Sunday 2nd

Research

Randomised Controlled Trials

• Singer. Enteral and supplemental parenteral nutrition enriched with omega-3 polyunsaturated fatty acids in intensive care patients - A randomized, controlled, double-blind clinical trial. Clin Nutr 2021;40(5):2544-2554
• Turra. Efficacy of speech therapy in post-intubation patients with oropharyngeal dysphagia: a randomized controlled trial. Codas 2021;33(2):e20190246

Systematic Reviews & Meta Analyses

• Ponnapa Reddy. Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019-A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished April 30th
• Annoni. Impact of therapeutic hypothermia during cardiopulmonary resuscitation on neurologic outcome: A systematic review and meta-analysis. Resuscitation 2021;162:365-371
  • Editorial:  Nielsen. Is the intra-arrest period the hot-spot for cooling? Resuscitation 2021;162:426-427
• Chang. Sodium bicarbonate administration during in-hospital pediatric cardiac arrest: A systematic review and meta-analysis. Resuscitation 2021;162:188-197

Observational Studies

• See. US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021. JAMA 2021;epublished April 30th
  • Editorial:  Karron. Assessing a Rare and Serious Adverse Event Following Administration of the Ad26.COV2.S Vaccine. JAMA 2021;epublished April 30th
• Hughes. Association of Delirium during Critical Illness With Mortality: Multicenter Prospective Cohort Study. Anesth Analg 2021;epublished April 30th
• Lemkes. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial. Resuscitation 2021;epublished April 28th
• Boede. Trajectories of depression in sepsis survivors: an observational cohort study. Crit Care 2021;25:161

Guidelines & Position Statements

• P-COSCA (Pediatric Core Outcome Set for Cardiac Arrest) in Children. An Advisory Statement From the International Liaison Committee on Resuscitation. Resuscitation 2021;162:351-364
• Clinical staging of accidental hypothermia: The Revised Swiss System. Recommendation of the International Commission for Mountain Emergency Medicine (ICAR MedCom). Resuscitation 2021;162:182-187

Narrative Reviews

Clinical

• Hites. Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis. Front Med 2021;8:640740
• Das. Current and Future Drug and Device Therapies for Pediatric Heart Failure Patients: Potential Lessons from Adult Trials. Children 2021;8(5):322

Editorials

• Cecconi. Diversity and inclusivity: the way to multidisciplinary intensive care medicine in Europe. Intensive Care Med 2021;epublished April 29th
• Citerio. And once the storm is over… ICM will remain the intensivist’s beacon. Intensive Care Med 2021;epublished April 28th
• Kennedy-Metz. Importance of high-performing teams in the cardiovascular intensive care unit. J Thorac Cardiovasc Surg 2021;epublished March 31st
• Husain-Syed. COVID-19: spot urine rather than bronchoalveolar lavage fluid analysis? Crit Care 2021;25(1):162

Correspondence

• Todorov. Gender differences in the provision of intensive care: a Bayesian approach. Intensive Care Med 2021;epublished April 21st
• Müller. Expanding controlled donation after the circulatory determination of death: stronger emphasis on different cultural, religious and legal backgrounds is needed. Intensive Care Med 2021;epublished April 27th
• Trahtemberg. COVID-19-associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med 2021;epublished April 30th
• Collins. A recurring case of ‘no trace, right place’ during emergency tracheal intubations in the critical care setting. Anaesthesia 2021;epublished April 19th
• Kelly. Oxygen enrichment in clinical areas using high‐flow nasal oxygen and non‐invasive respiratory support are provided. Anaesthesia 2021;epublished April 11th
• Stahl. Extracorporeal membrane oxygenation in non-intubated immunocompromised patients. Crit Care 2021;25(1):164
• Cammarota. PEEP-induced alveolar recruitment in patients with COVID-19 pneumonia: take the right time!. Crit Care 2021;25:163

Case Reports

• Schmidt. Extracorporeal Membrane Oxygenation Instead of Invasive Mechanical Ventilation in a Patient with Severe COVID-19-associated Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;epublished April 26th
• Ramos. Simultaneous Imaging of Lung Perfusion and Glucose Metabolism in COVID-19 Pneumonia. Am J Respir Crit Care Med 2021;203(9):1186–1187

News

• Rubin. How Sharing Clinical Notes Affects the Patient-Physician Relationship. JAMA 2021;325(16):1596-1598
• Dyer. Covid-19: Heavy use of oxygen brings new danger to world’s hospitals. BMJ 2021;373:n1117

Saturday 1st

Narrative Reviews

Clinical

• Moore. Trauma-induced coagulopathy. Nat Rev Dis Primers 2021;7(1):30
• Torres. Pneumonia. Nat Rev Dis Primers 2021;7:25
• Takla. General anaesthesia in end‐of‐life care: extending the indications for anaesthesia beyond surgery. Anaesthesia 2021;epublished April 20th
• Maritz. Palliative medicine in intensive care unit during a pandemic. Lung India 2021;38:258-62
• Murali. Orbital compartment syndrome: Pearls and pitfalls for the emergency physician. JACEP Open 2021;2:e12372
• Mastitskaya. Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease. Front Neurosci 2021;15:667036

Friday 30th

Research

Randomised Controlled Trials

• RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet 2021;397(10285):1637-1645
• Commentary:  Gupta. Tocilizumab in COVID-19: some clarity amid controversy. Lancet 2021;397(10285):1599-1601
• Küçük. The effect of preemptive airway pressure release ventilation on patients with high risk for acute respiratory distress syndrome: a randomized controlled trial. Braz J Anesthesiol. 2021 Apr 24:S0104-0014(21)00163-9
• Riishede. Point-of-care ultrasound of the heart and lungs in patients with respiratory failure: a pragmatic randomized controlled multicenter trial. Scand J Trauma Resusc Emerg Med 2021;29(1):60
• Kluger. Steroids to reduce the impact on delirium (STRIDE): a double‐blind, randomised, placebo‐controlled feasibility trial of pre‐operative dexamethasone in people with hip fracture. Anaesthesia 2021;epublished April 25th

Systematic Reviews & Meta Analyses

• Arango-Granados. Impact of red blood cell transfusion on oxygen transport and metabolism in patients with sepsis and septic shock: a systematic review and meta-analysis. Rev Bras Ter Intensiva 2021;33(1):154-166
• Jayasimhan. Cardiac biomarkers in acute respiratory distress syndrome: a systematic review and meta-analysis. J Intensive Care 2021;9:36
• Yasuda. Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis. J Intensive Care 2021;9:32
• Almuwallad. The impact of prehospital TXA on mortality among bleeding trauma patients: A systematic review and meta-analysis. J Trauma Acute Care Surg 2021;90(5):901-907
• Zuo. Thrombolytic therapy for pulmonary embolism. Cochrane Database Syst Rev 2021;4:CD004437
• Bhatt. Early versus Late Initiation of Renal Replacement Therapy: Have We Reached the Consensus? An Updated Meta-Analysis. Nephron 2021;epublished April 29th
• Tleyjeh. Efficacy and safety of tocilizumab in COVID-19 patients: A living systematic Review and meta-analysis: first update. Clin Microbiol Infect 2021;epublished April 26th

Observational Studies

• Carlton. Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome. J Crit Care 2021;64:160-164
• Benichou. Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial. Ann Intensive Care 2021;11:56
• Delorey. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature 2021;epublished April 29th

Thursday 29th

Guidelines & Position Statements

• Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021. Annals of Intensive Care 2021;11:66
• Chalmers. Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline. Eur Respir J 2021;57(4)
• AARC Clinical Practice Guideline: Management of Adult Patients with Tracheostomy in the Acute Care Setting. Respir Care 2021;66(1):156-169
• Management of Congenital Diaphragmatic Hernia Treated With Extracorporeal Life Support: Interim Guidelines Consensus Statement From the Extracorporeal Life Support Organization. ASAIO J 2021;67(2):113-120
• First Brazilian recommendation on physiotherapy with sensory motor stimulation in newborns and infants in the intensive care unit. Rev Bras Ter Intensiva 2021;33(1):12-30

Wednesday 28th

Reviews

Clinical

• Angriman. Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context. Lancet Respir Med 2021;epublished April 27th
• Yang. Coronavirus diseases 2019 and kidney injury: a brief review based on current evidence. Chin Med J 2021;134(8):993–995
• Lim. Practical considerations for the operative team in performing tracheostomy during the COVID-19 pandemic. Singapore Med J 2021;62(4):204-206
• Powell. Non-alcoholic fatty liver disease. Lancet 2021;epublished April 21st
• Selewski. Continuous renal replacement therapy in patients treated with extracorporeal membrane oxygenation. Seminars in Dialysis 2021;epublished March 25th

Commentaries

• Kadakia. Leveraging Open Science to Accelerate Research. N Engl J Med 2021;384:e61
• Perkis. Challenges in acute care surgery: penetrating vertebral artery injury in ‘extremis’ patient. Trauma Surgery & Acute Care Open 2021;6:e000684
• Cohn. Update in perioperative cardiac medicine 2021. Cleve Clin J Med 2021;88(4):216-220
• Badley. The Yin and Yang of SARS-CoV-2 Mutation and Evolution. Mayo Clin Proc 2021;96(4):863-865
• Dominelli. The Oxygen Cascade During Exercise in Health and Disease. Mayo Clin Proc 2021;96(4):1017-1032

Tuesday 27th

Editorials

• Peters. A COASTal view: where prior beliefs and uncertainty collide. Intensive Care Med 2021;epublished April 27th
• Kanthimathinathan. Paediatric intensive care challenges caused by indirect effects of the COVID-19 pandemic. Intensive Care Med 2021;epublished April 27th

Commentaries

• Matthay. The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included? Lancet Respir Med 2021;epublished April 26th

Correspondence

• Kamata. Why participation in an international clinical trial platform matters during a pandemic? Launching REMAP-CAP in Japan. J Intensive Care 2021;9:34
• Goligher. Post-Extubation Respiratory Support: Of Clinical Trials and Clinical Decisions. Am J Respir Crit Care Med 2021;epublished April 26th
• Müller. Expanding controlled donation after the circulatory determination of death: stronger emphasis on different cultural, religious and legal backgrounds is needed. Intensive Care Med 2021;epublished April 27th

Monday 26th

Narrative Reviews

Clinical

• Miller. FUSIC HD. Comprehensive haemodynamic assessment with ultrasound. JICS 2021;epublished April 23rd
• Wittenberg. Rapid development of a ventilator for use during the COVID-19 pandemic: Clinical, human factor & engineering considerations. JICS 2021;epublished April 19th
• Wood. Perioperative Management of Pulmonary Hypertension. A Review. The Journal of Critical Care Medicine 2021;7(2)
• Sady. Neuropalliative care: new perspectives of intensive care. Rev Bras Ter Intensiva 2021;33(1):146-153
• Ayoğlu. Occupational Risks for Anaesthesiologists and Precautions. Turk J Anaesthesiol Reanim 2021;49(2):93-9

Commentary

• Murthy. Incorporating Adult Evidence Into Pediatric Research and PracticeBayesian Designs to Expedite Obtaining Child-Specific Evidence. JAMA 2021;epublished April 26th

Sunday 25th

Narrative Reviews

Clinical

• Pillai. Where Does Interventional Radiology Fit in with Trauma Management Algorithm? Semin intervent Radiol 2021;38(01):003-008
• Lopera. Embolization in Trauma: Review of Basic Principles and Techniques. Semin intervent Radiol 2021;38(01):018-033
• Savioli. Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes. Medicines 2021;8(4):16
• Woodruff. Long-Term Outcomes and the Post-Intensive Care Syndrome in Critically Ill Children: A North American Perspective. Children 2021;8(4):254
• Garg. Neuroimaging Patterns in Patients with COVID-19-Associated Neurological Complications: A Review. Neurol India 2021;69:260-71
• Gavelli. Management of sepsis and septic shock in the emergency department. Intern Emerg Med 2021;epublished April 22nd
• Rousseau. Endovascular therapies for pulmonary embolism. Heliyon 2021;7(4):e06574
• Ruf. Roles of factor Xa beyond coagulation. J Thromb Thrombolysis 2021;epublished April 24th
• MacLeod. Chronic obstructive pulmonary disease exacerbation fundamentals: Diagnosis, treatment, prevention and disease impact. Respirology 2021;epublished April 24th

Saturday 24th

Research

Randomised Controlled Trials

• François. Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial. Lancet Infect Dis 2021;epublished April 21st
• Engelter. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial. Lancet Neurology 2021;20(5):341-350
• Zhao. Effects of erector spinae plane block and retrolaminar block on analgesia for multiple rib fractures: a randomized, double-blinded clinical trial. Braz J Anesth 2021;epublished April 22nd
• Georgevici. Negative drift of sedation depth in critically ill patients receiving constant minimum alveolar concentration of isoflurane, sevoflurane, or desflurane: a randomized controlled trial. Crit Care 2021;25:141
• Darazam. Role of interferon therapy in severe COVID-19: the COVIFERON randomized controlled trial. Sci Rep 2021 Apr 13;11(1):8059
• El-Nawawy. Outcome of Early Hemostatic Intervention in Children With Sepsis and Nonovert Disseminated Intravascular Coagulation Admitted to PICU: A Randomized Controlled Trial. Pediatr Crit Care Med 2021;22(3):e168-e177

Systematic Reviews & Meta Analyses

• Cioffi. The incidence of the Refeeding Syndrome. A systematic review and meta-analyses of literature. Clin Nutrition 2021;epublished April 21st
• Owen. Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis. Crit Care 2021;25:146
• Chaudhuri. Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis. Intensive Care Med 2021;epublished April 19th
• Yang. High-flow nasal cannula for acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. Heart Lung 2021;50(2):252-261
• Dmytriw. Outcomes of acute respiratory distress syndrome in COVID-19 patients compared to the general population: A systematic review and meta-analysis. Expert Rev Respir Med 2021;epublished April 21st
• Wang. The use of non-invasive ventilation in COVID-19: A systematic review. J Infect Dis 2021;106:254-261

Observational Studies

• Mac Sweeney. Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome. Thorax 2021;epublished April 22nd
• Jung. The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study. Crit Care 2021;25:149
• Madotto. Death in hospital following ICU discharge: insights from the LUNG SAFE study. Crit Care 2021;25:144
• Dauger. Necrotizing soft-tissue infections in pediatric intensive care: a prospective multicenter case-series study. Crit Care 2021;25:139
• Lebreton. Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study. Lancet Respir Med 2021;epublished April 19th
  • Commentary:  Lorusso. COVID-19 and ECMO: a call for close cooperation and more investigation. Lancet Respir Med 2021;epublished April 19th
• Fung. Electrographic Seizures and Outcome in Critically Ill Children. Neurology 2021;epublished April 23rd

Friday 23rd

Narrative Reviews

Clinical

• Bhaskar. Use of ECMO for Cardiogenic Shock in Pediatric Population. J Clin Med 2021:10(8):1573
• Darden. Dysregulated Immunity and Immunotherapy after Sepsis. J Clin Med 2021;10(8):1742
• Barker. Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness. J Clin Med 2021;10(8):1693
• Kennouche. Bedside voluntary and evoked forces evaluation in intensive care unit patients: a narrative review. Crit Care 2021;25:157
• Dwivedi. Pulmonary Hypertension in Association with Lung Disease: Quantitative CT and Artificial Intelligence to the Rescue? State-of-the-Art Review. Diagnostics 2021;11(4):679
• Rosano. Ultrasound of Small Bowel Obstruction: A Pictorial Review. Diagnostics 2021;11(4):617
• Nogueira. Cerebral Autoregulation in Ischemic Stroke: From Pathophysiology to Clinical Concepts. Brain Sci 2021;11(4):511
• Lade. Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus. Antibiotics 2021;10(4):398
• Kakoullis. Mechanisms of Antibiotic Resistance in Important Gram-Positive and Gram-Negative Pathogens and Novel Antibiotic Solutions. Antibiotics 2021;10(4):415
• Dreucean. Approach to Sedation and Analgesia in COVID-19 Patients on Venovenous Extracorporeal Membrane Oxygenation. Ann Pharmacother 2021;epublished April 22nd

Thursday 22nd

Commentaries

• Vincent. Addressing gender imbalance in intensive care. Crit Care 2021;25:147
• Hess. Loss of a Legend: Remembering Robert M. Kacmarek. Respir Care 2021;epublished April 21st
• Upadhye. VICE raises the GRADE: recommendations for CAEP clinical practice guidelines. Can J Emerg Med 2021;epublished April 20th
• McDermott. Remote Research and Clinical Trial Integrity During and After the Coronavirus Pandemic. JAMA 2021;epublished April 22nd
• Zider. Start With All the Little Things. JAMA 2021;325(15):1509-1510

Correspondence

• Dodd. Platform Trials — Beware the Noncomparable Control Group. N Engl J Med 2021; 384:1572-1573
• Eisenga. Iron Deficiency Defined by Hepcidin in Critically Ill Patients. Crit Care 2021;25:138
• Abraham. Trauma patients do not benefit from a viscoelastic haemostatic assay-guided protocol, but why? Intensive Care Med 2021;epublished April 15th
• Various. Cytokine Storm. N Engl J Med 2021;384:e59
• Various. Emergency Intubation in Covid-19. N Engl J Med 2021;epublished April 21st

Wednesday 21st

Editorials

• Wicky. Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact?. Crit Care 2021;25:153

Study Critiques

• Cheskes. Is there a role for ECMO-facilitated resuscitation for the management of out-of-hospital cardiac arrest (OHCA) with refractory ventricular fibrillation (VF)?. Can J Emerg Med 2021;epublished April 22nd

Case Reports

• Evangelista. Renal pyonephrosis with massive pleural empyema. Intensive Care Med 2021;epublished April 19th
• Meyer. Pericardial effusion, cardiomegaly, oedema, and IgA deficiency in a child: coeliac disease. Lancet 2021;397(10284):1576

Tuesday 20th

Guidelines & Position Statements

• Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure. Liver Research 2021;epublished April 20th
• Donato. Consensus for the management of analgesia, sedation and delirium in adults with COVID-19-associated acute respiratory distress syndrome. Rev Bras Ter Intensiva 2021;33(1):48-67

Monday 19th

Narrative Reviews

Clinical

• Natt. Airway Management in the Critically Ill Patient. Current Anesthesiology Reports 2021;epublished April 19th 
• Singh. High-Flow Nasal Cannula, a Boon or a Bane for COVID-19 Patients? An Evidence-Based Review. Current Anesthesiology Reports 2021;epublished March 2nd
• Tran. Point-of-Care Ultrasound: Applications in Low- and Middle-Income Countries. Current Anesthesiology Reports 2021;11:69–75
• Shah. Distance-Learning Initiatives Targeting Non-physician Anesthesia Providers in Low-Resource Environments. Current Anesthesiology Reports 2021;11:64–68
• Ludes. Role of Damage-Associated Molecular Patterns in Septic Acute Kidney Injury, From Injury to Recovery. Front Immunol 2021;12:606622
• Serifis. Machine Perfusion of the Liver: A Review of Clinical Trials. Front Surg 2021;8:625394

Pre-Clinical

• Reynolds. Preclinical Research Reporting in Shock: Room for Improvement. Shock 2021;55(5):573-580

Sunday 18th

Research

Randomised Controlled Trials

• Wong. Randomized Controlled Trial of a Novel Communication Device Assessed During Noninvasive Ventilation Therapy. 1531-1539

Observational Studies

• Zeitouni. Clinical Outcomes According to ECG Presentations in Infarct-Related Cardiogenic Shock in the Culprit Lesion Only PCI vs Multivessel PCI in Cardiogenic Shock Trial. Chest 2021;159(4):1415-1425
  • Editorial:  Fefer. In Non-STEMI, Go for the Culprit. Chest 2021;159(4):1319-1320
• Laupland. Decreasing Case-Fatality But Not Death Following Admission to ICUs in Australia, 2005-2018. Chest 2021;159(4):1503-1506

Case Reports

• Durrance. In Every “Vasoplegic” Patient, Don’t Ignore the Octopus in the Room. Chest 2021;159(4):e277-e279
• Fryman. A Patient With Coronavirus Disease 2019 Pneumonia and Sudden Decompensation While Receiving Mechanical Ventilatory Support. Chest 2021;159(4):e281-e283
• Gorbatov. A 58-Year-Old Man With Coronavirus Disease 2019 Pneumonia and Undifferentiated Shock. Chest 2021;159(4):e285-e288
• Rali. Refractory Hypoxemia Despite Extracorporeal Membrane Oxygenation. Point-of-Care Ultrasound Is Needed for Patients With COVID-19. Chest 2021;159(4):e289-e291
• Axiotakis. Laryngeal Injury Due to Amikacin Inhalation for Refractory Mycobacterium avium Complex Infection. Chest 2021;159(4):e185-e187
• Tatah. A Case Report of Portopulmonary Hypertension Precipitated by Transjugular Intrahepatic Portosystemic Shunt. Chest 2021;159(4):e193-e196
• Fong. A 27-Year-Old Man With Persistent Breathlessness After an Inhalational Injury. Chest 2021;159(4):e197-e201
• Tendolkar. Eosinophilic Pleural Effusion in a Young Woman With Pleural Nodularity and Lytic Skeletal Lesions. Chest 2021;159(4):e203-e208
• Pappas. A 27-Year-Old Man With Intermittent Chest Pain During the Last 4 Years. Chest 2021;159(4):e209-e214
• Abdalla. A Woman in Her Late 40s with Hypersensitivity Pneumonitis and Recurrent Pleural Effusions. Chest 2021;159(4):e215-e219
• Kattih. A 54-Year-Old Man With Chronic Cough and Recurrent Upper Respiratory Infection. Chest 2021;159(4):e221-e224
• Ucar. A 19-Year-Old-Woman With Backache, Hemoptysis, and Hypereosinophilia. Chest 2021;159(4):e231-e235
• Oppegard. A 44-Year-Old Man Presenting With Massive Hemoptysis and Dyspnea. Chest 2021;159(4):e237-e241
• Nakwan. A 43-Year-Old Man With Rapidly Respiratory Failure and Spontaneous Massive Hemothorax. Chest 2021;159(4):e243-e246
• Roy. A 44-Year-Old Woman With a 10-Year History of Dyspnea and Pulmonary Nodules. Chest 2021;159(4):e247-e250
• Stern. A 51-Year-Old Woman With Rapidly Progressive Dyspnea. Chest 2021;159(4):e251-e255
• Homsy. A 26-Year-Old Woman With Dyspnea on Exertion. Chest 2021;159(4):e257-e260
• Ido. Shortness of Breath in a 38-Year-Old Woman With Pulmonary and Hepatic Nodules. Chest 2021;159(4):e261-e266
• Benzaquen. Women Presenting With Asthma and Persistent Wheezing. A Case Series. Chest 2021;159(4):e267-e275

Correspondence

• Rothrock. Mortality Benefit Inconclusive, Based on This Review. Chest 2021;159(4):1676-1677
  • Zasowski. Response. Chest 2021;159(4):1677-1678
• Hong. Immortal Time Bias in Comparing Late vs Early Intubation in Patients With Coronavirus Disease 2019. Chest 2021;159(4):1679-1680
• Trisolini. Finding an Evidence-Based and Clinically Important Role for BAL in the Setting of Suspected SARS-Cov-2 Infection. Chest 2021;159(4):1680-1681
  • Hamed. Response. Chest 2021;159(4):1681-1682
• Lellouche. Decrease Dead Space Prior to Calling the ECMO! Chest 2021;159(4):1682-1683
  • Bullen. Response. Chest 2021;159(4):1684
• Pal. Sepsis-Induced Myocardial Dysfunction. “Right Ventricular Dysfunction” or “Biventricular Dysfunction”? Chest 2021;159(4):1684-1685
  
  • Lanspa. Response. Chest 2021;159(4):1685-1686
• John. Do Not Forget Daptomycin as a Cause of Eosinophilic Pneumonia! Chest 2021;159(4):1687-1688
  
  • Rosenberg. Response. Chest 2021;159(4):1688

Narrative Reviews

Clinical

• Szpilman. Management for the Drowning Patient. Chest 2021;159(4):1473-1483
• Chaudhuri. Dosing Fluids in Early Septic Shock. Chest 2021;159(4):1493-1502
• Garros. How Can I Survive This? Coping During Coronavirus Disease 2019 Pandemic. Chest 2021;159(4):1484-1492

Commentary

• Han. Improving Diversity in Activities of Critical Care Societies. Chest 2021;159(4):1334-1337

Saturday 17th

Guidelines & Position Statements

• Werdan. Infarction-Related Cardiogenic Shock— Diagnosis, Monitoring and Therapy. A German-Austrian S3 guideline. Dtsch Arztebl Int 2021;118:88-95
• Page. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. J Clin Epi 2021;epublished March 28th
• Diagnosis and Evaluation of Hypersensitivity Pneumonitis: CHEST Guideline and Expert Panel Report. Chest 2021;epublished April 13th
• Diagnosis and Evaluation of Hypersensitivity Pneumonitis: CHEST Guideline and Expert Panel Report − Executive Summary. Chest 2021;epublished April 15th

Narrative Reviews

Clinical

• McElvaney. Interleukin-6: obstacles to targeting a complex cytokine in critical illness. Lancet Respir Med 2021;epublished April 16th
• Sethi. Pediatric acute kidney injury: new advances in the last decade. Kidney Res Clin Pract 2021;40(1):40–51
• Kaptein. Pulmonary infarction in acute pulmonary embolism. Thromb Res 2021;202:162-169
• Loftus. Cardiovascular and RenalDisease in Chronic Critical Illness. J Clin Med 2021:10:1601
• Pantzaris. "The use of electroencephalography in patients with sepsis: A review of the literature" J Transl Int Med 2021;9(1):12-16

Editorials

• White. Rehabilitation after critical illness. BMJ 2021;epublished April 15th
• Bourgault. Time to Train More Critical Care Nurses: Supporting Our New Colleagues. Crit Care Nurse 2021;41(2):8–10
• Wu. "Potential new therapeutic intervention for ischemic stroke" J Transl Int Med 2021;9(1):1-3
• Yang. "From critical care nephrology to critical care blood purification" J Transl Int Med 2021;9(1):4-7

Commentaries

• Gorman. Non-invasive respiratory support strategies in COVID-19. Lancet Respir Med 2021;epublished April 16th
• Lippi. How will emerging SARS-CoV-2 variants impact herd immunity? Ann Transl Med 2021;9(7):585
• Christman. Can acute respiratory distress syndrome be treated? Future Med Chem 2021;13(8):687-690
• MacDonald. Fear and insight in the ICU bed. Intensive Care Med 2021;epublished April 15th
• Shiham. Journal club. Thorax 2021;76:526
• Gong. "ACEI/ARB drug therapy in COVID-19 patients: Yes or no?" J Transl Int Med 2021;9(1):8-11

Friday 16th

Research

Randomised Controlled Trials

• Rickard. Effect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (central venous access device)–non-inferiority (peripheral arterial catheter) trial. Lancet 2021;397(10283):1447-1458
• Sehgal. A randomized trial of Mycobacterium w in severe presumed Gram-negative sepsis (MIST). Chest 2021;epublished April 11th
• Broch. Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol 2021;77(15):1845-1855
  

Systematic Reviews & Meta Analyses

• Aitken. Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis. Thorax 2021;epublished April 15th
• Taeuber. Association of Intravenous Tranexamic Acid With Thromboembolic Events and MortalityA Systematic Review, Meta-analysis, and Meta-regression. JAMA Surg 2021;epublished April 14th
• Naorungroj. Time to Initiation of Renal Replacement Therapy Among Critically Ill Patients With Acute Kidney Injury: A Current Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished April 5th
  

Observational Studies

• Kurtz. Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months. Intensive Care Med 2021;epublished April 14th
• Perkins. Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT. Health Technol Assess 2021;25(25):1-166
• Curtis. Validation of the factors influencing family consent for organ donation in the UK. Anaesthesia 2021;epublished April 16th
• Hall. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN). Lancet 2021;397(10283):1459-1469
  

Case Reports

• Bayas. Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination. Lancet 2021;epublished April 14th
• Muster. Pulmonary embolism and thrombocytopenia following ChAdOx1 vaccination. Lancet 2021;epublished April 14th
• Thomas. Iatrogenic subclavian artery cannulation: Implications and management. Indian J Vasc Endovasc Surg 2021;8:190-1
• Ebrahimpour. Hemothorax: a rare presentation of COVID-19. Minerva Respiratory Medicine 2021 March;60(1):16-9
• Bertha. An Uncommon Cause of Hematemesis. Clin Liver Disease 2021;17(3):174-179
• Noro. COVID-19 and Posterior Reversible Encephalopathy Syndrome. Neurol Clin Pract Apr 2021;11(2):e202-e204
• Morvan. Fatal Necrotizing Encephalitis Associated With COVID-19. Neurol Clin Pract Apr 2021;11(2):e214-e215

Thursday 15th

Narrative Reviews

Clinical

• Ferstl. Acute Decompensation and Acute-on-Chronic Liver Failure. Clin Liver Dis 2021;25(2):419-430
• Bochnakova. Hepatic Venous Pressure Gradient. Clin Liver Disease 2021;17(3):144-148
• Zhong. Application and outlook of topical hemostatic materials: a narrative review. Ann Transl Med 2021;9(7):577
• Paveli ́c. A Perspective on COVID-19Management. J Clin Med 2021;10:1586

Annals of Translational Medicine series on Inhaled Therapy

• Editorial:  Luo. Demystifying medical aerosols in acute and critical care. Ann Transl Med 2021;9(7):587
• Saeed. Aerosol delivery via noninvasive ventilation: role of models and bioanalysis. Ann Transl Med 2021;9(7):589
• Li. Narrative review of practical aspects of aerosol delivery via high-flow nasal cannula. Ann Transl Med 2021;9(7):59
• Dailey. Review of aerosol delivery in the emergency department. Ann Transl Med 2021;9(7):591
• O’Toole. Fugitive aerosols in the intensive care unit: a narrative review. Ann Transl Med 2021;9(7):592
• Ari. A path to successful patient outcomes through aerosol drug delivery to children: a narrative review. Ann Transl Med 2021;9(7):593
• Clark. Essentials for aerosol delivery to term and pre-term infants. Ann Transl Med 2021;9(7):594
• Corcoran. Measurements of deposited aerosol dose in infants and small children. Ann Transl Med 2021;9(7):595
• Ke. Administration of dry powders during respiratory supports. Ann Transl Med 2021;9(7):596
• Liu. Inhaled pulmonary vasodilators: a narrative review. Ann Transl Med 2021;9(7):597
• Desgrouas. Inhaled antibiotics during mechanical ventilation—why it will work. Ann Transl Med 2021;9(7):598

Wednesday 14th

Narrative Reviews

Clinical

Annals of Translational Medicine series on Heart Failure Update and Advances in 2021

• Espinoza. Updates in pharmacotherapy of heart failure with reduced ejection fraction. Ann Transl Med 2021;9(6):516
• Suri. Optimal diuretic strategies in heart failure. Ann Transl Med 2021;9(6):517
• Cruz Rodriguez. Narrative review in the current role of angiotensin receptor-neprilysin inhibitors. Ann Transl Med 2021;9(6):518
• Cruz Rodriguez. Management of left ventricular thrombus: a narrative review. Ann Transl Med 2021;9(6):520
• Loyaga-Rendon. Antiplatelet and anticoagulation strategies for left ventricular assist devices. Ann Transl Med 2021;9(6):521
• Pirlamarla. Pulmonary vasodilator use in continuous-flow left ventricular assist device management. Ann Transl Med 2021;9(6):522
• Alejandro Paz. Narrative review: the holy grail: update on pharmacotherapy for heart failure with preserved ejection fraction. Ann Transl Med 2021;9(6):523

Tuesday 13th

Narrative Reviews

Clinical

• Rüdiger. Thrombocytopenia and Hemostatic Changes in Acute and Chronic Liver Disease: Pathophysiology, Clinical and Laboratory Features, and Management. J Clin Med 2021;10(7):1530
• Keshavamurthy. Donation after circulatory death (DCD)—lung procurement. Indian J Thorac Cardiovasc Surg 2021;epublished April 1st
• Pesce. Glomerulonephritis in AKI: From Pathogenesis to Therapeutic Intervention. Front Med 2021;7:582272
• Marinho. Perioperative hyperfibrinolysis—physiology and pathophysiology. Braz J Anesthesiol 2021;71(1):65-75
• Guo. The Immune System in Transfusion-Related Acute Lung Injury Prevention and Therapy: Update and Perspective. Front Mol Biosci 2021;8:639976
• Mazzeffi. COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management. Shock 2021;55(4):465-47
• Kearney. Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials. Adv Ther 2021;epublished April 12th

Commentary

• Adashi. Industry-Sponsored Speaker Programs—End of the Line? JAMA 2021;epublished April 12th

Multimedia

Audio

• Bagian. Space Travel and Human Health, Part 1: James Bagian, MD. JAMA 2021;epublished April 6th
• Auñón-Chancellor. Effect of Space Travel on Human Health, Part 2. JAMA 2021;epublished April 13th

Monday 12th

Research

Randomised Controlled Trials

• Cremer. Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial. Lancet Rheumatol 2021;epublished March 17th

Observational Studies

• Chang. Evaluation of Time-Limited Trials Among Critically Ill Patients With Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments. JAMA Intern Med 2021;epublished April 12th
  • Editorial:  Leiter. Time-Limited Trials and Potentially Nonbeneficial Treatment in the ICU—Willing to Wait for It. JAMA Intern Med 2021;epublished April 12th
• Martínez. Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis. J Hepatol 2021;epublished April 9th

Guidelines & Position Statements

• Song. Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy. Mil Med Res 2021;8(1):25

Editorials

• Bartlett. Extracorporeal membrane oxygenation. Indian J Thorac Cardiovasc Surg 2021;epublished April 12th
• Pooboni. ECMO: an evolving chapter. Indian J Thorac Cardiovasc Surg 2021;epublished April 5th
• Yadava. Extracorporeal membrane oxygenation—a moving target. Indian J Thorac Cardiovasc Surg 2021;epublished April 5th
• Sunder. Extracorporeal membrane oxygenation—the good, the bad and the ugly (for want of a “few dollars more”): and would “a fistful of dollars” make any difference?. Indian J Thorac Cardiovasc Surg 2021;epublished March 29th

Sunday 11th

Research

Randomised Controlled Trials

• Faqihi. Therapeutic plasma exchange in patients with life-threatening COVID-19: a randomized control clinical trial. Int J Antimicrob Agents 2021;epublished April 7th

Systematic Reviews & Meta Analyses

• Lv. Efficacy and safety of methylprednisolone against acute respiratory distress syndrome: A systematic review and meta-analysis. Medicine 2021;100(14):e25408
• Yasuda. Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis. Crit Care 2021;25:135
• Garcia. A systematic review and meta-analysis of propofol versus midazolam sedation in adult intensive care (ICU) patients. J Crit Care 2021;64:91-99
• Tharmarajah. IL-6 inhibition in the treatment of COVID-19: A meta-analysis and meta-regression. J Infect 2021;epublished March 18th
• Wieczorek. Efficacy of Targeted Temperature Management after Pediatric Cardiac Arrest: A Meta-Analysis of 2002 Patients. J Clin Med 2021;10(7):1389
• Nelson. A Systematic Review of Anticoagulation Strategies for Patients With Atrial Fibrillation in Critical Care. Thromb Haemost 2021;epublished April 8th

Observational Studies

• Greinacher. Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. N Engl J Med 2021;epublished April 9th
• Schultz. Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021;epublished April 9th
• Duprey. Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain. Am J Respir Crit Care Med 2021;epublished April 9th
• Koning. Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients. Intensive Care Med 2021;epublished April 9th

Saturday 10th

Narrative Reviews

Clinical

• Chotirmal. Update in COVID-19. AM J Respir Crit Care Med 2021;epublished April 8th
• Huang. The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review. BMC Pulm Med 2021;21(1):116
• Gameiro. Long-term consequences of acute kidney injury: a narrative review. Clin Kid J 2021;14(3):789–804
• Kiss. Management of COVID-19-associated multisystem inflammatory syndrome in children: A comprehensive literature review. Prog Pediatr Cardiol 2021;epublished April 9th
• Nagueh. Heart failure with preserved ejection fraction: insights into diagnosis and pathophysiology. Cardiovascular Research 2021;117(4):999–1014
• Lavalle. Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias. J Clin Med 2021;10(7):1456
• Almaani. ANCA-Associated Vasculitis: An Update. J Clin Med 2021;10(7):1446
• Palmisano. Acute Kidney Injury (AKI) before and after Kidney Transplantation: Causes, Medical Approach, and Implications for the Long-Term Outcomes. J Clin Med 2021;10(7):1484

Correspondence

• Abou-Arab. Comments on “Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness”: which parameter to assess right ventricular failure and venous congestion?. Crit Care 2021;25:136

Audio

• Rubin. Audio Interview: Antibody Responses to Natural Infection and Vaccination. N Engl J Med 2021;384:e65

Friday 9th

Guidelines & Position Statements

• Infectious Diseases Society of America Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa). Clin Infect Dis 2021;72(7):1109–1116
• Gandhi. Patient blood management in India - Review of current practices and feasibility of applying appropriate standard of care guidelines. A position paper by an interdisciplinary expert group. J Anaesthesiol Clin Pharmacol 2021;37:3-13
• American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2. Arthritis Rheumatol 2021;73(4):e13-e29

Thursday 8th

Narrative Reviews

Clinical

• Gupta. Evolution of videolaryngoscopy in pediatric population. J Anaesthesiol Clin Pharmacol 2021;37:14-27
• Kalopita. Ketamine-induced neurotoxicity in neurodevelopment: A synopsis of main pathways based on recent in vivo experimental findings. J Anaesthesiol Clin Pharmacol 2021;37:37-42
• Ahuja. Artificial Intelligence and technology in COVID Era: A narrative review. J Anaesthesiol Clin Pharmacol 2021;37:28-34
  • Editorial:  Garg. Emerging role of artificial intelligence in medical sciences—Are we ready!. J Anaesthesiol Clin Pharmacol 2021;37:35-6

Wednesday 7th

Research

Randomised Controlled Trial

• Zhu. Nasal High-Frequency Oscillatory Ventilation in Preterm Infants with Moderate Respiratory Distress Syndrome: A Multicenter Randomized Clinical Trial. Neonatology 2021 epublished April 7th

Systematic Review & Meta Analysis

• Nikolaou. A systematic review and meta-analysis of the effect of routine early angiography in patients with return of spontaneous circulation after Out-of-Hospital Cardiac Arrest. Resuscitation 2021;epublished April 7th

Observational Studies

• Duan. A 5G-powered robot-assisted teleultrasound diagnostic system in an intensive care unit. Crit Care 2021;25:134 
• Pijl. FDG-PET/CT in intensive care patients with bloodstream infection. Crit Care 2021;25:133
• Angel. Percutaneous Dilational Tracheostomy for Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation. Crit Care Med 2021;epublished April 8th
• Fiest. Long-Term Outcomes in Intensive Care Unit Patients with Delirium: A Population-Based Cohort Study. Am J Respir Crit Care Med 2021;epublished April 6th
• Diaz. ECMO for COVID-19-Associated Severe ARDS in Chile: A Nationwide Incidence and Cohort Study. Am J Respir Crit Care Med 2021;epublished April 6th
• Belay. Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic. JAMA Pediatr 2021;epublished April 6th
  • Editorial:  Blumenthal. Epidemiology of Multisystem Inflammatory Syndrome in Children. A Step Closer to Understanding Who, Where, and When. JAMA Pediatr 2021;epublished April 6th
• Goulden. Association of Intravenous Radiocontrast With Kidney Function. A Regression Discontinuity Analysis. JAMA Intern Med 2021;epublished April 5th

Commentary

• Sasisekharan. Preparing for the Future — Nanobodies for Covid-19? N Engl J Med 2021;epublished April 7th

Tuesday April 6th

Editorial

• Bose. Beyond survival: identifying what matters to survivors of critical illness. Crit Care 2021;25(1):129

Correspondence

• Dabrowski. The prone position must accommodate changes in IAP in traumatic brain injury patients. Crit Care 2021;25:132
• Hirota. Anaesthesia-related drugs and SARS-CoV-2 infection. Br J Anaesth 2021;epublished April 5th
• Smith. Pre‐oxygenation using high‐flow nasal oxygen vs. tight facemask during rapid sequence induction. Anaesthesia 2021;epublished April 7th
• Moyo-Gwete. Cross-Reactive Neutralizing Antibody Responses Elicited by SARS-CoV-2 501Y.V2 (B.1.351). N Engl J Med 2021;epublished April 7th
• Shen. Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351. N Engl J Med 2021;epublished April 7th

Monday April 5th

Research

Systematic Reviews & Meta Analyses

• Saha. Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis. Br J Anaesth 2021;epublished April 1st
• Price. Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery: a systematic review and expert consensus statement. Br J Anaesth 2021;126(4):774-790

Observational Studies

• Disma. Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study. Br J Anaesth 2021;epublished March 31st
• Sanders. Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study. Br J Anaesth 2021;126(4):791-798
• Phan. Effect of fluid strategy on stroke volume, cardiac output, and fluid responsiveness in adult patients undergoing major abdominal surgery: a sub-study of the Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) trial. Br J Anaesth 2021;126(4):818-825

Narrative Review

Non-Clinical

• Doleman. Methodologies for systematic reviews with meta-analysis of randomised clinical trials in pain, anaesthesia, and perioperative medicine. Br J Anaesth 2021;126(4):903-911

Commentary

• Pearce. Making the grade: has Cormack and Lehane grading stood the test of time? Anaesthesia 2021;epublished April 2nd

Sunday April 4th

Research

Randomised Controlled Trials

• Abraham. Trial of Furosemide to Prevent Acute Kidney Injury in Critically Ill Children: A Double-Blind, Randomized, Controlled Trial. Indian J Pediatr 2021;epublished April 2nd

Observational Studies

• Ahmad. The Leading Causes of Death in the US for 2020. JAMA 2021;epublished March 31st
• Woolf. Excess Deaths From COVID-19 and Other Causes in the US, March 1, 2020, to January 2, 2021. JAMA 2021;eublished April 2nd
  • Editorial:  Garber. Learning From Excess Pandemic Deaths. JAMA 2021;epublished April 2nd
• Bharat. Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries. Lancet Respir Med 2021;epublished March 31st
• Descamps. Anti-Xa activity and hemorrhagic events under extracorporeal membrane oxygenation (ECMO): a multicenter cohort study. Crit Care 2021;25(1):127
• Han. Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults. Chest 2021;epublished April 2nd

Narrative Reviews

Clinical

• Ravikanth. Review of lung ultrasound findings in coronavirus disease 2019 (COVID-19): Effectiveness, applications and approach to lung ultrasound during times of a pandemic. Saudi J Anaesth 2021;15:174-8
• Xu. Nosocomial Pneumonia in the Era of Multidrug-Resistance: Updates in Diagnosis and Management. Microorganisms 2021;9(3):534
• Zhang. An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity. Viruses 2021;13(4):560
• Olicker. Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome. Children 2021;8(3):246
• Bratti. Modalities of Left Ventricle Decompression during VA-ECMO Therapy. Membranes 2021;11(3):209
• Kyriakidis. Acinetobacter baumannii Antibiotic Resistance Mechanisms. Pathogens 2021;10(3):373
• Akhter. SARS-CoV-2 Infection: Modulator of Pulmonary Embolism Paradigm. J Clin Med 2021; 10(5):1064
• Li. An update: the emerging evidence of complement involvement in COVID-19. Med Microbiol Immunol 2021;epublished April 3rd
• Matek. Optical Devices in Tracheal Intubation-State of the Art in 2020. Diagnostics 2021;11(3):575
• Awad. Mechanical circulatory support—Challenges, strategies, and preparations. J Card Surg 2021;epublished January 13th
• Sporns. Neuroimaging of Acute Intracerebral Hemorrhage. J Clin Med 2021;10(5):1086
• Yusuf. An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria. J Clin Med 2021;10(5):1068
• Hessey. Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years. Front Pediatr 2021;9:648587
• Iida. State-of-the-art methods for the treatment of severe hemorrhagic trauma: selective aortic arch perfusion and emergency preservation and resuscitation-what is next? Acute Med Surg 2021;8(1):e641

Pre-Clinical

• Lotz. Mitochondria and Pharmacologic Cardiac Conditioning-At the Heart of Ischemic Injury. Int J Mol Sci 2021;22(6):3224

Commentaries

• Marini. Intra-cycle power: is the flow profile a neglected component of lung protection?. Intensive Care Med 2021;epublished April 2nd

Correspondence

• Gaudray. Renal replacement therapy in severe COVID-19 patients: Intermittent or continuous, the ongoing debate. Anaesth Crit Care Pain Med 2021;40(2):100839
• Levy. Not All Breaths that Follow a Ventilator Cycle Are Reverse Triggering. Ann Am Thorac Soc 2021;epublished March 29th
• Shimatani. Reply: Not All Breaths that Follow a Ventilator Cycle Are Reverse Triggering. Ann Am Thorac Soc 2021;epublished March 29th
• Marmiere. The five reasons why people die of COVID-19. J Cardiothorac Vasc Anesth 2021;epublished March 31st
• van Steenkiste. Impact of structured care systems on mortality in intensive care units. Intensive Care Med 2021;epublished April 2nd

Case Reports

• Ruby. Pulmonary aspergilloma on transthoracic ultrasound. Infection 2021;epublished March 9th
• Suresh. Dichlorvos Poisoning: A Mystery Case of Distributive Shock Unraveling with Atropine. Indian J Crit Care Med 2021;25(3):337–339
• Khanoria. Re-expansion Pulmonary Edema—A Rare Entity: A Thin Line between Pulmonary and Cardiac Decompensation. Indian J Crit Care Med 2021;25(3):343–345

Saturday April 3rd

Narrative Reviews

Clinical

• Matos. Differential diagnoses of acute ground-glass opacity in chest computed tomography: pictorial essay. Einstein (São Paulo) 2021;19:eRW5772
• Armaly. Renal Manifestations of Covid-19: Physiology and Pathophysiology. J Clin Med 2021;10(6):1216
• Shah. Extra Precautions while Caring for a Suspected COVID-19 Patient in an ICU beyond PPE and Hand Hygiene. Indian J Crit Care Med 2021;25(3):331–336
• Ficial. Physiological Basis of Extracorporeal Membrane Oxygenation and Extracorporeal Carbon Dioxide Removal in Respiratory Failure. Membranes 2021;11(3):225
• Kenny. Functional Hemodynamic Monitoring With a Wireless Ultrasound Patch. 2021;35(5):1509-1515

Editorials

• Le Dorze. COVID-19 and ethics: We learn as we go. But where are we going? Anaesth Crit Care Pain Med 2021;epublished March 27th
• Manecke. Volume Responsiveness: What It Does Not Tell Us. 2021;35(5):1307-1309
• Dryer. Overview of the 2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure with Reduced Ejection Fraction. 2021;epublished March 26th
• Pisano. Indications for Tracheal Intubation in Patients With Coronavirus Disease 2019 (COVID-19). J Cardiothorac Vasc Anesth 2021;35(5):1276-1280
• Machovec. Evidence-Based Medicine in the Time of COVID: We Have a Problem. J Cardiothorac Vasc Anesth 2021;35(5):1274-1275

Friday April 2nd

Research

Randomised Controlled Trials

• Gaudry. Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial. Lancet 2021;397(10281):1293-1300
• Casey. Protocolized Post-Extubation Respiratory Support to Prevent Reintubation: A Randomized Clinical Trial. Am J Respir Crit Care Med 2021;epublished April 1st

Systematic Reviews & Meta Analyses

• Dumas. Survival in Immunocompromised Patients Ultimately Requiring Invasive Mechanical Ventilation: A Pooled Individual Patient Data Analysis. Am J Respir Crit Care Med 2021;epublished March 22nd

Observational Studies

• Woolf. Excess Deaths From COVID-19 and Other Causes in the US, March 1, 2020, to January 2, 2021. JAMA 2021;epublished April 2nd
  • Editorial:  Garber. Learning From Excess Pandemic Deaths. JAMA 2021;epublished April 2nd
• Painvin. Inter-hospital transport of critically ill patients to manage the intensive care unit surge during the COVID-19 pandemic in France. Ann Intensive Care 2021;11:54
• Schneider. Amino acids and vitamins status during continuous renal replacement therapy: An ancillary prospective observational study of a randomised control trial. Anaesth Crit Care Pain Med 2021;40(2):100813

Thursday April 1st

Narrative Reviews

European Heart JournalSeries on Mechanical Circulatory Support

• Pappalardo. STATUS QUO 2020: what have we learned so far in temporary mechanical circulatory support? Use of Impella beyond the cathlab: open issues and clinical needs. Eur Heart J 2021;23(Suppl_A):A1–A2
• Schibilsky. Cardioprotective shock management: monitoring and supportive therapies. Eur Heart J 2021;23(Suppl_A):A3–A9
• Karatolios. Managing vascular access and closure for percutaneous mechanical circulatory support. Eur Heart J 2021;23(Suppl_A):A10–A14
• Montisci. Intensive care unit management of percutaneous mechanical circulatory supported patients: the role of imaging. Eur Heart J 2021;23(Suppl_A):A15–A22
• Møller. Pump flow setting and assessment of unloading in clinical practice. Eur Heart J 2021;23(Suppl_A):A23–A26
• Belohlavek. Left ventricular unloading and the role of ECpella. Eur Heart J 2021;23(Suppl_A):A27–A34
• Bertoldi. Escalation and de-escalation of mechanical circulatory support in cardiogenic shock. Eur Heart J 2021;23(Suppl_A):A35–A40
• Bertoldi. Weaning from Impella and mobilization of Impella patients. Eur Heart J 2021;23(Suppl_A):A41–A45

Wednesday March 31st

Research

Systematic Reviews & Meta Analyses

• Kouz. Agreement between continuous and intermittent pulmonary artery thermodilution for cardiac output measurement in perioperative and intensive care medicine: a systematic review and meta-analysis. Crit Care 2021;25:125
• Lin. Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids: an updated meta-analysis of randomized clinical trials with trial sequential analysis. Crit Care 2021;25:122
• Santa Cruz. High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome. Cochrane Database Syst Rev. 2021 Mar 30;3:CD009098

Narrative Reviews

Clinical

• Greco. Artificial Intelligence in the Intensive Care Unit. Semin Respir Crit Care Med 2021;42(01):002-009
• Welker . 2021 Acute Respiratory Distress Syndrome Update, With Coronavirus Disease 2019 Focus. J Cardiothorac Vasc Anesth 2021;epublished February 27th
• Characteristics of viral pneumonia in the COVID-19 era: an update. Infection 2021;epublished March 29th

Tuesday March 30th

Narrative Reviews

Current Opinion in Pumonary Medicine series on COVID-19

• Editorial:  Niederman. Coronavirus disease 2019 (COVID-19) – advances in epidemiology, diagnostics, treatments, host-directed therapies, pathogenesis, vaccines, and ongoing challenges. Curr Opin Pulm Med 2021;27(3):141-145
• Hui. Lethal zoonotic coronavirus infections of humans – comparative phylogenetics, epidemiology, transmission, and clinical features of coronavirus disease 2019, The Middle East respiratory syndrome and severe acute respiratory syndrome. Curr Opin Pulm Med 2021;27(3):146-154
• Huggett. COVID-19 new diagnostics development: novel detection methods for SARS-CoV-2 infection and considerations for their translation to routine use. Curr Opin Pulm Med 2021;27(3):155-162
• Axiaq. The role of computed tomography scan in the diagnosis of COVID-19 pneumonia. Curr Opin Pulm Med 2021;27(3):163-168
• LaFond. Care of the postcoronavirus disease 2019 patient. Curr Opin Pulm Med 2021;27(3):199-204
• Wilson. Coronavirus disease 2019 management. Curr Opin Pulm Med 2021;27(3):169-175
• Manansala. Management of immunosuppressants in the era of coronavirus disease-2019. Curr Opin Pulm Med 2021;27(3):176-183
• Borczuk. Pulmonary pathology of COVID-19: a review of autopsy studies. Curr Opin Pulm Med 2021;27(3):184-192
• Carsetti. COVID-19 – pathogenesis and immunological findings across the clinical manifestation spectrum. Curr Opin Pulm Med 2021;27(3):193-198
• Maeurer. Host-directed therapies for COVID-19. Curr Opin Pulm Med 2021;27(3):205-209
• Martin-Loeches. New guidelines for severe community-acquired pneumonia. Curr Opin Pulm Med 2021;27(3):210-215
• Gill. Atypical mycobacterial infections – management and when to treat. Curr Opin Pulm Med 2021;27(3):216-223

Monday March 29th

Narrative Reviews

Clinical

• Leong. Novel Diagnostics and Therapeutics in Sepsis. Biomedicines 2021;9(3):311
• Bos. Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research. Eur Respir Rev 2021;30:200317
• Bedawi. Advances in pleural infection and malignancy. Eur Respir Rev 2021;30:200002

Sunday 28th

Research

Randomised Controlled Trials

• Grieco. Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure. The HENIVOT Randomized Clinical Trial. JAMA 2021;epublished March 25th
  • Editorial:  Munshi. Respiratory Support During the COVID-19 Pandemic. Is It Time to Consider Using a Helmet? JAMA 2021;epublished March 25th
  • Video:  Various. Helmet Noninvasive Ventilation of COVID-19 Patients. JAMA 2021;epublished March 25th
• Martin. Standard versus Accelerated Speaking Valve Placement after Percutaneous Tracheostomy: A Randomized-Controlled Feasibility Study. Ann Am Thorac Soc 2021;epublished March 24th
• Fathy. The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial. Anaesth Crit Care Pain Med 2021;40(1):100731
• Dinh. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial. Lancet 2021;397(10280):1195-1203

Systematic Reviews & Meta Analyses

• Zhou. Renal replacement therapy modality in critically ill patients with acute kidney injury – A network meta-analysis of randomized controlled trials. J Crit Care 2021;epublished March 25th
• Qin. Amikacin nebulization for the adjunctive therapy of gram-negative pneumonia in mechanically ventilated patients: a systematic review and meta-analysis of randomized controlled trials. Sci Rep 2021;;11(1):6969

Observational Studies

• Martillo. Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019. Cohort Study From a New York City Critical Care Recovery Clinic. Crit Care Med 2021;epublished March 16th
• Papazian. National incidence rate and related mortality for acute respiratory distress syndrome in France. Anaesth Crit Care Pain Med 2021;40(1):100795
• Barhight. Non-resuscitation fluid in excess of hydration requirements is associated with higher mortality in critically ill children. Pediatr Res 2021;epublished March 17th

Guidelines & Position Statements

• Nadarajah. The management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: key points from the ESC 2020 Clinical Practice Guidelines for the general and emergency physician. Clin Med 2021;21:e206-e211
• De Simone. The management of surgical patients in the emergency setting during COVID-19 pandemic: the WSES position paper. World J Emerg Surg 2021;16:14
  Laursen. European Respiratory Society statement on thoracic ultrasound. Eur Respir J 2021;57:2001519
• Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019: Expert Recommendations from The Korean Society for Thoracic and Cardiovascular Surgery. J Chest Surg 2021;54(1):2-8
• Preprint:  Schell. Essential Emergency and Critical Care – a consensus among global clinical experts. MedRxiv 2021;epublished March 25th

Narrative Reviews

Clinical

• Wang. Understanding COVID-19-associated coagulopathy: From PIC to SIC or DIC. JIM 2021;epublished March 27th
• Fergie. Immunity to SARS-CoV-2: Lessons Learned. Front Immunol 2021;12:654165

Commentaries

• Cadd. An A-E assessment of post-ICU COVID-19 recovery. J Intensive Care 2021;9:29

Correspondence

• White. Guidelines should not pool evidence from uncomplicated and severe COVID-19. Lancet 2021;epublished March 22nd
• Puel. What place for virtual reality in the intensive care unit during medical procedures?. J Intensive Care 2021;9:30

Multimedia

Audio

• Rubin. Audio Interview: What Earlier Epidemics Teach Us about Covid-19. N Engl J Med 2021;384(12):e55

Saturday 27th

Case Reports

• Best. Progressive neurological symptoms following a fall. Clin Med 2021;21:153-154
• Mullarkey. Lessons of the month: A challenging presentation of hypopituitarism secondary to an intracerebral aneurysm. Clin Med 2021;21:e228-e230
• Hesford. Lessons of the month: ANCA-associated vasculitis – granulomatosis with polyangiitis: ‘the great mimic’. Clin Med 2021;21:e231-e233
• Manning. Lessons of the month: Acute liver failure: a case close to the heart. Clin Med 2021;21:e234-e236
• Hokama. Image of the month: Target the bugs: Strongyloides stercoralis hyperinfection. Clin Med 2021;21:e239-e240
• Zilio. Cardiac arrest complicating cardiogenic shock: from pathophysiological insights to Impella-assisted cardiopulmonary resuscitation in a pheochromocytoma-induced Takotsubo cardiomyopathy—a case report. Euro Heart J Case Reports 2021;5(3):ytab092

Journal of Thoracic Disease series on Minimally Invasive Cardiac Surgery

• Ali. Minimally invasive cardiac surgery—a Fad or the Future?. J Thorac Dis 2021;13(3):1882-1885
• White. Anesthesia for minimally invasive cardiac surgery. J Thorac Dis 2021;13(3):1886-1898
• Akowuah. Endoscopic vein harvesting. J Thorac Dis 2021;13(3):1899-1908
• Anastasiadis. From less invasive to minimal invasive extracorporeal circulation. J Thorac Dis 2021;13(3):1909-1921
• Bonatti. Minimally invasive and robotic coronary artery bypass grafting—a 25-year review. J Thorac Dis 2021;13(3):1922-1944
• Di Bacco. Minimally invasive aortic valve surgery. J Thorac Dis 2021;13(3):1945-1959
• Abu-Omar. Minimally invasive mitral valve surgery. J Thorac Dis 2021;13(3):1960-1970
• Toolan. Robotic mitral valve surgery: a review and tips for safely negotiating the learning curve. J Thorac Dis 2021;13(3):1971-1981
• Abdelbar. Minimally invasive tricuspid valve surgery. J Thorac Dis 2021;13(3):1982-1992
• Kenawy. Minimally invasive resection of benign cardiac tumors. J Thorac Dis 2021;13(3):1993-1999
• Witkowska. Insights from advancements and pathbreaking research on the minimally invasive treatment of atrial fibrillation. J Thorac Dis 2021;13(3):2000-2009
• Al-Naamani. Minimally invasive ventricular assist device implantation. J Thorac Dis 2021;13(3):2010-2017

Friday 26th

Commentaries

• Gostin. The Coronavirus Pandemic 1 Year On—What Went Wrong? JAMA 2021;325(12):1132-1133
• Chan. Is dexamethasone an effective treatment for severe COVID-19 patients: Journal Club review. CJEM 2021;23(2):159-161
• Boldrini. How COVID-19 Affects the Brain. JAMA Psychiatry 2021;epublished March 26th

Thursday 25th

Narrative Reviews

Clinical

• De Maria. Novel device-based therapies to improve outcome in ST-segment elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care 2021;epublished March 24th
• Isseh. A Critical Review of Hemodynamically Guided Therapy for Cardiogenic Shock: Old Habits Die Hard. Curr Treat Options Cardiovasc Med 2021;23(5):29
• Shahrokhi. Infections in Burns. Burn Care and Treatment 2020;epublished December 22nd
• Villa. Hemodynamic Instability during Acute Kidney Injury and Acute Renal Replacement Therapy: Pathophysiology and Clinical Implications. Blood Purif 2021;epublished March 23rd
• Nalbandian. Post-acute COVID-19 syndrome. Nat Med 2021;epublished March 22nd
• Valente. Progress and Pitfalls of Bacteriophage Therapy in Critical Care: A Concise Definitive Review. Crit Care Explor 2021;3(3):e0351
• Verhoef. Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Crit Care Explor 2021;3(3):e0374
• Rizvi. New Decade, Old Debate: Blocking the Cytokine Pathways in Infection-Induced Cytokine Cascade. Crit Care Explor 2021;3(3):e0364
• Papadimitriou. Novel Therapies in Heart Failure with Reduced Ejection Fraction: from Soluble Guanylyl Cyclase Stimulators to Cardiac Myosin Activators. Curr Treat Options Cardio Med 2021;23:33
• Voudris. Complete Revascularization in Patients With STEMI and Multivessel Coronary Artery Disease: Is It Beneficial? Curr Treat Options Cardio Med 2021;23:15

Pre-Clinical

• Amarelle. Hyperoxia and Lungs: What We Have Learned From Animal Models. Front Med 2021;8:606678

Wednesday 24th

Guidelines & Position Statements

• Perkins. European Resuscitation Council Guidelines 2021: Executive summary. Resuscitation 2021;161:1-60
• Gräsner. European Resuscitation Council Guidelines 2021: Epidemiology of cardiac arrest in Europe. Resuscitation 2021;161:61-79
• Semeraro. European Resuscitation Council Guidelines 2021: Systems saving lives. Resuscitation 2021;161:80-97
• Olasveengen. European Resuscitation Council Guidelines 2021: Basic Life Support. Resuscitation 2021;161:98-114
• Soar. European Resuscitation Council Guidelines 2021: Adult advanced life support. Resuscitation 2021;161:115-151
• Lott. European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances. Resuscitation 2021;161:152-219
• Nolan. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care. Resuscitation 2021;161:220-269
• Zideman. European Resuscitation Council Guidelines 2021: First aid. Resuscitation 2021;161:270-290
• Madar. European Resuscitation Council Guidelines 2021: Newborn resuscitation and support of transition of infants at birth. Resuscitation 2021;161:291-326
• Van de Voorde. European Resuscitation Council Guidelines 2021: Paediatric Life Support. Resuscitation 2021;161:327-387
• Greif. European Resuscitation Council Guidelines 2021: Education for resuscitation. Resuscitation 2021;161:388-407
• Mentzelopoulos. European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions. Resuscitation 2021;161:408-432

Tuesday 23rd

Research

Observational Studies

• Russotto. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries. JAMA 2021;325(12):1164-1172
• Burns. Ventilator Weaning and Discontinuation Practices for Critically Ill Patients. JAMA 2021;325(12):1173-1184

Monday 22nd

Narrative Reviews

Surgery (Oxford) Series:  Critical illness and intensive care – I

• Clancy. Design, organization and staffing of the intensive care unit. Surgery (Oxf) 2021;39(1):7-14
• Martin. Transporting the adult critically ill patient. Surgery (Oxf) 2021;39(1):15-21
• Stretch. Criteria for intensive care unit admission and severity of illness. Surgery (Oxf) 2021;39(1):22-28
• Jackson. Care of the critically ill patient. Surgery (Oxf) 2021;39(1):29–36
• Avery. Management of and indications for tracheostomy in care of the critically ill patient. Surgery (Oxf) 2021;39(1):37-47
• Savjani. Measuring quality and outcomes in intensive care. Surgery (Oxf) 2021;39(1):48-52
• Morgan. Long-term outcomes from critical care. Surgery (Oxf) 2021;39(1):53-57

Sunday March 21st

Narrative Reviews

Clinical

• Checchia. The Evolution of Pediatric Cardiac Critical Care. Crit Care Med 2021;49(4):545-557
• MacIntyre. Fifty Years of Mechanical Ventilation—1970s to 2020. Crit Care Med 2021;49(4):558-574
• Cantón. Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic. Curr Opin Crit Care 2021;26(5):433-441
• van den Hoogen. Care for the organ transplant recipient on the intensive care unit. J Crit Care 2021;epublished March 13th
• Vetrugno. Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports. Scand J Trauma Resusc Emerg Med 2021;29:47
• Babini. Cardiac function after cardiac arrest: what do we know? Minerva Anestesiologica 2021;87(3):358-67
• Jablonski. Future in regional anesthesia and pain medicine: the pharmacological view. Minerva Anestesiologica 2021;87(3):351-7
• Pasternak. Neuroanesthesiology Update. J Neurosurg Anesthesiol 2021;33(2):107-136
• Mendelson. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp 2021;9(1):14
• Benmansour. Complement cascade in severe forms of COVID-19: recent advances in therapy. Eur J Immunol 2021;epublished March 19th

Basic Science

• Bhat. SARS-CoV-2: Insight in genome structure, pathogenesis and viral receptor binding analysis – An updated review. International Immunopharmacology 2021;95:107493

Saturday March 20th

Correspondence

• Yoshihiro. A reassessment about included studies and certainty of evidence on a systematic review and meta-analysis of steroid for patients with acute respiratory distress syndrome. J Intensive Care 2021;9:25
• Schortgen. Efficiency of transmission-based precautions (TBPs) against SARS-CoV-2 501Y.V2 variant transmissibility in the ICU. Intensive Care Med 2021;epublished March 18th
• Mongodi. High prevalence of acute stress disorder and persisting symptoms in ICU survivors after COVID-19. Intensive Care Med 2021;epublished March 17th
• Herzog. Goal-directed therapy in the perioperative management: is a complete hemodynamics bundle of care better?. Crit Care 2021;25:105
• Kenny. Stroke volume is the key measure of fluid responsiveness. Crit Care 2021;25:104  
• Laurens. Drug induced acute interstitial nephritis in the critical care: should we consider it? Minerva Anestesiologica 2021;87(3):368-9

Case Reports

• Pellegrini. All that glitters is not gold: an unusual presentation of S. aureus sepsis during ECMO. Intensive Care Med 2021;epublished March 21st
• Ferry. Extracorporeal cardiopulmonary resuscitation for severe chloroquine intoxication in a child – a case report. Scand J Trauma Resusc Emerg Med 2021;29:48
• Cascarano. Extracorporeal immune modulation in COVID-19 induced immune dysfunction and secondary infections: the role of oXiris® membrane. Minerva Anestesiologica 2021;87(3):384-5

News

• Rubin. COVID-19 Vaccines vs Variants—Determining How Much Immunity Is Enough. JAMA 2021;epublished March 17th

Audio

• Rubin. Audio Interview: A New SARS-CoV-2 Vaccine and a New Look at Treatment. N Engl J Med 2021;384(9):e46

Friday March 19th

Guidelines & Position Statements

• SARS-CoV-2 infection, COVID-19 and timing of elective surgery: A multidisciplinary consensus statement on behalf of the Association of Anaesthetists, the Centre for Peri-operative Care, the Federation of Surgical Specialty Associations, the Royal College of Anaesthetists and the Royal College of Surgeons of England. Anaesthesia 2021;epublished March 18th

Editorials

• Giannini. Who gets the last bed? Ethics criteria for scarce resource allocation in the era of COVID-19. Minerva Anestesiologica 2021;87(3):267-71
• Bláha. Our decisions are only as good as the information we have. Minerva Anestesiologica 2021;87(3):275-7
• Ventre. The inscrutable signatures of patient-ventilator asynchrony: all the light we cannot see. Minerva Anestesiologica 2021 March;87(3):278-82
• Bellomo. Novel renal biomarkers of acute kidney injury and their implications. Intern Med J 2021;51(3):316-318

Commentaries

• Schober. Kaplan-Meier Curves, Log-Rank Tests, and Cox Regression for Time-to-Event Data. Anesthesia & Analgesia 132(4):969-970
• Experts Discuss COVID-19—Vaccine Questions, School Openings, and More. JAMA 2021;epublished March 17th
• Rousseau. Long-term outcomes after critical illness: recent insights. Crit Care 2021;25:108

Thursday 18th

Research

Randomised Controlled Trials

• INSPIRATION Investigators. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit. The INSPIRATION Randomized Clinical Trial. JAMA 2021;epublished March 18th
  • Editorial:  Al-Samkari. Finding the Optimal Thromboprophylaxis Dose in Patients With COVID-19. JAMA 2021;epublished March 18th
• Mukaida. Oxygen delivery-guided perfusion for the prevention of acute kidney injury: A randomized controlled trial. J Thorac Cardiovasc Surg 2021;epublished March 16th
• Chapman. Blinded, Double-Dummy, Parallel-Group, Phase 2a Randomized Clinical Trial to Evaluate the Efficacy and Safety of a Highly Selective 5-Hydroxytryptamine Type 4 Receptor Agonist in Critically Ill Patients With Enteral Feeding Intolerance. JPEN J Parenter Enteral Nutr 2021;45(1):115-124
• Lee. Comparison of dynamic needle tip positioning versus conventional long-axis in-plane techniques for ultrasound-guided internal jugular venous catheterization: a randomized controlled trial. Minerva Anestesiologica 2021;87(3):294-301

Systematic Reviews & Meta Analyses

• Lau. Health-Related Quality-of-Life and Cost Utility Analyses in Critical Care: A Systematic Review. Crit Care Med 2021;49(4):575-588
• Lim. A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients With Coronavirus Disease 2019. Crit Care Med 2021;epublished March 12th
• Chan. Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care. A Systematic Review and Meta-Analysis of Observational Studies. Crit Care Med 2021;epublished March 1st
• Shah. Use of Corticosteroids in Cardiac Arrest—A Systematic Review and Meta-Analysis.Crit Care Med 2021;epublished February 23rd
• Grasselli. Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review. Crit Care 2021;25;115
• Lyu. The effect of neuromuscular blocking agents uses in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. Minerva Anestesiologica 2021;87(3):341-50

Observational Studies

• Edara. Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination. JAMA 2021;epublished March 19th
• The Writing Committee for the COMEBAC Study Group. Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19. JAMA 2021;epublished March 17th
  
  • Editorial:  Prescott. Outcomes for Patients Following Hospitalization for COVID-19. JAMA 2021;epublished March 17th
• Volpicelli. Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study. Intensive Care Med 2021;epublished March 20th
• Martillo. Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019. Cohort Study From a New York City Critical Care Recovery Clinic. Crit Care Med 2021;epublished March 16th
• Hansen. Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study. Lancet 2021;epublished March 17th
  
  • Commentary:  Boyton. Risk of SARS-CoV-2 reinfection after natural infection. Lancet 2021;epublished March 17th
• He. Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study. Lancet 2021;397(10279):1075-1084
  
  • Commentary:  Strugnell. Sustained neutralising antibodies in the Wuhan population suggest durable protection against SARS-CoV-2. Lancet 2021;397(10279):1037-1039
• Busana. Prevalence and outcome of silent hypoxemia in COVID-19. Minerva Anestesiologica 2021;87(3):325-33

Wednesday 17th

Narrative Reviews

Clinical

• Loo. COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms. Thorax 2021;76:412-420
• See. Acute cor pulmonale in patients with acute respiratory distress syndrome: A comprehensive review. World J Crit Care Med 2021;10(2):35-42
• Lindberg. Perioperative stroke after non-cardiac, non-neurological surgery. BJE Education 2021;21(2):59-65
• Ashken. Regional anaesthesia in patients at risk of bleeding. BJE Education 2021;21(2):84-94
• Corbell. Management of hypoxemia in severe acute respiratory syndrome coronavirus 2 infection: Lessons learned from one year of experience, with a special focus on silent hypoxemia. J Intensive Med 2021;epublished March 9th

Tuesday 16th

Guidelines & Position Statements

• Nasa. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care 2021;25:106

Narrative Reviews

Clinical

• Sen. Chemical incidents. BJA Education 2021;21(4):126-132

Commentaries

• Inouye. The Importance of Delirium and Delirium Prevention in Older Adults During Lockdowns. JAMA 2021;epublished March 15th

Monday 15th

Guidelines & Position Statements

• Pappas. The Evidence Supporting the Revised EORTC/MSGERC Definitions for Invasive Fungal Infections. Clin Infect Dis 2021;72(S2):S77–S78
• Alexander. Guidance on Imaging for Invasive Pulmonary Aspergillosis and Mucormycosis: From the Imaging Working Group for the Revision and Update of the Consensus Definitions of Fungal Disease from the EORTC/MSGERC. Clin Infect Dis 2021;72(S2):S79–S88
• Mercier. Defining Galactomannan Positivity in the Updated EORTC/MSGERC Consensus Definitions of Invasive Fungal Diseases. Clin Infect Dis 2021;72(S2):S89–S94
• White. Aspergillus Polymerase Chain Reaction—An Update on Technical Recommendations, Clinical Applications, and Justification for Inclusion in the Second Revision of the EORTC/MSGERC Definitions of Invasive Fungal Disease. Clin Infect Dis 2021;72(S2):S95–S101
• Lamoth. Assessment of the Role of 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Fungal Infections in Adults. Clin Infect Dis 2021;72(S2):S102–S108

Sunday 14th

Research

Randomised Controlled Trials

• Preprint:  Goligher. Therapeutic Anticoagulation in Critically Ill Patients with Covid-19-Preliminary Report. MedRxiv 2021;epublished March 12th
• Preprint:  The RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. MedRxiv 2021;epublished March 10th
• Preprint:  Jayakumar. Awake prone position in adult nonintubated patients with acute hypoxaemic respiratory failure secondary to COVID-19:A multi-centre feasibility randomized controlled trial. MedRxiv 2021;epublished March 13th
• Zarbock. Prevention of Cardiac Surgery-Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial. Anesth Analg 2021;epublished March 8th
• Cinotti. Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study. Crit Care 2021;25:98

Systematic Reviews & Meta Analyses

• Thiago. Systematic review of cognitive impairment and brain insult after mechanical ventilation. Crit Care 2021;25:99
• Chorath. Association of Early vs Late Tracheostomy Placement With Pneumonia and Ventilator Days in Critically Ill Patients: A Meta-analysis. JAMA Otolaryngol Head Neck Surg 2021;epublished March 11th
• Anand. Effect of awake prone positioning in COVID-19 patients- A systematic review. Trends Anaesth Crit Care 2021;36:17-22
• Lewis. High-flow nasal cannulae for respiratory support in adult intensive care patients. Cochrane Database Syst Rev 2021 Mar 4;3:CD010172
• Juschten. Between-trial heterogeneity in ARDS research. Intensive Care Med 2021;epublished March 13th
• Howatt. Carbapenem Antibiotics for the Empiric Treatment of Nosocomial Pneumonia. A Systematic Review and Meta-analysis. Chest 2021;159(3):1041-1054
  • Editorial:  Rhodes. Empiric Carbapenems for Nosocomial Pneumonia. Is Hindsight Clearer in 2020? Chest 2021;159(3):897-899
• Jiménez. Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019. A Systematic Review and Meta-analysis. Chest 2021;159(3):1182-1196
  • Editorial:  Moores. Don’t Do Anything! Just Stand There! Chest 2021;159(3):908-909
• Ge. Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis. Eur J Emerg Med 2021;epublished March 9th

Observational Studies

• Shehabi. Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial. Intensive Care Med 2021;epublished March 8th
• Lieveld. Chest CT in COVID-19 at the ED: Validation of the COVID-19 Reporting and Data System (CO-RADS) and CT Severity Score. A Prospective, Multicenter, Observational Study. Chest 2021;159(3):1126-1135

Correspondence

• Nguyen. Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis. Intensive Care Med (2021;epublished March 10th
• Garg. Covid and cholesterol (C&C): Something to worry about or much ado about nothing? Trends Anaesth Crit Care 2021;36:39-40
• Davies. Videolaryngoscopy post COVID-19. Trends Anaesth Crit Care 2021;36:49-51
• de Almeida Monteiro. Can lung ultrasound predict histologic pattern of lung injury in critically ill patients with COVID-19? Author’s reply. Intensive Care Med 2021;epublished March 12th
• Nguyen. Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis. Intensive Care Med 2021;epublished March 10th
• Al-Hindawi. Process Leading to Missing Data Has Meaning. Fluid Response Evaluation in Sepsis Hypotension and Shock. Chest 2021;159(3):1300
• Vijayakumar. Is Fibrosis Really Fibrosis? Am J Respir Crit Care Med 2021;epublished March 12th
• van Gassel. Reply to: Is Fibrosis Really Fibrosis? Am J Respir Crit Care Med 2021;epublished March 12th

Case Reports

• Penaud. A Sengstaken–Blakemore tube to rescue respiratory failure due to oesophageal-pulmonary fistula. Intensive Care Med 2021;epublished March 9th
• Saffo. Circumferential esophageal perforation resulting in tension hydropneumothorax in a patient with septic shock. Acute Crit Care 2021;epublished March 11st
• Coomes. A 51-Year-Old Woman With a Mediastinal Mass. Chest 2021;159(3):e141-e145
• Chong. A 69-Year-Old Woman With Ulcerative Colitis and Pulmonary Nodules. Chest 2021;159(3):e147-e150
• Werst. A 64-Year-Old Man With Multifocal Infiltrates. Chest 2021;159(3):e151-e154
• Sehgal. A Young Girl With Bronchiectasis and Elevated Sweat Chloride. Chest 2021;159(3):e155-e158
• Mahieu. A 78-Year-Old Woman With Diarrhea and Respiratory Failure. Chest 2021;159(3):e159-e162
• Ismail. A Life-threatening Complication of Multiple System Atrophy. Chest 2021;159(3):e163-e166
• Tan. Recurrent Cardiogenic Syncope From Extrinsic Organ Anomaly. Chest 2021;159(3):e167-e171
• Zeb. A 52-Year-Old Man With Sudden Dyspnea, Chest Pain, and Seizure. Chest 2021;159(3):e173-e179

Saturday 13th

Narrative Reviews

Clinical

• Stoller. Leadership Essentials for CHEST Medicine Professionals. Models, Attributes, and Styles. Chest 2021;159(3):1147-1154
• Editorial:  Kelley. Physician Leadership. New Responsibilities Require New Skills. Chest 2021;159(3):902-903
• Lutchmansingh. A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY. Learning From the Past, Looking to the Future. Chest 2021;159(3):949-958
• Ali. Inpatient Diuretic Management of Acute Heart Failure: A Practical Review. Am J Cardiovasc Drugs 2021;epublished March 12th
• Giraud. The use of extracorporeal CO2 removal in acute respiratory failure. Ann. Intensive Care 2021;11:43
• Stevens. Continuous renal replacement therapy and the COVID pandemic. Semin Dial 2021;epublished March 11th
• Rali. Viscoelastic Haemostatic Assays in Cardiovascular Critical Care. Cardiac Failure Review 2021;7:e01
• Arrigo. Pulmonary Embolism and Heart Failure: A Reappraisal. Cardiac Failure Review 2021;7:e03
• Raffaello. De Novo HF Versus ADCHF. Cardiac Failure Review 2021;7:e02

Heart Failure Series from Cardiovascular Diagnosis & Therapy

• Editorial:  Hetzer. Heart failure in the young and old: insights into various therapies. Cardiovasc Diagn Ther 2021;11(1):336-338
• Javier Delmo. Heart failure in the young: Insights into myocardial recovery with ventricular assist device support. Cardiovasc Diagn Ther 2021;11(1):148-163
• Javier Delmo. Evolution of heart transplantation since Barnard’s first. Cardiovasc Diagn Ther 2021;11(1):171-182
• Biffi. Hybrid transcatheter left ventricular reconstruction for the treatment of ischemic cardiomyopathy. Cardiovasc Diagn Ther 2021;11(1):183-192
• Javier Delmo. The role of ventricular assist device in children. Cardiovasc Diagn Ther 2021;11(1):193-201
• Szlapka. Conventional cardiac surgery in patients with end-stage coronary artery disease: yesterday and today. Cardiovasc Diagn Ther 2021;11(1):202-212
• Hetzer. Organ-saving surgical alternatives to treatment of heart failure. Cardiovasc Diagn Ther 2021;11(1):213-225
• Dandel. Weaning from ventricular assist device support after recovery from left ventricular failure with or without secondary right ventricular failure. Cardiovasc Diagn Ther 2021;11(1):226-242
• Javier. Heart transplantation: the Berlin experience and perspectives. Cardiovasc Diagn Ther 2021;11(1):243-253
• Schwinger. Pathophysiology of heart failure. Cardiovasc Diagn Ther 2021;11(1):263-276
• Loforte. Ventricular assist devices implantation: surgical assessment and technical strategies. Cardiovasc Diagn Ther 2021;11(1):277-291
• Saia. Innovative transcatheter procedures for the treatment of heart failure. Cardiovasc Diagn Ther 2021;11(1):292-300
• Benedetto. Heart failure: role and point of view of cardiac intensivist. Cardiovasc Diagn Ther 2021;11(1):301-308
• Hetzer. Mechanical circulatory support systems: evolution, the systems and outlook. Cardiovasc Diagn Ther 2021;11(1):309-322
• Ahmed. Medical management of pediatric heart failure. Cardiovasc Diagn Ther 2021;11(1):323-335

Friday 12th

Guidelines & Position Statements

• Lamontagne. A living WHO guideline on drugs to prevent covid-19. BMJ 2021;372:n526
• Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers. Am J Trop Med Hyg 2021;epublished March 11th
• Chalmers. Management of hospitalised adults with coronavirus disease-19 (COVID-19): A European Respiratory Society living guideline. Eur Respir J 2021;epublished March 10th
• Foley. Difficult Airway Management in Adult COVID-19 Patients: Statement by the Society of Airway Management. Anesth Analg 2021;epublished March 12th

Editorials

• Yang. Immune Regulation in Kidney Diseases: Importance, Mechanism and Translation. Front Med 2021;8:616880
• Lichtenberger. AKI and CKD. Acta Physiol 2021;epublished March 8th
• Becker. Medical publishing during the COVID-19 pandemic: then and now. J Thromb Thrombolysis 2021;epublished March 9th
• Husain-Syed. Coronavirus disease 2019 and acute kidney injury-what have we learned? Kidney Int Rep 2021;epublished March 3rd
• Singh. Anesthetist and pandemic: Past and present. Trends Anaesth Crit Care 2021;36:5-8

Commentaries

• Liu. Candida Colonization in the Respiratory Tract: What Is the Significance? Front Med 2021;7:598037
• Li. CJEM journal club: corticosteroids use for critically ill COVID-19 patients. CJEM 2021;23(2):162-163

Thursday 11th

Narrative Reviews

Clinical

• Ferstl. Acute Decompensation and Acute-on-Chronic Liver Failure. Clin Liver Dis 2021;epublished March 9th
• Ombrello . COVID-19 and Cytokine Storm Syndrome: Are there lessons from Macrophage Activation Syndrome? Transl Res 2021;epublished March 5th
• Ehie. Professionalism: microaggression in the healthcare setting. Curr Opin Anaesthesiol 2021;34(2):131-136
• Deana. Insights into neurological dysfunction of critically ill COVID-19 patients. Trends Anaesth Crit Care 2021;36:30-38
• Alessandri. Seizures and Sepsis: A Narrative Review. J Clin Med 2021;10(5):1041
• Sporns. Neuroimaging of Acute Intracerebral Hemorrhage. J Clin Med 2021;10(5):1086
• Barkhudaryan. Ischemic Stroke and Heart Failure: Facts and Numbers. An Update. J Clin Med 2021;10(5):1146
• Yusuf. An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria. J Clin Med 2021;10(5):1068
• Al-Jeabory. Efficacy and Safety of Tranexamic Acid in Emergency Trauma: A Systematic Review and Meta-Analysis. J Clin Med 2021;10(5):1030
• Hetzer. Mechanical circulatory support systems: evolution, the systems and outlook. Cardiovasc Diagn Ther 2021;11(1):309–322
• Attaway. Severe covid-19 pneumonia: pathogenesis and clinical management. BMJ 2021;372:n436
• Singh. Challenges faced in establishing a dedicated 250 bed COVID-19 intensive care unit in a temporary structure. Trends Anaesth Crit Care 2021;36:9-16
• Round. Speech intelligibility in respiratory protective equipment - Implications for verbal communication in critical care. Trends Anaesth Crit Care 2021;36:23-29

Wednesday March 10th

Editorials

• Yang. Immune Regulation in Kidney Diseases: Importance, Mechanism and Translation. Front Med 2021;8:616880
• Lichtenberger. AKI and CKD. Acta Physiol 2021;epublished March 8th
• Becker. Medical publishing during the COVID-19 pandemic: then and now. J Thromb Thrombolysis 2021;epublished March 9th
• Singh. Anesthetist and pandemic: Past and present. Trends Anaesth Crit Care 2021;36:5-8

Commentaries

• Liu. Candida Colonization in the Respiratory Tract: What Is the Significance? Front Med 2021;7:598037
• Husain-Syed. Coronavirus disease 2019 and acute kidney injury-what have we learned? Kidney Int Rep 2021;epublished March 3rd

Tuesday March 9th

Narrative Reviews

Clinical

• Giani. Extracorporeal Gas Exchange for Acute Respiratory Distress Syndrome: Open Questions, Controversies and Future Directions. Membranes 2021;11(3):172
• Marinho. Perioperative hyperfibrinolysis – physiology and pathophysiology. Braz J Anesthesiol 2021;71(1):65-75
• Busani. Adjunctive Immunotherapy With Polyclonal Ig-M Enriched Immunoglobulins for Septic Shock: From Bench to Bedside. The Rationale for a Personalized Treatment Protocol. Front Med 2021;8:616511
• Belli. Airway Clearance Techniques: The Right Choice for the Right Patient. Front Med 2021;8:544826
• Fragkou. Update in Viral Infections in the Intensive Care Unit. Front Med 2021;8:575580
• Szabo. PRO: The pulmonary artery catheter has a paramount role in current clinical practice. Ann Card Anaesth 2021;24:4-7
• Navas-Blanco. CON: Pulmonary artery catheter use should be forgone in modern clinical practice. Ann Card Anaesth 2021;24:8-11
  • Editorial:  Sarkar. Pulmonary artery catheter – Dilemma is still on?. Ann Card Anaesth 2021;24:1-3
• Allado. The Fundamentals of Respiratory Physiology to Manage the COVID-19 Pandemic: An Overview. Front Physiol 2021;11:615690
• Singh. High-Flow Nasal Cannula, a Boon or a Bane for COVID-19 Patients? An Evidence-Based Review. Curr Anesthesiol Rep 2021;epublished March 2nd
• Aslam. Spontaneous Versus Controlled Mechanical Ventilation in Patients with Acute Respiratory Distress Syndrome. Curr Anesthesiol Rep 2021;epublished March 3rd
• Nakajima. Ex vivo lung perfusion in lung transplantation. Gen Thorac Cardiovasc Surg 2021;epublished March 8th

Monday March 8th

Guidelines & Position Statments

• Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation 2021;epublished March 4th
• Opioid-Associated Out-of-Hospital Cardiac Arrest: Distinctive Clinical Features and Implications for Health Care and Public Responses: A Scientific Statement From the American Heart Association. Circulation 2021;epublished March 8th

Narrative Reviews

Clinical

• Gong. Mechanical Complications of Acute Myocardial Infarction.  JAMA Cardiol 2021;6(3):341-349
• Ito. Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation. Crit Care 2021;25:95

Sunday March 7th

Editorials

• Shelton. Prevention of Complications in the Cardiac Intensive Care Unit. J Cardiothorac Vasc Anesth 2021;epublished January 29th

Commentaries

• Supady. Ten things to consider when implementing rationing guidelines during a pandemic. Intensive Care Med 2021;epublished March 7th
• Salluh. COVID-19 research in critical care: the good, the bad, and the ugly. Intensive Care Med 2021;epublished March 1st
• McMurray. How Should We Sequence the Treatments for Heart Failure and a Reduced Ejection Fraction? A Redefinition of Evidence-Based Medicine. Circulation 2021;143:875–877
• Wijdicks. Historical Appreciation of Brain Vulnerability from Pure Hypoxemia. Neurocrit Care 2021;epublished February 23rd
• Murray. The Potential Future of the COVID-19 Pandemic. Will SARS-CoV-2 Become a Recurrent Seasonal Infection? JAMA 2021;epublished March 3rd
• Kirschen. Brain Death Evaluation in Children With Suspected or Confirmed Coronavirus Disease 2019. Ped Crit Care Med 2021;22(3):318-322

Multimedia

Audio

• Rubin. Audio Interview: A New SARS-CoV-2 Vaccine and a New Look at Treatment. N Engl J Med 2021;384(9):e46
• Cao. Multiple Comparison Procedures from the JAMA Guide to Statistics and Methods. JAMA 2021;epublished March 4th

Saturday March 6th

Narrative Reviews

Clinical

• Ibanez. The year in cardiovascular medicine 2020: acutecoronary syndromes and intensive cardiac care. Eur Heart J 2021;42:884–895
• Fenner. Immunological Endotyping of Chronic Critical Illness After Severe Sepsis. Front Med (Lausanne) 2021;epublished February 15;7:616694
• Yang. Immune storm and coagulation storm in the pathogenesis of amniotic fluid embolism. Eur Rev Med Pharmacol Sci 2021;25(4):1796-1803
• Ohsumi. Perioperative circulatory support for lung transplantation. Gen Thorac Cardiovasc Surg 2021;epublished March 5th
• Udwadia. Post-COVID lung fibrosis: The tsunami that will follow the earthquake. Lung India 2021;38(Suppl S1):41-7
• Lio. Coagulopathy in COVID-19. Lung India 2021;38, Suppl S1:53-7
• Brindley. Assessing on-line medical education resources: A primer for acute care medical professionals and others. JICS 2021;epublished March 5th
• Kamel. Use of Urine Electrolytes and Urine Osmolalityin Clinical Diagnosis of Fluid, Electrolytes, and Acid-Base Disorders. Kidney Int Rep 2021;epublished February 12th
• De Stasio. Integrated imaging evaluation in infective endocarditis: A pictorial essay on clinical cases of extracardiac complications. Int J Infect Dis 2021;105:62-67

Friday March 5th

Correspondence

• Uraco. Artificial Intelligence Application on Point-of-Care Ultrasound. J Cardiothorac Vasc Anesth 2021;epublished March 4th
• Various. Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl J Med 2021;384:881-882
• Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med 2021;epublished March 3rd
• Lellouche. Instrumental dead space in ventilator management. Lancet Respir Med 2021;9(3):e22
• Schultz. Instrumental dead space in ventilator management – Authors' reply. Lancet Respir Med 2021;9(3):e23
• Babla. Racial microaggressions within respiratory and critical care medicine. Lancet Respir Med 2021;9(3):e27-e28
• Hidalgo. Critical care trainees call for pulse oximetry reform. Lancet Respir Med 2021;epublished March 1st
• Permpalung. Diagnostic dilemma in COVID-19-associated pulmonary aspergillosis. Lancet Infect Dise 2021;epublished March 1st
• Jabeen. Diagnostic dilemma in COVID-19-associated pulmonary aspergillosis. Lancet Infect Dise 2021;epublished March 1st
  • Koehler. Diagnostic dilemma in COVID-19-associated pulmonary aspergillosis – Authors' reply. Lancet Infect Dise 2021;epublished March 1st

Case Reports

• Chuzi. Hidden in Plain Sight. An Elusive Cause of Cardiogenic Shock. Circulation. 2021;143:959–964
• Matsuura. Amiodarone-induced pneumonitis. QJM: An International Journal of Medicine 2021;epublished February 27th
• Zadikany. Total Artificial Heart as Bridge to Cardiac Retransplantation. ASAIO Journal 2021;67(3):e77-e79

Thursday March 4th

Research

Randomised Controlled Trials

• Lescure. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med 2021;epublished March 4th
• Soin. Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial. Lancet Respir Med 2021;epublished March 4th
  • Murthy. IL-6 blockade for COVID-19: a global scientific call to arms. Lancet Respir Med 2021;epublished March 4th
• Stewart. High flow oxygen and risk of mortality in patients with a suspected acute coronary syndrome: pragmatic, cluster randomised, crossover trial. BMJ 2021;372:n355

Systematic Reviews & Meta Analyses

• Chang. Sodium bicarbonate administration during in-hospital pediatric cardiac arrest: a systematic review and meta-analysis. Resuscitation 2021;epublished March 1st
• Andonovic. Timing of renal replacement therapy for patients with acute kidney injury: A systematic review and meta-analysis. J Intensive Care Soc 2021;22(1):67-77
• Tan. Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis. Thorax 2021;epublished February 23rd
• Walayat. Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review. Ann Gastroenterol 2021;34(2):235-240

Observational Studies

• Haywood. Long term outcomes of participants in the PARAMEDIC2 randomised trial of adrenaline in out-of-hospital cardiac arrest. Resuscitation 2021;160:84-91
• Menga. High Failure Rate of Noninvasive Oxygenation Strategies in Critically Ill Subjects With Acute Hypoxemic Respiratory Failure Due to COVID-19. Respir Care 2021;epublished March 2nd
• The CORIMUNO-19 Collaborative group. Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia: a randomised controlled trial. Lancet Respir Med. 2021;epublished January 22nd
  • Cavalli. The right place for IL-1 inhibition in COVID-19. Lancet Respir Med 2021;9(3):223-224
• Bloom. Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. Lancet Respir Med 2021;epublished March 4th

Wednesday March 3rd

Research

Randomised Controlled Trials

• Wong. Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome. N Engl J Med 2021; 384:818-828
• China. A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis. N Engl J Med 2021;384:808-817

Commentary

• Murray. The Potential Future of the COVID-19 Pandemic. Will SARS-CoV-2 Become a Recurrent Seasonal Infection? JAMA 2021;epublished March 3rd

Guidelines & Position Statements

• Depreitere. Cerebrovascular Autoregulation Monitoring in the Management of Adult Severe Traumatic Brain Injury: A Delphi Consensus of Clinicians. Neurocrit Care 2021;epublished January 25th
  • Commentary:  Lazaridis. Cerebral Autoregulation: The Concept the Legend the Promise. Neurocrit Care 2021;epublished January 25th

Narrative Reviews

Clinical

• Battaglini. Ten golden rules to individualize mechanical ventilation in acute respiratory distress syndrome. Journal of Intensive Medicine 2021;epublished March 1st
• Singer. Nutritional and metabolic management of the COVID 19 intensive care patient. Journal of Intensive Medicine 2021;epublished March 1st
• Annane. Corticosteroids for COVID-19. Journal of Intensive Medicine 2021;epublished March 1st
• Welker. 2021 Acute Respiratory Distress Syndrome (ARDS) Update with COVID 19 Focus. J Cardiothorac Vasc Anesth 2021;epublished February 27th
• Lazaridis. To Decompress or Not? An Expected Utility Inspired Approach To Shared decision-making For Supratentorial Ischemic Stroke. Neurocrit Care 2021;epublished February 18th
• Cattel. Use of exogenous pulmonary surfactant in acute respiratory distress syndrome (ARDS): Role in SARS-CoV-2-related lung injury. Respir Physiol Neurobiol 2021;epublished February 28th

Tuesday March 2nd

Guidelines & Position Statements

• Universal Definition and Classification of Heart Failure. A Report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure. J Cardiac Failure 2021;epublished March 1st

Narrative Reviews

Clinical

• Lat.. The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients. ICMx 2021;9:10
• Bootsma. The contemporary pulmonary artery catheter. Part 1: placement and waveform analysis. J Clin Monit Comput 2021;epublished February 10th
• Bootsma. The contemporary pulmonary artery catheter. Part 2: measurements, limitations, and clinical applications. J Clin Monit Comput 2021;epublished March 1st

Non-Clinical

• Ko. General considerations for sample size estimation in animal study. Korean J Anesthesiol 2021;74(1):23-29

Monday March 1st

Research

Systematic Reviews & Meta Analyses

• Chang. Sodium bicarbonate administration during in-hospital pediatric cardiac arrest: a systematic review and meta-analysis. Resuscitation 2021;epublished March 1st
• Andonovic. Timing of renal replacement therapy for patients with acute kidney injury: A systematic review and meta-analysis. J Intensive Care Soc 2021;22(1):67-77
• Tan. Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis. Thorax 2021;epublished February 23rd

Observational Studies

• Kowalski. Recovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury. JAMA Neurol 2021;epublished March 1st
  • Editorial:  Kim. Holding Out Hope After Traumatic Brain Injury. JAMA Neurol 2021;epublished March 1st
• Haywood. Long term outcomes of participants in the PARAMEDIC2 randomised trial of adrenaline in out-of-hospital cardiac arrest. Resuscitation 2021;160:84-91

Sunday January 31st

Research

Observational Studies

• Heijnen. Biological Subphenotypes of ARDS Show Prognostic Enrichment in Mechanically Ventilated Patients Without ARDS. Am J Respir Crit Care Med 2021;epublished January 27th
• Lumlertgul. Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study). Crit Care 2021;25:39
• Friedrichson. Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs. Crit Care 2021;25:38
• Bravata. Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic. JAMA Netw Open 2021;4(1):e2034266
• Hariri. Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients. Crit Care 2021;25:33
• Hunziker. Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study. Crit Care 2021;25:32
• Combes. Global absence and targeting of protective immune states in severe COVID-19. Nature 2021;epublished January 25th
• Toporek. Balanced Crystalloids versus Saline in Critically Ill Adults with Hyperkalemia or Acute Kidney Injury: Secondary Analysis of a Clinical Trial. Am J Respir Crit Care Med 2020;epublished January 27th
• Lowery. Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation. JAMA Otolaryngol Head Neck Surg 2021;epublished January 28th
  • Audio:  Gelbard. Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation. JAMA Otolaryngol Head Neck Surg 2021;epublished January 28th

Protocols

• Liu. Acetate Ringer's solution versus 0.9% saline for septic patients: study protocol for a multi-center parallel controlled trial. Trials 2021;22(1):89
• Solanich. Pragmatic, open-label, single-center, randomized, phase II clinical trial to evaluate the efficacy and safety of methylprednisolone pulses and tacrolimus in patients with severe pneumonia secondary to COVID-19: The TACROVID trial protocol. Contemp Clin Trials Commun. 2021;21:100716

Guidelines & Position Statements

• Zimmerman. Choosing Wisely For Critical Care. The Next Five. Crit Care Med 2021;epublished January 28th
• Akl. Use of Chest Imaging in the Diagnosis and Management of COVID-19: A WHO Rapid Advice Guide. Radiology 2021;298(2):E63-E69

Narrative Reviews

Clinical

• Redant. Severe Acute Respiratory Syndrome Coronavirus-2-Associated Acute Kidney Injury. A Narrative Review Focused Upon Pathophysiology. Crit Care Med 2021;epublished January 7th
• Kollef. Nosocomial Infection. Crit Care Med 2021;49(2):169-187
• Bellomo. ICU-Based Renal Replacement Therapy. Crit Care Med 20210;epublished January 28th
• Kerlin. The Society of Critical Care Medicine at 50 Years. ICU Organization and Management. Crit Care Med 20210;epublished January 28th
• Mermiri. Critical emergency medicine and the resuscitative care unit. Acute Crit Care 2021;epublished January 28th
• Mermiri. Critical emergency medicine and the resuscitative care unit. Acute Crit Care 2021;epublished January 28th

Saturday January 30th

Research

Randomised Controlled Trials

• Hui. Safety and efficacy of long-term mild hypothermia for severe traumatic brain injury with refractory intracranial hypertension (LTH-1): A multicenter randomized controlled trial, EClinicalMedicine 2021;epublished January 28th
• Parke. A Multicenter, Open-Label, Randomized Controlled Trial of a Conservative Fluid Management Strategy Compared With Usual Care in Participants After Cardiac Surgery
  The Fluids After Bypass Study. Crit Care Med 2021;epublished January 28th
• Eslami. A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial of High-Dose, Short-Term Vitamin D Administration in the Prevention of Acute Kidney Injury after Cardiac Surgery. Cardiorenal Med 2021;epublished January 26th
• Franco. Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial. Ann Intensive Care 2021;11(1):15

Systematic Reviews & Meta Analyses

• Wan. Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review. Biomarkers 2021;26(1):1-12
• Al Duhailib. The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. Can J Anaesth 2021;epublished January 25th
• Wang. Inhaled nitric oxide and acute kidney injury risk: a meta-analysis of randomized controlled trials. Ren Fail 2021;43(1):281-290
• Zhu. Extracorporeal membrane oxygenation versus mechanical ventilation alone in adults with severe acute respiratory distress syndrome: a systematic review and meta‐analysis. Internation Journal of Clinical Practice 2021;epublished January 24th
• Yang. Safety Assessment Criteria for Early Active Mobilization in Mechanically Ventilated ICU Subjects. Respir Care 2021;66:307-315
• Mitra. Concurrent Use of Renal Replacement Therapy during Extracorporeal Membrane Oxygenation Support: A Systematic Review and Meta-Analysis. J Clin Med 2021;10(2):241
• Song. Low- versus High-Chloride Content Intravenous Solutions for Perioperative Patients: A Systematic Review and Meta-Analysis. Biomed Res Int 2021;2021:3571397
• Deng. Early versus late tracheotomy in ICU patients: A meta-analysis of randomized controlled trials. Medicine 2021;100(3):e24329
• Pappal. Awareness With Paralysis in Mechanically Ventilated Patients in the Emergency Department and ICU. A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished January 20th

Friday January 29th

Commentaries

• Vincent. COVID-19: What we’ve done well and what we could or should have done better—the 4 Ps. Crit Care 2021;25:40
• Cook. The safety of anaesthetists and intensivists during the first COVID-19 surge supports extension of use of airborne protection PPE to ward staff. Clin Med 2021;epublished January 28th
• Bhatia. Pro: Venoarterial ECMO Should Be Considered in Patients With COVID-19. J Cardiothorac Vasc Anesth 2021;35(3):703-706
• McLean. Con: Venoarterial ECMO Should Not Be Considered in Patients With COVID-19. J Cardiothorac Vasc Anesth 2021;35(3):707-710

Thursday January 28th

Case Reports

• Hu. The Anesthetic Management of the First Lung Transplant for a Patient with COVID-19 Respiratory Failure. J Cardiothorac Vasc Anesth 2021;35(3):917-920
• Lalabekyan. Torsades de Pointes in Coronavirus Disease 2019 Infection. J Cardiothorac Vasc Anesth 2021;35(3):954-955
• Kothari. The Risk of Malposition: A Tale of Two Devices. J Cardiothorac Vasc Anesth 2021;35(3):963-966
• Jounieaux. Pure SARS-CoV-2 related AVDS (Acute Vascular Distress Syndrome). BMC Infect Dis 2021;21:122

Wednesday January 27th

Correspondence

• Aberegg. Aspergillosis in the ICU: Hidden Enemy or Bogeyman? Am J Respir Crit Care Med 2021;epublished January 26th
  • Reply:  Loughlin. Reply to: Aspergillosis in the ICU: Hidden Enemy or Bogeyman? Am J Respir Crit Care Med 2021;epublished January 26th
• Pagel. Very Rare, but Not Unique. J Cardiothorac Vasc Anesth 2021;35(3):957
• Kim. Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19. N Engl J Med 2021;epublished January 27th

Tuesday January 26th

Editorials

• Vincent. COVID-19: it is all about sepsis. Future Microbiol 2021;epublished January 25th
• Colak. Five principles for the intelligent use of AI in medical imaging. Intensive Care Med 2021;epublished January 15th
• Isgro. The Right Ventricle in COVID-19 Lung Injury: Proposed Mechanisms, Management, and Research Gaps. J Cardiothorac Vasc Anesth 2021;epublished January 15th
• Dale. Leaving a mark: pressure injury research in the intensive care unit. Intensive Care Med 2021;epublished January 27th

Monday January 25th

Narrative Reviews

Clinical

• Wildi. The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine? J Intensive Care 2021;9:14
• Ponzo. The Refeeding Syndrome: a neglected but potentially serious condition for inpatients. A narrative review. Intern Emerg Med 2021;16:49–60
• Aitken. Which preoperative screening tool should be applied to older patients undergoing elective surgery to predict short-term postoperative outcomes? Lessons from systematic reviews, meta-analyses and guidelines. Intern Emerg Med 2021;16:37–48
• Bihari. Albumin as a drug: its biological effects beyond volume expansion. Crit Care Resusc 2020;22(3):257-265
• Willcox. Implications of direct oral anticoagulation and antiplatelet therapy in intensive care. Crit Care Resusc 2020;22(3):181-188
• Kichloo. Utilization of extracorporeal membrane oxygenation during the COVID-19 pandemic. World J Crit Care Med 2021;10(1):1-11
  
  
  

Sunday January 24th

Case Reports

• Gonçalves. An unwanted intruder. Neth Heart J 2021;29:111–112
  • Answer
• Nguyên. Slowing down too fast. Neth Heart J 2021;29:113–114
• Martelli. Pneumothorax and pulmonary air leaks as ventilator-induced injuries in COVID-19. Acute Crit Care 2021;epublished January 13th
• Bylund. Man With Shortness of Breath. Ann Emerg Med 2021;77(2):178
• Fiutko. Man With Double Vision. Ann Emerg Med 2021;77(2):220
• Manzur-Sandoval. Giant inverted T waves in a patient with COVID-19 infection. Ann Emerg Med 2021;77(2):264-267
• Tu. Woman With Fever and Drowsiness. Ann Emerg Med 2021;77(2):e71-e72
• Lambermont. SARS-CoV-2 in carotid body. Intensive Care Med 2021;epublished January 22nd

Saturday January 23rd

Correspondence

• Ho. Is Tranexamic Acid for Upper Gastrointestinal Bleeding Under Debate? Ann Emerg Med 2021;77(2):279-281
• David. Adjuvant therapeutic plasma exchange in septic shock. Intensive Care Med 2021;epublished January 20th
• Herman. COVID-19: Airway management considerations. Anaesthesiol Intensive Ther 2020;52(4):339–340
• Gómez-Ríos. The role of videolaryngoscopy in airway management of COVID-19 patients. Anaesthesiol Intensive Ther 2020;52(4):344–345
• Yamamoto. Risk of propofol use for sedation in COVID-19 patient. Anaesthesiol Intensive Ther 2020;52(4):354–355
• Pilcher. Learning from the First Wave of the Pandemic in England, Wales and Northern Ireland. Am J Respir Crit Care Med 2021;epublished January 21st

Friday January 22nd

Commentaries

• Tukpah. COVID-19 Racial and Ethnic Inequities in Acute Care and Critical Illness Survivorship. Ann Am Thor Soc 2021;18(1):23-25
• Lazzeri. Echocardiographic assessment of the right ventricle in COVID -related acute respiratory syndrome. Intern Emerg Med 2021;16:1–5
• Izzedine. Acute kidney injury in patients with COVID-19: an update on the pathophysiology. Nephrol Dial Transplant. 2021;36(2):224–226

Thursday January 21st

Editorials

• Colak. Five principles for the intelligent use of AI in medical imaging. Intensive Care Med 2021;epublished January 15th
• Pergolizzi. Four pandemics: lessons learned, lessons lost. Signa Vitae 2021;17(1):1-5

Wednesday January 20th

Research

Randomised Controlled Trials

• Schjørring. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. N Engl J Med 2021;epublished January 20th

Systematic Reviews & Meta Analyses

• Mitra. Concurrent Use of Renal Replacement Therapy during Extracorporeal Membrane Oxygenation Support: A Systematic Review and Meta-Analysis. J Clin Med 2021;10(2):241
• Song. Low- versus High-Chloride Content Intravenous Solutions for Perioperative Patients: A Systematic Review and Meta-Analysis. Biomed Res Int 2021;2021:3571397

Observational Studies

• Bravata. Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic. JAMA Netw Open 2021;4(1):e2034266

Tuesday January 19th

Narrative Reviews

Clinical

• Page. Mechanisms of thrombosis and cardiovascular complications in COVID-19. Thromb Res 2021;200:1-8
• Barchitta. Lung Semiotics Ultrasound in COVID-19 Infection. J Cardiovasc Echogr 2020;30(Suppl 2):S1–S5
• Cianci. Lung Ultrasound in the COVID-19 Pandemic. J Cardiovasc Echogr 2020;30(Suppl 2):S6–S10
• Cresti. Echocardiography and Multimodality Cardiac Imaging in COVID-19 Patients. J Cardiovasc Echogr 2020;30(Suppl 2):S18–S24
• Landini. The Role of Imaging in COVID-19 Pneumonia Diagnosis and Management: Main Positions of the Experts, Key Imaging Features and Open Answers. J Cardiovasc Echogr 2020;30(Suppl 2):S25–S30
• Greatorex. Echocardiographic assessment and critical care management of peri-partum women with unexpected left ventricular failure. JICS 2021;epublished January 5th
• Passi. The patient with cirrhosis in the intensive care unit and the management of acute-on-chronic liver failure. JICS 2020;epublished December 28th
• Asim. A contemporary insight of metabolomics approach for COVID-19: Potential for novel therapeutic and diagnostic targets. Nepal J Epidemiol 2020;10(4):923-927

Pre-Clinical

• Vázquez-Carballo. Toll-Like Receptors in Acute Kidney Injury. Int J Mol Sci 2021;22(2):816

Monday January 18th

Narrative Reviews

Clinical

• Amodio. Lights and Shadows in Hepatic Encephalopathy Diagnosis. J Clin Med 2021;10(2):341
• Łagocka. Favipiravir in Therapy of Viral Infections. J Clin Med 2021;10(2):273
• Iba. Proposal of the Definition for COVID-19-Associated Coagulopathy. J Clin Med 2021;10(2):191
• Wennig. Mushroom Poisoning. Dtsch Arztebl Int 2020;117:701-8
• Jung. Frailty as a Prognostic Indicator in Intensive Care. Dtsch Arztebl Int 2020;117:668-73

Sunday January 17th

Research

Randomised Controlled Trials

• Kyriazopoulou. Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial. Am J Respir Crit Care Med 2021;202(3):202–210
  • Editorial:  Niederman. Antibiotic Use in Sepsis: How and Why Less Can Really Mean More (Survival). Am J Respir Crit Care Med 2021;203(2):157–158
• Wittermans. Adjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: A randomised clinical trial. Eur Respir J 2021;epublished January 14th
• Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med 2021;epublished January 13th
  • Editorial:  WHO Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation. Placebo-Controlled Trials of Covid-19 Vaccines — Why We Still Need Them. N Engl J Med 2021; 384:e2
• Garcia Guerra.. Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial. J Intensive Care 2021;9:7

Systematic Reviews & Meta Analyses

• Walayat. Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review. Ann Gastroenterol 2021;34(1):1-6
• Cristobal. Cardiopulmonary Resuscitation in the Prone Position in the Operating Room or in the Intensive Care Unit: A Systematic Review. Anesth Analg 2021;132(2):285-292
• Barbateskovic. Higher vs Lower Oxygenation Strategies in Acutely Ill Adults. A Systematic Review With Meta-Analysis and Trial Sequential Analysis. Chest 2021;159(1):154-173

Observational Studies

• Biancari. Five-year survival after post-cardiotomy veno-arterial extracorporeal membrane oxygenation. Eur Heart J Acute Cardiovascular Care 2021;epublished January 12th
• Eck. Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies. Crit Care 2021;25:27
• Sklar. Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Crit Care 2021;25:26
• Dupuis. Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs. Crit Care 2021;25:24
• Levy. Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study. Crit Care 2020;25:21
• Ramani. Post-ICU COVID-19 Outcomes. A Case Series. Chest 2021;159(1):215-218
• de Almeida Monteiro. Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings. Intensive Care Med 2021;epublished January 3rd
• Joyner. Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19. N Engl J Med 2021;epublished January 13th
  • Editorial:  Katz. (A Little) Clarity on Convalescent Plasma for Covid-19. N Engl J Med 2021;epublished January 13th
• Ranzani. Characterisation of the first 250 000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data. Lancet Respir Med 2021;epublished January 15th
• Gupta. Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. Lancet Respir Med 2021;epublished January 11th
  • Commentary:  Wynants. Improving clinical management of COVID-19: the role of prediction models. Lancet Respir Med 2021;epublished January 11th
• Goligher. Effect of Lowering Tidal Volume on Mortality in ARDS Varies with Respiratory System Elastance. Am J Respir Crit Care Med 2021;epublished January 13th
• Dorward. Tissue-Specific Immunopathology in Fatal COVID-19. 192–201
• Editorial:  Welte. SARS-CoV-2–triggered Immune Reaction: For COVID-19, Nothing Is as Old as Yesterday’s Knowledge. Am J Respir Crit Care Med 2021;203(2):156

Saturday January 16th

Editorials

• Colak. Five principles for the intelligent use of AI in medical imaging. Intensive Care Med 2021;epublished January 15th
• Maslove. Artificial intelligence in telemetry: what clinicians should know. Intensive Care Med 2021;epublished January 2nd

Commentaries

• Should Corticosteroids Be Routine Treatment in Early ARDS? Chest 2021;159(1):25-37
  • Meduri - Yes  |  Hensley - No  |  Meduri- Rebuttal  |  Hensley - Rebuttal
• Schober. Logistic Regression in Medical Research. Anesth Analg 2021;132(2):365-366
• Piller. Many scientists citing two scandalous COVID-19 papers ignore their retractions. Science 2021;epublished January 15th
• Zitter. Hummingbird Lessons. JAMA 2021;325(2):131-132
• Jaffe. Rochelle Walensky: new Director of the US CDC. Lancet 2021;epublished January 14th
• Millington. Lung Ultrasound for Patients With Coronavirus Disease 2019 Pulmonary Disease. Chest 2021;159(1):205-211

Podcasts

• Bauchner. Coronavirus Critical Care Update With Lennie Derde and Christopher Seymour. JAMA 2021;epublished January 15th
• Rubin. Audio Interview: Covid-19 in South Africa and a New SARS-CoV-2 Variant. N Engl J Med 2021;384:e14

News

• Kuehn. Health Workers’ Antibody Levels Wane After SARS-CoV-2 Infection. JAMA 2021;325(2):122
• Venkatesan. NICE guideline on long COVID. Lancet Respir Med 2021;epublished January 13th

Friday January 15th

Case Reports

• Patel. Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019. Chest 2021;159(1):e7-e11
• Park. Case of a 21-Year-Old Man With Hemoptysis, Recurrent Pneumothorax, and Cavitary Lung Lesions. Chest 2021;159(1):13-e17
• Ji. A 49-Year-Old Man Presents With Fever of Unknown Origin and Cough. Chest 2021;159(1):e25-e28
• Gul. A 65-Year-Old Woman With Dyspnea After Atrial Fibrillation Ablation. Chest 2021;159(1):e29-e33
• Odackal. A 28-Year-Old Man With Chest Pain, Shortness of Breath, and Hemoptysis After Recovery From Coronavirus Disease 2019 Pneumonia. Chest 2021;159(1):e35-e38
• Hawkins. A 33-Year-Old Man With Dyspnea, Chest Pain, and a Massive Pleural Effusion. Chest 2021;159(1):e39-e43
• Zirek. A 2-Year-Old Boy With Hypoxemia, Pulmonary Hypertension, and Digital Clubbing. Chest 2021;159(1):e45-e48
• Miller. A 56-Year-Old Man With Chronic Cough, Hemoptysis, and a Left Lower Lobe Infiltrate. Chest 2021;159(1):e53-e56
• Sia. Reversal of Acute Right Ventricular Failure Early Post Left Ventricular Assist Device Placement by Intratracheal Milrinone Administration. Chest 2021;159(1):e57-e60
• Almajthoub. A 58-Year-Old Man With Abdominal Ascites. Chest 2021;159(1):e61-e63
• Mart. Pneumomediastinum in Acute Respiratory Distress Syndrome from COVID-19. Am J Respir Crit Care Med 2021;203(2):237–238

Thursday January 14th

Correspondence

• Tobin. Pondering the atypicality of ARDS in COVID-19 is a distraction for the bedside doctor. Intensive Care Med 2021;epublished January 15th
• Supady. Hospital networks and patient transport capacity during the COVID-19 pandemic when intensive care resources become scarce. Crit Care 2021;25:28
• Añón. Ten reasons why corticosteroid therapy reduces mortality in severe COVID-19. Intensive Care Med 2021;January 2nd
• Iglesias. Would You Withhold Fruit From the Critically Ill? Chest 2021;159(1):452-453
• Brenner. Assessing Candidacy for Tracheostomy in Ventilated Patients With Coronavirus Disease 2019. Aligning Patient-Centered Care, Stakeholder Engagement, and Health-Care Worker Safety. Chest 2021;159(1):454-455
  • Reply:  Lamb. Chest 2021;159(1):455-456
• de Chambrun. Clarkson’s Disease Episode or Secondary Systemic Capillary Leak-Syndrome. That Is the Question! Chest 2021;159(1):441
• Wijdicks. “We believe your father is in a vegetative state”. “You mean he is a vegetable? He never wanted that”. Intensive Care Med 2021;epublished January 15th
• Lorusso. ECMO for COVID-19 patients in Europe and Israel. Intensive Care Med 2021;epublished January 9th
• Thompson. Sex differences in response to adjunctive corticosteroid treatment for patients with septic shock. Intensive Care Med 2021;epublished January 7th
• Diao. Clinical Implications of Removing Race From Estimates of Kidney Function. JAMA 2021;325(2):184-186
• Chen. Assessing the importance of interleukin-6 in COVID-19. Lancet Respiratory Med 2021;epublished January 15th
• Leisman. Assessing the importance of interleukin-6 in COVID-19 – Authors' reply. Lancet Respiratory Med 2021;epublished January 15th
• Chen. Pulmonary Vasculature: A Target for COVID-19. Am J Respir Crit Care Med 2021;203(2):260–261
• Jha. Pulmonary Vascular Changes in Acute Respiratory Distress Syndrome due to COVID-19. Am J Respir Crit Care Med 2021;203(2):259–260
• Caviedes. Pulmonary Angiopathy in Severe COVID-19: Physiological Conclusions Derived from Ventilatory Ratio? Am J Respir Crit Care Med 2021;203(2):258–259
• Sanfilippo. COVID-19, Hypercoagulability, and Cautiousness with Convalescent Plasma. Am J Respir Crit Care Med 2021;203(2):257–258
  • Arachchillage. Reply to Sanfilippo et al. and to Caviedes et al. Am J Respir Crit Care Med 2021;203(2):261–263
• Cherian. Positive Bubble Study in Severe COVID-19 Indicates the Development of Anatomical Intrapulmonary Shunts in Response to Microvascular Occlusion. Am J Respir Crit Care Med 2021;203(2):263–265
  • Reynolds. Reply to Cherian et al.: Positive Bubble Study in Severe COVID-19 Indicates the Development of Anatomical Intrapulmonary Shunts in Response to Microvascular Occlusion. Am J Respir Crit Care Med 2021;203(2):265–266
• Roedl. Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19. Am J Respir Crit Care Med 2021;203(2):242–245
   

Wednesday January 13th

Commentaries

• Supady. Allocating scarce intensive care resources during the COVID-19 pandemic: practical challenges to theoretical frameworks. Lancet Respir Med 2021;epublished January 12th
• Tsang. Twenty articles that critical care clinicians should read about COVID-19. Intensive Care Med 2021;epublished January 3rd
• Cavaleri. The European Medicines Agency's EU conditional marketing authorisations for COVID-19 vaccines. Lancet 2021;epublished January 13th
• Downar. Improving family access to dying patients during the COVID-19 pandemic. Lancet Respir Med 2021;epublished January 12th
• Praschan. Implications of COVID-19 sequelae for health-care personnel. Lancet Respir Med 2021;epublished January 11th

Tuesday January 12th

Narrative Reviews

Clinical

• Csete. Basic Science of Frailty—Biological Mechanisms of Age-Related Sarcopenia. Anesth Analg 2021;132(2):293-304
• De Groot. Is secondary chemical exposure of hospital personnel of clinical importance? Clinical Toxicology 2021;epublished January 15th
• Leasa. Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic. Crit Care 2021;25:22
• Murphy. Acute flaccid myelitis: cause, diagnosis, and management. Lancet 2021;epublished December 21st
• Moonen. Energy expenditure and indirect calorimetry in critical illness and convalescence: current evidence and practical considerations. J Intensive Care Med 2021;9:8
• Zheng. A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management. Ann Transl Med 2021;9(1):69
• Saracoglu. Advanced airway management in out-of-hospital cardiac arrest – to intubate or not to intubate: a narrative review of the existing literature. Anaesthesiol Intensive Ther 2020;52(5):425–433
• Smędra. The notion of grievous bodily harm and the legal obligation to notify law enforcement authorities. Anaesthesiol Intensive Ther 2020;52(5):418–424
• Jasiński. COVID-19 and haemodynamic failure: a point of view on mechanisms and treatment. Anaesthesiol Intensive Ther 2020;52(5):409–417
• Wujtewicz. Occupational hazards in anaesthesiology during the COVID-19 pandemic. Anaesthesiol Intensive Ther 2020;52(5):400–408

Monday January 11th

Narrative Reviews

Clinical

• Bulut. Hemostatic Balance in Pediatric Acute Liver Failure: Epidemiology of Bleeding and Thrombosis, Physiology, and Current Strategies. Front Pediatr 2020;8:618119

Anaesthesia Series on Regional Anaesthesia

• Editorial:  Chin. Advancing towards the next frontier in regional anaesthesia. Anaesthesia 2021;76(S1):3-7
• Chen. The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review. Anaesthesia 2021;76(S1):8-17
• McCombe. Regional anaesthesia: risk, consent and complications. Anaesthesia 2021;76(Suppl. 1):18–26
• Macfarlane. Updates in our understanding of local anaesthetic systemic toxicity: a narrative review. Anaesthesia 2021;76(S1):27-39
• Johnston. Defining success in regional anaesthesia. Anaesthesia 2021;76(S1):40-52
• Ramlogan. Contemporary training methods in regional anaesthesia: fundamentals and innovations. Anaesthesia 2021;76(S1):53-64
• Gadsden. The role of peripheral nerve stimulation in the era of ultrasound‐guided regional anaesthesia. Anaesthesia 2021;76(S1):65-73
• Heydinger. Fundamentals and innovations in regional anaesthesia for infants and children. Anaesthesia 2021;76(S1):74-88
• Hamilton. Regional anaesthesia quality indicators for adult patients undergoing non‐cardiac surgery: a systematic review. Anaesthesia 2021;76(S1):89-99
• Desai. Local anaesthetic adjuncts for peripheral regional anaesthesia: a narrative review. Anaesthesia 2021;76(S1):100-109
• Chin. Ultrasound‐guided fascial plane blocks of the chest wall: a state‐of‐the‐art review. Anaesthesia 2021;76(S1):110-126
• Levy. Regional anaesthesia in patients with diabetes. Anaesthesia 2021;76(S1):127-135
• Sultan. Regional anaesthesia for labour, operative vaginal delivery and caesarean delivery: a narrative review. Anaesthesia 2021;76(S1):136-147
• Dockrell. The role of regional anaesthesia in the emerging subspecialty of onco‐anaesthesia: a state‐of‐the‐art review. Anaesthesia 2021;76(S1):148-159
• McLeod. Novel approaches to needle tracking and visualisation. Anaesthesia 2021;76(S1):160-170
• McKendrick. The use of artificial intelligence and robotics in regional anaesthesia. Anaesthesia 2021;76(S1):171-181

Sunday January 10th

Editorials

• Chalmers. Pandemic trials: evidence-based medicine on steroids. Eur Respir J 2020;56:2004116
• Wald. COVID-19-Associated Acute Kidney Injury: Learning from the First Wave. J Am Soc Nephrol 2021;32(1):4-6

Commentaries

• Godoy. Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”. Crit Care 2021;25:19
• Lauring. Genetic Variants of SARS-CoV-2—What Do They Mean? JAMA 2021;epublished January 6th
  
  • Audio:  Lauring. Understanding SARS-CoV-2 Genetic Variants. JAMA 2021;epublished January 6th
• Kirby. New variant of SARS-CoV-2 in UK causes surge of COVID-19. Lancet Respir Med 2021;epublished January 5th

Saturday January 9th

Guidelines & Position Statements

• Alyamani. Perioperative pain management in COVID-19 patients: Considerations and recommendations by the Saudi Anesthesia Society (SAS) and Saudi Society of Pain Medicine (SSPM). Saudi J Anaesth 2021;15:59-69

Narrative Reviews

Clinical

• Bulut. Hemostatic Balance in Pediatric Acute Liver Failure: Epidemiology of Bleeding and Thrombosis, Physiology, and Current Strategies. Front Pediatr 2020;8:618119

Non-Clinical

• Lund. Evidence-Based Research Series-Paper 2 : Using an Evidence-Based Research approach before a new study is conducted to ensure value. J Clin Epi 2021;129:158-166
• Lund. Evidence-Based Research Series-Paper 3: Using an Evidence-Based Research approach to place your results into context after the study is performed to ensure usefulness of the conclusion. J Clin Epi 2021;129:167-171

Friday January 8th

Research

Randomised Controlled Trials

• PrePrint:  The REMAP-CAP Investigators. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – Preliminary report. medRxiv 2021;epublished January 7th
• Full Text:  Salama. Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med 2021;384:20-30
• Full Text:  Edalatifard. Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial. Eur Respir J 2020;56:2002808
• Full Text:  Libster. Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. N Engl J Med 2021;epublished January 6th
• Full Text:  Macedo. A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients. Crit Care 2021;25:18

Systematic Reviews & Meta Analysis

• Full Text:  Menges. Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis. Crit Care 2021;25:16
• Full Text: Li. Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis. Crit Care 2021;25:15
• Abstract:  Sud. Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe ARDS: Network Meta-Analysis. Am J Respir Crit Care Med 2021;epublished January 6th
• Abstract:  Patell. Pharmacologic Thromboprophylaxis and Thrombosis in Hospitalized Patients with COVID-19: A Pooled Analysis. Thromb Haemost 2020;epublished December 30th

Observational Studies

• Full Text:  Yasuda. Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study). J Intensive Care 2021;9:3
• Abstract:  Couturaud. Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms. JAMA 2021;325(1):59-68
• Full Text: Huang. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021;epublished January 8th
  • Commentary:  Cortinovis. Long-term follow-up of recovered patients with COVID-19. Lancet 2021;epublished January 8th
• Full Text:  Pun. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med 2021;epublished January 8th
  • Commentary:  Page. Sedation in mechanically ventilated patients with COVID-19. Lancet Respir Med 2021;epublished January 8th

Thursday January 7th

Correspondence

• Joffre. Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers?. Ann. Intensive Care 2021;11:1
• Lee. Microvascular Injury in the Brains of Patients with Covid-19. N Engl J Med 2021;epublished December 30th
• Various. Tocilizumab in Covid-19. N Engl J Med 2021;384:86-87
• Zhang. ECMO support for COVID-19: a balancing act. Lancet 2021;397(10269):94-95
  
  • Barbaro. ECMO support for COVID-19: a balancing act – Authors' reply. Lancet 2021;397(10269):95
• Camporota. Consensus on the referral and admission of patients with severe respiratory failure to the NHS ECMO service. Lancet Respir Med 2020;epublished January 8th

Wednesday January 6th

Case Reports

• Arena. Fever and dyspnoea in a tracheostomised patient. Breathe 2020 16: 200115
• Hamid. A male with recurrent infections and mediastinal mass. Breathe 2020;16(4):200065
• Agarwal. Leg weakness and paraesthesia provide a clue to sudden death due to aortic dissection. Lancet 2021;397(10269):128

Tuesday January 5th

Narrative Reviews

Clinical

• Redant. Management of late onset urea cycle disorders—a remaining challenge for the intensivist?. Ann. Intensive Care 2021;11:2
• Trung. Microvascular Fluid Exchange: Implications of the Revised Starling Model for Resuscitation of Dengue Shock Syndrome. Front Med 2020;7:601520
• Thrailkill. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): update and insights into current practices and future directions for research and implementation. Scand J Trauma Resusc Emerg Med 2021;29:8
• Spencer. Update: Microdialysis for Monitoring Cerebral Metabolic Dysfunction after Subarachnoid Hemorrhage. J Clin Med 2021;10(1):100
• Tenovuo. Assessing the Severity of Traumatic Brain Injury—Time for a Change? J Clin Med 2021;10(1):148
• Scholkmann. The Role of Methemoglobin and Carboxyhemoglobin in COVID-19: A Review. J Clin Med 2021;10(1):50
• Robba. Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. J Clin Med 2021;10(1):140

Monday January 4th

Narrative Reviews

Clinical

• Higham. COVID-19 and COPD: a narrative review of the basic science and clinical outcomes. Eur Respir Rev 2020;29:200199
• Kim. Management of tracheo-oesophageal fistula in adults. Eur Respir Rev 2020;29:200094
• Rodrigues. Current developments and future directions in respiratory physiotherapy. Eur Respir Rev 2020;29:200264
• Rosell. Therapeutic bronchoscopy for central airway diseases. Eur Respir Rev 2020;29:190178
• Kapoor. COVID-19 and the perioperative neuroscience - A narrative review. Saudi J Anaesth 2021;15:19-26
• Goudra. Anesthesia for GI endoscopy in the era of COVID-19. Saudi J Anaesth 2021;15:27-32
• Mishra. Pain management in COVID-19 pediatric patients—An evidence- based review. Saudi J Anaesth 2021;15:33-9