Welcome to the 478th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature for the week of February 1st to 7th.
The highlights of this week's edition are the latest results from the RECOVERY Collaborative Group, investigating azithromycin in hospitalised patients with COVID-19; systematic reviews and meta analyses on convalescent plasma therapy for COVID-19 & the mortality of older patients admitted to the ICU; and observational studies on SARS-CoV-2 evolution during treatment of chronic infection & the occurrence of invasive pulmonary fungal infections in ICU patients with severe COVID-19. There are also guidelines on heart donation and transplantation after circulatory determination of death & post-cardiac arrest care and targeted temperature management; narrative reviews on ARDS during COVID-19 & vasopressor therapy in the ICU; an editorial on biomarkers to guide ventilation and readiness for extubation; as well as correspondence on percutaneous tracheostomy & monoclonal antibody therapy for patients with Covid-19.
If you only have time to read one review article this week, try this one on post-resuscitation shock.
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Research
Randomised Controlled Trials
- RECOVERY Collaborative Group. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet 2021;epublished February 2nd
- Fuller. Prehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT. Health Technol Assess 2021;25(7):1-92
- Chapple. Effects of Standard Versus Energy-Dense Formulae on Gastric Retention, Caloric Delivery, and Glycaemia in Critically Ill Patients. JPEN J Parenter Enteral Nutr 2021;epublished February 5th
Systematic Reviews & Meta Analyses
- Vegivinti. Efficacy of convalescent plasma therapy for COVID-19: A systematic review and meta-analysis. J Clin Apher 2021;epublished February 5th
- Xu. Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19. BMC Nephrol. 2021;22(1):52
- Bartlett. Systematic review and meta-analysis of intravascular temperature management vs. surface cooling in comatose patients resuscitated from cardiac arrest. Resuscitation 2020;146:82-95
- Vallet. Mortality of Older Patients Admitted to an ICU: A Systematic Review. Crit Care Med 2021;49(2):324-334
- Zhang. Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis. Crit Care Med 2021;49(2):335-346
- Tripathi. The Practice and Complications of Midline Catheters: A Systematic Review. Crit Care Med 2021;49(2):e140-e150
- Minozzi. Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation. Cochrane Database Syst Rev 2021;epublished January 22nd
Observational Studies
- Kemp. SARS-CoV-2 evolution during treatment of chronic infection. Nature 2021;epublished February 5th
- Ouldali. Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children. JAMA 2021;epublished February 1st
- Bain. COVID-19 versus Non-COVID ARDS: Comparison of Demographics, Physiologic Parameters, Inflammatory Biomarkers and Clinical Outcomes. Ann Am Thorac Soc 2021;epublished February 5th
- Heijnen. Biological subphenotypes of acute respiratory distress syndrome may not reflect differences in alveolar inflammation. Physiol Rep 2021;9(3):e14693
- Giacobbe. Incidence and Prognosis of Ventilator-Associated Pneumonia in Critically Ill Patients with COVID-19: A Multicenter Study. J Clin Med 2021;10(4):555
- Ebinger. Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin. JAMA 2021;325(5):454-466
- Shaefi. Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19. Intensive Care Med 2021;epublished February 2nd
- Fekkar. Occurrence of Invasive Pulmonary Fungal Infections in Patients with Severe COVID-19 Admitted to the ICU. Am J Respir Crit Care Med 2021;203(3):307–317
- Dennis. Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020. Crit Care Med 2021;49(2):209-214
- Broman. The Relationship Between Heart Rate and Body Temperature in Critically Ill Patients. Crit Care Med 2021;epublished January 20th
- Domecq. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies. The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med 2021;epublished January 28th
- Douglas. Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure. Crit Care Med 2021;epublished January 28th
- Faustino. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children. A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Crit Care Med 2021;January 20th
- Skrifvars. A Post Hoc Analysis of Osmotherapy Use in the Erythropoietin in Traumatic Brain Injury Study—Associations With Acute Kidney Injury and Mortality. Crit Care Med 2021;January 20th
- Scheffenbichler. Effects of the Level and Duration of Mobilization Therapy in the Surgical ICU on the Loss of the Ability to Live Independently. An International Prospective Cohort Study. Crit Care Med 2021;January 8th
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Guidelines
- Shemie. Heart donation and transplantation after circulatory determination of death: expert guidance from a Canadian consensus building process. Can J Anaesth 2021;epublished February 5th
- Brazilian guidelines for the management of brain-dead potential organ donors. The task force of the AMIB, ABTO, BRICNet, and the General Coordination of the National Transplant System
Ann Intensive Care 2020;10:169 - Post-cardiac arrest care and targeted temperature management: A consensus of scientific statement from the Taiwan Society of Emergency & Critical Care Medicine, Taiwan Society of Critical Care Medicine and Taiwan Society of Emergency Medicine. J Formos Med Assoc 2021;120(1):569-587
- Pristipino. European position paper on the management of patients with patent foramen ovale. Part II - Decompression sickness, migraine, arterial deoxygenation syndromes and select high-risk clinical conditions. Eur Heart J 2021;epublished January 28th
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Reviews
COVID-19
- Thakur. Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations. J Clin Med 2021;10(3):446
- Cormican. Severe Acute Respiratory Syndrome Coronavirus-2 Cardiovascular Complications: Implications for Cardiothoracic Anesthesiology. J Cardiothorac Vasc Anesth 2021;35(3):932-943
- Vitiello. Colchicine and SARS-CoV-2: Management of the hyperinflammatory state. Resp Med 2021;epublished January 31st
- Pandian. COVID-19 survivorship: How otolaryngologist-head and neck surgeons can restore quality of life after critical illness. Am J Otolaryngol 2021;42(3):102917
- Capaccione. Pathophysiology and Imaging Findings of COVID-19 Infection: An Organ-System Based Review. Acad Radiol 2021;epublished February 4th
- White. Mitigating Inequities and Saving Lives with ICU Triage during the COVID-19 Pandemic. Am J Respir Crit Care Med 2021;203(3):287–295
- Kopar. Critical Ethics: How to Balance Patient Autonomy With Fairness When Patients Refuse Coronavirus Disease 2019 Testing. Crit Care Explor 2021;3(1):e0326
- Polverino. COVID-19, COPD, and AECOPD: Immunological, Epidemiological, and Clinical Aspects. Front Med 2021;7:627278
- Williams. Acute Respiratory Distress Syndrome: Contemporary Management and Novel Approaches during COVID-19. Anesthesiology 2021;134:270–282
Neurology
Circulatory
- De Charrière. ECMO in Cardiac Arrest: A Narrative Review of the Literature. J Clin Med 2021;10(3):534
- Miraglia. Extracorporeal cardiopulmonary resuscitation for adults with shock‐refractory cardiac arrest. J Am Coll Emerg Physicians Open 2021;2(1):e12361
- Jozwiak. Post-resuscitation shock: recent advances in pathophysiology and treatment. Ann Intensive Care 2020;10:170
- Russell. Vasopressor Therapy in the Intensive Care Unit. Semin Respir Crit Care Med 2021;42(01):059-077
- Rawish. Current Knowledge and Future Challenges in Takotsubo Syndrome: Part 1—Pathophysiology and Diagnosis. J Clin Med 2021;10(3):479
- Santoro. Current Knowledge and Future Challenges in Takotsubo Syndrome: Part 2—Treatment and Prognosis. J Clin Med 2021;10(3):468
- Qu. Ventricular Assist Device-Specific Infections. J Clin Med 2021;10(3):453
- Simons. Do-(Not-)Mechanical-Circulatory-Support Orders: Should We Ask All Cardiac Surgery Patients for Informed Consent for Post-Cardiotomy Extracorporeal Life Circulatory Support? J Clin Med 2021;10(3):383
- Italiano. Novelties in 3D Transthoracic Echocardiography. J Clin Med 2021;10(3):408
Respiratory
Gastrointestinal
Renal
Sepsis
Trauma
Perioperative
Miscellaneous
Non-Clinical
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Editorials
- Jean-Jacques. Vaccine Distribution—Equity Left Behind? JAMA 2021;epublished January 29th
- Raventós. Biomarkers to Guide Ventilation Management and Readiness for Extubation. Am J Respir Crit Care Med 2021;epublished January 27th
- Pergolizzi. Four pandemics: lessons learned, lessons lost. Signa Vitae 2021;17(1):1-5
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Commentaries
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Correspondence
- Various. Percutaneous Tracheostomy. N Engl J Med 2021;epublished February 3rd
- Various. Monoclonal Antibody for Patients with Covid-19. N Engl J Med 2021;epublished February 3rd
- Lee. Microvascular Injury in the Brains of Patients with Covid-19. N Engl J Med 2021; 384:481-483
- Singer. High oxygen flow rates with the UCL Ventura CPAP device - Authors' reply. Lancet Respir Med 2021;epublished February 2nd
- Devarakonda. Pulsating Internal Jugular Vein Due to Atrial Flutter Mimicking the Carotid Artery During Ultrasound-Guided Central Venous Cannulation. J Cardiothorac Vasc Anesth 2021;35(3):958-959
- Pepper. Choosing Sides: Contralateral Tension Pneumothorax after Thoracotomy. J Cardiothorac Vasc Anesth 2021;35(3):960-961
- Meduri. The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19. Author's reply. Intensive Care Med 2021;epublished January 28th
- Proudfoot. Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experience. Intensive Care Med 2021;epublished January 28th
- Jha. Anatomical, physiological and clinical similarities and differences in ARDS physiological subtypes. Intensive Care Med2021;epublished February 2nd
- Epker. Double data and dubious conclusions, ‘Houston do we have a problem?’. Intensive Care Med 2021;epublished February 2nd
- Chiumello. Complexity and unanswered questions in the pathophysiology of COVID-19 ARDS. Intensive Care Med 2021;epublished February 1st
- High Prevalence of Pulmonary Sequelae at 3 Months after Hospital Discharge in Mechanically Ventilated Survivors of COVID-19. Am J Respir Crit Care Med 2021;203(3):371–374
- Chiang. Transpulmonary Bubble Transit in Severe COVID-19: Pulmonary Vasodilatation or Angiogenesis? Am J Respir Crit Care Med 2021;203(3):388-389
- Swenson. Positive Bubble Study in Severe COVID-19: Bubbles May Be Unrelated to Gas Exchange Impairment. Am J Respir Crit Care Med 2021;203(3):389–390
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Case Reports
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News
- Hampton. Autoantibodies May Drive COVID-19 Blood Clots. JAMA 2021;325(5):425
- Slomski. “Important Conversations” Are Needed to Explain the Nocebo Effect. JAMA 2021;epublished February 3rd
- Zarocostas. WHO team begins COVID-19 origin investigation. Lancet 2021;397(10273):459
- Burki. Understanding variants of SARS-CoV-2. Lancet 2021;397(10273):462
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Multimedia
I hope you find this newsletter useful.
Until next week
Rob
Supported by the Health Research Board
