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CCR Down Under 2025

The Best Critical Care Trials in the World

Melbourne, December 9th & 10th


In Partnership With

Trialists

First presentations of major trials results


Carol Hodgson

Co-Chief Investigator, ECMO Rehab

Professor Carol Hodgson is a clinical trialist with expertise in long-term functional outcomes after critical illness. She is Head of the Division of Clinical Trials and Cohort Studies in the School of Public Health and Preventive Medicine, and Co-Director of the Australian and New Zealand Intensive Care Research Centre, Monash University. She is Chair of the Australian Health Research Alliance and the Executive Director of Monash Partners Research Translation Network, which aims to ensure research is implemented and translated into healthcare to improve patient outcomes. She sits on the Australian NHMRC Research Committee which fosters research across the spectrum of health and medical research, including the awarding of grants and providing research support. She has worked in ICU at Alfred Health for over 25 years as a Specialist Physiotherapist.

Lisa Higgins

Co-Chief Investigator, ECMO Rehab

Lisa Higgins, PhD, MPH, BPhysio is a clinical trialist, senior research fellow and health economist at the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, where she leads the Health Economics Program. Her research focuses on clinical trial methodology, long-term outcomes, and conducting economic evaluations alongside clinical trials in critical care. Lisa has served as a member of the management committees of more than 25 large-scale national and international randomised controlled trials, and is currently leading an RCT evaluating a post-discharge intervention to improve long-terms outcomes for ECMO survivors. Lisa has more than 140 publications with over 15,000 citations and has multiple clinical trial publications in high impact journals including the NEJM and JAMA.

Evangelos Giamarellos

Chief Investigator, ImmunoSep Trial

Evangelos Giamarellos is Professor of Internal Medicine and Infectious Diseases at the Medical School of the National and Kapodistrian University of Athens and director of the MSc program of Infectious Diseases at the University of Athens.

His main research contribution is immunomodulation in sepsis and in auto-inflammatory disorders. He has 573 publications in international peer-reviewed journals with more than 42,000 citations and h-index 95. He is the current chairman of the European Sepsis Alliance and the current President of the Hellenic Society of Chemotherapy. His main achievement is the approval of anakinra for COVID-19 pneumonia in adults by the European Medicines Agency and the Food and Drug Administration through the phase 2 and 3 trials SAVE and SAVE-MORE that he designed and conducted.

Michael Reade

Chief Investigator, CLIP II

Michael Reade is Head of the Greater Brisbane Clinical School of the University of Queensland, an intensivist at the Royal Brisbane and Women’s Hospital and an anaesthetist at Ipswich Hospital. Since 2011 he has been the Professor of Military Medicine and Surgery at the Australian Defence Force’s Joint Health Command. He represents Australia on the NATO Blood Panel, Chairs the military Five Eyes Science and Technology Military Medicine Panel, and is a member of the WHO Medical Civil-Military Technical Working Group. His research programs cover blood and fluid resuscitation in trauma, traumatic brain injury, and the management of acute cognitive dysfunction in critical illness.

Ary Serpa Neto

Ary Serpa Neto

Co-Investigator, ACTiVE Trial

Ary Serpa Neto, MD, MSc, PhD is an Intensivist and Director of Intensive Care Research at Austin Hospital in Melbourne, Australia. He is also an Associate Professor at the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, where he leads the Mechanical Ventilation and Renal & Metabolic Programs. He is a founding member of the Protective Ventilation Network (PROVENet) and a member of the Scientific Committee of the Brazilian Research in Intensive Care Network (BRICNet). His research focuses on mechanical ventilation, renal and metabolic care, and advanced clinical trial methodology, with a strong emphasis on translating evidence into clinical practice.

Ary has authored over 430 publications, including multiple articles in The New England Journal of Medicine, JAMA, and The Lancet Respiratory Medicine, and his work has been cited in several international guidelines. He currently leads several large-scale international randomised clinical trials in Australia, including the NHMRC-funded SODa-BIC, DRIVE and GuARDS trials.

Perof Brenda O'Neill

Brenda O'Neill

Co-Chief Investigator, iRehab Trial

Brenda is a Professor in Physiotherapy at Ulster University in Northern Ireland. She leads research focused on the health and rehabilitation of people after critical Illness and people with respiratory conditions. She has expertise with a range of research methodologies and is involved in several multi-centre research programmes funded (each over £1million) by the NIHR.

Brenda is the lead for the Centre for Health and Rehabilitation Technologies (CHaRT) School of Health Sciences, Ulster University, completing research in collaboration with local hospitals, and national and international colleagues, and she has key roles in Northern Ireland (NI) research infrastructure e.g. Clinical Research Facility (NICRF) Management Group.

She is a member of several professional bodies that support advancing education and research in respiratory health and recovery after critical illness and is an Associate Editor for Physiotherapy Canada. She has successfully supervised PhD students, MSc students, and research staff (> 50) and published widely (h-index 21). Recent achievements include winner of the Advancing Healthcare Awards Northern Ireland: Award for Research and Development (2023) and was recent president of the International Confederation of Cardiorespiratory Physiotherapists (2019-2023), World Physiotherapy.

Danny McAuley

Danny McAuley

Co-Chief Investigator, iRehab Trial

Danny McAuley is a Consultant and Professor in Intensive Care Medicine at the Regional Intensive Care Unit at the Royal Victoria Hospital and Queen’s University of Belfast. He undertook his training in Belfast, Birmingham, London and San Francisco. He is Programme Director for the MRC/NIHR Efficacy and Mechanism Evaluation (EME) programme and Co-Director of Research for the UK Intensive Care Society. He has several research interests including Acute Respiratory Distress Syndrome and clinical trials. He is involved in multiple clinical trials, including being an executive team member of the PANTHER trial, a Bayesian adaptive platform randomized clinical trial studying novel interventions to improve outcomes for patients with acute hypoxaemic respiratory failure. 

Twitter: @dfmcauley

Arthur Kwizera

Arthur Kwizera

Chief Investigator, ARISE-AFRICA

Dr Arthur Kwizera is a Ugandan specialist in anaesthesia and intensive care, with advanced training from the University of British Columbia, Canada, and a fellowship in critical care interventional pulmonology from Pordenone, Italy. He has been an invited speaker at major international congresses, including the European Society of Intensive Care Medicine (ESICM), International Fluid Academy (IFAD), and the Society of Critical Care Medicine (SCCM). He is the first African recipient of honorary membership from ESICM, recognising his leadership in advancing critical care in low- and middle-income countries.

He is the founder and president of the Intensive Care Society of Uganda and a foundation fellow of the College of Anaesthesiologists of East, Central, and Southern Africa (CANECSA). He serves on global expert panels for the World Health Organisation (WHO), the Surviving Sepsis Campaign (SSC), the World Federation of Societies of Anaesthesiologists (WFSA), and, in the past, the USAID Technical Advisory Group on oxygen therapy.

Sander Rozemeijer

Co-Ordinator, VITaCCA Trial

Sander Rozemeijer is an anesthesiology resident at Amsterdam UMC in the Netherlands. After graduating medical school with honours in 2018, he started his doctoral program in the field of Intensive Care Medicine. His research focusses on the effects of vitamin C in ischemia-reperfusion injury. He coordinated the multicenter VITaCCA-trial, investigating the effect of early high-dose vitamin C in post-cardiac arrest patients.

Angelique de Man

Chief Investigaator, VITaCCA Trial

Dr Angelique de Man is an intensivist at Amsterdam UMC in the Netherlands. She has extensive experience in clinical and, since she is also a medical biologist, also in translational research. Her domains of expertise in research comprise hyperoxia, cardiac arrest, vitamin C and micronutrients in critical care setting.

She coordinated the O2-ICU trial, investigating low-normal vs high-normal PaO2 target in 400 critically ill patients with SIRS (JAMA 2021). She was coauthor of the micronutrient guidelines (doi: 10.1016/j.clnu.2022.02.015) and is currently leader of the micronutrients working group of the ESICM. Furthermore, she is a member of the ESPEN special interest group for micronutrients. Together with her PhD-student Sander Rozemeijer, she coordinated the VITaCCA trial, an RCT investigating the effect of 2 different doses (3 and 10 g per day) of intravenously administered vitamin C versus placebo in 270 post cardiac arrest patient. Furthermore, she recently received the MSCA-DN grant of the EU for the BIO-MICRO (Biomarkers and Intervention Outcomes in Micronutrient Optimization) project. In this project 13 PhDs in 4 different countries (Netherlands, Germany, Ireland and Italy) will develop new analytics to enable reliably determination of functional micronutrient body status, investigate potential subphenotypes of patients most likely to benefit from micronutrient supplementation and enable guidance with appropriate timing of micronutrient therapy.

Jonathan Casey

Co-Chief Investigator, RSI Trial

Dr. Jonathan Casey is a pulmonary and critical care physician and clinical researcher with a focus on conducting pragmatic comparative effectiveness clinical trials. He is the director of the Coordinating Center for the Pragmatic Critical Care Research Group, which has led more than 25 trials, enrolling more 50,000 patients. He has published more than 190 manuscripts, including 20 manuscripts in The New England Journal of Medicine or JAMA, and his research has identified multiple beneficial interventions that have changed care for critically ill patients around the world. 

Dr. Casey also serves as Co-PI of the NCATS-funded Vanderbilt Trial Innovation Center which supports the development and conduct of multi-center trials across the United States. He cares for patients in the Vanderbilt University Medical Intensive Care Unit.

Matthew Semler

Co-Chief Investigator, RSI Trial

Matthew W. Semler MD, MSc is an Associate Professor of Medicine, Anesthesiology, and Biomedical Informatics at Vanderbilt University where he practices as a critical care physician, serves as Associate Director of the Medical Intensive Care Unit, and directs the Center for Learning Healthcare. Dr. Semler co-directs the Pragmatic Critical Care Research Group, a network of emergency medicine, anesthesia, and critical care clinicians and researchers at 25 centers across the US that embeds pragmatic trials into clinical care to determine which treatments produce the best patient outcomes.

Randomized trials he has helped lead, including 15 published in the New England Journal of Medicine or JAMA, have identified effective treatments in the fields of fluid management, tracheal intubation, and respiratory support.


Editorialists


Kimberley Haines

iRehab Trial

Associate Professor Kimberley Haines is a NHMRC Emerging Leader Fellow and Principal Research Fellow in the Department of Critical Care, School of Medicine, at The University of Melbourne. Kimberley is also the Physiotherapy Research Lead and Senior Critical Care Physiotherapist at Western Health, Melbourne, Victoria. She is an international leader in the field of critical care survivorship with methodological expertise in patient and family engagement, co-design, and qualitative research in vulnerable cohorts. She currently leads the icuRESOLVE research program that is focused on advancing the science of peer support and post-ICU care. Associate Professor Haines holds several leadership positions including as an executive member of the ANZICS Clinical Trials Group, Co-Chair of the ANZICS Patient and Family Engagement Working Group, and she serves on other international committees including for the American Thoracic Society Critical Care Assembly.

Mark Plummer

VITaCCA Trial

Mark is an NHMRC Emerging Leader Fellow and Head of Research and Innovation at the Royal Adelaide Hospital. His research interests include sepsis, acute brain injury and developing large animal models for translational research in critical care. He currently leads a programme of MRFF and NHMRC funded work into the therapeutic potential of mega-doses of sodium ascorbate (the base salt of vitamin C) in sepsis and brain injury.

 

Elissa Milford

Elissa Milford

CLIP II Trial

Elissa is an Intensivist and clinician researcher. She is a full-time Intensive Care Specialist in the Australian Army through which she works at the Royal Brisbane and Women's Hospital. She also holds honorary academic titles at the University of Queensland and Monash University. Her PhD was on the role of the endothelial glycocalyx in severe trauma, and she is building a research program that spans the management of severe burns, trauma, blood transfusion, military medicine, and endothelial dysfunction in critical illness.

She has a strong interest in the design of novel clinical trials and is currently completing a Masters in Biostatistics. She is an emerging leader in critical care clinical trials, currently leading the Australian sites of the international, multi-centre, T4P clinical trial, and is a member of the management committee of several other large multi-centre clinical trials. She is an active member of the ANZICS Clinical Trials Group community and supervises several student research projects. 

Michelle Kho

ECMO Rehab

Dr. Michelle Kho is a Professor in the School of Rehabilitation Science at McMaster University in Hamilton, Canada. As a clinician-scientist, she is a member of the Physiotherapy Department and cares for patients in the intensive care unit at St. Joseph’s Healthcare Hamilton.

In collaboration with the Canadian Critical Care Trials Group, Dr. Kho led CYCLE, the largest randomized clinical trial of early in-bed cycling in mechanically ventilated patients to improve patient outcomes (www.icucycle.com). She held a Tier II Canada Research Chair in Critical Care Rehabilitation and Knowledge Translation from the Canadian Institutes of Health Research (CIHR) for this research. Dr. Kho is also co-leading REVIVe, a 900-patient national study of frailty, rehabilitation, and outcomes in critically ill adult and pediatric survivors of COVID-19 and acute respiratory infection. Her research is funded by agencies including the CIHR and the Canadian Foundation for Innovation.

Twitter:  @khome

Danny McAuley

ACTiVE

Danny McAuley is a Consultant and Professor in Intensive Care Medicine at the Regional Intensive Care Unit at the Royal Victoria Hospital and Queen’s University of Belfast. He undertook his training in Belfast, Birmingham, London and San Francisco. He is Programme Director for the MRC/NIHR Efficacy and Mechanism Evaluation (EME) programme and Co-Director of Research for the UK Intensive Care Society. He has several research interests including Acute Respiratory Distress Syndrome and clinical trials. He is involved in multiple clinical trials, including being an executive team member of the PANTHER trial, a Bayesian adaptive platform randomized clinical trial studying novel interventions to improve outcomes for patients with acute hypoxaemic respiratory failure.

Twitter: @dfmcauley

Sarah Sasson

Sarah Sasson

ImmunoSep Trial

Sarah Sasson is a Clinical Immunologist, Immunopathologist, and Group Leader at The Kirby Institute of Infection and Immunity at The University of New South Wales where she leads wet-laboratory research. She has a growing research program in understanding the immunopathogenesis of sepsis/SIRS in the hope of identifying novel therapeutic targets. Sarah has led translational research projects in T-cell biology, Immune Checkpoint Inhibitor toxicities and COVID-19 vaccination in people who are immunocompromised. Sarah is currently funded by the Australian Medical Research Future Fund, a UNSW Scientia Fellowship, The Australian Intensive Care Foundation, and a USA National Institute of Health R21 Grant.

Twitter:  @sarah_sasson


Panelists & Chairs


Jonathan Casey

Jonathan Casey

Dr. Jonathan Casey is a pulmonary and critical care physician and clinical researcher with a focus on conducting pragmatic comparative effectiveness clinical trials. He is the director of the Coordinating Center for the Pragmatic Critical Care Research Group, which has led more than 25 trials, enrolling more 50,000 patients. He has published more than 190 manuscripts, including 20 manuscripts in The New England Journal of Medicine or JAMA, and his research has identified multiple beneficial interventions that have changed care for critically ill patients around the world. 

Dr. Casey also serves as Co-PI of the NCATS-funded Vanderbilt Trial Innovation Center which supports the development and conduct of multi-center trials across the United States. He cares for patients in the Vanderbilt University Medical Intensive Care Unit.

Kimberley Haines

iRehab Trial

Associate Professor Kimberley Haines is a NHMRC Emerging Leader Fellow and Principal Research Fellow in the Department of Critical Care, School of Medicine, at The University of Melbourne. Kimberley is also the Physiotherapy Research Lead and Senior Critical Care Physiotherapist at Western Health, Melbourne, Victoria. She is an international leader in the field of critical care survivorship with methodological expertise in patient and family engagement, co-design, and qualitative research in vulnerable cohorts. She currently leads the icuRESOLVE research program that is focused on advancing the science of peer support and post-ICU care. Associate Professor Haines holds several leadership positions including as an executive member of the ANZICS Clinical Trials Group, Co-Chair of the ANZICS Patient and Family Engagement Working Group, and she serves on other international committees including for the American Thoracic Society Critical Care Assembly.

Carol Hodgson

Carol Hodgson

Professor Carol Hodgson is a clinical trialist with expertise in long-term functional outcomes after critical illness. She is Head of the Division of Clinical Trials and Cohort Studies in the School of Public Health and Preventive Medicine, and Co-Director of the Australian and New Zealand Intensive Care Research Centre, Monash University. She is Chair of the Australian Health Research Alliance and the Executive Director of Monash Partners Research Translation Network, which aims to ensure research is implemented and translated into healthcare to improve patient outcomes. She sits on the Australian NHMRC Research Committee which fosters research across the spectrum of health and medical research, including the awarding of grants and providing research support. She has worked in ICU at Alfred Health for over 25 years as a Specialist Physiotherapist.

Naomi Hammond

Naomi Hammond

Associate Professor Naomi Hammond, RN, BN, MN (Crit. Care), MPH (with Merit) PhD, is an intensive care nurse researcher. She works part-time as the Critical Care and Sepsis Australia Program Head at The George Institute for Global Health and part-time as the Executive Director, Research for the Northern Sydney Local Health District. Naomi holds several other appointments including NHMRC Emerging Leader Fellow; Conjoint Associate Professor at the Faculty of Medicine, University of New South Wales; Treasurer of the Asia Pacific Sepsis Alliance, and Chair of the Australian Critical Care Nurses Research Advisory Panel.

Naomi’s research interests include fluid resuscitation, sepsis, fever management, knowledge translation and implementation research, health economics, and long-term outcomes post critical illness. Naomi has experience supervising and mentoring medical trainees, nursing staff, higher degree, and medical students in both the clinical and academic environment. Additional to Naomi’s academic portfolio, she has extensive clinical trials operational management experience including finance, regulatory processes, personnel, project, and program management in a clinical and NGO environment.

Twitter: @NaomiHammond

Lisa Higgins

Lisa Higgins

Lisa Higgins, PhD, MPH, BPhysio is a clinical trialist, senior research fellow and health economist at the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, where she leads the Health Economics Program. Her research focuses on clinical trial methodology, long-term outcomes, and conducting economic evaluations alongside clinical trials in critical care. Lisa has served as a member of the management committees of more than 25 large-scale national and international randomised controlled trials, and is currently leading an RCT evaluating a post-discharge intervention to improve long-terms outcomes for ECMO survivors. Lisa has more than 140 publications with over 15,000 citations and has multiple clinical trial publications in high impact journals including the NEJM and JAMA.

Michelle Kho

Dr. Michelle Kho is a Professor in the School of Rehabilitation Science at McMaster University in Hamilton, Canada. As a clinician-scientist, she is a member of the Physiotherapy Department and cares for patients in the intensive care unit at St. Joseph’s Healthcare Hamilton.

In collaboration with the Canadian Critical Care Trials Group, Dr. Kho led CYCLE, the largest randomized clinical trial of early in-bed cycling in mechanically ventilated patients to improve patient outcomes (www.icucycle.com). She held a Tier II Canada Research Chair in Critical Care Rehabilitation and Knowledge Translation from the Canadian Institutes of Health Research (CIHR) for this research. Dr. Kho is also co-leading REVIVe, a 900-patient national study of frailty, rehabilitation, and outcomes in critically ill adult and pediatric survivors of COVID-19 and acute respiratory infection. Her research is funded by agencies including the CIHR and the Canadian Foundation for Innovation.

Twitter:  @khome

Francois Lamontagne

Francois Lamontagne

Dr. Lamontagne holds a Master’s degree in pharmacology and another in health research methodology. He was recruited as a critical care specialist and clinician-scientist by the Université de Sherbrooke and the Centre de recherche du CHU de Sherbrooke in 2010. He has received peer-reviewed funds from the Canadian Institutes of Health Research, the Fonds de Recherche du Québec – Santé, the National Institute for Health Research, and the Lotte & John Hecht Memorial Foundation. His research activities include clinical trials of resuscitation interventions (65 Trial – PMID 32049269, LOVIT Trial – PMID 31915072), knowledge syntheses, and trustworthy guidelines.

Dr. Lamontagne currently co-leads the Critical Care Comparative Effectiveness Platform(e) d’Évaluation Clinique Comparée en soins Critiques (CEPEC), which evaluates supportive care interventions that are used routinely in ICUs, and the Canadian Clinical Research Network (CCRN), which provides real-time information on the content and progress of the health research portfolio in Canada.

Shay McGuinness

Shay McGuinness is a Specialist Intensivist and Director of Research at the Cardiothoracic & Vascular Intensive Care Unit (CVICU) at Auckland City Hospital, the Medical Director of New Zealand Air Ambulance Service and an Honorary Professor at the University of Auckland. Shay is actively involved in multiple large scale clinical trials through the ANZICS Clinical Trials Group, ANZCA Clinical Trials Network and other large international collaborations across Critical Care, Anaesthesia and Cardiac Surgery. He is the NZ representative on the Asia–Pacific Extracorporeal Life Support Organisation (APELSO).

When not working he enjoys sailing, scuba diving and flying.

Elissa Milford

Elissa Milford

CLIP II Trial

Elissa is an Intensivist and clinician researcher. She is a full-time Intensive Care Specialist in the Australian Army through which she works at the Royal Brisbane and Women's Hospital. She also holds honorary academic titles at the University of Queensland and Monash University. Her PhD was on the role of the endothelial glycocalyx in severe trauma, and she is building a research program that spans the management of severe burns, trauma, blood transfusion, military medicine, and endothelial dysfunction in critical illness.

She has a strong interest in the design of novel clinical trials and is currently completing a Masters in Biostatistics. She is an emerging leader in critical care clinical trials, currently leading the Australian sites of the international, multi-centre, T4P clinical trial, and is a member of the management committee of several other large multi-centre clinical trials. She is an active member of the ANZICS Clinical Trials Group community and supervises several student research projects. 

Nchafatso Obonyo

Dr Nchafatso Obonyo, (MD/PhD) is the Deputy Director of the Preclinical Innovative Medical and Engineering Laboratory (PRIMELab) at the Critical Care Research Group (CCRG) based at The Prince Charles Hospital in Brisbane, Australia. He is also a Postdoctoral Research Fellow at the Institute for Molecular Bioscience-University of Queensland funded through The Prince Charles Hospital Foundation. His clinical and research interests are in cardiac critical care and sepsis with a focus on septic shock cardiomyopathy and microvascular endotheliopathy.

He trained at the University of Nairobi and began his clinical research career at the Kenya Medical Research Institute-Wellcome Trust Research Programme funded through the Initiative to Develop African Research Leaders (IDeAL) in Kilifi, Kenya. In 2013, he was awarded the prestigious Global Health Research Fellowship at Imperial College London. His PhD research on myocardial and microvascular physiology in septic shock and response to volume expansion treatment was supervised by Professors John Fraser and Kathryn Maitland. In 2023, he received the Top Scientist Award in Africa under 40-years (Africa Top Forty Under-40).

Brenda O'Neill

Brenda O'Neill

Brenda is a Professor in Physiotherapy at Ulster University in Northern Ireland. She leads research focused on the health and rehabilitation of people after critical Illness and people with respiratory conditions. She has expertise with a range of research methodologies and is involved in several multi-centre research programmes funded (each over £1million) by the NIHR.

Brenda is the lead for the Centre for Health and Rehabilitation Technologies (CHaRT) School of Health Sciences, Ulster University, completing research in collaboration with local hospitals, and national and international colleagues, and she has key roles in Northern Ireland (NI) research infrastructure e.g. Clinical Research Facility (NICRF) Management Group.

She is a member of several professional bodies that support advancing education and research in respiratory health and recovery after critical illness and is an Associate Editor for Physiotherapy Canada. She has successfully supervised PhD students, MSc students, and research staff (> 50) and published widely (h-index 21). Recent achievements include winner of the Advancing Healthcare Awards Northern Ireland: Award for Research and Development (2023) and was recent president of the International Confederation of Cardiorespiratory Physiotherapists (2019-2023), World Physiotherapy.

Sandra Peake

Sandra Peake

Professor Peake (BM BS, BSc(Hons), PhD, FCICM) is a senior staff specialist and clinician researcher in the Department of Intensive Care Medicine at The Queen Elizabeth Hospital, Adelaide, a Professor in the School of Medicine at the University of Adelaide and an Adjunct Professor in the School of Epidemiology and Preventive Medicine at Monash University, Melbourne. Professor Peake undertook her PhD at the University of Adelaide on immunotherapeutic strategies in septic shock. Her main research interest now is large scale clinical trials to improve patient outcomes for the critically ill. She led the multinational ARISE randomised trial of early goal-directed therapy in early septic shock (NEJM 2014) and the TARGET randomised trial of energy-dense enteral nutrition in mechanically ventilated patients (NEJM 2018). She is currently the chief investigator for the ARISE FLUIDS randomised trial evaluating a restrictive fluid strategy for early septic shock. Professor Peake is the Immediate Past Chair of the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Twitter: @sandrapeake01

Mark Plummer

VITaCCA Trial

Mark is an NHMRC Emerging Leader Fellow and Head of Research and Innovation at the Royal Adelaide Hospital. His research interests include sepsis, acute brain injury and developing large animal models for translational research in critical care. He currently leads a programme of MRFF and NHMRC funded work into the therapeutic potential of mega-doses of sodium ascorbate (the base salt of vitamin C) in sepsis and brain injury.

 

Matthew Semler

Matthew Semler

Matthew W. Semler MD, MSc is an Associate Professor of Medicine, Anesthesiology, and Biomedical Informatics at Vanderbilt University where he practices as a critical care physician, serves as Associate Director of the Medical Intensive Care Unit, and directs the Center for Learning Healthcare. Dr. Semler co-directs the Pragmatic Critical Care Research Group, a network of emergency medicine, anesthesia, and critical care clinicians and researchers at 25 centers across the US that embeds pragmatic trials into clinical care to determine which treatments produce the best patient outcomes.

Randomized trials he has helped lead, including 15 published in the New England Journal of Medicine or JAMA, have identified effective treatments in the fields of fluid management, tracheal intubation, and respiratory support.

Michelle Kho

Michelle Kho

Dr. Michelle Kho is a Professor in the School of Rehabilitation Science at McMaster University in Hamilton, Canada. As a clinician-scientist, she is a member of the Physiotherapy Department and cares for patients in the intensive care unit at St. Joseph’s Healthcare Hamilton.

In collaboration with the Canadian Critical Care Trials Group, Dr. Kho led CYCLE, the largest randomized clinical trial of early in-bed cycling in mechanically ventilated patients to improve patient outcomes (www.icucycle.com). She held a Tier II Canada Research Chair in Critical Care Rehabilitation and Knowledge Translation from the Canadian Institutes of Health Research (CIHR) for this research. Dr. Kho is also co-leading REVIVe, a 900-patient national study of frailty, rehabilitation, and outcomes in critically ill adult and pediatric survivors of COVID-19 and acute respiratory infection. Her research is funded by agencies including the CIHR and the Canadian Foundation for Innovation.

Angelique de Man

Angelique de Man

Dr Angelique de Man is an intensivist at Amsterdam UMC in the Netherlands. She has extensive experience in clinical and, since she is also a medical biologist, also in translational research. Her domains of expertise in research comprise hyperoxia, cardiac arrest, vitamin C and micronutrients in critical care setting.

She coordinated the O2-ICU trial, investigating low-normal vs high-normal PaO2 target in 400 critically ill patients with SIRS (JAMA 2021). She was coauthor of the micronutrient guidelines (doi: 10.1016/j.clnu.2022.02.015) and is currently leader of the micronutrients working group of the ESICM. Furthermore, she is a member of the ESPEN special interest group for micronutrients. Together with her PhD-student Sander Rozemeijer, she coordinated the VITaCCA trial, an RCT investigating the effect of 2 different doses (3 and 10 g per day) of intravenously administered vitamin C versus placebo in 270 post cardiac arrest patient. Furthermore, she recently received the MSCA-DN grant of the EU for the BIO-MICRO (Biomarkers and Intervention Outcomes in Micronutrient Optimization) project. In this project 13 PhDs in 4 different countries (Netherlands, Germany, Ireland and Italy) will develop new analytics to enable reliably determination of functional micronutrient body status, investigate potential subphenotypes of patients most likely to benefit from micronutrient supplementation and enable guidance with appropriate timing of micronutrient therapy.

Christopher Seymour

Christopher Seymour

Dr. Seymour is an Associate Professor in the Departments of Critical Care, Emergency Medicine, and Clinical and Translational Science at the University of Pittsburgh School of Medicine. Over the past 10 years, his research program has focused on clinical and translational studies involving sepsis, biomarkers, and large electronic health record databases. Dr. Seymour completed his NIGMS Career Development Award (K23), mentored by Dr. Derek Angus, titled “Prehospital identification of high-risk sepsis.” This successful award led to funding of a NIH/NIGMS R35 ESI-Merit Investigator Research Award, “Sepsis endotypes during emergency care.” He is Director of the Clinical and Translational Science Program in the Department of Critical Care Medicine, member of the International Sepsis Forum (ISF), and Associate Editor for Critical Care at JAMA. His research has been published in the New England Journal of Medicine, JAMA, and The Lancet, among others.

Paul Young

Paul Young

Paul Young’s primary research interest is in the design and conduct of large-scale multicentre randomised clinical trials in the field of Intensive Care Medicine. An active member of the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG), Paul is a leading member of the international intensive care research community.

Alongside his role at the MRINZ, Paul is the Medical Director of the Wakefield Hospital ICU and co-clinical leader of the Intensive Care Research Unit at Wellington Hospital. Paul is Clinical Associate Professor, Department of Critical Care, at the University of Melbourne, an Adjunct Professor at the Australian and New Zealand Intensive Care Research Centre, Monash University, and the acting co Editor-in-Chief for Critical Care and Resuscitation, the highest impact journal in the field of Intensive Care Medicine outside the US and Europe.

Involved in research collaborations with colleagues worldwide, Paul has published over 250 peer-reviewed journal articles, including numerous high impact publications in the New England Journal of Medicine, the Lancet, and the Journal of the American Medical Association.

Twitter: @DogICUma

Sarah Sasson

Sarah Sasson

ImmunoSep Trial

Sarah Sasson is a Clinical Immunologist, Immunopathologist, and Group Leader at The Kirby Institute of Infection and Immunity at The University of New South Wales where she leads wet-laboratory research. She has a growing research program in understanding the immunopathogenesis of sepsis/SIRS in the hope of identifying novel therapeutic targets. Sarah has led translational research projects in T-cell biology, Immune Checkpoint Inhibitor toxicities and COVID-19 vaccination in people who are immunocompromised. Sarah is currently funded by the Australian Medical Research Future Fund, a UNSW Scientia Fellowship, The Australian Intensive Care Foundation, and a USA National Institute of Health R21 Grant.

Twitter:  @sarah_sasson


Statisticians


Anais Charles-Nelson

Dr Charles-Nelson is a biostatistician specialising in the development of clinical trial methodology including the statistical aspects of study design, sample size, statistical analysis plans, statistical programming and data management. She joined the ANZIC-RC as a Senior Research Fellow in 2022. Dr Charles-Nelson also holds a joint appointment with the Biostatistics Unit within the School of Public Health and Preventive Medicine at Monash University. Prior to joining the ANZIC-RC, she was a Senior Biostatistician and Research Engineer in the Clinical Research Unit at Georges-Pompidou European Hospital in Paris, France. She has a PhD in Biostatistics from the Sorbonne University, Paris.

Jessica Kasza

Jessica Kasza

Professor of Biostatistics in Monash University’s School of Public Health and Preventive Medicine

Jessica Kasza is a Professor of Biostatistics in Monash University’s School of Public Health and Preventive Medicine, and holds an NHMRC Leadership (Level 1) Investigator Grant. Jess is a trial statistician for several trials, leading the statistical aspects of these trials across their lifetime: from their design, through their conduct, analysis, and reporting of results. She has a particular interest in cluster randomised trials and co-leads the Cluster Cluster at Monash University: a group of researchers interested in all things to do with cluster randomised trials. She regularly collaborates with international leaders in the development of methodology for these designs, and with trialists who conduct these trials. Jess was President of the Statistical Society of Australia from 2020-2022.

Bluesky: @jesskasza.bsky.social

Liz Ryan

Liz Ryan

School of Public Health and Preventive Medicine, Monash University

Dr Elizabeth (Liz) Ryan is a Biostatistician in the School of Public Health and Preventive Medicine, Monash University. Her PhD was on Bayesian statistical methods for the design of experiments, with applications in clinical trial design. She has ten years’ experience working as a clinical trials statistician in both Australia and the UK, across various health domains. Her current research
interests include innovative clinical trial designs, particularly Bayesian adaptive designs and platform
trials.

Twitter: @whizzfizzlizz

Michael Bailey

Michael Bailey

Head Statistician at the ANZ Intensive Care Research Centre, Monash University

Michael Bailey is a Professor in the Department of Epidemiology and Preventive Medicine and the Head Statistician at the ANZ Intensive Care Research Centre (ANZIC-RC) at Monash University. With 28 years of experience as a biostatistician at Monash University, including 17 years with the ANZIC-RC, Prof. Bailey is recognized as the most heavily published intensive care statistician globally and one of the top 10 most published intensive care authors worldwide.

Prof. Bailey is ranked in the top 1% globally for his expertise in “Statistical Models” (0.51%). He boasts an h-index of 114 and has authored over 650 peer-reviewed publications, with more than 180 of those published in the past five years. His rigorous analyses have led to robust findings published in high-impact journals, including 26 articles in the New England Journal of Medicine, The Lancet, and JAMA. His work has been heavily cited, with over 27,000 citations in the past five years and more than 57,000 career citations


Journal Editors


Christopher Seymour

Christopher Seymour

Associate Editor for Critical Care, JAMA

Dr. Seymour is an Associate Professor in the Departments of Critical Care, Emergency Medicine, and Clinical and Translational Science at the University of Pittsburgh School of Medicine. Over the past 10 years, his research program has focused on clinical and translational studies involving sepsis, biomarkers, and large electronic health record databases. Dr. Seymour completed his NIGMS Career Development Award (K23), mentored by Dr. Derek Angus, titled “Prehospital identification of high-risk sepsis.” This successful award led to funding of a NIH/NIGMS R35 ESI-Merit Investigator Research Award, “Sepsis endotypes during emergency care.” He is Director of the Clinical and Translational Science Program in the Department of Critical Care Medicine, member of the International Sepsis Forum (ISF), and Associate Editor for Critical Care at JAMA. His research has been published in the New England Journal of Medicine, JAMA, and The Lancet, among others.