Critical Care Reviews Meeting 2023
Welcome to the 578th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials comparing remifentanil with neuromuscular blockers during rapid sequence intubation & norepinephrine plus dobutamine with epinephrine in children with fluid refractory cold septic shock; systematic reviews and meta analyses on muscle wasting during critical illness & epinephrine administration interval during adult cardiac arrest; and observational studies on the effect of blood pressure on mortality following out-of-hospital cardiac arrest & the association of appropriate empirical antimicrobial therapy with in-hospital mortality in patients with bloodstream infections.
There are also guidelines on thrombectomy procedures in stroke patients & pediatric traumatic hemorrhagic shock; narrative reviews on post-cardiac arrest syndrome & hemorrhagic shock; editorials on clinical practice guideline methodology & perioperative dialysis; and commentaries on acute kidney injury & the dangers of non-randomized, observational studies.
If you only have time to read one review article this week, try this one on new antibiotics for Gram-negative pneumonia.
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Research
Randomised Controlled Trials
- Grillot. Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration. A Randomized Clinical Trial. JAMA 2023;329(1):28-38
- Banothu. A Randomized Controlled Trial of Norepinephrine Plus Dobutamine Versus Epinephrine As First-Line Vasoactive Agents in Children With Fluid Refractory Cold Septic Shock. Crit Care Explor 2023;5(1):e0815
- Abrard. Postoperative prophylactic intermittent noninvasive ventilation versus usual postoperative care for patients at high risk of pulmonary complications: a multicentre randomised trial. Br J Anaesth 2023;130(1):e160-e168
- Yu. Association between driving pressure and postoperative pulmonary complications in patients undergoing lung resection surgery: A randomised clinical trial. Anaesth Crit Care Pain Med 2023;42(1):101160
- Duyu. Comparison of chlorhexidine impregnated dressing and standard dressing for the prevention of central-line associated blood stream infection and colonization in critically ill pediatric patients: A randomized controlled trial. Pediatr Int 2022;64(1):e15011
Systematic Review & Meta Analyses
- Montgomery. Transfusion Guidelines in Traumatic Brain Injury: A Systematic Review and Meta-Analysis of the Currently Available Evidence. Neurotrauma reports 2022;epublished December 22nd
- Fazzini. The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis. Crit Care 2023;27:2
- Chad. Right Ventricular Injury Increases Mortality in Patients With Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis. ASAIO J 2023;69(1):e14-e22
- Wongtanasarasin. How Epinephrine Administration Interval Impacts the Outcomes of Resuscitation during Adult Cardiac Arrest: A Systematic Review and Meta-Analysis. J Clin Med 2023;12(2):481
Observational Studies
- McGuigan. The effect of blood pressure on mortality following out-of-hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database. Crit Care 2023;27:4
- Ohnuma. Association of Appropriate Empirical Antimicrobial Therapy With In-Hospital Mortality in Patients With Bloodstream Infections in the US. JAMA Netw Open 2023;6(1):e2249353
- Kim. In-hospital mortality of atrial fibrillation-associated acute ischemic stroke in the intensive care unit. J Neurocrit Care 2022;15(2):88-95
- Kreitmann. Relationship between immunosuppression and intensive care unit-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter cohort study. Intensive Care Med 2023;epublished January 2nd
- Walsh. Optimising intravenous salbutamol in children: a phase 2 study. Archives of Disease in Childhood 2022;epublished December 29th
- McNicholas. Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies. Crit Care 2023;27:3
- Rosa. Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study. Intensive Care Med 2023;epublished January 4th
- Brito. The effects of timing of prehospital tranexamic acid on outcomes after traumatic brain injury: Subanalysis of a randomized controlled trial. J Trauma Acute Care Surg 2023;94(1):86-92
- Fuest. Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU. Crit Care 2023;27(1):1
- Kayambankadzanja. Towards definitions of critical illness and critical care using concept analysis. BMJ Open 2022;12(9):e060972
Protocols
- Reade. Cryopreserved platelets compared with liquid-stored platelets for the treatment of surgical bleeding: protocol for two multicentre randomised controlled blinded non-inferiority trials (the CLIP-II and CLIPNZ-II trials). BMJ Open 2022;12(12):e068933
- Taccone. TRansfusion strategies in Acute brain INjured patients (TRAIN): a prospective multicenter randomized interventional trial protocol. Trials 2023;24(1):20
Guidelines
- Quintard. Anaesthetic and peri-operative management for thrombectomy procedures in stroke patients. Anaesth Crit Care Pain Med 2023;42(1):101188
- Pediatric traumatic hemorrhagic shock consensus conference recommendations. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S2-S10
- Pediatric traumatic hemorrhagic shock consensus conference research priorities. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S11-S18
Reviews
Clinical
COVID-19
- Chary. COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Xenobiotics). J Med Toxicol 2022;19:26–36
- Gupta. COVID-19 associated Mucormycosis (CAM): Implications for perioperative physicians – A narrative review. Saudi J Anaesth 2023;17:58-64
- Witt. The impact of COVID-19 on multidrug-resistant organisms causing healthcare-associated infections: a narrative review. JAC Antimicrob Resist 2022;epublished December 29th
- Polyzogopoulou. Acute liver injury in COVID-19 patients hospitalized in the intensive care unit: Narrative review. World J Gastroenterol 2022;28(47):6662–6688
Neurological
- Kim. Quantitative assessments of pupillary light reflexes in neurocritically ill patients. J Neurocrit Care 2022;15(2):79-87
- Kälviäinen. When is it time for palliative and end-of-life care in status epilepticus? Epilepsy Behavior 2023;epublished January 4th
- Hendershot. Respiratory Complications and Weaning Considerations for Patients with Spinal Cord Injuries: A Narrative Review. J Pers Med 2023;13:97
- Motes. Monitoring sedation during mechanical ventilation. Southwest Respir Crit Care Chron 2022;10(45):19–27
Circulatory
- Balthazar. Hemolysis during short-term mechanical circulatory support: from pathophysiology to diagnosis and treatment. Expert Rev Med Devices 2022;19(6):477-488
- Sethi. Broken Heart Syndrome: Evolving Molecular Mechanisms and Principles of Management. J Clin Med 2023;12(1):125
- Ziaka. The Heart Is at Risk: Understanding Stroke-Heart-Brain Interactions with Focus on Neurogenic Stress Cardiomyopathy—A Review. Journal of Stroke 2023;epublished January 3rd
- Marrazzo. Multimodality Imaging Approach to Spontaneous Coronary Artery Dissection. J Clin Med 2023;12(1):154
- Heuts. Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications. Eur Heart J 2023;44(2):7
- Saito. Complete revascularization in acute myocardial infarction: a clinical review. Cardiovasc Interv and Ther 2023;epublished January 7th
Resuscitation
- Lazzarin. Post-Cardiac Arrest: Mechanisms, Management, and Future Perspectives. J Clin Med 2023;12(1):259
- Ornowska. The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature. CNS Neurosci Ther 2023;29(1):104-110
Respiratory
- Slobod. Pathophysiology and Clinical Meaning of Ventilation-Perfusion Mismatch in the Acute Respiratory Distress Syndrome. Biology 2023;12:67
- Al-Tawfiq. Parasitic lung diseases. Eur Respir Rev 2022;31(166):220093
- Murali. Lung ultrasound for evaluation of dyspnea: a pictorial review. Acute Crit Care 2022;37(4):502-515
- Omar. Technique and uses of Lung Ultrasonography in Critical Care Setting. Egyptian J Intensive Care Emerg Med 2022;2(2):1-20
- Cobilinschi. Ventilation in critically ill obese patients—Why it should be done differently?. Signa Vitae 2022;epublished November 10th
- Zhu. Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines. Front Pharmacol 2022;13:1103309
Gastrointestinal
Renal
Sepsis
- Bassetti. New antibiotics for Gram-negative pneumonia. Eur Respir Rev 2022;31(166):220119
- Póvoa. How to use biomarkers of infection or sepsis at the bedside: guide to clinicians. Intensive Care Med 2023;epublished January 2nd
- Klinkmann. Therapeutic apheresis in sepsis. Ther Apher Dial 2022;26 Suppl 1:64-72
Trauma
Toxicology
Perioperative
- Gams. Regional anesthesia for cardiothoracic surgery. Signa Vitae 2022;epublished August 31st
- Hyland. Acute Pain Management Pearls: A Focused Review for the Hospital Clinician. Healthcare 2023;11(1):34
Miscellaneous
- Foocharoen. Management review of scleroderma renal crisis: An update with practical pointers. Mod Rheumatol 2023;33(1):12-20
- Holland. The United Kingdom’s National Early Warning Score: should everyone use it? A narrative review. Intern Emerg Med 2023;epublished January 5th
Non-Clinical
- Yang. Network meta-analysis. Southwest Respir Crit Care Chron 2022;10(45):79-82
- Lee. Machine learning and medicine- a brief introduction. Southwest Respir Crit Care Chron 2022;10(45):28-36
Pre-Clinical
Series from Journal of trauma & Acute Care Surgery on Paediatric Trauma
- Upperman. Building an optimal pediatric trauma program. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S19-S21
- Upperman. Building an optimal pediatric trauma program. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S19-S21
- Sullivan. Time is tissue: Barriers to timely transfusion after pediatric injury. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S22-S28
- Morgan. Resuscitative practices and the use of low-titer group O whole blood in pediatric trauma. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S29-S35
- Borgman. Tranexamic acid in pediatric hemorrhagic trauma. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S36-S40
- Wong. Blood banking considerations in pediatric trauma. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S41-S49
- Dong. Detecting traumatic brain injury–induced coagulopathy: What we are testing and what we are not. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S50-S55
- Russell. Preface: Pediatric traumatic hemorrhagic shock consensus conference. J Trauma Acute Care Surg 2023;94(1S Suppl 1):S1
Editorials
- Wilson. Clinical Practice Guideline Methodology: An Evolving Science. Am J Respir Crit Care Med 2022;207(1):1-2
- Redfern. Fatigue in anaesthesiology. Call for a change of culture and regulations. Eur J Anaesthesiol 2023;40(2):78-81
- Cronin. Perioperative Dialysis: What is “Just Right”? J Cardiothor Vasc Anaesth 2023;epublished January 4th
- Radosevich. Levosimendan And Septic Cardiomyopathy: A Key That May Have Found Its Lock? J Cardiothorac Vasc Anesth 2022;epublished December 19th
Commentaries
- Ostermann. Acute kidney injury. Intensive Care Med 2023;epublished January 2nd
- Hill. The dangers of non-randomized, observational studies: experience from the COVID-19 epidemic. J Antimicrob Chemother 2022;epublished December 28th
- Lakens. Is my study useless? Why researchers need methodological review boards. Nature 2023;613:9
Correspondence
Case Reports
- Hong. Use of droxidopa for blood pressure augmentation after acute spinal cord injury: case reports. Acute Crit Care 2022;epublished December 7th
- Shirazy. Ramping Position to Aid Non-invasive Ventilation (NIV) in Obese Patients in the ICU. J Crit Care med 2023(9)1
- Dhoon. Laryngeal granuloma formation following endotracheal intubation for coronary artery bypass grafting surgery. Anaesth Pain Intensive Care 2022;26(6):811−814
- Sung. Massive microbleeds in posterior circulation territory in an immunocompromised patient with sepsis. J Neurocrit Care 2022;15(2):150-152
- Sung. Axitinib-induced posterior reversible encephalopathy syndrome in a patient with renal cell carcinoma. J Neurocrit Care 2022;15(2):146-147
- Primiani. Fixed and dilated pupils by pupillometer in lateralized periodic discharges: a case report in the neurocritical care unit. J Neurocrit Care 2022;15(2):136-140
- Watchi. Negative-pressure helmet restores cerebral hemodynamic parameters in sinking skin flap syndrome: a case report. J Neurocrit Care 2022;15(2):126-130
- Nguyen. Management of propofol-related infusion syndrome and discussion of POLG mitochondrial mutation: a case report. J Neurocrit Care 2022;15(2):122-125
- Mombrun. Massive gaseous embolism during cardiopulmonary resuscitation for massive hemoptysis in a COVID-19-associated pulmonary aspergillosis. Intensive Care Med 2023;epublished January 2nd
I hope you find this newsletter useful.
Until next week
Rob