Critical Care Reviews Newsletter
Newsletter 475 | January 18th 2021
Welcome to the 475th Critical Care Reviews Newsletter. It's a different look at present as I familiarise myself with a new website and emailing application. The big news this week is that it's finally time for eCCR21.
The meeting is being live streamed for free on Vimeo, as well as on Twitter, LinkedIn and on the Critical Care Reviews website. Registration is open and only necessary if you wish to claim the 18 CPD / CME points which the meeting has been approved for by the Royal College of Anaesthetists. If you don't need to register, just tune in whenever you can. I've updated the website significantly, which is part of a refocusing on critical care trials. The old site was over 10 years old and contained almost 9000 webpages. It will take a while to reimport the key pages, but much of the little used material has been removed. At present the site is functioning via a domain redirect (www.ccrtestsite.com), due to my soon to be ex-host messing up spectacularly. I'll get it fixed after the meeting.
Please do let your colleagues know about the meeting. We are hosting 5 major trial results, 14 trial presentations, as well as talks on publishing, pilot trials and the honorary annual John Hinds Lecture. For those who can't make it, everything will be recorded and released as soon as possible.
Randomised Controlled Articles
- Kyriazopoulou. Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial. Am J Respir Crit Care Med 2021;202(3):202–210
- Wittermans. Adjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: A randomised clinical trial. Eur Respir J 2021;epublished January 14th
- Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med 2021;epublished January 13th
- Garcia Guerra.. Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial. J Intensive Care 2021;9:7
Systematic Reviews & Meta Analyses
- Walayat. Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review. Ann Gastroenterol 2021;34(1):1-6
- Cristobal. Cardiopulmonary Resuscitation in the Prone Position in the Operating Room or in the Intensive Care Unit: A Systematic Review. Anesth Analg 2021;132(2):285-292
- Barbateskovic. Higher vs Lower Oxygenation Strategies in Acutely Ill Adults. A Systematic Review With Meta-Analysis and Trial Sequential Analysis. Chest 2021;159(1):154-173
Observational Studies
- Biancari. Five-year survival after post-cardiotomy veno-arterial extracorporeal membrane oxygenation. Eur Heart J Acute Cardiovascular Care 2021;epublished January 12th
- Eck. Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies. Crit Care 2021;25:27
- Sklar. Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Crit Care 2021;25:26
- Dupuis. Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs. Crit Care 2021;25:24
- Levy. Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study. Crit Care 2020;25:21
- Ramani. Post-ICU COVID-19 Outcomes. A Case Series. Chest 2021;159(1):215-218
- de Almeida Monteiro. Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings. Intensive Care Med 2021;epublished January 3rd
- Joyner. Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19. N Engl J Med 2021;epublished January 13th
- Ranzani. Characterisation of the first 250 000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data. Lancet Respir Med 2021;epublished January 15th
- Gupta. Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. Lancet Respir Med 2021;epublished January 11th
- Goligher. Effect of Lowering Tidal Volume on Mortality in ARDS Varies with Respiratory System Elastance. Am J Respir Crit Care Med 2021;epublished January 13th
- Dorward. Tissue-Specific Immunopathology in Fatal COVID-19. 192–201
- Editorial: Welte. SARS-CoV-2–triggered Immune Reaction: For COVID-19, Nothing Is as Old as Yesterday’s Knowledge. Am J Respir Crit Care Med 2021;203(2):156
Clinical
- Csete. Basic Science of Frailty—Biological Mechanisms of Age-Related Sarcopenia. Anesth Analg 2021;132(2):293-304
- De Groot. Is secondary chemical exposure of hospital personnel of clinical importance? Clinical Toxicology 2021;epublished January 15th
- Leasa. Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic. Crit Care 2021;25:22
- Murphy. Acute flaccid myelitis: cause, diagnosis, and management. Lancet 2021;epublished December 21st
- Moonen. Energy expenditure and indirect calorimetry in critical illness and convalescence: current evidence and practical considerations. J Intensive Care Med 2021;9:8
- Zheng. A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management. Ann Transl Med 2021;9(1):69
- Saracoglu. Advanced airway management in out-of-hospital cardiac arrest – to intubate or not to intubate: a narrative review of the existing literature. Anaesthesiol Intensive Ther 2020;52(5):425–433
- Smędra. The notion of grievous bodily harm and the legal obligation to notify law enforcement authorities. Anaesthesiol Intensive Ther 2020;52(5):418–424
- Jasiński. COVID-19 and haemodynamic failure: a point of view on mechanisms and treatment. Anaesthesiol Intensive Ther 2020;52(5):409–417
- Wujtewicz. Occupational hazards in anaesthesiology during the COVID-19 pandemic. Anaesthesiol Intensive Ther 2020;52(5):400–408
- Bulut. Hemostatic Balance in Pediatric Acute Liver Failure: Epidemiology of Bleeding and Thrombosis, Physiology, and Current Strategies. Front Pediatr 2020;8:618119
Anaesthesia Series on Regional Anaesthesia
- Editorial: Chin. Advancing towards the next frontier in regional anaesthesia. Anaesthesia 2021;76(S1):3-7
- Chen. The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review. Anaesthesia 2021;76(S1):8-17
- McCombe. Regional anaesthesia: risk, consent and complications. Anaesthesia 2021;76(Suppl. 1):18–26
- Macfarlane. Updates in our understanding of local anaesthetic systemic toxicity: a narrative review. Anaesthesia 2021;76(S1):27-39
- Johnston. Defining success in regional anaesthesia. Anaesthesia 2021;76(S1):40-52
- Ramlogan. Contemporary training methods in regional anaesthesia: fundamentals and innovations. Anaesthesia 2021;76(S1):53-64
- Gadsden. The role of peripheral nerve stimulation in the era of ultrasound‐guided regional anaesthesia. Anaesthesia 2021;76(S1):65-73
- Heydinger. Fundamentals and innovations in regional anaesthesia for infants and children. Anaesthesia 2021;76(S1):74-88
- Hamilton. Regional anaesthesia quality indicators for adult patients undergoing non‐cardiac surgery: a systematic review. Anaesthesia 2021;76(S1):89-99
- Desai. Local anaesthetic adjuncts for peripheral regional anaesthesia: a narrative review. Anaesthesia 2021;76(S1):100-109
- Chin. Ultrasound‐guided fascial plane blocks of the chest wall: a state‐of‐the‐art review. Anaesthesia 2021;76(S1):110-126
- Levy. Regional anaesthesia in patients with diabetes. Anaesthesia 2021;76(S1):127-135
- Sultan. Regional anaesthesia for labour, operative vaginal delivery and caesarean delivery: a narrative review. Anaesthesia 2021;76(S1):136-147
- Dockrell. The role of regional anaesthesia in the emerging subspecialty of onco‐anaesthesia: a state‐of‐the‐art review. Anaesthesia 2021;76(S1):148-159
- McLeod. Novel approaches to needle tracking and visualisation. Anaesthesia 2021;76(S1):160-170
- McKendrick. The use of artificial intelligence and robotics in regional anaesthesia. Anaesthesia 2021;76(S1):171-181
- Supady. Allocating scarce intensive care resources during the COVID-19 pandemic: practical challenges to theoretical frameworks. Lancet Respir Med 2021;epublished January 12th
- Tsang. Twenty articles that critical care clinicians should read about COVID-19. Intensive Care Med 2021;epublished January 3rd
- Cavaleri. The European Medicines Agency's EU conditional marketing authorisations for COVID-19 vaccines. Lancet 2021;epublished January 13th
- Downar. Improving family access to dying patients during the COVID-19 pandemic. Lancet Respir Med 2021;epublished January 12th
- Praschan. Implications of COVID-19 sequelae for health-care personnel. Lancet Respir Med 2021;epublished January 11th
- Should Corticosteroids Be Routine Treatment in Early ARDS? Chest 2021;159(1):25-37
- Schober. Logistic Regression in Medical Research. Anesth Analg 2021;132(2):365-366
- Piller. Many scientists citing two scandalous COVID-19 papers ignore their retractions. Science 2021;epublished January 15th
- Zitter. Hummingbird Lessons. JAMA 2021;325(2):131-132
- Jaffe. Rochelle Walensky: new Director of the US CDC. Lancet 2021;epublished January 14th
- Millington. Lung Ultrasound for Patients With Coronavirus Disease 2019 Pulmonary Disease. Chest 2021;159(1):205-211
- Tobin. Pondering the atypicality of ARDS in COVID-19 is a distraction for the bedside doctor. Intensive Care Med 2021;epublished January 15th
- Supady. Hospital networks and patient transport capacity during the COVID-19 pandemic when intensive care resources become scarce. Crit Care 2021;25:28
- Añón. Ten reasons why corticosteroid therapy reduces mortality in severe COVID-19. Intensive Care Med 2021;January 2nd
- Iglesias. Would You Withhold Fruit From the Critically Ill? Chest 2021;159(1):452-453
- Brenner. Assessing Candidacy for Tracheostomy in Ventilated Patients With Coronavirus Disease 2019. Aligning Patient-Centered Care, Stakeholder Engagement, and Health-Care Worker Safety. Chest 2021;159(1):454-455
- de Chambrun. Clarkson’s Disease Episode or Secondary Systemic Capillary Leak-Syndrome. That Is the Question! Chest 2021;159(1):441
- Wijdicks. “We believe your father is in a vegetative state”. “You mean he is a vegetable? He never wanted that”. Intensive Care Med 2021;epublished January 15th
- Lorusso. ECMO for COVID-19 patients in Europe and Israel. Intensive Care Med 2021;epublished January 9th
- Thompson. Sex differences in response to adjunctive corticosteroid treatment for patients with septic shock. Intensive Care Med 2021;epublished January 7th
- Diao. Clinical Implications of Removing Race From Estimates of Kidney Function. JAMA 2021;325(2):184-186
- Chen. Assessing the importance of interleukin-6 in COVID-19. Lancet Respiratory Med 2021;epublished January 15th
- Leisman. Assessing the importance of interleukin-6 in COVID-19 – Authors' reply. Lancet Respiratory Med 2021;epublished January 15th
- Chen. Pulmonary Vasculature: A Target for COVID-19. Am J Respir Crit Care Med 2021;203(2):260–261
- Jha. Pulmonary Vascular Changes in Acute Respiratory Distress Syndrome due to COVID-19. Am J Respir Crit Care Med 2021;203(2):259–260
- Caviedes. Pulmonary Angiopathy in Severe COVID-19: Physiological Conclusions Derived from Ventilatory Ratio? Am J Respir Crit Care Med 2021;203(2):258–259
- Sanfilippo. COVID-19, Hypercoagulability, and Cautiousness with Convalescent Plasma. Am J Respir Crit Care Med 2021;203(2):257–258
- Cherian. Positive Bubble Study in Severe COVID-19 Indicates the Development of Anatomical Intrapulmonary Shunts in Response to Microvascular Occlusion. Am J Respir Crit Care Med 2021;203(2):263–265
- Roedl. Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19. Am J Respir Crit Care Med 2021;203(2):242–245
- Patel. Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019. Chest 2021;159(1):e7-e11
- Park. Case of a 21-Year-Old Man With Hemoptysis, Recurrent Pneumothorax, and Cavitary Lung Lesions. Chest 2021;159(1):13-e17
- Ji. A 49-Year-Old Man Presents With Fever of Unknown Origin and Cough. Chest 2021;159(1):e25-e28
- Gul. A 65-Year-Old Woman With Dyspnea After Atrial Fibrillation Ablation. Chest 2021;159(1):e29-e33
- Odackal. A 28-Year-Old Man With Chest Pain, Shortness of Breath, and Hemoptysis After Recovery From Coronavirus Disease 2019 Pneumonia. Chest 2021;159(1):e35-e38
- Hawkins. A 33-Year-Old Man With Dyspnea, Chest Pain, and a Massive Pleural Effusion. Chest 2021;159(1):e39-e43
- Zirek. A 2-Year-Old Boy With Hypoxemia, Pulmonary Hypertension, and Digital Clubbing. Chest 2021;159(1):e45-e48
- Miller. A 56-Year-Old Man With Chronic Cough, Hemoptysis, and a Left Lower Lobe Infiltrate. Chest 2021;159(1):e53-e56
- Sia. Reversal of Acute Right Ventricular Failure Early Post Left Ventricular Assist Device Placement by Intratracheal Milrinone Administration. Chest 2021;159(1):e57-e60
- Almajthoub. A 58-Year-Old Man With Abdominal Ascites. Chest 2021;159(1):e61-e63
- Mart. Pneumomediastinum in Acute Respiratory Distress Syndrome from COVID-19. Am J Respir Crit Care Med 2021;203(2):237–238
Until next week
Rob