Critical Care Reviews Newsletter
Newsletter 543 | May 8th 2022
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CCR22 is Approved for 18 CPD / CME Points
Welcome to the 543rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials comparing early and standard approaches to tracheostomy in patients with severe stroke receiving mechanical ventilation & intraoperative warming versus routine thermal management during non-cardiac surgery; systematic reviews and meta analyses on long-term survival after out-of-hospital cardiac arrest & short- versus prolonged-course antibiotic therapy for sepsis or infectious diseases in critically ill adults; and observational studies on venovenous ECMO in patients with acute COVID-19 associated respiratory failure & the association between cardiopulmonary resuscitation duration and favorable neurological outcome after out-of-hospital cardiac arrest.
There are also guidelines on cardiac arrest in the cardiac catheter laboratory & peri-operative management of people with cardiac implantable electronic devices; narrative reviews on autonomic disorders in the neurocritical care unit & lung transplantation for ARDS; editorials on REBOA & ventricular assist devices in children; and commentaries on oxygen targets & vasopressors.
If you only have time to read one review article this week, try this one on molecular dogmas in human sepsis using mathematical reasoning.
Critical Care Reviews Meeting 2022
If you are interested in critical care trials and the scientific evidence which underpins our practice, the Critical Care Reviews Meeting is the event for you. With 6 major trial results, reviews of 8 of the best trials of the past year, three panel discussions and the annual honorary John Hinds Lecture, our scientific programme is second to none. With a run and either pilates or yoga classes on Thursday and Friday mornings, and live music every night, our social programme isn't bad either.
For those who have registered for CCR22, accommodation is anticipated to be limited in Belfast in mid-June as the city will be very busy. If you haven't yet booked your hotel, please do so. Our delegate rates are available on the meeting webpage. Some offers will now have expired as there is less than six weeks to the meeting. Similarly, the social events are also filling up, so please book these soon if you plan to attend them. There are just a couple of places left for the Friday night social event. Our social events come with live music, food and drink. Similarly. we have just one space left in our free, on-site, professional creche.
The meeting has now been approved for 18 CPD/CME points by the Royal College of Anaesthetists. Registration for CCR22, on June 15th to 17th at Titanic Belfast, is open.
Research
Randomised Controlled Trials
- Bösel. Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation The SETPOINT2 Randomized Clinical Trial. JAMA 2022;epublished May 4th
- de la Ossa. Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban AreasThe RACECAT Randomized Clinical Trial. JAMA 2022;epublished May 5th
- Hubert. Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany. JAMA 2022;epublished May 5th
- WHO Solidarity Trial Consortium. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses. Lancet 2022;epublished May 2nd
- Sessler. Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial. Lancet 2022;399(10337):1799-1808
- Saito-Benz. Effects of Freshly Irradiated vs Irradiated and Stored Red Blood Cell Transfusion on Cerebral Oxygenation in Preterm Infants: A Randomized Clinical Trial. JAMA Pediatr 2022;176(5):e220152
- Zhou. Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study. Crit Care 2022;26:122
Systematic Review & Meta Analyses
- Amacher. Long-term Survival After Out-of-Hospital Cardiac Arrest. A Systematic Review and Meta-analysis. JAMA Cardiol 2022;epublished May 4th
- Russo. Comparison of hemodynamic instability among continuous, intermittent and hybrid renal replacement therapy in acute kidney injury: A systematic review of randomized clinical trials. J Crit Care 2022;69:153998
- Kubo. Short- versus prolonged-course antibiotic therapy for sepsis or infectious diseases in critically ill adults: a systematic review and meta-analysis. Infect Dis (Lond) 2022;54(3):213-223
- Okano. Respiratory support strategy in adults with acute hypoxemic respiratory failure: a systematic review and network meta-analysis. JA Clin Rep 2022;8(1):34
- Pallanch. Effects on health-related quality of life of interventions affecting survival in critically ill patients: a systematic review. Crit Care 2022;26:126
- Chen. Comparative effectiveness of non-pharmacological interventions for preventing delirium in critically ill adults: A systematic review and network meta-analysis. Int J Nurs Stud 2022;131:104239
Observational Studies
- Urner. Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study. BMJ 2022;377:e068723
- Vigstedt. The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infection. J Crit Care 2022;69:154010
- Matsuyama. Cardiopulmonary resuscitation duration and favorable neurological outcome after out-of-hospital cardiac arrest: a nationwide multicenter observational study in Japan (the JAAM-OHCA registry). Crit Care 2022;26:120
- Svedung Wettervik. Cerebral Blood Flow and Oxygen Delivery in Aneurysmal Subarachnoid Hemorrhage: Relation to Neurointensive Care Targets. Neurocrit Care 2022;epublished April 21st
- Cumberworth. Major complications of airway management: a prospective multicentre observational study. Anaesthesia 2022;77(6):640-648
Protocols
- Khaled. Intraoperative protective mechanical ventilation in patients requiring emergency abdominal surgery: the multicentre prospective randomised IMPROVE-2 study protocol. BMJ Open 2022;12(5):e054823
- George. Fibrinogen Early In Severe paediatric Trauma studY (FEISTY junior): protocol for a randomised controlled trial. BMJ Open 2022;12(5):e057780
Guidelines
- Joint British Societies' guideline on management of cardiac arrest in the cardiac catheter laboratory. Heart 2022;epublished April 25th
- Guidelines for the peri-operative management of people with cardiac implantable electronic devices. Guidelines from the British Heart Rhythm Society. Anaesthesia 2022;epublished April 16th
- Mertes. Guidelines on enhanced recovery after cardiac surgery under cardiopulmonary bypass or off-pump. Anaesth Crit Care Pain Med 2022;41(3):101059
- Substance use disorder in the anaesthetist. Guidelines from the Association of Anaesthetists. Anasethesia 2022;77(6):691-699
Reviews
Clinical
COVID-19
Revista Española De Quimioterapia
Current concepts in diagnosis of pneumonia
- Martínez. Usefulness of monocyte distribution width (MDW) as a sepsis biomarker. Rev Esp Quimioter 2022;35(Suppl. 1):2-5
- Sagasti. Urgent need for a rapid microbiological diagnosis in critically ill pneumonia. Rev Esp Quimioter 2022;35(Suppl. 1):6-14
- Burillo. Value of syndromic panels in the management of severe community-acquired pneumonia. Rev Esp Quimioter 2022;35 (Suppl. 1):15-20
- Pallarés. Usefulness of thoracic ultrasound for diagnosis and follow-up of pneumonia. Rev Esp Quimioter 2022;35(Suppl. 1):21-24
New antimicrobial alternatives in the treatment of pneumonia
- Méndez. Ceftobiprole medocaril. Rev Esp Quimioter 2022;35(Suppl. 1):25-27
- Cilloniz. Ceftaroline in severe community-acquired pneumonia. Rev Esp Quimioter 2022;35 (Suppl. 1):28-30
- Soriano. Cefiderocol. Rev Esp Quimioter 2022;35(Suppl. 1):31-34
- Candel. Ceftolozane-tazobactam in nosocomial pneumonia. Rev Esp Quimioter 2022;35(Suppl. 1):35-39
- Herrero. Ceftazidime-avibactam. Rev Esp Quimioter 2022;35(Suppl. 1):40-42
- Guillot. New evidence in severe pneumonia: meropenem-vaborbactam. Rev Esp Quimioter 2022;35(Suppl. 1):43-45
- Girón. New evidence in severe pneumonia: imipenem/ cilastatin/relebactam. Rev Esp Quimioter 2022;35(Suppl. 1):46-49
Update in SARS-COV-2 pneumonia
- Gordo. Ventilation support in SARS-CoV-2 pneumonia. Strategy and indications. Rev Esp Quimioter 2022;35(Suppl. 1):50-53
- Cilloniz. Steroid therapy and antiviral treatment in SARSCoV-2 pneumonia: clinical contexts and indications. Rev Esp Quimioter 2022;35(Suppl. 1):54-58
- Menéndez. Immune treatment in COVID-19. Rev Esp Quimioter 2022;35(Suppl. 1):59-63
- Del Pozo. Respiratory infections in Coronavirus disease 2019. Rev Esp Quimioter 2022;35(Suppl. 1):64-66
- Molina-Molina. Respiratory consequences after COVID-19: outcome and treatment. Rev Esp Quimioter 2022;35(Suppl. 1):67-72
Special issues in pneumonia 2021
- Niederman. Aspiration pneumonia. Rev Esp Quimioter 2022;35(Suppl. 1):73-77
- Sancho. Top-ten papers in pneumonia (2020-2021). Rev Esp Quimioter 2022;35(Suppl. 1):78-81
- Yandiola. Diagnostic and therapeutic approach to occupational pneumonia. Rev Esp Quimioter 2022;35(Suppl. 1):82-88
- Lletí. Etiology, diagnosis, and management of pneumonia in immunosuppressed patients. Rev Esp Quimioter 2022;35(Suppl. 1):89-96
- Fortún. Diagnostic and therapeutic approach to fungal pneumonia in the critically ill patient. Rev Esp Quimioter 2022;35(Suppl. 1):97-103
- Luna. Impact of vaccination on the epidemiology and prognosis of pneumonia. Rev Esp Quimioter 2022;35(Suppl. 1):104-110
Neurological
- Abraham. Understanding and Managing Autonomic Disorders in the Neurocritical Care Unit: A Comprehensive review. Neurol India 2022;70:485-90
- Machado. Brain Death Diagnosis in Primary Posterior Fossa Lesions. Neurol India 2022;70:670-5
- Picetti. Perioperative management of severe brain injured patients. Minerva Anestesiologica 2022;88(5):380-9
- Singleton. Perioperative management in complex spine surgery. Minerva Anestesiologica 2022;88(5):396-406
Airway
Respiratory
Hepatobiliary
Renal
- Esson. Cutaneous manifestations of acute kidney injury. Clin Kid J 2022;15(5):855–864
- Braet. Treatment of acute kidney injury in cancer patients. Clin Kid J 2022;15(5):873–884
Sepsis
Editorials
- Solomon. Mortality risk prediction models: Methods of assessing discrimination and calibration and what they mean. South Afr J Crit Care 2022;38(1):2
- Perlman. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): Looking back, Moving Forward. J Cardiothorac Vasc Anesth 2022;epublished May 6th
- Valencia. Ventricular Assist Devices: Improving the Lives of Children With Heart Failure. J Cardiothorac Vasc Anesth 2022;36(6):1509-1510
- Daubenspeck. Clinical Importance of Quantitative Assessment of Myocardial Blood Flow. J Cardiothorac Vasc Anesth 2022;36(6):1511-1515
- Zochios. The Right Ventricle During Veno-Venous Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: Can We Protect the Injured Ventricle? ASAIO 2022;68(4):456-460
- Anonymous. COVID-19: the next phase and beyond. Lancet 2022;399(10337):1753
- Curtis. Providing Compassionate Care in the ICU. Am J Respir Crit Care Med 2022;205(9):990-991
- Monnet. Should We Wean Patients off Vasopressors before Weaning Them off Ventilation? Am J Respir Crit Care Med. 2022;205(9):980-981
Commentaries
- Legrand. Ten tips to optimize vasopressors use in the critically ill patient with hypotension. Intensive Care Med 2022;epublished May 3rd
- Jonkman. Lung recruitment. Intensive Care Med 2022;epublished May 2nd
- Chou. Less pharmacotherapy is more in delirium. Intensive Care Med 2022;epublished April 30th
- Gattinoni. In search of the Holy Grail: identifying the best PEEP in ventilated patients. Intensive Care Med 2022;epublished May 5th
- Young. Oxygen targets. Intensive Care Med 2022;epublished May 5th
- Guerci. When to start vasopressin in septic shock: the strategy we propose. Crit Care 2022;26(1):125
- De Waele. Routine use of indirect calorimetry in critically ill patients: pros and cons. Crit Care 2022;26:123
- Moss. Demystifying the Black Box: The Importance of Interpretability of Predictive Models in Neurocritical Care. Neurocrit Care 2022;epublished May 6th
- Gravesteijn. Modern Learning from Big Data in Critical Care: Primum Non Nocere. Neurocrit Care 2022;epublished May 5th
- Wijdicks. It was 40 Years Ago Today: AIDS and the Brain. Neurocrit Care 2022;36:682–686
- McDonald. Achieving Equity in Diagnostic Excellence. JAMA 2022;epublished May 6th
Correspondence
- Ortoleva. Normalizing the Abnormal: Hypoxemia in Venovenous ECMO. J Cardiothor Vasc Anesth 2022;epublished May 6th
- Kairaitis. Ventilation Is Not Depressed in Patients with Hypoxemia and Acute COVID-19 Infection. Am J Respir Crit Care Med 2022;205(9):1119-1120
- Pérez-Bárcena. Barbiturate coma for refractory intracranial hypertension in adult head trauma. Minerva Anestesiologica 2022;88(5):418
Case Reports
- Al Balushi. COVID-19 Associated Mucormycosis: Opportunistic Fugal Infection. A case series and review. Int J Infect Dis 2022;epublished May 6th
- Berlot. Diffuse aspergillosis in a patient with SARS-CoV-2 pneumonia. Intensive Care Med 2022;48:609–610
- Goldberg. Successful Heart Transplantation Recovered From a Brain-Dead Donor on Veno-Arterial Extracorporeal Membrane Oxygenation Support. ASAIO J 2022;68(4):e64-e65
- Zoghbi. Internal necklace as a nasogastric tube placement complication. Minerva Anestesiologica 2022;88(5):415-6