Sections

1. Vinsonneau. Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: A multicentre randomised trial. Lancet 2006; 368:379-385
2. Uehlinger. Comparison of continuous and intermittent renal replacement therapy for acute renal failure. Nephrol Dial Transplant 2005;20:1630-1637
3. Augustine. A randomized controlled trial comparing intermittent with continuous dialysis in patients with ARF. Am J Kidney Dis 2004;44:1000–1007
4. Mehta. A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure. Kidney Int 2001; 60:1154-1163.

1. Gaudry. Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet 2021;395(10235):1506-1515
2. The STARRT-AKI Investigators. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med 2020;383:240-251
3. Barbar. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis (IDEAL-ICU Trial). N Engl J Med 2018;379:1431-1442
4. Zarbock. Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury. The ELAIN Randomized Clinical Trial. JAMA 2016;epublished May 22nd
5. Gaudry. Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit (AKIKI Study). N Engl J Med 2016;epublished May 15th
6. Combes. Early high-volume hemofiltration versus standard care for post-cardiac surgery shock. The HEROICS Study. Am J Respir Crit Care Med 2015;192:1179-1190
7. Jamale. Earlier-start versus usual-start dialysis in patients with community-acquired acute kidney injury: a randomized controlled trial. Am J Kidney Dis 2013;62:1116-1121
8. Bouman. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: A prospective, randomized trial. Crit Care Med 2002; 30:2205-2211

General

1. RENAL Replacement Therapy Study Investigators. Intensity of continuous renal-replacement therapy in critically ill patients (RENAL study). N Engl J Med 2009;361(17):1627-38
2. Palevsky. Intensity of renal support in critically ill patients with acute kidney injury (Acute Renal Failure Trial). N Engl J Med 2008; 359:7-20
3. Saudan. Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. Kidney Int 2006; 70:1312-1317
4. Schiffl. Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 2002;346: 305–310
5. Ronco. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 2000;356:26–30

Sepsis

1. Chung. High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial (RESCUE). Critical Care 2017;21:289
2. Park. High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial (HICORES Trial). Am J Kidney Dis 2016;epublished April 12th

Citrate

1. Zarbock. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury. A Randomized Clinical Trial. JAMA 2020;324(16):1629-1639
2. Gatas. A Randomized Controlled Trial of Regional Citrate Versus Regional Heparin Anticoagulation for Continuous Renal Replacement Therapy in Critically Ill Adults. Crit Care Med 2015;epublished April 6th
3. Stucker. Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial. Critical Care 2015;19:91

1. Skofic. Intermittent high-volume predilution on-line haemofiltration versus standard intermittent haemodialysis in critically ill patients with acute kidney injury: a prospective randomized study.Nephrol Dial Transplant 2012;27(12):4348-4356

1. Atan. A Double-Blind Randomized Controlled Trial of High Cutoff Versus Standard Hemofiltration in Critically Ill Patients With Acute Kidney Injury. Crit Care Med 2018;epublished August 1st

1. Fealy. Faster Blood Flow Rate Does Not Improve Circuit Life in Continuous Renal Replacement Therapy: A Randomized Controlled Trial. Crit Care Med 2017;45(10):1018-1025

General

1. Jaber. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet 2018;392(10141):31-40
2. Haase. Prophylactic Perioperative Sodium Bicarbonate to Prevent Acute Kidney Injury Following Open Heart Surgery: A Multicenter Double-Blinded Randomized Controlled Trial. PLoS Med 2013;10(4):e1001426

1. Cantarovich. High-dose furosemide for established ARF: A prospective, randomized, double-blind, placebo-controlled, multicenter trial. Am J Kidney Dis 2004; 44:402-40
2. Shilliday. Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study. Nephrol Dial Transplant 1997;12:2592–2596

1. Bellomo. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 2000; 356: 2139-43.

1. Bove. Effect of Fenoldopam on Use of Renal Replacement Therapy Among Patients With Acute Kidney Injury After Cardiac Surgery: A Randomized Clinical Trial. JAMA 2014;2014;312(21):2244-2253

1. Pickkers. Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury (STOP-ICU): A Randomized Clinical Trial. JAMA 2018;320(19):1998-2009

Cardiac Surgery

1. Billings. High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery. A Randomized Clinical Trial. JAMA 2016;epublished February 23rd

Paediatric Cardiac Surgery

1. Axelrod. A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial of Aminophylline to Prevent Acute Kidney Injury in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass. Ped Crit Care Med 2016;17(2):135–143