CCR26
Announcing the trials for the Critical Care Reviews Meeting 2026
Day 10 - The ABC post-ICU Trial
CCR Down Under is barely over and we now turn our focus back to Belfast for CCR26, June 10th to 12th, 2026.
Over the rest of December we'll announce the the major trial results to be presented at Titanic Belfast.
Our 10th trial is ABC post-ICU, a multicentre randomised trial investigating whether active treatment of anaemia after intensive care unit discharge can improve recovery in ICU survivors. Adult patients with haemoglobin ≤94 g/L at the point of ICU discharge are randomised to either usual restrictive transfusion care or a more liberal strategy using single-unit red blood cell transfusions targeting a haemoglobin of 100–120 g/L during the remainder of the hospital stay. The trial focuses on patient-centred outcomes, with the primary endpoint being physical health-related quality of life measured by the SF-36 Physical Component Summary score at 90 days. Secondary outcomes include fatigue, disability, mental health, mortality, transfusion safety, and cost-effectiveness, assessed out to 180 days. By shifting transfusion practice beyond the ICU, ABC post-ICU addresses a major evidence gap in post-critical illness recovery and post-intensive care syndrome.
Registration for CCR26 opens soon!
Added December 31st
ImmunoSep Trial
Prof Evangelos Giamarellos-Bourboulis (Athens) presents the results of the ImmunoSep trial at CCR Down Under 2025 in Melbourne. ImmunoSep investigates a precision medicine approach for immune modulation in sepsis. An independent editorial is delivered by Prof Sarah Sasson (Sydney). Prof Andrew Udy (Melbourne) chairs a panel discussion between Sandra Peake (Adelaide), Chris Seymour (Pittsburgh) and Jessica Kasza (Melbourne). The ImmunoSep trial was simultaneously published in JAMA on December 9th, 2025.
added December 31st
Trialists' Summary
Prof Evangelos Giamarellos-Bourboulis (Athens) summarises the ImmunoSep trial
Papers
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Guideline
added October 27th
Narrative Review
Randomised Controlled Trial
Randomised Controlled Trial
Systematic Review & Meta Analysis
Systematic Review & Meta Analysis
added October 17th
Narrative Reviews
added October 17th
Narrative Review
added October 17th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR24
BLING III Trial Results
Jeff Lipman, Dorrilyn Rajbhandari, Joel Dulhunty & Mohd (Hafiz) Abdul-Aziz present the results of the BLING III trial and associated systematic review and meta analysis at the Critical Care Reviews Meeting 2024, in Titanic Belfast. BLING III compared continuous with intermittent beta lactam antibiotic administration in critically ill patients with sepsis.
added December 30th
CCR Content