Welcome to the 598th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on platelet transfusion before CVC placement in patients with thrombocytopenia & inhaled tobramycin in patients with ventilator-associated pneumonia; systematic reviews and meta analyses on low-dose hydrocortisone in adults with septic shock & diagnostic accuracy of point-of-care ultrasound for shock; and observational studies on persistent pain symptoms after critical care illness & hypothermia after extracorporeal cardiopulmonary resuscitation in children.

There are also multiple guidelines, including on aneurysmal subarachnoid hemorrhage & cardiac arrest in the perioperative period; narrative reviews on hypovolemia with peripheral edema & traumatic hemorrhage and chain of survival; editorials on oxygen therapy targets in post cardiac arrest patients with hypoxic respiratory failure & brain-lung crosstalk; and commentaries on the limitation of life‑sustaining therapies in critically ill patients with COVID‑19 & physical rehabilitation in the intensive care unit.

If you only have time to read one review article this week, try this one on the use or misuse of albumin in critical iIl patients.

Critical Care Reviews Meeting 2023

There are now just 2 weeks until CCR23. We are hosting 7 major trial results, reviewing 6 of the best trials of the past year, and having two panel discussions. This year the John Hinds Lecture will be delivered by Prof Flavia Machado from São Paulo, Brazil. The title of her talk is "BRICNET: a roadmap for high quality research". If you haven't yet registered for the meeting, you can do so here. Our social programme events are filling up. We have a small amount of availability remaining for the Thursday night's live music in the Dark Horse and slightly more for the Wednesday night's live music in the Common Market. If you plan to take part in either the early morning Thursday or Friday pilates / yoga classes or run, please This email address is being protected from spambots. You need JavaScript enabled to view it.. If you can't make it to Belfast, we will be livestreaming the entire conference. You can avail of the 18 CPD points by registering for virtual attendance. If you just want to watch the trial presentations and discussions without the CPD points, the livestream will be freely embedded on the CCR website. If you do watch it for free, please consider making a small donation to support our work. We are one of very few major conferences to livestream their event for the benefit of everyone, everywhere.

New CCR Newsletter Model

As explained in last week's newsletter, sadly, after 14 years of providing a free newsletter, we are moving to a subscription-based model. You can subscribe here, and help fund our work in disseminating the latest evidence in critical care. Those who contribute to producing content for CCR or have supported our work with a donation over the past year will be automatically added to the new subscription circulation list. If you would like to enquire about a unit level subscription, for the staff in your ICU, ED or other department, This email address is being protected from spambots. You need JavaScript enabled to view it.. Those working in a low-income or low-middle income country can email and ask for complimentary subscription. Next week's newsletter, our 599th consecutive issue, will be our last free edition, so please do subscribe to maintain your service and support our work.