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The Best Critical Care Trials in the World

ACIOS Study


Key Findings

  • 1 in 8 (12.5%) hospital inpatients are critically ill
  • 69% of the critically ill are treated in general wards (not in HDUs or ICUs)
  • 56% are not receiving EECC
  • 21% die within 7 days (compared to just 2.7% of non critically ill patients)
ACIOS Infographic

urinary measurement bag

Paper of the Day

Friday, February 28th

Hamesch. Practical management of severe acute pancreatitis. Eur J Intern Med 2024;epublished November 29th

Join us to read one paper per day and cover the spectrum of critical care across 2024. Previous papers of the day are available here.

Have it emailed to you!

image: Shutterstock / Lorena Huerta



John Hinds Lecture 2025


"Ukuthola ubuhle"


John Myburgh

Prof John Myburgh

Sydney, Australia

Dr John Hinds

Dr John Hinds was a remarkable doctor and person. He worked as a prehospital physician, providing medical cover to professional motorbike road races, as well as being an intensivist and anaesthetist at Craigavon Area Hospital in County Armagh, Northern Ireland.

Sadly, in 2015, John died whilst on duty at the Skerries 100 Road Race in Dublin. He leaves a legacy of improved trauma care, not just in Northern Ireland, but with a vision and passion that had impact worldwide through his lectures and talks. Locally, he was one of the most prominent voices campaigning for a HEMS service, which is now established and highly successful.

Every year at the Critical Care Reviews Meeting, we remember our friend and colleague with the John Hinds Lecture, delivered by a world leading critical care clinician. The 2025 edition will be delivered by Prof John Myburgh, another impressive individual with a remarkable story to tell. The lecture is titled "Ukuthola ubuhle".

John Myburgh

Dr John Hinds

1980 - 2015

added February 21st


CCR Newsletter icon

Newsletter 689

Critical Care Reviews Newsletter 689, bringing you the best critical care research and open access articles for the week January 17th to 23rd.

Subscriptions are available to individuals and departments.

added February 23rd

Renal ultrasound

Narrative Review

image: Shutterstock / hospital man


Check out this short video from the Critical Care Reviews Meeting 2024. If you're interested in critical care trials, this is the meeting for you.

The Critical Care Reviews Meeting is a focused trials meeting. We host the results of the most impactful and important critical care trials in the world. In 2024, between our Belfast and Melbourne meetings, we hosted 19 major trial results, plus many accompanying systematic reviews and meta analyses.

Many of these presentations were in conjunction with simultaneous publications in the New England Journal of Medicine, JAMA and NEJM Evidence.

If you haven't been yet, check out our video - there's no other meeting like it.

Trial Announcements


PRINCE

Ischaemic Preconditioning in Non Cardiac Surgery

ANH

Acute normovolemic hemodilution in cardiac surgery patients
RESCUE 3 Trial logo

RESCUE 3

Temporary Transvenous Diaphragm Pacing versus Standard of Care for Weaning From Mechanical Ventilation

Trial Registration  |  Trial Protocol  |  RESCUE 2

INDex-CTP

CT Perfusion for the Neurological Determination of Death

Trial Registration  |  Trial Protocol

ENCOMPASS Trial logo

ENCOMPASS

Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship
TTM2 Trial Logo

TTM2 Biomarker

Biomarkers of Brain Injury after Cardiac Arrest
PROMIZING Trial Logo

PROMIZING

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation

NOTACS

Nasal High-Flow Oxygen Therapy after Cardiac Surgery

FLUID

Crystalloid FLUID Choices for Resuscitation of Hospital Patients

UK-ROX

Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care

GASTROSAM

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition

TARGET Protein

Augmented Administration of Enteral Protein to Critically Ill Adults

updated February 4th


CCR Down Under 2025

December 9th & 10th

Due to the success of CCR Down Under, we're heading back to Melbourne in December 2025 for another 2 day event.

Join us in the Edge, Federation Square, to hear the results of the best critical care trials in the world.

Registration will open in May.

CCR Down Under is run in partnership with The Alfred Intensive Care Academic Centre.

Audience at CCR Down Under raising their hands