Critical Care Reviews Newsletter

Welcome to the 537th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on antiplatelet therapy in critically ill patients with COVID-19 & high-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure; systematic reviews and meta analyses on the use of the clinical frailty scale in COVID-19 patients & extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest; and observational studies on factors associated with acute mesenteric ischemia in critically ill ventilated patients with shock & the risk of dementia and structural brain changes following nonneurological infections.

There are also guidelines on extracorporeal circulations for cardiac and circulatory failure & type B aortic dissection; narrative reviews on major burns & acute kidney injury in critically ill patients with cancer; editorials on angiotensin II for the treatment of vasoplegia & videolaryngoscopy for all intubations; and commentaries on mechanical circulatory support in cardiogenic shock and post-myocardial infarction mechanical complications & terlipressin; as well as correspondence on phenotypic characterization of right ventricular dysfunction and prognostication in COVID-19–induced ARDS.

The annual series of articles from the excellent Annual Update in Intensive Care and Emergency Medicine are also available. If you only have time to read one review article this week, try this one on massive transfusion in trauma.

Critical Care Reviews Meeting 2022

We're hoping to shortly announce another major trial results presentation at CCR22 in Titanic Belfast in June. Already, we will be hosting the results of the CLASSIC trial, investigating a restrictive fluid approach in septic shock; the LOVIT trial, examining vitamin C in sepsis; the FIRST ABC trial (step up), comparing high flow nasal oxygen with continuous positive airway pressure in critically ill children with acute respiratory failure; and LONG-HOT, the one year outcomes of the HOT-ICU trial, testing restrictive and liberal oxygenation targets in patients with acute hypoxaemic respiratory failure. If you haven't yet registered, don't miss out.

Next Trial Results Presentation Livestream - FIRST ABC Trial (step down)

On Thursday April 7th, at 19:30 UTC+1, Dr Padmanabhan Ramnarayan from Imperial College London will present the results of the FIRST ABC (step down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated critically ill children. Join us as we hear the results of the first component of this two trial project. The second will be presented in person at CCR22.