Niklas Nielsen presents the TTM2 Trial at CCR22
Welcome to the 560th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on preoperative restriction of sulfur‐containing amino acid intake for the prevention of acute kidney injury after cardiac surgery & discomfort improvement for critically ill patients using electronic relaxation devices; systematic reviews and meta analyses on thromboelastography-guided therapy in cirrhotic patients & the use of dexmedetomidine in patients with sepsis; and observational studies on extubation in neurocritical care patients & strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure.
There are also guidelines on infective endocarditis in people who inject drugs & lung ultrasound; narrative reviews on antifibrinolytics for traumatic brain injury & platelet transfusion for trauma resuscitation; an editorial on the nephrotoxicity of adding piperacillin–tazobactam to vancomycin; and commentaries on compartmentalisation of immune responses in critical illness & paediatric ventilator liberation; as well as correspondence on decision-making process during meetings on the limitation of life-sustaining support in French ICUs & intracranial pressure pulse morphology.
If you only have time to read one review article this week, try this one on acute colchicine poisoning.
CCR22
The latest video to be released from CCR22 is Niklas Nielsen's presentation of the TTM2 trial, which coincides with Jakub Fronczek's visual abstract on this landmark trial.
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Research
Randomised Controlled Trials
- Osterholt. Preoperative Short‐Term Restriction of Sulfur‐Containing Amino Acid Intake for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Double‐Blind, Translational Trial. J Am Heart Assoc 2022;0:e025229
- Merliot-Gailhoustet. Discomfort improvement for critically ill patients using electronic relaxation devices: results of the cross-over randomized controlled trial E-CHOISIR (Electronic-CHOIce of a System for Intensive care Relaxation). Crit Care 2022;26:263
- Pallesen. The effects of preoperative focused cardiac ultrasound in high-risk patients: A randomised controlled trial (PREOPFOCUS). Acta Anaesthesiol Scand 2022;epublished August 18th
- Bissett. Does mechanical threshold inspiratory muscle training promote recovery and improve outcomes in patients who are ventilator-dependent in the intensive care unit? The IMPROVE randomised trial. Aust Crit Care 2022;epublished August 27th
Systematic Review & Meta Analyses
- Hartmann. Thromboelastography-Guided Therapy Enhances Patient Blood Management in Cirrhotic Patients: A Meta-analysis Based on Randomized Controlled Trials. Semin Thromb Hemost 2022;epublished September 2nd
- Heavner. Systematic review and meta-analysis of the correlation between bispectral index (BIS) and clinical sedation scales: Toward defining the role of BIS in critically ill patients. Pharmacotherapy 2022;42(8):667-676
- Zhang. Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials. Ann. Intensive Care 2022;12:81
- Zhu. Extracorporeal Carbon Dioxide Removal in Patients with Acute Respiratory Distress Syndrome or Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Blood Purif 2022;epublished August 29th
Observational Studies
- Quenot. Renal Replacement Therapy for Acute Kidney Injury in French Intensive Care Units: A Nationwide Survey of Practices. Blood Purif 2022;51:698–707
- Picetti. The acute phase management of spinal cord injury affecting polytrauma patients: the ASAP study. World J Emerg Surg 2022;17:20
- Luther. Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study. Crit Care 2022;26:262
- Watchorn. Decreased renal cortical perfusion, independent of changes in renal blood flow and sublingual microcirculatory impairment, is associated with the severity of acute kidney injury in patients with septic shock. Crit Care 2022;26:261
- Cinotti. Extubation in neurocritical care patients: the ENIO international prospective study. Intensive Care Med 2022;epublished August 29th
- Dianti. Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial. Crit Care 2022;26(1):259
Guidelines
- Management of Infective Endocarditis in People Who Inject Drugs: A Scientific Statement From the American Heart Association. Circulation 2022;epublished August 31st
- Guidelines of the Polish Society of Anaesthesiology and Intensive Therapy defining the rules of qualification and criteria for admitting patients to anaesthesiology and intensive care units. Anaesthesiol Intensive Ther 2022;epublished September 1st
- Demi. New International Guidelines and Consensus on the Use of Lung Ultrasound. J Ultrasound Med 2022;epublished August 22nd
Reviews
Clinical
COVID-19
- Mina. COVID-19 and Fungal Infections: A Double Debacle. Microbes Infect 2022;epublished August 24th
- Selickman. COVID-19-Related ARDS: Key Mechanistic Features and Treatments. J Clin Med 2022;11(16):4896
- Pu. A narrative review of COVID-19-related acute respiratory distress syndrome (CARDS): “typical” or “atypical” ARDS? Ann Transl Med 2022
- Achkar. Post-COVID lung disease(s). Ann Thorac Med 2022;17(3):137–144
- Katal. Black Fungus and beyond: COVID-19 associated infections. Clin Imaging 2022;90:97-109
- Rizk. To Anticoagulate or Not to Anticoagulate in COVID-19: Lessons after 2 Years. Semin Thromb Hemost 2022;epublished April 25th
- Iba. Platelet Activation and Thrombosis in COVID-19. Semin Thromb Hemost 2022;epublished June 23rd
- Zhang. Coagulopathy in COVID-19 and anticoagulation clinical trials. Best Pract Res Clin Haematol 2022;epublished August 23rd
- Pu. A narrative review of COVID-19-related acute respiratory distress syndrome (CARDS): “typical” or “atypical” ARDS? Ann Transl Med 2022;epublished August 8th
- Andaluz-Ojeda. Immunomodulatory therapy for the management of critically ill patients with COVID-19: A narrative review. World J Crit Care Med 2022;11(4):269-297
Neurological
- Schober. Antifibrinolytics in the treatment of traumatic brain injury. Curr Opin Anaesth 2022;35(5):583-592
- Demers-Marcil. Cerebral metabolic derangements following traumatic brain injury. Curr Opin Anaesth 2022;35(5):562-569
- Klimek. Hyperlactatemia and other perioperative metabolic disturbances in neuroanesthesia. Curr Opin Anaesth 2022;35(5):537-542
Circulatory
- Scheitz. Stroke–Heart Syndrome: Recent Advances and Challenges. J Am Heart Assoc 2022;0:e026528
- Murphy. Cardiac arrest: An interdisciplinary scoping review of clinical literature from 2020. JACEP Open 2022;3(4):e12773
Respiratory
- Wick. Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome. Lancet Respir Med 2022;epublished August 29th
- Wallace. Benefits and options for voice restoration in mechanically ventilated intensive care unit patients with a tracheostomy. J Intensive Care Soc 2022;epublished July 10th
Hepatobiliary
- Zhu. Hepatitis of unknown etiology in children: What we know and what we can do? Front Microbiol 202;13:956887
- Kulkarni . Early Diagnosis and Prevention of Infections in Cirrhosis. Semin Liver Dis 2022;42(03):293-312
Renal
- Pang. Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms. Crit Care 2022;26(1):258
- Levine. Prolonged Intermittent Kidney Replacement Therapy. Clin J Am Soc Nephrol 2022;epublished August 29th
Endocrine
Sepsis
- Rogobete. Multimodal Diagnostic Methods of Sepsis in Critically Ill Patients. Diagnostics 2022;12(8):1950
- Sivakorn. Treatment of adults with severe dengue in Thailand. Clin Crit Care 2022;30:e0005
Trauma
- Starr. Platelet Transfusion for Trauma Resuscitation. Curr Trauma Rep 2022;8:147–159
- Kanlerd. Non-operative management for abdominal solid organ injuries: A literature review. Chin J Traumatol 2022;25(5):249-256
Toxicology
Paediatrics
Pre-Clinical
Commentaries
- Conway Morris. Compartmentalisation of immune responses in critical illness: does it matter?. Intensive Care Med 2022;epublished September 1st
- Liu. Methods of liberation from mechanical ventilation: Which one is best? Front Med 2022;9:917369
- Helms. Thromboprophylaxis in critical care. Intensive Care Med 2022;epublished August 29th
- Gathier. Slow recruitment in the HIMALAIA study: lessons for future clinical trials in patients with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage based on feasibility data. Pilot Feasibility Stud 2022;8(1):193
- Liu. Methods of liberation from mechanical ventilation: Which one is best? Front Med 2022;9:917369
- Rizk. Against Therapeutic Anticoagulation in Critically Ill COVID-19 Patients. Semin Thromb Hemost 2022;epublished September 2nd
- Darmon. Monitoring of renal perfusion. Intensive Care Med 2022;epublished September 2nd
- Beitler. Volatile anesthetics for ICU sedation: the future of critical care or niche therapy? Intensive Care Med 2022;epublished September 3rd
- Ramnarayan. What’s new in paediatric ventilator liberation? Intensive Care Med 2022;epublished September 1st
- Filho. We need to talk about critical care in Brazil. Clinics 2022;77:100096
Correspondence
- Tarcy. Decision-making process during limitation life-sustaining support meetings in French intensive care units. Intensive Care Med 2022;epublished August 29th
- Brasil. Intracranial pressure pulse morphology: the missing link? Intensive Care Med 2022;epublished August 29th
- Chotalia. Definition and evolution of right ventricular dysfunction in critically ill COVID-19 patients. Ann Intensive Care 2022;12:82
- Waite. Is your study acronym someone else’s intellectual property? J Intesive Care Soc 2022;epublished September 1st
I hope you find this newsletter useful.
Until next week
Rob