Critical Care Reviews Newsletter
Newsletter 546 | May 29th 2022
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Just 2 Weeks to the Critical Care Reviews Meeting 2022
Welcome to the 546th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are a randomised controlled trial investigating a liberal approach to glucose control in critically ill patients with type 2 diabetes & the long-term outcomes of the VAM-IHCA trial; systematic reviews and meta analyses on probiotics in critical illness & ECMO during the first 2 years of the COVID-19 pandemic; and observational studies on one-year outcomes of mechanically ventilated COVID-19 ICU survivors & lung microbiota of critically ill COVID-19 patients.
There are also narrative reviews on temperature management and its role in cardiac arrest patients & precision medicine in ARDS; editorials on predicting the quality of survival after critical illness & cardiac surgery-associated acute kidney injury; commentaries on catheter dressings & the beginning of the end or the end of the beginning of COVID-19; as well as correspondence on the ethical justifications for time-limited trial of intensive care & the role of tranexamic acid in trauma.
If you only have time to read one review article this week, try this one on blood transfusion reactions.
Critical Care Reviews Meeting 2022
There are just two weeks to CCR22, where we host:
- 5 major trial results - LOVIT (vitamin C in sepsis), SuDDICU (selective digestive decontanimation), FIRST-ABC (CPAP vs HFNO in acutely ill children), PREPARE II (fluid bolus for the prevention of cardiovascular collapse in emergency intubation), & CLASSIC (conservative versus liberal fluid therapy in septic shock)
- review 10 of the best trials of the previous year - VAM-IHCA, TTM2, Prague OHCA Study, RePHILL, PLUS, BASICS, COCA, BOUGIE, LONG-HOT & COAST
- have three panel discussions - Trial Interpretation - Controversies & Misunderstandings, Publishing in the Top Tier Journals, and the Future of Funding of Clinical Trials
- John Hinds Lecture - Prof Howard Bauchner on "Open Science and the Future of Scientific Communication".
Our social programme is packed too, with a run or yoga/pilates class both Thursday and Friday mornings, and social events Wednesday, Thursday and Friday nights.
The meeting is approved for 18 CPD points by the Royal College of Anaesthetists, with attendance available in-person (1 day, 2 day and 3 day options), virtually with CPD/CME points (paid) or virtually without CPD/CME points (free).
Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open.
Research
Randomised Controlled Trials
- Poole. The Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial. Am J Respir Crit Care Med 2022;epublished May 20th
- Granfeldt. Effect of vasopressin and methylprednisolone vs. placebo on long-term outcomes in patients with in-hospital cardiac arrest a randomized clinical trial. Resuscitation 2022;175:67-71
- Marasco. Rib fixation in non-ventilator-dependent chest wall injuries: A prospective randomized trial. J Trauma Acute Care Surg 2022;92(6):1047-1053
- Denkel. Effect of antiseptic bathing with chlorhexidine or octenidine on central line-associated bloodstream infections in intensive care patients: a cluster-randomized controlled trial. Clin Microbiol Infect 2022;28(6):825-831
- Wolfe. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial. Lancet Respir Med 2022;epublished May 23rd
- Darie. Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial. Lancet Respir Med 2022;epublished May 23rd
Systematic Review & Meta Analyses
- Sharif. Probiotics in Critical Illness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med 2022;epublished May 25th
- Ling. Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis. Crit Care 2022;26(1):147
- Côté. Diuretic combinations in critically ill patients with respiratory failure: A systematic review and meta-analysis. World J Crit Care Med 2022;11(3):178-191
Observational Studies
- Bels. One-year Outcomes of Mechanically Ventilated COVID-19 ICU Survivors: A Prospective Cohort Study. Am J Respir Crit Care Med 2022;epublished May 20th
- Wendel-Garcia. Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome. Crit Care 2022;26:148
- van der Vlegel. Health care utilization and outcomes in older adults after Traumatic Brain Injury: a CENTER-TBI study. Injury 2022;epublished May 25th
- Kullberg. Lung Microbiota of Critically Ill COVID-19 Patients are Associated with Non-Resolving Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2022;epublished May 26th
- Greco. Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study. Intensive Care Med 2022;epublished May 21st
- Søgaard. Thromboembolic Risk in Patients With Pneumonia and New-Onset Atrial Fibrillation Not Receiving Anticoagulation Therapy. JAMA Netw Open 2022;5(5):e2213945
Reviews
Clinical
COVID-19
Circulatory
- Richter. Cerebral oxygenation monitoring in patients during and after cardiac arrest -- a narrative review of current methods and evidence. Signa Vitae 2021;17(6):18-24
- Markota. Temperature management and its role in cardiac arrest patients—a review. Signa Vitae 2022;18(3):1-8
- Monnet. Prediction of fluid responsiveness. What's new? Ann Intensive Care 2022;12(1):46
Respiratory
- Campaña-duel. Therapeutic agents for ARDS. Signa Vitae 2022;epublished May 17th
- Battaglini. New insights in mechanical ventilation and adjunctive therapies in ARDS. Signa Vitae 2021;epublished November 15th
- Ruoyang. From preclinical to clinical models of acute respiratory distress syndrome. Signa Vitae 2022;18(1):3-14
- Nanon. Precision medicine in Acute Respiratory Distress Syndrome. Signa Vitae 2021;epublished November 15th
Nutrition
Renal
Haematological
Sepsis
- Gorham. Drug Regimens of Novel Antibiotics in Critically Ill Patients with Varying Renal Functions: A Rapid Review. Antibiotics 2022;11(5):546
- Losito. New Drugs for the Treatment of Pseudomonas aeruginosa Infections with Limited Treatment Options: A Narrative Review. Antibiotics 2022;11(5):579
- Nandhini. Recent Developments in Methicillin-Resistant Staphylococcus aureus (MRSA) Treatment: A Review. Antibiotics 2022;11(5):606
- van den Bogaart. Antibiotic Therapy for Difficult-to-Treat Infections in Lung Transplant Recipients: A Practical Approach. Antibiotics 2022;11(5):612
- Baracaldo-Santamaría. Therapeutic Drug Monitoring of Antifungal Agents in Critically Ill Patients: Is There a Need for Dose Optimisation? Antibiotics 2022;11(5):645
- Hussain. Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response. Metabolites 2022;12(5):376
Paediatrics
Miscellaneous
- Lupușoru. Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology. Biomedicines 2022;10(5):1012
- Satpanich. Gout flare in the critical care setting: diagnostic challenges and treatment options. Signa Vitae 2022 18(3);9-17
Clinical Liver Disease Series on Liver Transplantation
- Kaur. Pretransplant management of the patient with severe acute-on-chronic liver failure. Clin Liver Dis 2022;19:187–190
- Queck. Transplantation in Acute-on-Chronic Liver Failure: Feasibility and Futility. Clin Liver Dis 2022;19:191-193
- Lin. Posttransplant complications in the setting of acute-on-chronic liver failure and considerations regarding immunosuppression. Clin Liver Dis 2022;19:194–197
- Patel Palliative Care in the Patient With Acute-on-Chronic Liver Failure. Clin Liver Dis 2022;19:198-202
- Westbrook. PRO: Patients With Acute-on-Chronic Liver Failure Should Receive Priority on the Liver Transplant Waiting List. Clin Liver Dis 2022;19:203-206
- Mahmud. Con: Patients With Acute-on-Chronic Liver Failure Should Not Receive Priority on the Waiting List. Clin Liver Dis 2022;19:207-212
- Duong Identifying the patient with acute-on-chronic liver failure: navigating through multiple definitions. Clin Liver Dis 2022;19:183-186
Non-Clinical
Editorials
- Ortega-Loubon. Cardiac Surgery-Associated Acute Kidney Injury: Current Updates and Perspectives. J Clin Med 2022;11(11):3054
- Usman. The Evolution of Percutaneous Right Ventricular Support and Development of a Right Ventricular Mechanical Support team lead by Cardiac Anesthesiologists. J Cardiothor Vasc Anaesth 2022;epublished May 26th
- Nguyen. Towards predicting the quality of survival after critical illness. Intensive Care Med 2022;epublished May 23rd
- Mascellino. Multi-Drug-Resistant Gram-Negative Microorganisms: Epidemiology, Treatment and Alternative Approach. Antibiotics 2022;11(5):678
Commentaries
- Wang. Tools Are Needed to Promote Sedation Practices for Mechanically Ventilated Patients. Front Med 2021;8:744297
- Florez. Guidelines developed under pressure. The case of the COVID-19 low-quality “rapid” guidelines and potential solutions. J Clin Epi 2021;epublished November 12th
- Mema. Who am I? Narratives as a window to transformative moments in critical care. PLoS One 2021;16(11):e0259976
- Deep. Non-transplant options in paediatric acute liver failure—what is new?. Intensive Care Med 2021;epublished November
- Neville. Brave enough. Intensive Care Med 2021;epublished November 17th
- Brasel. Lofty goals and strategic plans are not enough to achieve and maintain a diverse workforce: an American Association for the Surgery of Trauma Diversity, Equity, and Inclusion Committee conversation. Trauma Surgery & Acute Care Open 2021;6:e000813
- Spyropoulos. Studying the coagulopathy of COVID-19. Lancet 2021;epublished November 17th
- Omer. Promoting COVID-19 vaccine acceptance: recommendations from the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA. Lancet 2021;epublished November 15th
- Zarbock. Why the renin–angiotensin–aldosterone system (RAAS) in critically ill patients can no longer be ignored. Crit Care 2021;25:389
Correspondence
- Honore. Difference of 11 years between two periods of VV-ECMO does not impact mortality in large centres: we are not sure. Crit Care 2022;26:149
- Cheung. Beyond failure or success: reflections on the ethical justifications for time-limited trial of intensive care. Intensive Care Med 2022;epublished May 26th
- Roberts. The role of tranexamic acid in trauma — a life-saving drug with proven benefit. Nat Rev Dis Primers 2022;8(1):34
- Ruste. Noninferiority trials: a specific design with a particular methodology. Ann. Intensive Care 2022;12:45