General Critical Care

1. Hebert. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999;340:409-17

Sepsis

1. Holst. Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock. TRISS Trial Group and the Scandinavian Critical Care Trials Group. New Engl J Med 2014;epublished October 1st

Acute Myocardial Infarction

1. Ducrocq. Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and AnemiaThe REALITY Randomized Clinical Trial. JAMA 2021;325(6):552-560

Cardiac Surgery

General Critical Care

1. Lacroix. Age of Transfused Blood in Critically Ill Adults (ABLE Study). N Engl J Med 2015;epublished March 17th

Cardiac Surgery

1. Steiner. Effects of Red-Cell Storage Duration on Patients Undergoing Cardiac Surgery (RECESS study). N Engl J Med 2015;372:1419-1429

General Critical Care

1. Corwin. Efficacy and Safety of Epoetin Alfa in Critically Ill Patients. N Engl J Med 2007; 357:965-976
2. Corwin. Efficacy of Recombinant Human Erythropoietin in Critically Ill Patients: A Randomized Controlled Trial. JAMA. 2002;288(22):2827-2835

Traumatic Brain Injury

1. Nichol. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet 2015;epublished October 7th 
2. Robertson. Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury:  A Randomized Clinical Trial. JAMA 2014;312(1):36

Post Cardiac Arrest

1. Cariou. Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial. J Am Coll Cardiol 2016;68(1):40

1. Holcomb. Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma:  The PROPPR Randomized Clinical Trial. JAMA 2015;313(5):471

1. Sperry. Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock. N Engl J Med 2018; 379:315-326
2. Moore. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial (COMBAT). Lancet 2018;epublished July 19th

Trauma

1. Shakur. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376(9734):23–32

Traumatic Brain Injury

1. The CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet 2019;394(10210):1713-1723

Obstetrics

1. Shakur. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet 2017;389(10084):2105–16