Simon Finfer presents the results of the PLUS trial
Welcome to the 528th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlight of this week's edition is the recording of the PLUS trial results livestream, comparing plasmalyte with 0.9 saline in critically ill patients, including a systematic review and meta analysis comparing balanced crystalloids with 0.9% saline in critically ill adults. The other highlights include an observational study on dyspnea in critically ill patients receiving invasive ventilation; a guideline from ELSO on adult and pediatric anticoagulation for ECMO; narrative reviews on when is parenteral nutrition indicated & viscoelastic point-of-care tests; editorials on the ethics and quality of end-of-life care in intensive care & neonatal ECMO; commentaries on how COVID-19 will continue but the end of the pandemic is near & lessons to improve preparedness for the next pandemic; as well as correspondence on the effect of proning and recruitment on physio-anatomical variables in COVID-19 pneumonia & one-year mortality after ICU admission due to COVID-19 infection.
If you only have time to read one review article this week, try this one on diaphragm ultrasound in cardiac surgery.
Critical Care Reviews Meeting 2022
Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open.
Research
Randomised Controlled Trials
- Finfer. Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. N Engl J Med 2022;epublished January 18th
- Kentish-Barnes. A three-step support strategy for relatives of patients dying in the intensive care unit: a cluster randomised trial. Lancet 2022;epublished January 19th
- Desebbe. Control of Postoperative Hypotension Using a Closed-Loop System for Norepinephrine Infusion in Patients After Cardiac Surgery: A Randomized Trial. Anesth Analg 2022;epublished January 21st
- Berger. Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19A Randomized Clinical Trial. JAMA 2022;327(3):227-236
- Ferguson. Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: the FAKT study - a randomized clinical trial. Acad Emerg Med. 2022 January 22nd
- Ali. Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial. CMAJ 2022;epublished January 19th
Systematic Review & Meta Analyses
- Hammond. Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis. NEJM Evidence 2022;epublished January 18th
- Papazian. Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. Intensive Care Med 2022;epublished January 17th
- Srivastava. Ultrafiltration for acute heart failure. Cochrane Database Syst Rev 2022;epublished January 21st
Observational Studies
- Demoule. Prevalence, Intensity and Clinical Impact of Dyspnea in Critically Ill Patients Receiving Invasive Ventilation. Am J Respir Crit Care Med 2022;epublished January 21st
- Cox. Assessment of Clinical Palliative Care Trigger Status vs Actual Needs Among Critically Ill Patients and Their Family Members. JAMA Netw Open 2022;5(1):e2144093
- Moazed. Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. Am J Respir Crit Care Med 2022;epublished January 20th
- Sutton. Intensive care unit observation after pancreatectomy: Treating the patient or the surgeon? J Surg Oncol 2022;epublished January 20th
- Mang. wake ECMO for COVID-19 Induced Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2022;epublished January 19th
- Nakamura. Relationship between nutrition therapy in the acute phase and outcomes of ventilated patients with COVID-19 infection: a multicenter prospective observational study. Am J Clin Nutr 2022;epublished January 19th
- Karatasakis. Prevalence and Patterns of Resuscitation-Associated Injury Detected by Head-to-Pelvis Computed Tomography After Successful Out-of-Hospital Cardiac Arrest Resuscitation. J Am Heart Assoc 2022;epublished January 19th
- Tacconelli. Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study. Lancet Infect Dis 2022;epublished January 19th
- Servia-Goixart. Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality? Clin Nutr ESPEN 2022;47:325-332
- Fisher. Ammonia Clearance with Different Continuous Renal Replacement Therapy Techniques in Patients with Liver Failure. Blood Purif 2022;epublished January 18th
Protocols
- Grieco. Individualized positive end-expiratory pressure guided by end-expiratory lung volume in early acute respiratory distress syndrome: study protocol for the multicenter, randomized IPERPEEP trial. Trials 2022;23(1):63
- De Jong. Non-invasive ventilation versus oxygen therapy after extubation in patients with obesity in intensive care units: the multicentre randomised EXTUB-OBESE study protocol. BMJ Open 2022;12(1):e052712
- Patel. Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)-trial protocol. Trials 2022;23(1):47
Guidelines
Reviews
Clinical
COVID-19
- Luján. Non-invasive Respiratory Support in COVID-19: A Narrative Review. Front Med 2022;8:788190
- Sullivan. Noninvasive respiratory support for COVID-19 patients: when, for whom, and how?. J Intensive Care 2022;10:3
- Visco. Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems. J Clin Med 2022;11(3):524
Neurological
Respiratory
- Fromentin. Lung Microbiome in Critically Ill Patients. Life 2021;12(1):7
- Liaqat. Evidence-Based Mechanical Ventilatory Strategies in ARDS. J Clin Med 2022;11(2):319
- Fayssoil. Diaphragm Ultrasound in Cardiac Surgery: State of the Art. Medicines 2022;9(1):5
Nutrition
Renal
Endocrine
Haematological
Sepsis
Trauma
Toxicology
Perioperative
Non-Clinical
Pre-Clinical
Editorials
- Dzeng. The role of policy and law in shaping the ethics and quality of end-of-life care in intensive care. Intensive Care Med 2022;epublished January 22nd
- Wollborn. Cardiac Anesthesiologists’ and Intensivists’ Impact on the Treatment of Patients at Advanced Heart Failure Centers. J Cardiothorac Vasc Anesth 2022;epublished December 16th
- Cavallaro. Neonatal ECMO in 2019: Where Are We Now? Where Next? Front Pediatr 2022;9:796670
- Molloy. Paediatric and neonatal sepsis and inflammation. Pediatr Res 2022;epublished January 19th
Commentaries
- Murray. COVID-19 will continue but the end of the pandemic is near. Lancet 2022;epublished January 19th
- Berra. In memoriam: Warren M. Zapol. Intensive Care Med 2022;epublished January 21st
- Emanuel. A National Strategy for the “New Normal” of Life With COVID. JAMA 2022;327(3):211-212
- Nuzzo. The First 2 Years of COVID-19. Lessons to Improve Preparedness for the Next Pandemic. JAMA 2022;327(3):217-218
Correspondence
- Wu. Three-dose vaccination elicits neutralising antibodies against omicron. Lancet 2022;epublished January 19th
- Gurjar. Effect of proning and recruitment on physio-anatomical variables in COVID-19 pneumonia. Intensive Care Med 2022;epublished January 21st
- Ceccato. One-year mortality after ICU admission due to COVID-19 infection. Intensive Care Med 2022;epublished January 18th
- Scheer. Do not forget the blood cultures!. Intensive Care Med 2022;epublished January 17th
- Iba. Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines. J Intensive Care 2022;10:4
- Györgyi. The European Society of Paediatric Radiology's position statement on point-of-care ultrasound. Pediatr Radiol 2022;epublished January 21st
Case Reports
- Imkamp. Zoonotic Chlamydiae as rare causes of severe pneumonia. Swiss Med Wkly 2022;152:w30102
- Wang. Huge and ruptured amoebic liver abscess diagnosed by mNGS: A case report. J Intensive Med 2022;epublished January 13th
- Bawaskar. Stung to the Heart. JACC Case Rep 2022;4(1):54-58
- Soler-Silva. Negative pressure therapy as a safe alternative in the treatment of massive subcutaneous emphysema in critically ill patients COVID-19. Heart Lung 2022;epublished January 13th
I hope you find this newsletter useful.
Until next week
Rob
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