Welcome to the 541st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. The highlights of this week's edition are randomised controlled trials on vitamin C in septic shock & a comparison of 20% albumin with plasmalyte in patients with cirrhosis and sepsis-induced hypotension; systematic reviews and meta analyses on fluid resuscitation with balanced crystalloids versus normal saline & probiotics for the prevention of ventilator-associated pneumonia; and observational studies on clinical frailty in patients with sepsis & echocardiography findings in COVID-19 patients admitted to intensive care units.
There are also guidelines on the use of high-flow nasal cannula in acute respiratory failure & hemophagocytic lymphohistiocytosis; narrative reviews on invasive respiratory fungal infections in COVID-19 critically ill patients & the brain in pediatric critical care; editorials on extracorporeal CPR & why physiology is vital to precision medicine in ARDS and sepsis; and commentaries on learning the art and science of diagnosis & the paradox of immunosuppressants and COVID-19; as well as correspondence on permissive acidosis & intrinsic severity of the SARS-CoV-2 Omicron variant .
If you only have time to read one review article this week, try this one on the intensivist's perspective of shock, volume management, and hemodynamic monitoring.
There are just 50 days to CCR22, our unique meeting focused on the best critical care trials in the world. In June, we host 6 major trial results and review 8 of the best trials of 2021. In addition, we also have 3 panel discussions and our annual honorary John Hinds Lecture. Our social programme is packed too, with events every night, plus the option for exercise on two of the three mornings of the meeting. Visit our trade exhibition and take in the workshops our industry partners will be providing also. Don't miss the opportunity to see the wonderful city of Belfast and the spectacular surrounding countryside. The days are long in June, with daylight lasting from 4am to 10:30 pm. And if you need someone to look after the kids, we can do that in our free, on-site professional creche. Just remember to book this, as well as your hotel soon, as Belfast will be busy and accommodation will be limited during the Summer.
Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open.