Tim Walsh and Christopher Weir present the results of the A2B trial at the Critical Care Reviews Meeting 2024. Yahya Shehabi (Melbourne) delivers an editorial. Chris Nutt (Belfast) chairs a panel discussion including Deborah Cook (Hamilton), Lydia Emerson (Edinburgh), Alistair Nichol (Dublin), Ranjit Lall (Warwick) and Carol Hodgson (Melbourne).
A2B compared dexmedetomidine and clonidine-based sedation with propofol in critically ill patients.
Steve Webb and Scott Berry present the results of the REMAP-CAP steroids for non-COVID-19 severe community-acquired pneumonia domain at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
This domain of the REMAP-CAP platform trial compared a 7-day fixed hydrocortisone dose with standard care in this patient group.
The results were published in Intesive Care Medicine in April 2025.
Jeff Lipman, Dorrilyn Rajbhandari, Joel Dulhunty & Mohd (Hafiz) Abdul-Aziz present the results of the BLING III trial and associated systematic review and meta analysis at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
BLING III compared continuous with intermittent beta lactam antibiotic administration in critically ill patients with sepsis.
Giovanni Landoni and Martina Baiardo Redaelli present the results of the PROTECTION trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
PROTECTION investigates the efficacy of amino acid infusion post cardiac surgery for the prevention of acute kidney injury.
Adam Deane delivers an independent editorial and Lennie Derde chairs a panel discussion amongst Charuhas Thakar, David Harrison, Stephen Webb and Kathy Rowan.
PROTECTION was simultaneously published in the New England Journal of Medicine.
Michelle Kho and Heather O'Grady present the results of the CYCLE trial at the Critical Care Reviews Meeting 2024. CYCLE investigates the use of in-bed ergometry in the critically ill mechanically ventilated patient.
The session is chaired by Marion Campbell. Panellists include Andrew Althouse, Carol Hodgson, Kevin Gibbs and Paul Mouncey.
CYCLE was simultaneously published in NEJM Evidence.
Jonathan Casey and Kevin Gibbs present the results of the PRE-OXI trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast. PRE-OXI investigated non-invasive ventilation for preoxygenation in emergency intubation in the critically ill.
Yonathan Freund delivers an independent editorial. Catriona Kelly chairs a panel discussion with Anthony Gordon, Sheila Myatra, Victoria Cornelius and Jan Gunst.
PRE-OXI was simultaneously published in the New England Journal of Medicine.
Alexis Turgeon and Francois Lauzier (both Quebec City) present the results of the HEMOTION trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. HEMOTION compared liberal with restrictive transfusion thresholds in critically ill patients with traumatic brain injury.
The session is chaired by Catriona Kelly (Dublin). John Myburgh (Sydney) delivers an independent editorial. Anthony Gordon (London), Marion Campbell (Aberdeen), Alistair Nichol (Dublin) and Carol Hodgson (Melbourne) contribute to a panel discussion.
HEMOTION was simultaneously published in the New England Journal of Medicine.
Profs Caio Tavares and Fernando Zampieri present the results of the DEFENDER trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
DEFENDER investigated the efficacy of dapagliflozin in the critically ill.
Danny McAuley delivers an independent editorial and Christopher Seymour chairs a panel discussion between Simon Finfer, Lennie Derde, Marion Campbell and Catherine McKenzie.
Giovanni Landoni and Giacomo Monti (both Milan) present the results of the NAVIGATE trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
NAVIGATE investigated the use of early non-invasive ventilation for acute respiratory failure on the general medical wards.
Danny McAuley (Belfast) delivers the editorial. The panelists are Victoria Cornelius (London), Alexis Turgeon (Quebec City), Michelle Kho (Hamilton) and Jonathan Casey (Nashville). The session is chaired by Bronwen Connolly (Belfast).
Deborah Cook and Adam Deane present the results of the REVISE trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast.
REVISE investigates the efficacy of stress ulcer prophylaxis with pantoprazole in critically ill mechanically ventilated patients.
Kathy Rowan delivers an editorial and Darren Taichman chairs a panel discussion between David Harrison, Martina Baiardo Redaelli, Madiha Hasmi and Danny McAuley.
REVISE was simultaneously published in the New England Journal of Medicine.
Simon Finfer (Sydney) and Derick Adigbli (Melbourne) present the results of an IPDMA of intensive glucose control in the critically ill at the Critical Care Reviews Meeting 2024. Lennie Derde (Utrecht) delivers an independent editorial. Danny McAuley (Belfast) chairs the session.
This IPDMA was simultaneously published in NEJM Evidence.
Yonathan Freund (Paris) presents the NICO trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. Sheila Myatra (Mumbai) delivers an independent editorial. The session is chaired by Danny McAuley (Belfast).
The NICO trial investigated non-invasive airway management of patients comatose from acute poisoning.
Jan Gunst (Leuven) presents the TGC-FAST trial at the Critical Care Reviews Meeting 2024. Lennie Derde delivers an independent editorial. The session is chaired by Danny McAuley (Belfast).
TGC-FAST was published in the New England Journal of Medicine.
Tom Hills presents the statin domain of the REMAP-CAP platform trial at CCR24. Peter McGuigan gives an editorial on the trial. Bronwen Connolly chairs the session.
This trial was published in the New England Journal of Medicine.
Prof Kirsten Bibbins-Domingo talks about how clinical trials can be routinely integrated into clinical practice.
John Hinds Lecture
Professor Kathy Rowan delivers the 2024 John Hinds Lecture, entitled "ICNARC at 30 - Back to the Future".
CCR24 has come and gone. We hosted an amazing 11 major trial result presentations and 3 systematic reviews and meta analyses presentations. Ten of these have been published across the New England Journal of Medicine, JAMA and NEJM Evidence.
We will start to add the edited recording of these talks, both in video and audio versions, to the website over the next couple of weeks. These will be free to view as usual.
Thanks to the trialists for travelling to Belfast to present their amazing trials, our wonderful faculty for their insightful discussions, our expert audience for their contributions, the major journals for facilitating the timings of the simultaneous publications, and our sponsors for supporting us:
Special Sponsors - Visit Belfast, Belfast City Council, Tourism NI, HSC R&D Division, the Belfast trust
