Critical Care Reviews Newsletter

Welcome to the 549th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature for the week of CCR22 - June 13th to 19th. We're two weeks behind due to the workload from the Meeting, but should catch up this coming week.

The highlights of this week's edition are the major trial results presentations we hosted at CCR22, as well as a couple of systematic reviews and meta analysis, and a position paper also presented in Titanic Belfast. Firstly, Francois Lamontagne and Neill Adhikari reported the LOVIT trial, demonstrating harm with vitamin C in sepsis. Secondly, Padmanabhan Ramnarayan and Paul Mouncey presented the results of the FIRST-ABC step-up trial, demonstrating non-inferiority of high flow nasal cannulae with CPAP in critically ill children with respiratory failure. Thirdly, Derek Russell and Jon Casey reported the PREPARE II trial, showing a lack of benefit from an IV fluid bolus for the prevention of circulatory collapse in critically ill patients undergoing emergency intubation. Fourthly, Tine Sylvest Meyhoff described the results of the CLASSIC trial, showing similar outcomes between a restrictive fluid regime and standard care in patients with septic shock. In addition, Niklas Nielsen presented a meta analysis of the TTM1 and TTM2 trials, comparing hypothermic with normothermic temperature control after cardiac arrest, and Neill Adhikari delivered the results of an up-to-date meta analysis of parenteral vitamin C in patients with severe infection. All these papers were simultaneous published in NEJM, JAMA or NEJM Evidence. Finally, David Maslove briefly described a new paper on redefining critical illness, which was also published by Nature Medicine during the meeting.

The recordings of the talks will start to be released next week on the CCR website. Viewing is, as always, free.  If you are interested in attending CCR23, it's on June 14th to 16th, in Titanic Belfast.

We also released the Critical Care Reviews Book 2022 in time for CCR22. Twenty-two of the best critical care trials of 2021 are summarised, critiqued and placed in context. The pdf can be downloaded from the CCR website, or a print version purchased for a low cost.

To help fund our work, we have started a CCR Supporter facility, where you can contribute as little as the price of a cup of coffee per month, or make a one-off donation, to help support our efforts. Our aim is to share science for the benefit of all. While it is free to use, it's very costly to produce. If you value what we do, please support us in our efforts to continue keeping everyone up-to-date with the latest advances in critical care.