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Get the Critical Care Reviews Newsletter - there's nothing else like it!
Latest Randomised Trials
- Abogabal. Sevoflurane sedation as an alternative for awake fiberoptic intubation in difficult airway patients: a randomized controlled trial. Minerva Anestesiol 2025;epublished Jul 21st
- Katheria. Deferred Cord Clamping With High Oxygen in Extremely Preterm Infants: A Randomized Clinical Trial. JAMA Pediatr 2025;epublished Jul 21st
- Frassanito. High-Flow Nasal Oxygen versus Mechanical Ventilation Through a Laryngeal Mask During General Anesthesia Without Muscle Paralysis: A Randomized Clinical Trial. Anesth Analg 2025;epublished Jul 21st
- Miatello. Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial. Lancet Respir Med 2025;epublished July 15th
Last updated July 24th
Latest Meta Analyses
- Abdollahifard. Timing of Intracranial Pressure Monitoring in Traumatic Brain Injury: A Systematic Review and Meta-Analysis. World Neurosurg 2025;199:124136
- Pazo-Palacios. Effects of in-bed cycling in critically ill adults: A systematic review and meta-analysis of randomised clinical trials. Ann Phys Rehabil Med 2025;68(5):101953
- Romantsik. Midazolam for sedation of infants in the neonatal intensive care unit. Cochrane Database Syst Rev 2025;7(7):CD002052
- Leong. A systematic review and meta-analysis of noradrenaline compared to adrenaline in the management of septic shock. Afr J Emerg Med 2025;15(3):100881
- Tang. Melatonin Use in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med 2025;epublished July 15th
- Jiang. Factors Influencing Quality of Life After Intensive Care: A Systematic Review and Meta-Analysis. Crit Care Med 2025;epublished July 15th
Last updated July 24th
Latest Observational Studies
- Kiernan. Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation. Am J Respir Crit Care Med 2025;epublished Jul 16th
- Nemlaghi-Zdiria. Impact of Chest Wall Injuries After Cardiopulmonary Resuscitation in Non-Traumatic and Successfully Resuscitated Cardiac Arrest: Insights from the DISCAR study. Resuscitation 2025;epublished Jul 18th
- Sarma. Evaluating the generalisability of formulas used to set tidal volumes in mechanically ventilated patients: an observational, multicohort, retrospective study. Lancet Respir Med 2025;epublished July 15th
- Tangchitthavorngul. Epidemiology and long-term outcomes of critically ill patients with severe AKI in India and Southeast Asia. Intensive Care Med 2025;epublished July 14th
- Ostadal. Cardiac index, SvO2 or pCO2 gap may determine benefit from ECMO in cardiogenic shock: post-hoc analysis of the multicenter, randomized ECMO-CS trial. Crit Care 2025;29:303
Last updated July 24th
Latest Guidelines
- Godwin. Clinical Policy: Critical Issues in the Management of Adult Patients Requiring Endotracheal Intubation in the Emergency Department. Ann Emerg Med 2025;86(2):e29-e68
- Borland. Australasian Bronchiolitis Guideline: 2025 Update. J Paediatr Child Health 2025;epublished Jul 20th
- Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 2025;epublished July 18th
- Nelson-Piercy. Pregnancy-associated acute kidney injury — consensus report of the 32nd Acute Disease Quality Initiative workgroup. Nat Rev Nephrol 2025;epublished
Last updated July 20th
Latest Narrative Reviews
- Kosyakovsky. Macrovascular Hemodynamics and Peripheral Perfusion in Cardiogenic Shock: Exploring Current Targets and Future Directions. JACC Adv 2025;epublished July 23rd
- Perrault. Post-traumatic vasospasm: Epidemiology, specificities, risk factors, and therapeutics. J Intensive Med 2025;epublished July 25th
- Tolonen. Diagnosis and management of acute mesenteric ischemia: What you need to know. J Trauma Acute Care Surg 2025;99(2):151-161
- Swanson. Optimization of physiology in organ donors in the intensive care unit: What you need to know. J Trauma Acute Care Surg 2025;99(2):162-168
- Katz. Balloon Pericardiotomy: A Comprehensive Review and Case Series. J Soc Cardiovasc Angiogr Interv 2025;epublished July 23rd
Last updated July 25th
Latest Editorials
- Landoni,. Neurotoxicity of sedative drugs: a matter of concern in adults?. Intensive Care Med 2025;epublished July 24th
- Annane. Corticosteroids in sepsis: certainties and shadows. Intensive Care Med 2025;epublished July 23rd
- Bellone. Let PEEP do the talking?. Intensive Care Med 2025;epublished July 22nd
- Gaudry. Does ability and willingness to use continuous RRT improve patient outcomes? A few answers, plenty of questions and opportunities for research. Intensive Care Med 2025;epublished July 21st
Last updated July 24th
Latest Commentaries
- McLean. Rinaldo Bellomo – An Intensive Care Medicine Icon. Crit Care 2025;29:319
- Deana. Muscle mass evaluation at lumbar level in ICU patients: a call for collaborative approach between intensivists and radiologists. Crit Care 2025;29:317
- Swain. Unplanned intensive care unit admissions in trauma patients: A critical appraisal. World J Crit Care Med 2025;14(3):105147
- Chervenkov. Utilizing artificial intelligence as an arbitrary tool in managing difficult COVID-19 cases in critical care medicine. World J Crit Care Med 2025;14(3):102808
- Asikanius. Clinical trials with interim analyses: standardizing terminology to increase clarity. Trials 2025;26:247
Last updated July 24th
CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.
If you missed the presentations last December, the presentations of the so far published trials are available here.



CCR Content

Paper of the Day
Friday, July 25th
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Newsletter 710
Critical Care Reviews Newsletter 710, bringing you the best critical care research and open access articles for the week July 14th to 20th.
Subscriptions are available to individuals and departments.
added July 20th

Foundational Trials
We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.
added July 15th

Highlighted Narrative Reviews
With thousands of open access narrative reviews listed across the website, CCR provides a comprehensive educational resource. We'll highlight one topic here every few days. Today, we look at Acute Kidney Injury
added July 15th

Highlighted Guidelines
Need a guideline, or just want to refresh your knowledge on the evidence-based management of a particular condition? We provide more up-to-date guidelines than any other critical care resource. have a look at our Burns guideline section
added July 13th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR24
The PRE-OXI Trial Results
Jonathan Casey and Kevin Gibbs present the results of the PRE-OXI trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast. PRE-OXI investigated non-invasive ventilation for preoxygenation in emergency intubation in the critically ill.
Yonathan Freund delivers an independent editorial. Catriona Kelly chairs a panel discussion with Anthony Gordon, Sheila Myatra, Victoria Cornelius and Jan Gunst.
PRE-OXI was simultaneously published in the New England Journal of Medicine.
added July 21st