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About
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Support CCR
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Narrative Reviews
Paracetamol Toxicity
Image: Shutterstock / Sonis Photography
Major Toxicology Trials |
Major Paracetamol Guidelines
Sections
General
|
Monitoring & Investigations
|
Therapies
General
General
Chidiac. Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opin Drug Metab Toxicol 2023;19(5):297-317
Analgesia
Freo. Paracetamol: A Review of Guideline Recommendations. J Clin Med 2021;10:3420
Background
Pathophysiology
Li. The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Cell Biosci 2022;12(1):187
Li. Advances in the study of acetaminophen-induced liver injury. Front Pharmacol 2023;14:1239395
Conditions
Liver Failure
Jaeschke. Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury. Annu Rev Pathol 2024;19:453-478
Complications
Complication
Monitoring & Investigations
Biomarkers
Umbaugh. Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity. Expert Rev Gastroenterol Hepatol 2021;15(4):363-375
Therapies
General
Akakpo. Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert Opin Drug Metab Toxicol 2020;16(11):1039-1050
N-Acetylcysteine
Thanacoody. Large paracetamol overdose – Higher dose NAC is NOT required. Br J Clin Pharmacol 2023;89(1):39-42
Bateman. Large paracetamol overdose—Higher dose acetylcysteine is required. Br J Clin Pharmacol 2023;89(1):34-38