Dr Padmanabhan Ramnarayan (London) presents the results of the FIRST-ABC (step down) trial
Welcome to the 539th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlight of this week's edition is the presentation of the FIRST-ABC trial on a Critical Care Reviews Livestream on Thursday night, with a simultaneous publication in JAMA. There are also guidelines on aneurysmal subarachnoid hemorrhage & diaphragm ultrasonography; narrative reviews on angiotensin II in poisoning-induced shock & beta-blockers in septic shock; plus editorials on parenteral nutrition & beta errors in anaesthetic randomised controlled trials.
If you only have time to read one review article this week, try this one on point-of-care ultrasound for critically-ill patients.
Critical Care Reviews Meeting 2022
CCR22 is now just 65 days away. It features 6 major trial result presentations, 8 reviews of the best trials of the previous year, 3 panel discussions and the annual honorary John Hinds Lecture. If you are interested in the science and evidence which underpins clinical practice, this is the meeting for you. Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open.
Research
Randomised Controlled Trials
- Ramnarayan. Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill Children: A Randomized Clinical Trial. JAMA 2022;epublished April 7th
- Yoshimura. Endovascular Therapy for Acute Stroke with a Large Ischemic Region. N Engl J Med 2022;386:1303-1313
- Yoshimura. Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia. The GRACE-VAP Randomized Clinical Trial. JAMA Netw Open 2022;5(4):e226136
- Bruen. Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial. Crit Care 2022;26(1):101
- Chaudhuri. Helmet noninvasive ventilation compared to facemask noninvasive ventilation and high-flow nasal cannula in acute respiratory failure: a systematic review and meta-analysis. Eur Respir J 2022;59:2101269
Systematic Review & Meta Analyses
- Chaudhuri. Helmet noninvasive ventilation compared to facemask noninvasive ventilation and high-flow nasal cannula in acute respiratory failure: a systematic review and meta-analysis. Eur Respir J 2022;59:2101269
- Chaudhuri. Helmet noninvasive ventilation compared to facemask noninvasive ventilation and high-flow nasal cannula in acute respiratory failure: a systematic review and meta-analysis. Eur Respir J 2022;59(3):2101269
- Azadian. Mortality Benefit From the Passive Leg Raise Maneuver in Guiding Resuscitation of Septic Shock Patients: A Systematic Review and Meta-Analysis of Randomized Trials. J Intensive Care Med 2022 May;37(5):611-617
- Grossen. Update on intrathecal management of cerebral vasospasm: a systematic review and meta-analysis. Neurosurg Focus 2022;52(3):E10
Observational Studies
- Thiolliere. Intensive care-related loss of quality of life and autonomy at 6 months post-discharge: Does COVID-19 really make things worse?. Crit Care 2022;26:94
- Gaudry. Continuous renal replacement therapy versus intermittent hemodialysis as first modality for renal replacement therapy in severe acute kidney injury: a secondary analysis of AKIKI and IDEAL-ICU studies. Crit Care 2022;26:93
- Gendreau. Partitioning Mechanical Ventilator Duration in COVID-19 Related Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2022;epublished April 8th
- Ghneim. Traumatic Brain Injury in Older Adults: Characteristics, Outcomes, and Considerations. Results From the American Association for the Surgery of Trauma Geriatric Traumatic Brain Injury (GERI-TBI) Multicenter Trial. J Am Med Dir Assoc 2022;23(4):568-575.e1
- Bradley. Pneumonia Severity Index and CURB-65 Score Are Good Predictors of Mortality in Hospitalized Patients With SARS-CoV-2 Community-Acquired Pneumonia. Chest 2022;161(4):927-936
Guidelines
- Picetti. Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)–Part 1. J Anesth Analg Crit Care 2022;2:13
- Gray. Consensus Obtained for the Nephrotoxic Potential of 167 Drugs in Adult Critically Ill Patients Using a Modified Delphi Method. Drug Saf 2022;epublished April 7th
- Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India. Lancet Infect Dis 2022;epublished April 4th
- Li. A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020). Front Pharmacol 2022;13:845689
- Haaksma. EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care setting. Crit Care 2022;26(1):99
- EAACI guidelines: Anaphylaxis (2021 update). Allergy 2022;77(2):357-377
Reviews
Clinical
COVID-19
- Zhou. Advances in Pathogenesis, Progression, Potential Targets and Targeted Therapeutic Strategies in SARS-CoV-2-Induced COVID-19. Front Immunol 2022;13:834942
- Montani. Post-acute COVID-19 syndrome. Eur Respir Rev 2022;31:210185
- Long. Clinical update on COVID-19 for the emergency and critical care clinician: Medical management. Am J Emerg Med 2022;56:158-170
- Ruiz-Rodríguez. Blood purification in sepsis and COVID-19: what´s new in cytokine and endotoxin hemoadsorption. J Anesth Analg Crit Care 2022;2:15
Circulatory
- Flick. What is new in hemodynamic monitoring and management? J Clin Monit Comput 2022;epublished April 8th
- Chen. The Role of Angiotensin II in Poisoning-Induced Shock—a Review. J Med Toxicol 2022;18:145–154
- Matanes. An Update on Refractory Hypertension. Curr Hypertens Rep 2022;epublished April 6th
Airway
Respiratory
- Van Slambrouck. A Focused Review on Primary Graft Dysfunction after Clinical Lung Transplantation: A Multilevel Syndrome. Cells 2022;11(4):745
- Pearson. Management of Respiratory Failure. Ventilator Management 101 and Noninvasive Ventilation. CJASN 2022;17(4):572-580
- Hamblin. Diagnosis, course and management of hypersensitivity pneumonitis. Eur Respir Rev 2022;31:210169
Renal
Haematological
Sepsis
- Lescroart. Beta-blockers in septic shock: What is new? J Intensive Med 2022;epublished April 3rd
- Raabe. Lassa Virus Infection: a Summary for Clinicians. Int J Infect Dis 2022;epublished April 5th
Trauma
- Luft. The Damage Control Resuscitation and Surgical Team: The New French Paradigm for Management of Combat Casualties. Military Medicine 2022;187(3-4):e275–e281
- Khorram-Manesh. Review of Military Casualties in Modern Conflicts—The Re-emergence of Casualties From Armored Warfare. Military Medicine 2022;187(3-4):e313–e321
Toxicology
Perioperative
Miscellaneous
Editorials
- How to prescribe parenteral nutrition the safest way: case by case or using machine learning? J Intensive Med 2022;epublished March 30th
- Gibbs. Beta errors in anaesthesia randomised controlled trials in which no statistical significance is found: Is there an elephant in the room? Anaesth Intensive Care 2022;epublished March 31st
- Temsah. Guidance for the pharmacological management of COVID-19 in the emergency setting. Expert Opin Pharmacother 2022;23(6):639-642
- Haines. Peer support to improve recovery after critical care for COVID-19. J Physiother 2022;epublished April 2nd
- Devlin. What language conveys distress and reassurance?. Intensive Care Med 2022;epublished March 29th
- Strauss. Porcine Orthotopic Cardiac Xenotransplantation: The Role and Perspective of Anesthesiologists. J Cardiothoracic Vasc Anaesth 2022;April 8th
Commentaries
- Szewczak. Bringing research to the intensive care setting. Cell 2022;epublished March 31st
- Helmers. The Sword of Damocles: Family Presence and Extracorporeal Life Support During The COVID-19 Pandemic and Beyond. ASAIO Journal 2022;epublished April 4th
- Frush. POINT: Is It Ethically Appropriate for Physicians to Offer to Pray With Patients in the ICU? Yes. Chest 2022;161(4):882-884
- Tan. Critical but stable—critical care communication in the COVID-19 pandemic. Intensive Care Med 2022;epublished March 28th
Correspondence
- Ehsan. An open letter to the Executive Board of WHO from the surgical and anaesthesia community. Lancet 2022;399(10333):1380-1381
- Best. Early increases in anti-SARS-CoV-2 antibody isotypes associated with organ dysfunction and mortality in patients hospitalized with COVID-19. Intensive Care Med 2022;epublished April 2nd
- Kraaijenbrink. Defining basic (lung) ultrasound skills: not so basic after all? Intensive Care Med 2022;epublished
- Mongodi. Defining basic (lung) ultrasound skills; not so basic after all? Intensive Care Med 2022;epublished March 31st
- Matchett. Ketamine for emergency endotracheal intubation: insights into post-induction hemodynamic instability. Intensive Care Med 2022;epublished March 31st
Case Reports
- Patel. Uninterrupted Continuation of VV-ECMO without Anticoagulation for 44 days in COVID-19 ARDS: A Precarious Quandary. J Cardiothoracic Vasc Anaesth 2022;epublished April 9th
- Gaba. Risen Alive: The Lazarus Phenomenon. Case Reports Crit Care 2022;2022:ID 3322056
- Sheikh. A 40-Year-Old Man With Respiratory Failure and Sepsis. Chest 2022;161(4):e241-e243
- Chieng. A 24-Year-Old Man With Dyspnea and a Broken Left Femur. Chest 2022;161(4):e225-e231
- Tripathi. A 58-Year-Old Man With Hemoptysis After COVID-19 Infection. Chest 2022;161(4):e213-e217
- Clark. A 31-Year-Old Man With Asthma, Chest Discomfort, and Shortness of Breath. Chest 2022;161(4):e209-e212
- Iwahashi. Worsening Dyspnea in Patients With Idiopathic Portal Hypertension. Chest 2022;161(4):E245-E248
- Steenhuis. A 20-Year-Old Woman With Thoracic Pain and Progressive Dyspnea on Exertion. Chest 2022;161(4):E233-E240
- Tomiyasu. A 70-Year-Old Woman With Long-Term Nonresolving Pneumonia. Chest 2022;161(4):E219-E223
- Clark. A 31-Year-Old Man With Asthma, Chest Discomfort, and Shortness of Breath. Chest 2022;161(4):E209-E212
- Wong. A 73-Year-Old Woman With Progressive Shortness of Breath and Right-Sided Hemithorax Opacity. Chest 2022;161(4):E203-E207
I hope you find this newsletter useful.
Until next week
Rob
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