- Yang. Short-term light sedation with remimazolam besylate versus propofol in the ICU (SHOSREB): a multicentre, randomized, single-blind, controlled trial. Intensive Care Med 2026;epublished March 31st
- Sonneville. Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial. JAMA 2026;epublished March 17th
- Glinsky. Safety and efficacy of intensive task-specific training in people with recent spinal cord injury: a phase 3, pragmatic, randomised, assessor-blinded, superiority trial. Lancet Neurol 2026;25(3):234-244
- Ma. Tenecteplase for acute non–large vessel occlusion 4.5 to 24 hours after ischemic stroke: the OPTION randomized clinical trial. JAMA 2026;epublished February 5th
- Broderick. Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet 2026;epublished February 4th
- Xiong Y, Alemseged F, Cao Z, et al. Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial. Lancet. 2026;epublished February 5th
- Solomon. Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial. Lancet Neurol 2026;25(2):136-146
- Lu. Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial. Lancet 2026;epublished January 30th
- Litton. High-Flow Nasal Oxygen Therapy After Cardiac Surgery: A Randomized Clinical Trial. JAMA Netw Open 2026;9(4):e265447
- Yuan. Electrical impedance tomography-guided positive end-expiratory pressure and mortality of patients with the acute respiratory distress syndrome: the EITVent randomized clinical trial. Am J Respir Crit Care Med 2026;212(3):440-451
- Frat. High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure. N Engl J Med 2026;epublished March 17th
- Banerjee. Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia. The FAST Randomized Clinical Trial. JAMA 2026;epublished April 18th 🔴 CCR summary
- Neyra. Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial. Lancet Respir Med 2026;epublished March 23rd 🔴 CCR summary
- Todd. Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Respir Med 2026;epublished March 22nd 🔴 CCR summary
- Sakr. Albumin replacement therapy in septic shock: a randomized clinical trial. JAMA Netw Open 2026;9(2):e2559297
Last updated April 18th, 2026