Major Trials
Renal
Renal Replacement Therapy
Image: Shutterstock | sfam_photo
IHD vs CRRT
- Vinsonneau. Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: A multicentre randomised trial. Lancet 2006; 368:379-385
- Uehlinger. Comparison of continuous and intermittent renal replacement therapy for acute renal failure. Nephrol Dial Transplant 2005;20:1630-1637
- Augustine. A randomized controlled trial comparing intermittent with continuous dialysis in patients with ARF. Am J Kidney Dis 2004;44:1000–1007
- Mehta. A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure. Kidney Int 2001; 60:1154-1163.
Image: Shutterstock | AlteredR
Timing of Initiation
- Gaudry. Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet 2021;395(10235):1506-1515
- The STARRT-AKI Investigators. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med 2020;383:240-251
- Barbar. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis (IDEAL-ICU Trial). N Engl J Med 2018;379:1431-1442
- Zarbock. Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury. The ELAIN Randomized Clinical Trial. JAMA 2016;epublished May 22nd
- Gaudry. Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit (AKIKI Study). N Engl J Med 2016;epublished May 15th
- Combes. Early high-volume hemofiltration versus standard care for post-cardiac surgery shock. The HEROICS Study. Am J Respir Crit Care Med 2015;192:1179-1190
- Jamale. Earlier-start versus usual-start dialysis in patients with community-acquired acute kidney injury: a randomized controlled trial. Am J Kidney Dis 2013;62:1116-1121
- Bouman. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: A prospective, randomized trial. Crit Care Med 2002; 30:2205-2211
Image: Shutterstock | zlikovec
Dose Intensity
General
- RENAL Replacement Therapy Study Investigators. Intensity of continuous renal-replacement therapy in critically ill patients (RENAL study). N Engl J Med 2009;361(17):1627-38
- Palevsky. Intensity of renal support in critically ill patients with acute kidney injury (Acute Renal Failure Trial). N Engl J Med 2008; 359:7-20
- Saudan. Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. Kidney Int 2006; 70:1312-1317
- Schiffl. Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 2002;346: 305–310
- Ronco. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 2000;356:26–30
Sepsis
- Chung. High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial (RESCUE). Critical Care 2017;21:289
- Park. High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial (HICORES Trial). Am J Kidney Dis 2016;epublished April 12th
Image: Shutterstock |smolaw
Anticoagulation
Citrate
- Zarbock. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury. A Randomized Clinical Trial. JAMA 2020;324(16):1629-1639
- Gatas. A Randomized Controlled Trial of Regional Citrate Versus Regional Heparin Anticoagulation for Continuous Renal Replacement Therapy in Critically Ill Adults. Crit Care Med 2015;epublished April 6th
- Stucker. Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial. Critical Care 2015;19:91
Drug Therapy
Image: Shutterstock |
Sodium Bicarbonate
General
- Jaber. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet 2018;392(10141):31-40
- Haase. Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial. PLoS Med 2013;10(4):e1001426
Image: Shutterstock |
Diuretics
- Cantarovich. High-dose furosemide for established ARF: A prospective, randomized, double-blind, placebo-controlled, multicenter trial. Am J Kidney Dis 2004; 44:402-40
- Shilliday. Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study. Nephrol Dial Transplant 1997;12:2592–2596
Contrast-Induced Nephropathy
Image: Shutterstock |
General
- Weisbord. Outcomes after angiography with sodium bicarbonate and acetylcysteine. N Engl J Med 2018;378:603–614
- Valette. Sodium Bicarbonate Versus Sodium Chloride for Preventing Contrast-Associated Acute Kidney Injury in Critically Ill Patients: A Randomized Controlled Trial. Crit Care Med 2017;epublished February 7th
