Critical Care Reviews Newsletter
Newsletter 504 | August 15th 2021
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Dr Bronwen Connolly during the RECOVERY-RS Trial Results Livestream, August 5th, 2021
Welcome to the 504th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature for the week August 2nd to 8th.
Due to three livestream trial results sessions in 6 nights, I'm way behind with the newsletter. On Wednesday, August 4th, we had the results of the multiplatform COVID-19 anticoagulation trial; the next night the RECOVERY-RS trial was presented, and on Tuesday, August 10th, the results of the BaSICS fluid trial was delivered. The unedited videos are available, with the edited versions being added to the website over the next few days.
The highlights of this week's edition are the publications of our livestream trials - Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 & non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 (BASICS will be in the next week's newsletter). There is also a guideline on the management of perioperative cardiac arrest; narrative reviews on out of hospital cardiac arrest & hemodynamics for the heart failure clinician; an editorial on hypothalamic-pituitary axis disorder; a commentary on what does "ARDS" mean during the COVID-19 pandemic; as well as correspondence on COVID-19-associated invasive pulmonary aspergillosis.
If you only have time to read one article this week, try this one on targeted temperature management and cardiac arrest after the TTM-2 study.
Research
Randomised Controlled Trials
- The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med 2021;epublished August 4th
- The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med 2021;epublished August 4th
- Mathew. Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock. N Engl J Med 2021;385:516-525
- Preprint: Perkins. An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19. medRxiv 2021;epublished August 5th
- Blackwood. Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial (SANDWICH). JAMA 2021;326(5):401-410
- Taylor. Awake Prone Positioning Strategy for Nonintubated Hypoxic Patients with COVID-19: A Pilot Trial with Embedded Implementation Evaluation. Ann Am Thorac Soc 2021;18(8):1360–1368
- Lewis. Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients: A Pilot Randomised Controlled Trial. Ann Am Thorac Soc 2021;epublished July 9th
Systematic Review & Meta Analyses
- Cammarota. Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis. Crit Care 2021;25:268
- Santacruz. Association of cerebrospinal fluid protein biomarkers with outcomes in patients with traumatic and non-traumatic acute brain injury: systematic review of the literature. Crit Care 2021;25:278
Observational Studies
- Avidan. Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study. Lancet Respir Med 2021;epublished August 5th
- van Veen. Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study. Intensive Care Med 2021;epublished August 5th
- Costa. Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;204(3):303–311
- Monteiro. Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial. Crit Care 2021;25:271
- Kooistra. Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients. Crit Care 2021;25:281
- Boscolo. Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDS. Crit Care 2021;25:263
- Gamberini. Resuscitative endovascular occlusion of the aorta (REBOA) for refractory out of hospital cardiac arrest. An Utstein-based case series. Resuscitation 2021;165:161-169
- Kienzle. The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest. Am J Respir Crit Care Med 2021;epublished July 15th
Guidelines
- Chalkias. Clinical practice recommendations on the management of perioperative cardiac arrest: A report from the PERIOPCA Consortium. Crit Care 2021;25:265
- Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report – Executive Summary. Chest 2021;epublished August 2nd
- Enhancing Recruitment and Retention of Minority Populations for Clinical Research in Pulmonary, Critical Care, and Sleep Medicine: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med 2021;204(3):e26–e50
Reviews
Clinical
COVID-19
- Luo. Tailoring glucocorticoids in patients with severe COVID-19: a narrative review. Ann Transl Med 2021;9(15):1261
- Kaushal. Tips and Pearls for Tracheostomy during the Covid-19 Pandemic. Int Arch Otorhinolaryngol 2021;25(3):e459-e462
- Dimopoulos. COVID-19-associated pulmonary aspergillosis (CAPA). J Intensive Med 2021;epublished August 7th
Neurological
- Allen. Multi-Organ Dysfunction in Cerebral Palsy. Front Pediatr 2021;9:668544
Circulatory
- Rea. Out of hospital cardiac arrest: Past, present, and future. Resuscitation 2021;165:101-109
- Hsu. Hemodynamics for the Heart Failure Clinician: A State-of-the-Art Review. J Card Fail 2021;epublished August 10th
- Tilea. Critical Care Management of Decompensated Right Heart Failure in Pulmonary Arterial Hypertension Patients – An Ongoing Approach. The Journal of Critical Care Medicine 2020;7(3):170-183
- Conti. Evidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap. Drug Des Devel Ther 2021;15:3391-3409
Respiratory
- van den Bosch. Breathing variability—implications for anaesthesiology and intensive care. Crit Care 2021;25:280
- Marini. Improving lung compliance by external compression of the chest wall. Crit Care 2021;25:264
Renal
- Lara-Prado. Acute Kidney Injury and Organ Dysfunction: What Is the Role of Uremic Toxins? Toxins 2021;13:551
- Bouajram. A Clinician’s Guide to Dosing Analgesics, Anticonvulsants, and Psychotropic Medications in Continuous Renal Replacement Therapy. Kidney Int Rep 2021;6(8):2033-2048
Endocrine
Trauma
Miscellaneous
Non-Clinical
Editorials
- Grigorescu. Hypothalamic-pituitary axis disorder – “the puppet master” of multiple organ dysfunction in brain-dead patients. JCCM 2021;epublished July 24th
- Guideline Production Group of the European Academy of Neurology. Guidelines should be guidelines: Time to leave the terms "consensus" and "position" for other purposes. Eur J Neurol 2021;28(8):2461-2466
Commentaries
- Taccone. Targeted temperature management and cardiac arrest after the TTM-2 study. Crit Care 2021;25:275
- Lynch. Ignoring Nurses: Media Coverage during the COVID-19 Pandemic. Ann Am Thorac Soc 2021;18(8):1278–1282
- Oxman. The Crisis in Crisis Standards of Care. Ann Am Thorac Soc 2021;18(8):1283–1284
- Brown. What Does "ARDS" Mean during the COVID-19 Pandemic? Ann Am Thorac Soc 2021;epublished July 21st
Correspondence
- Rouzé. COVID-19-associated invasive pulmonary aspergillosis: high incidence or difficult diagnosis?. Intensive Care Med 2021;epublished August 3rd
- Johnson. Patient-directed Prone Positioning in Awake Patients with COVID-19 Requiring Hospitalization (PAPR). Ann Am Thorac Soc 2021;18(8):1423-1426
- Rosén. Letter to the Editor in response to “Find the real responders and improve the outcome of awake prone positioning”. Crit Care 2021;25:273
- Hofmaenner. What every intensivist should know about Tocilizumab. Crit Care 2021;25: 262
- Orlob. Never quite there? — Hyperventilation in cardiopulmonary resuscitation. Resuscitation 2021;165:138-139
- Vieillard-Baron. The difficulty in defining right ventricular failure at the bedside and its clinical significance. Ann Intensive Care 2021;11:122
I hope you find this newsletter useful.
Until next week
Rob
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