
Mobilisation & Rehabilitation
Mobilisation / Rehabilitation in ICU
- Schaller. Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet 2016;388(10052):1377–1388
- Schweickert. Early physical and occupational therapy in mechanically ventilated, critically ill patients: A randomised controlled trial. Lancet 2009; 373:1874–1882
Mobilisation / Rehabilitation in the Ward
- Morris. Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure. A Randomized Clinical Trial. JAMA 2016;315(24):2694-2702
- Kayambu. Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial. Intensive Care Med 2015;epublished April 8th
- Gruther. Can Early Rehabilitation on the General Ward After an Intensive Care Unit Stay Reduce Hospital Length of Stay in Survivors of Critical Illness?: A Randomized Controlled Trial. Am J Phys Med Rehabil 2017;96(9):607-615
- Jensen. A recovery program to improve quality of life, sense of coherence and psychological health in ICU survivors: a multicenter randomized controlled trial, the RAPIT study. Intensive Care Med 2016;epublished September 30th
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