REMAP- CAP COVID Domain 180 Day Trial Results at CCR23
Welcome to the 590th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
There are just 10 weeks until the Critical Care Reviews Meeting 2023, in Titanic Belfast, on June 14th to 16th. The programme is starting to come together, with 3 major trial results presentations and reviews of 5 of the best trials of the past year now confirmed. This week we announced the addition of the REMAP-CAP trial 180 day outcomes paper, which was published in JAMA in December. Dr Lisa Higgins from Melbourne will present the results and open the topic for discussion. We'll be announcing more trials over the next week or two, which means our international faculty will continue to grow. If you haven't yet registered, you can attend in person, virtually with a paid CPD option (this helps fund our work), or virtually for free - just go to the website on the day for the livestream.
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Research
Randomised Controlled Trials
- Tamura. Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial. eClinMed 2023;epublished March 17th
- Heydari. Evaluating the effect of montelukast tablets on respiratory complications in patients following blunt chest wall trauma: A double-blind, randomized clinical trial. Chin J Traumatol 2023;26(2):116-120
- Mourão PAS. Inhaled nebulised unfractionated heparin (UFH) for the treatment of hospitalised patients with COVID-19: A randomised controlled pilot study. Pulm Pharmacol Ther 2023;epublished March 27th
- Schweickert. Structured Mobilization for Critically Ill Patients: A Pragmatic Cluster-Randomized Trial. Am J Respir Crit Care Med 2023;epublished March 30th
Systematic Review & Meta Analyses
- Pitre. Higher- versus Lower-Dose Corticosteroids for Severe to Critical COVID-19: A Systematic Review and Dose–Response Meta-analysis. Ann Am Thorac Soc 2023;20(4):596–604
- Itagaki. Emergency administration of fibrinogen concentrate for haemorrhage: systematic review and meta-analysis. World J Emerg Surg 2023;18(1):27
- Li. High-flow nasal cannula reduces intubation rate in patients with COVID-19 with acute respiratory failure: a meta-analysis and systematic review. BMJ Open 2023;13(3):e067879
- Bertini. Early versus late tracheostomy for traumatic brain injury: a systematic review and meta-analysis. Minerva Anestesiologica 2023;epublished March 29th
Observational Studies
- Bosch. Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock. JAMA Intern Med 2023;epublished March 27th
- Andersen-Ranberg. Haloperidol vs. placebo for the treatment of delirium in ICU patients: a pre-planned, secondary Bayesian analysis of the AID–ICU trial. Intensive Care Med 2023;epublished March 27th
- Papazian. High-level burnout in physicians and nurses working in adult ICUs: a systematic review and meta-analysis. Intensive Care Med 2023;epublished March 27th
- Deeb. Optimal Prehospital Crystalloid Resuscitation Volume in Trauma Patients at Risk for Hemorrhagic Shock. J Am Coll Surg 2023;epublished March 28th
- Ledoux-Hutchinson. Fluid Management for Critically Ill Patients with Acute Kidney Injury Receiving Kidney Replacement Therapy: An International Survey. Clin J Am Soc Nephrol 2023;epublished March 28th
- Potter. Return to Driving After Critical Illness. JAMA Intern Med 2023;epublished March 27th
- Weiss. The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study. Crit Care Med 2023;epublished March 28th
- Pienkos. Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials. Crit Care 2023;27(1):126
- Lindén. Blood volume in patients likely to be preload responsive: a post hoc analysis of a randomized controlled trial. ICMx 2023;11:14
- Bembea. Extracorporeal Membrane Oxygenation Characteristics and Outcomes in Children and Adolescents With COVID-19 or Multisystem Inflammatory Syndrome Admitted to U.S. ICUs. Pediatr Crit Care Med 2023 March 30th
- Shehabi. Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III). Am J Respir Crit Care Med 2023;207(7):876–886
- Zinter. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. Am J Respir Crit Care Med 2023;207(7):945-949
Protocols
- Bosma. Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study. Trials 2023;24(1):232
- von Groote. Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial. BMJ Open 2023;13(3):e070240
- Ferré. Impact of corticosteroids on the duration of ventilatory support during severe acute exacerbations of chronic obstructive pulmonary disease in patients in the intensive care unit: a study protocol for a multicentre, randomized, placebo-controlled, double-blind trial. Trials 2023;24(1):231
Guidelines
- Emergency Point-of-Care Ultrasound Stewardship – A Joint Position Paper by EuSEM and EFSUMB and Endorsed by IFEM and WFUMB. Ultraschall Med 2023;epublished March 30th
- Symptom Assessment for Mechanically Ventilated Patients: Principles and Priorities: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 2023;20(4):491–498
- Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med 2023;207(7):e49–e68
Reviews
Clinical
COVID-19
Neurological
- De Georgia. Blood pressure management in ischemic stroke patients undergoing mechanical thrombectomy. Neurol Res Pract 2023;5(1):12
- Lynch. Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review. J Clin Med 2023;12(6):2179
Circulatory
- Jentzer. Mechanical Circulatory Support Devices in Acute Myocardial Infarction-Cardiogenic Shock: Current Studies and Future Directions. Catheter Cardiovasc Interv 2023;2(2):100586
- Arrigo. Current and future trial design in refractory cardiogenic shock. Eur J Heart Failure 2023;epublished March 29th
- Polyzogopoulou. Early Recognition and Risk Stratification in Cardiogenic Shock: Well Begun Is Half Done. J Clin Med 2023;12:2643
Respiratory
- Gupta. Early total care to early appropriate care - What every anesthesiologist must know! J Anaesthesiol Clin Pharmacol 2023;39(1):3-10
- Dippenaar. The management of postoperative pain after musculoskeletal surgery – a narrative review. South Afr J Anaesth Analg. 2023;29(1):43-48
- Chatwin. Mechanical Insufflation-Exsufflation: Considerations for Improving Clinical Practice. J Clin Med 2023;12:2626
- Nguyen. Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options. J Clin Med 2023;12:2579
- Piccolo. Management of Non-Culprit Lesions in STEMI Patients with Multivessel Disease. J Clin Med 2023;12:2572
Gastrointestinal
Renal
- Gallo. New Insight in Cardiorenal Syndrome: From Biomarkers to Therapy. Int J Mol Sci 2023;24:5089
- Gopolan. Conflict Nephrology: War and Natural Disasters. Kidney360 2023;4(3):405-408
Sepsis
- Cheng. The Blood Microbiome and Health: Current Evidence, Controversies, and Challenges. Int J Mol Sci 2023;24(6):5633
- Rusu. Overview of Side-Effects of Antibacterial Fluoroquinolones: New Drugs versus Old Drugs, a Step Forward in the Safety Profile? Pharmaceutics 2023;15(3):804
- Lakbar. Interactions between Gender and Sepsis-Implications for the Future. Microorganisms 2023;11(3):746
- McLeod. Clinical Appraisal of Cefiderocol in the Treatment of Non-fermenting Gram-Negative Bacilli. Curr Infect Dis Rep 2023;25:45–60
Trauma
Toxicology
- Noga. Review of Possible Therapies in Treatment of Novichoks Poisoning and HAZMAT/CBRNE Approaches: State of the Art. J Clin Med 2023;12:2221
- Stašek. Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients—A Narrative Review. Antibiotics 2023;12(3):568
Paediatrics
Perioperative
Non-Clinical
Editorials
- Wittwer. Oxygen Targets: Too Much or Too Little; Does It Matter? J Cardiothorac Vasc Anesth 2023;37(5):687-689
- Beam. Artificial Intelligence in Medicine. N Engl J Med 2023; 388:1220-1221
- Sandoval. High-risk acute pulmonary embolism: the enemy is still out there. J Cardiothorac Vasc Anaesth 2023;epublished March 31st
- Zochios. Veno-Pulmonary Arterial Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: Should We Consider Mechanical Support of the Pulmonary Circulation From the Outset? ASAIO J 2023;epublished April 1st
Commentaries
- Volpicelli. Lung ultrasound: are we diagnosing too much?. Ultrasound J 2023;15:17
- Park. Bias in Artificial Intelligence. Basic Primer. Clin J Am Soc Nephrol 2023;18(3):394-396
- Heilbroner. Deep Learning in Medicine. Clin J Am Soc Nephrol 2023;18(3):397-399
- Arivazhagan. Natural Language Processing Basics. Clin J Am Soc Nephrol 2023;18(3):400-401
- Dorr. Harnessing the Promise of Artificial Intelligence Responsibly. JAMA 2023;epublished March 27th
- Haupt. AI-Generated Medical Advice—GPT and Beyond. JAMA 2023;epublished March 27th
- Myers. Just the facts: sodium bicarbonate usage in the emergency department. Can J Emerg Med 2023;epublished March 26th
- Gardner. How to write a retrospective observational study. Anaesthesia 2023;78(4):521-525
Correspondence
- Penketh. Use of videolaryngoscopy as the first option for all tracheal intubations: technical benefits and a simplified algorithm for airway management. Br J Anaesth 2023;130(4):E425-E426
- Fillatre. Antimicrobial Exposure: Do Not Forget the Patient’s Condition Beneath the Extracorporeal Membrane Oxygenation Support! Am J Respir Crit Care Med 2023;207(7):950-951
- Li. Altered Antibiotic Pharmacokinetics during Extracorporeal Membrane Oxygenation: Cause for Renal Function? Am J Respir Crit Care Med 2023;207(7):951–952
- Abdul-Aziz. Reply to Fillatre et al. and Li et al. Am J Respir Crit Care Med 2023;207(7):952–953
I hope you find this newsletter useful.
Until next week
Rob