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RECOVERY-RS Trial Results

Thursday, August 5th

The RECOVERY-RS trial investigators present the results of this randomised controlled trial, comparing both continuous positive airway pressure and high flow nasal oxygen with standard care in hypoxic patients with COVID-19.

Published Paper

RECOVERY-RS is presently unpublished

RECOVERY-RS Trial Results Presentation

Drs Bronwen Connolly (Belfast) and Keith Couper (Coventry) present the results of the RECOVERY-RS trial, investigating non-invasive ventilation modalities in severe COVID-19


Editorial

Prof Manu Shankar-Hari (London) delivers an independent editorial on the RECOVERY-RS trial, investigating non-invasive ventilation modalities in severe COVID-19

Viewer's Questions

Co-chief investigators Profs Danny McAuley (Belfast) and Gavin Perkins (Coventry) answer questions from the views, asked by Dr Chris Nutt (Belfast), during the livestreamed RECOVERY-RS trial results presentation.

Panel Discussion

Dr Rob Mac Sweeney (Belfast) hosts a panel discussion on the RECOVERY-RS trial. The panelists include Profs Leticia Kawano-Dourado (Sao Paulo), Janet Diaz (San Francisco) & John Norrie (Edinburgh), plus Dr Stephen Webb (Cambridge).


The countdown has begun

Days
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Hours
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Minutes
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Seconds

Selected Global Timings

São Paulo

15:30 to 17:30

Washington DC

14:30 to 16:00

Vancouver

11:30 to 13:00

Auckland (6th)

06:30 to 08:00

Perth (6th)

02:30 to 04:00

Karachi

23:30 to 01:00

Tbilisi

22:30 to 00:00

Prague

20:30 to 22:00

Belfast

19:30 to 21:00

Schedule

00:00
Background & Methods

Bronwen Connolly

00:15
Results

Keith Couper

00:30
Editorial

Manu Shankar-Hari

00:45
Reply to Editorial

Danny McAuley & Gavin Perkins

00:50
Questions

Open to Viewers

01:00
Panel Discussion

Bronwen Connolly 

Keith Couper

Danny McAuley 

Gavin Perkins

Manu Shankar Hari

John Norrie

Leticia Kwano-Dourado

Janet Diaz

Stephen Webb

01:30
End

Speakers

Bronwen Connolly

Senior Lecturer in Critical Care, Queen's University Belfast, Northern Ireland

Dr Bronwen Connolly is a critical care physiotherapist, and Senior Lecturer in Critical Care at Queen’s University Belfast, UK. The recipient of three previous NIHR Fellowships (Doctoral, Postdoctoral, Clinical Trials), her research interests focus on acute respiratory and rehabilitation physiotherapy, the recovery, long-term outcome, and survivorship of post critical illness patients, and clinical trial methodology around complex rehabilitation interventions. Her current work includes leading a multiprofessional team developing a randomized controlled trial investigating the effectiveness of mucoactive drugs in acute respiratory failure, and the development of a core outcome set for trials of physical rehabilitation in critical illness. Bronwen is involved with a number of major national and international research organisations including the NIHR Critical Care Specialty Group, the UK Critical Care Research Group, and the International Forum for Acute Care Trialists.

Twitter:  @bronwenconnolly

Keith Couper

Assistant Professor in Emergency and Critical Care, England

Keith Couper is an Assistant Professor in Emergency and Critical Care. His clinical background is critical care nursing, and he continues to work clinically as a critical care outreach nurse practitioner at University Hospitals Birmingham NHS Foundation Trust. Keith completed his PhD on debriefing after cardiac arrest in 2015. He was subsequently awarded a prestigious NIHR post-doctoral research fellowship to explore the use of mechanical chest compression devices at in-hospital cardiac arrest.

Keith holds volunteer roles with the International Liaison Committee on Resuscitation (ALS task force member), Resuscitation Council UK (ALS sub-committee member), Royal College of Nursing (Research Forum committee member) and National Institute of Health Research (HTA prioritisation committee member). He is a member of the editorial board of Resuscitation, and is an associate editor of Resuscitation Plus.

Twitter:  @KeithCouper

Danny McAuley

Professor in Intensive Care Medicine, Queen's University Belfast, Northern Ireland

Danny McAuley is a Consultant and Professor in Intensive Care Medicine at the Regional Intensive Care Unit at the Royal Victoria Hospital and Queen’s University of Belfast. He undertook his training in Belfast, Birmingham, London and San Francisco. He is Programme Director for the MRC/NIHR Efficacy and Mechanism Evaluation (EME) programme and Co-Director of Research for the UK Intensive Care Society. He has several research interests including Acute Respiratory Distress Syndrome and clinical trials. He is the co-chief investigator for the RECOVERY-RS trial

Twitter: @dfmcauley

Gavin Perkins

Professor of Critical Care Medicine at the University of Warwick, England

Gavin Perkins is Professor of Critical Care Medicine at the University of Warwick. He leads the emergency and critical care group within Warwick Clinical Trials Unit. He served as Chief Investigator for the BALTI, BALTI-prevention and PARAMEDIC-1 (LUCAS) trial and is currently Chief Investigator for the PARAMEDIC-2 (Adrenaline) and Breathe Trials. Clinically he holds appointments as a Consultant Physician in Critical Care Medicine at Heart of England NHS Foundation Trust and MERIT Team Consultant with West Midlands Ambulance Service. Prof Perkins is a Director of Research for the Intensive Care Foundation and Clinical Speciality Lead for Critical Care (West Midlands CRN), Division 6 Clinical Research Lead (West Midlands CRN). He has been a member (2000-10) and then chairman (2010-present) of the ALS Sub-committee during which time he developed, evaluated and implemented the e-ALS course. He has served as ILCOR and ERC Co-chair for BLS/AED since 2010. In these roles he has developed collaborative networks with international partners and co-ordinated the revision to the 2015 Utstein cardiac arrest template. He was elected as ILCOR Co-chair in 2015.

Twitter:  @perkins_gd

Manu Shankar-Hari

Professor of Critical Care Medicine, King's College London, England

Manu Shankar-Hari is clinician-scientist in Intensive Care Medicine, and group lead for a translational research group at King’s College London. Manu obtained his PhD from King’s College London, for his work on B cell abnormalities in sepsis and completed his formal training in epidemiology from the London School of Hygiene and Tropical Medicine. He holds the prestigious National Institute for Health Research (NIHR) Clinician Scientist Award in Intensive Care Medicine. Manu is a tenured faculty in Intensive Care Medicine at Guy’s and St Thomas’ NHS Foundation Trust, London, UK. Manu’s translational research focuses on Immunobiology Lymphocyte abnormalities in sepsis-related critical illness and in sepsis survivors Clinical epidemiology Methods to enrich sepsis and ARDS populations on dominant mechanisms for immune therapy Epidemiology and proximate determinants of Sepsis and ARDS related critical illness For further details, please see webpage https://www.kcl.ac.uk/research/shankar-hari-group

Twitter:  @msh_manu

John Norrie

Professor of Medical Statistics and Trial Methodology, University of Edinburgh, Scotland

Professor John Norrie is Professor of Medical Statistics and Trial Methodology, Director of the Edinburgh Clinical Trials Unit and Co-Head of the Centre for Population Health Sciences at the University of Edinburgh.  He specialises in genetic, molecular and population health sciences.

Leticia Kawano-Dourado

Clinical Researcher at Hospital do Coracao and University of Sao Paulo, Brazil

Dr. Leticia Kawano-Dourado is a pulmonologist and clinical researcher at HCor Research Institute, and at the University of Sao Paulo, Sao Paulo, Brazil. Currently, she is on a sabbatical at the University of Paris, Paris, France. She does research in non-invasive support for acute respiratory failure as the PI of the RENOVATE trial, and in interstitial lung diseases. More recently, she shifted her research focus to COVID-19: 1. she is part of the  Brazilian initiative Coalition Brazil COVID-19 that ran several RCT in drug repurposing in COVID in Brazil (published on the NEJMJAMABMJ). 2. She is a member of the steering committee of the WHO O2CoV2 study, and 3. she is a panel member of the Guideline Development Group of the WHO Living Guidelines on Treatments for COVID-19. Dr. Kawano Dourado is also a gender equity advocate in Medicine.

Twitter:  @leticiakawano

Janet Diaz

Head of Clinical Care, World Health Organization Emergencies Programme

Janet Diaz is pulmonologist and specialist in intensive care medicine with expertise in clinical medicine and global health.  She is committed to working with medical and public health professionals to deliver quality, safe, and cost-efficient care to critically ill patients in resource-limited regions.  Since 2010, she has worked for the WHO Epidemic Clinical Management Team, as the Technical Lead for the Severe Acute Respiratory Infection (SARI) Critical Care Training project which has trained over 1000 doctors globally. In San Francisco, she works at the California Pacific Medical Center, a tertiary referral center.  She received her post-graduate training in Internal, Pulmonary, and Critical Care Medicine at the University of California San Francisco (UCSF).  From 2006-2010, she served as the Medical Director of the MICU at San Francisco General Hospital and as an Assistant Clinical Professor at UCSF where she was recognized for her leadership in hospital quality, patient safety, and clinical teaching

Twitter: @diazjv

Stephen Webb

Intensivist, Papworth Hospital, Cambridge, England, and Preseident of the Intensive Care Society

Stephen Webb is Consultant in Intensive Care & Deputy Medical Director at Royal Papworth Hospital Cambridge. His clinical, education and research interests lie in Cardiothoracic intensive care, Patient safety and Quality improvement.

He is also President of the Intensive Care Society (ICS), Chair of the Medusa Injectable Medicines Guide Advisory Board and Member of the East of England Clinical Senate Council.

Dr Webb was previously Clinical Lead of the Eastern Academic Health Science Network (EAHSN) Patient Safety Collaborative and Clinical Lead for Postgraduate Leadership Development at Cambridge University Health Partners.

Twitter: @stephen_t_webb

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