Top Circulatory Trials



Cardiac Arrest

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Targeted Temperature Management


  1. Dankiewicz. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. N Engl J Med 2021;384:2283-2294
  2. Lascarrou. Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm. N Engl J Med N Engl J Med 2019;381:2327-2337
  3. Nordberg. Effect of trans-nasal evaporative intra-arrest cooling on functional neurologic outcome in out-of-hospital cardiac arrest: the PRINCESS randomized clinical trial. JAMA 2019;321(17):1677–85
  4. Kirkegaardl. Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 2017;318:341-350
  5. Bernard. Induction of Therapeutic Hypothermia During Out-of-Hospital Cardiac Arrest Using a Rapid Infusion of Cold Saline: The RINSE Trial (Rapid Infusion of Cold Normal Saline). Circulation 2016;134(11):797-805
  6. Moler. Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children (THAPCA Trial). N Engl J Med 2015;epublished April 25th
  7. Nielsen. Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM study). N Engl J Med 2013;369:2197-2206 
  8. Kim. Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest:  A Randomized Clinical Trial. JAMA 2014;311(1):45-52
  9. Bernard. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med 2002; 346:557-563
  10. The Hypothermia after Cardiac Arrest Study Group. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest. N Engl J Med 2002; 346:549-556

Method of Temperature Control

  1. Deye. Endovascular versus external targeted temperature management for patients with out-of-hospital cardiac arrest: a randomized, controlled study (ICEREA). Circulation 2015;132(3):182–93

Vasoactive Therapy

Goal Directed therapy

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