Welcome to the 484th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are a randomised controlled trial comparing intermediate-dose with standard-dose prophylactic anticoagulation in critically ill patients with COVID-19; systematic reviews and meta analyses on corticosteroids in cardiac arrest & neuromuscular blocking agents in ARDS; and observational studies on the four-month clinical status of a cohort of patients after hospitalization for COVID-19 & the assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020.
There are also guidelines on the diagnosis of invasive fungal infections and an expert consensus statement on the management of COVID-19-related acute respiratory failure; narrative reviews on COVID-19, immunothrombosis and venous thromboembolism & cardiac function after cardiac arrest; editorials on ethics criteria for scarce resource allocation in the era of COVID-19 & novel renal biomarkers of acute kidney injury; and commentaries on long-term outcomes after critical illness & Kaplan-Meier curves, log-rank tests, and Cox regression for time-to-event data.
If you only have time to read one review article this week, try this one on fifty years of mechanical ventilation—1970s to 2020.
Research
Randomised Controlled Trials
- INSPIRATION Investigators. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit. The INSPIRATION Randomized Clinical Trial. JAMA 2021;epublished March 18th
- Mukaida. Oxygen delivery-guided perfusion for the prevention of acute kidney injury: A randomized controlled trial. J Thorac Cardiovasc Surg 2021;epublished March 16th
- Chapman. Blinded, Double-Dummy, Parallel-Group, Phase 2a Randomized Clinical Trial to Evaluate the Efficacy and Safety of a Highly Selective 5-Hydroxytryptamine Type 4 Receptor Agonist in Critically Ill Patients With Enteral Feeding Intolerance. JPEN J Parenter Enteral Nutr 2021;45(1):115-124
- Lee. Comparison of dynamic needle tip positioning versus conventional long-axis in-plane techniques for ultrasound-guided internal jugular venous catheterization: a randomized controlled trial. Minerva Anestesiologica 2021;87(3):294-301
Systematic Reviews & Meta Analyses
- Lau. Health-Related Quality-of-Life and Cost Utility Analyses in Critical Care: A Systematic Review. Crit Care Med 2021;49(4):575-588
- Lim. A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients With Coronavirus Disease 2019. Crit Care Med 2021;epublished March 12th
- Chan. Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care. A Systematic Review and Meta-Analysis of Observational Studies. Crit Care Med 2021;epublished March 1st
- Shah. Use of Corticosteroids in Cardiac Arrest—A Systematic Review and Meta-Analysis.Crit Care Med 2021;epublished February 23rd
- Grasselli. Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review. Crit Care 2021;25;115
- Lyu. The effect of neuromuscular blocking agents uses in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. Minerva Anestesiologica 2021;87(3):341-50
Observational Studies
- Edara. Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination. JAMA 2021;epublished March 19th
- The Writing Committee for the COMEBAC Study Group. Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19. JAMA 2021;epublished March 17th
- Volpicelli. Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study. Intensive Care Med 2021;epublished March 20th
- Martillo. Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019. Cohort Study From a New York City Critical Care Recovery Clinic. Crit Care Med 2021;epublished March 16th
- Hansen. Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study. Lancet 2021;epublished March 17th
- He. Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study. Lancet 2021;397(10279):1075-1084
- Busana. Prevalence and outcome of silent hypoxemia in COVID-19. Minerva Anestesiologica 2021;87(3):325-33
Guidelines
- Nasa. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care 2021;25:106
- Pappas. The Evidence Supporting the Revised EORTC/MSGERC Definitions for Invasive Fungal Infections. Clin Infect Dis 2021;72(S2):S77–S78
- Alexander. Guidance on Imaging for Invasive Pulmonary Aspergillosis and Mucormycosis: From the Imaging Working Group for the Revision and Update of the Consensus Definitions of Fungal Disease from the EORTC/MSGERC. Clin Infect Dis 2021;72(S2):S79–S88
- Mercier. Defining Galactomannan Positivity in the Updated EORTC/MSGERC Consensus Definitions of Invasive Fungal Diseases. Clin Infect Dis 2021;72(S2):S89–S94
- White. Aspergillus Polymerase Chain Reaction—An Update on Technical Recommendations, Clinical Applications, and Justification for Inclusion in the Second Revision of the EORTC/MSGERC Definitions of Invasive Fungal Disease. Clin Infect Dis 2021;72(S2):S95–S101
- Lamoth. Assessment of the Role of 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Fungal Infections in Adults. Clin Infect Dis 2021;72(S2):S102–S108
- SARS-CoV-2 infection, COVID-19 and timing of elective surgery: A multidisciplinary consensus statement on behalf of the Association of Anaesthetists, the Centre for Peri-operative Care, the Federation of Surgical Specialty Associations, the Royal College of Anaesthetists and the Royal College of Surgeons of England. Anaesthesia 2021;epublished March 18th
Reviews
Clinical
COVID-19
- Benmansour. Complement cascade in severe forms of COVID-19: recent advances in therapy. Eur J Immunol 2021;epublished March 19th
- Loo. COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms. Thorax 2021;76:412-420
- Corbell. Management of hypoxemia in severe acute respiratory syndrome coronavirus 2 infection: Lessons learned from one year of experience, with a special focus on silent hypoxemia. J Intensive Med 2021;epublished March 9th
Neurological
- Lindberg. Perioperative stroke after non-cardiac, non-neurological surgery. BJE Education 2021;21(2):59-65
- Pasternak. Neuroanesthesiology Update. J Neurosurg Anesthesiol 2021;33(2):107-136
Circulatory
- Checchia. The Evolution of Pediatric Cardiac Critical Care. Crit Care Med 2021;49(4):545-557
- Babini. Cardiac function after cardiac arrest: what do we know? Minerva Anestesiologica 2021;87(3):358-67
Respiratory
- MacIntyre. Fifty Years of Mechanical Ventilation—1970s to 2020. Crit Care Med 2021;49(4):558-574
- See. Acute cor pulmonale in patients with acute respiratory distress syndrome: A comprehensive review. World J Crit Care Med 2021;10(2):35-42
Sepsis
- Cantón. Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic. Curr Opin Crit Care 2021;26(5):433-441
- Mendelson. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp 2021;9(1):14
Trauma
Toxicology
Perioperative
- Ashken. Regional anaesthesia in patients at risk of bleeding. BJE Education 2021;21(2):84-94
- ablonski. Future in regional anesthesia and pain medicine: the pharmacological view. Minerva Anestesiologica 2021;87(3):351-7
Miscellaneous
Pre-Clinical
Editorials
- Giannini. Who gets the last bed? Ethics criteria for scarce resource allocation in the era of COVID-19. Minerva Anestesiologica 2021;87(3):267-71
- Bláha. Our decisions are only as good as the information we have. Minerva Anestesiologica 2021;87(3):275-7
- Ventre. The inscrutable signatures of patient-ventilator asynchrony: all the light we cannot see. Minerva Anestesiologica 2021 March;87(3):278-82
- Bellomo. Novel renal biomarkers of acute kidney injury and their implications. Intern Med J 2021;51(3):316-318
Commentaries
- Inouye. The Importance of Delirium and Delirium Prevention in Older Adults During Lockdowns. JAMA 2021;epublished March 15th
- Schober. Kaplan-Meier Curves, Log-Rank Tests, and Cox Regression for Time-to-Event Data. Anesthesia & Analgesia 132(4):969-970
- Experts Discuss COVID-19—Vaccine Questions, School Openings, and More. JAMA 2021;epublished March 17th
- Rousseau. Long-term outcomes after critical illness: recent insights. Crit Care 2021;25:108
Correspondence
- Yoshihiro. A reassessment about included studies and certainty of evidence on a systematic review and meta-analysis of steroid for patients with acute respiratory distress syndrome. J Intensive Care 2021;9:25
- Schortgen. Efficiency of transmission-based precautions (TBPs) against SARS-CoV-2 501Y.V2 variant transmissibility in the ICU. Intensive Care Med 2021;epublished March 18th
- Mongodi. High prevalence of acute stress disorder and persisting symptoms in ICU survivors after COVID-19. Intensive Care Med 2021;epublished March 17th
- Herzog. Goal-directed therapy in the perioperative management: is a complete hemodynamics bundle of care better?. Crit Care 2021;25:105
- Kenny. Stroke volume is the key measure of fluid responsiveness. Crit Care 2021;25:104
- Laurens. Drug induced acute interstitial nephritis in the critical care: should we consider it? Minerva Anestesiologica 2021;87(3):368-9
Case Reports
- Pellegrini. All that glitters is not gold: an unusual presentation of S. aureus sepsis during ECMO. Intensive Care Med 2021;epublished March 21st
- Ferry. Extracorporeal cardiopulmonary resuscitation for severe chloroquine intoxication in a child – a case report. Scand J Trauma Resusc Emerg Med 2021;29:48
- Cascarano. Extracorporeal immune modulation in COVID-19 induced immune dysfunction and secondary infections: the role of oXiris® membrane. Minerva Anestesiologica 2021;87(3):384-5
I hope you find this newsletter useful.
Until next week
Rob
Supported by the Health Research Board
