The LOVIT Trial Visual Abstract
Welcome to the 553rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the week July 11th to 17th. After the demands of CCR22, we're just one week behind and should catch up fully this week!
The highlights of this week's edition are randomised controlled trials on erythropoietin for hypoxic–ischemic encephalopathy in newborns & nicotine patches in mechanically ventilated patients with severe COVID‑19; systematic reviews and meta analyses on spirituality in serious illness & beta-blocker treatment in the critically ill; and observational studies on presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures & bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation.
There are also guidelines on glycemic management of critically ill patients & indications and triaging for adult transthoracic echocardiography; narrative reviews on intracranial pressure & imaging the acute respiratory distress syndrome; and commentaries on virtual reality in intensive care & point-of-care ultrasound for the diagnosis and management of acute heart failure.
If you only have time to read one review article this week, try this one on poor physical recovery after critical illness.
We've started an Instagram account, where we'll post various media, including photographs from CCR22, and our latest addition to the platform, visual abstracts on the major critical care trials. We're delighted to say Dr Jakub Fronczek, from Cracow, Poland, has joined the CCR team and will lead on the development of these.
If you'd like to support our work, please join our CCR Supporter Club, where you can contribute as little as the price of a cup of coffee per month or make a one-off donation.
Research
Randomised Controlled Trials
- Wu. Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns. N Engl J Med 2022;387:148-159
- Labro. Nicotine patches in patients on mechanical ventilation for severe COVID‑19: a randomized, double‑blind, placebo‑controlled, multicentre trial. Intensive Care Med 2022;epublished June 9th
- Brown. Bolus gastric feeds improve nutrition delivery to mechanically ventilated pediatric medical patients: Results of the COntinuous vs BOlus multicenter trial. JPEN J Parenter Enteral Nutr 2022;46(5):1011-1021
- Messina. Pharmacodynamic analysis of a fluid challenge with 4 ml kg -1 over 10 or 20 min: a multicenter cross-over randomized clinical trial. J Clin Monit Comput 2022;36(4):1193-1203
Systematic Review & Meta Analyses
- Balboni. Spirituality in Serious Illness and Health. JAMA 2022;328(2):184-197
- Heliste. Beta-blocker treatment in the critically ill: a systematic review and meta-analysis. Ann Med 2022;54(1):1994-2010
- Sedhai. Vasopressin versus norepinephrine as the first-line vasopressor in septic shock: A systematic review and meta-analysis. J Clin Transl Res 2022;8(3):185–199
Observational Studies
- Gottlieb. Assessment of Racial and Ethnic Differences in Oxygen Supplementation Among Patients in the Intensive Care Unit. JAMA Intern Med 2022;epublished July 11th
- Mansour. Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study. Intensive Care Med 2022;epublished July 13th
- Lukaszewski. Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures. Intensive Care Med 2022;epublished July 13th
- Miano. Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Med 2022;epublished July 14th
- Rezaiguia-Delclaux. Oxygenation versus driving pressure for determining the best positive end-expiratory pressure in acute respiratory distress syndrome. Crit Care 2022;26:214
- Pavlovsky. Effects of PEEP on regional ventilation-perfusion mismatch in the acute respiratory distress syndrome. Crit Care 2022;26:211
- Mallat. Passive leg raising-induced changes in pulse pressure variation to assess fluid responsiveness in mechanically ventilated patients: a multicentre prospective observational study. Br J Anaesth 2022;epublished July 13th
- Otto. Clinical Characteristics and Outcomes of Critically Ill Patients with 1, 2 and 3 doses of Vaccination against COVID-19 in Australia. Intern Med J 2022;epublished July 16th
- Dimitriadis. Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC. Crit Care 2022;26(1):217
Guidelines
- Wu. Expert consensus on the glycemic management of critically ill patients. J Intensive Med 2022;2(3):131-145
- Clinical indications and triaging for adult transthoracic echocardiography: a consensus statement by the British Society of Echocardiography in collaboration with British Heart Valve Society. Echo Res Pract 2022;9:5
Reviews
Clinical
COVID-19
- Smith. Managing Severe Hypoxic Respiratory Failure in COVID-19. Curr Emerg Hosp Med Rep 2022;epublished May 11th
- Hartman. An Executed Plan to Combat COVID-19 in the United States. Advances in Anaesthesia 2022;epublished July 12th
Neurological
- Hawryluk. Intracranial pressure: current perspectives on physiology and monitoring. Intensive Care Med 2022;epublished July 11th
- Stolp. Anesthetic considerations for endovascular treatment in stroke therapy. Curr Opin Anaesthesiol 2022;35(4):472-478
Circulatory
- Gorder. Mechanical Circulatory Support in COVID-19. Cardiol Clin 2022;40(3):329-335
- Meuwese. The ABCDE approach to difficult weaning from venoarterial extracorporeal membrane oxygenation. Crit Care 2022;26:216
- Kubena. Push-dose vasopressors in the Emergency Department: a narrative review. J Emerg Crit Care Med 2022;epublished June 17th
Respiratory
Nutrition
Hepatobiliary
Renal
- Sanchez-Alamo. Facing the Challenge of Drug-Induced Acute Interstitial Nephritis. Nephron 2022;epublished July 13th
- Shah. Pregnancy-Related Acute Kidney Injury: Do We Know What to Do? Nephron 2022;epublished July 6th
- Ali. Strategies for Renal Protection in Cardiovascular Interventions. Korean Circ J 2022;52(7):485-495
- Lindner. Hyponatremia in the emergency department. Am J Emerg Med 2022;60:1-8
Haematological
Sepsis
- Zhang. The gut–liver axis in sepsis: interaction mechanisms and therapeutic potential. Crit Care 2022;26:213
- Umpleby. Antimicrobial stewardship programmes focused on de-escalation: a narrative review of efficacy and risks. J Emerg Crit Care Med 2022;epublished June 6th
Trauma
Perioperative
Miscellaneous
- Singh. Chimeric antigen receptor T cell: A cancer immunotherapy. Indian J Pharmacol 2022;54:226-33
- Boelens. Poor physical recovery after critical illness: incidence, features, risk factors, pathophysiology, and evidence-based therapies. Curr Opin Crit Care 2022;28(4):409-416
Non-Clinical
Commentaries
- Bruno. Virtual reality in intensive care. Intensive Care Med 2022;epublished July 11th
- Gottlieb. Just the facts: point-of-care ultrasound for the diagnosis and management of acute heart failure. Can J Emerg Med 2022;epublished July 14th
- Araiza. Administration of vasopressors through peripheral venous catheters. CMAJ 2022;194(21):E739
Correspondence
- Sanfilippo. Cardiorenal syndrome in Intensive Care Unit and echocardiography: a balance between systole, diastole and volume! Minerva Anestesiologica 2022;88(7-8):636-7
- Ahiskalioglu. From ultrasound to artificial intelligence: a new era of the regional anesthesia. Minerva Anestesiologica 2022;88(7-8):640-2
- Alessandri. Face-mask noninvasive ventilation plus high flow nasal oxygen in COVID-19 patients: “one size fits all” or tailored approach? Minerva Anestesiologica 2022;88(7-8):643-4
- Wiedermann. Institutional recommendation for the withdrawal of scientific articles from Joachim Boldt. Intensive Care Med 2022;epublished July 12th
- Cheung. The effects of family presence in the intensive care unit are yet to be unveiled. Intensive Care Med 2022;epublished July 13th
I hope you find this newsletter useful.
Until next week
Rob
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