COCA Trial Results Livestream - Tuesday November 30th
Welcome to the 520th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on prostacyclin in mechanically ventilated patients with COVID-19 & midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension; systematic reviews and meta analyses on noninvasive respiratory support following extubation in critically ill adults & esophageal pressure monitoring during mechanical ventilation; and observational studies on mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia & fungal infections in mechanically ventilated patients with COVID-19.
There is also a guidelines on prehospital blood product transfusion; narrative reviews on acute pulmonary embolism & temporary mechanical circulatory support in cardiogenic shock; an editorial on randomized controlled trials versus systematic reviews and meta-analyses; and a commentary on decarbonizing the U.S. health sector.
If you only have time to read one review article this week, try this one on coagulopathies in intensive care medicine.
COCA Livestream Trial Results Presentation
The results of the COCA trial, investigating calcium for out-of-hospital cardiac arrest, will be presented at a Critical Care Reviews Trial Results Livestream, on Tuesday November 30th at 19:30 UTC+0. Further details are available on the livestream webpage. As always, viewing is free; in addition, we have applied for CPD points for those wishing to claim them - these will be available shortly for a small charge.
Other Upcoming Livestreams
BOUGIE Trial Results Presentation - Wednesday, December 8th, 19:30 UTC +0
- Bougie vs stylet for emergency intubation in the critically ill
PLUS Trial - Date and Time to be confirmed
- Plasma-Lyte 148® vs saline for intravascular volume resuscitation and crystalloid fluid therapy in the ICU
Critical Care Reviews Meeting 2022
After the virtual eCCR21 meeting this year, in 2022 we return to the iconic Titanic Belfast for our 10th anniversary meeting next June, 15th to 17th, 2022. Including major trial results presentations, reviews of the best trials of the preceding year and talks on various aspects of trials, CCR22 has become the niche meeting for the latest in critical care trials. Registration will open shortly, initially for registered CCR subscribers, before opening to the wider critical care community. The meeting sells out every year, so don't wait and miss out.
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Research
Randomised Controlled Trials
- Johansson. Prostacyclin in Mechanically Ventilated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized, Clinical Trial. Am J Respir Crit Care Med 2021;epublished November 23rd
- Costa-Pinto. A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study. J Crit Care
2021;67:166-171 - Toner. Aspirin as a Treatment for Acute Respiratory Distress Syndrome: a randomised placebo controlled clinical trial. Chest 2021;epublished November 13th
- Bellingan. Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial. Intensive Care Med 2021;epublished November 23rd
- Katz. Use of a Procalcitonin-guided Antibiotic Treatment Algorithm in the Pediatric Intensive Care Unit. Pediatr Infect Dis J 2021;40(4):333-337
Systematic Review & Meta Analyses
- Fernando. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis. Intensive Care Med 2021;epublished November 25th
- Garegnani. Esophageal pressure monitoring during mechanical ventilation in critically ill adult patients: A systematic review and meta-analysis. Med Intensiva 2021;45(7):387-394
- Helgeson. Transbronchial Forceps Biopsy in the Intensive Care Unit: A Systematic Review and Meta-analysis. J Bronchology Interv Pulmonol 2021;28(4):281-289
Observational Studies
- Ingels. C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery. Intensive Care Med 2021;epublished November 24th
- Lombardi. External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals. Intensive Care Med 2021;47:1426–1439
- Anesi. Association of Intensive Care Unit Admission and Outcomes in Sepsis and Acute Respiratory Failure. Am J Respir Crit Care Med 2021;epublished November 24th
- Duclos. Brain Responses to Propofol in Advance of Recovery From Coma and Disorders of Consciousness: A Preliminary Study. Am J Respir Crit Care Med 2021;epublished November 5th
- Thille. Beneficial Effects of Non-Invasive Ventilation After Extubation in Obese or Overweight Patients: A Post-Hoc Analysis of a Randomized Clinical Trial. Am J Respir Crit Care Med 2021;epublished November 23rd
- Bradley. Pneumonia Severity Index and CURB-65 Are Good Predictors of Mortality in Hospitalized Patients with SARS-CoV-2 Community-Acquired Pneumonia. Chest 2021;epublished November 2nd
- Gannon. Safety and Feasibility of a Protocolized Daily Assessment of Readiness for Liberation From Venovenous Extracorporeal Membrane Oxygenation. Chest 2021;160(5):1693-1703
- Al-Fares. Achieving Safe Liberation During Weaning From VV-ECMO in Patients With Severe ARDS. The Role of Tidal Volume and Inspiratory Effort. Chest 2021;160(5):1704-1713
- McPeake. Multimorbidity and Its Relationship With Long-Term Outcomes After Critical Care Discharge. Chest 2021;160(5):1681-1692
- Gacouin. 1-hour t-piece spontaneous breathing trial vs 1-hour zero pressure support spontaneous breathing trial and reintubation at day 7: A non-inferiority approach. J Crit Care 2021;67:95-99
- Bogaerts. The effect of fluid bolus administration on cerebral tissue oxygenation in post-cardiac arrest patients. Resuscitation 2021;168:1-5
- Rossi. Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia. Intensive Care Med 2021;epublished November 26th
- Gangneux. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study. Lancet Respir Med 2021;epublished November 26th
- Pensier. A multivariate model for successful publication of intensive care medicine randomized controlled trials in the highest impact factor journals: the SCOTI score. Ann. Intensive Care 2021;11:165
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Guidelines
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Reviews
Clinical
COVID-19
- Polastri. Extracorporeal membrane oxygenation and rehabilitation in patients with COVID-19: A scoping review. Artificial Organs 2021;epublished November 14th
- Lamoth. Navigating the Uncertainties of COVID-19–Associated Aspergillosis: A Comparison With Influenza-Associated Aspergillosis. J Infect Dis 2021;224(10):1631–1640
- Duric. The role of rotational thromboelastometry in understanding the coagulation problems in COVID-19 associated critical illness. Anaesthesiol Intensive Ther 2021;53(4):336–342
- Vincent. Prevention and management of thrombosis in hospitalised patients with COVID-19 pneumonia. Lancet Respir Med 2021;epublished November 25th
Circulatory
- Schultheiss. Viral Myocarditis-From Pathophysiology to Treatment. J Clin Med 2021;10(22):5240
- Rali. Interhospital Transfer of Patients With Acute Pulmonary Embolism. Challenges and Opportunities. Chest 2021;160(5):1844-1852
- Jamil. Current interventional therapies in acute pulmonary embolism. Prog Cardiovasc Dis 2021;epublished November 22nd
- Obradovic. Temporary mechanical circulatory support in cardiogenic shock. Prog Cardiovasc Dis 2021;epublished November 18th
- Mielnicki. A systematic approach to transoesophageal echocardiography in the intensive care unit – a practical guide for intensivists. Anaesthesiol Intensive Ther 2021;53(3): 329–335
- Soliman-Aboumarie. Echocardiography in the intensive care unit: An essential tool for diagnosis, monitoring and guiding clinical decision-making. Physiol Int 2021;epublished November 25th
Airway
Respiratory
- Kondili. COVID-19 ARDS: Points to Be Considered in Mechanical Ventilation and Weaning. J Pers Med 2021;11(11):1109
- Fröhlich. Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics. Biomedicines 2021;9(11):1732
- Wick. Promises and challenges of personalized medicine to guide ARDS therapy. Crit Care 2021;25:404
Hepatobiliary
- Zaccherini. Management of Ascites in Patients with Cirrhosis: An Update. J Clin Med 2021;10(22):5226
Renal
Haematological
Sepsis
Paediatrics
- Peshimam. Sepsis in children: state-of-the-art treatment. Ther Adv Infect Dis 2021;epublished November 23rd
- Biban. Advances in Neonatal Critical Care: Pushing at the Boundaries and Connecting to Long-Term Outcomes. Crit Care Med 2021;49(12):2003-2016
Miscellaneous
- Kleinpell. The Society of Critical Care Medicine at 50 Years: Interprofessional Practice in Critical Care: Looking Back and Forging Ahead. Crit Care Med 2021;49(12):2017-2032
- Abma. Comparing the Dutch ICU triage guidelines to guidelines from abroad: differences and similarities. Neth J Crit Care November 2021;29(6):238-245
- Juffermans. Development of a research agenda for critical care medicine in the Netherlands: the time is now. Neth J Crit Care 2021;29(6):246-252
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Editorials
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Commentaries
- Dzau. Decarbonizing the U.S. Health Sector — A Call to Action. N Engl J Med 2021;epublished October 13th
- Levi. Tocilizumab in severe COVID-19: A promise fulfilled. Eur J Intern Med 2021;epublished November 22nd
- Buckley. Sand and water. Intensive Care Med 2021;47:1513
- Farrell. Finding My Belonging in Critical Care. Chest 2021;160(5):1984-1985
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Correspondence
- Kuindersma. Time to Tailor the One Size Fits All Approach? Am J Respir Crit Care Med 2021;epublished November 24th
- Sanfilippo. Monitoring of cerebral oxygenation during cardiopulmonary resuscitation may dramatically reduce the incidence of severe hyperoxia. Resuscitation 2021;epublished November 22nd
- Scquizzato. No more unwitnessed out-of-hospital cardiac arrests in the future thanks to technology. Resuscitation 2021;epublished November 22nd
- Salcido. Re: Targeted temperature management in adult cardiac arrest: Systematic review and meta-analysis. Resuscitation 2021;epublished November 22nd
- Kummer. Paradoxically Improved Respiratory Compliance With Abdominal Compression in COVID-19 ARDS. Chest 2021;160(5):1739-1742
- Nugent. Outcomes Using Fluid Responsiveness to Manage Fluid Resuscitation. Chest 2021;160(5):e539
- The SRLF Trial Group. End of life in the critically ill patient: evaluation of experience of end of life by caregivers (EOLE study). Ann Intensive Care 2021;11:162
- Cheung. Partial Code in Cardiac Arrest. Should It Be Allowed as an Exception? Chest 2021;160(5):e541-e542
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Case Reports
- Corrêa. Exclusively Tracheobronchial Paracoccidioidomycosis. A Rare Presentation. Chest 2021;160(5):e499-e501
- Fakili. A 24-Year-Old Woman With Dyspnea, Chest Pain, and Dry Cough. Chest 2021;160(5):e503-e506
- Okereke. A 31-Year-Old Pregnant Woman With Asthma, Presenting With Worsening Dyspnea, Wheeze, and Hoarseness. Chest 2021;160(5):e507-e512
- Goel. A 56-Year-Old Man With Emphysema, Rash, and Arthralgia. Chest 2021;160(5):e513-e518
- Johnson. An 8-Month-Old Infant With Respiratory Failure After a Fall. Chest 2021;160(5):e519-e522
- Baltaji. Case of a 57-Year-Old Man With Malignant Mesothelioma Presenting With Miliary Nodules on Chest Imaging. Chest 2021;160(5):e523-e526
- Cui. Echocardiographic Image of a Cannula in the Inferior Vena Cava After Decannulation of Venoarterial Extracorporeal Membrane Oxygenation. Chest 2021;160(5):e527-e530
- Granati. A 61-Year-Old Man With Respiratory Failure and Shock. Chest 2021;160(5):e531-e533
- Gao. A Young Woman With Severe Hypotension After Right Lung Lobectomy. Chest 2021;160(5):e535-e537
- Roerhorst. A rare case of auto-intoxication with an antidote: fampridine. Neth J Crit Care 2021;29(6):254-256
- Klijn. A subarachnoid haemorrhage heralding bacterial endocarditis. Neth J Crit Care 2021;29(6):258-261
I hope you find this newsletter useful.
Until next week
Rob
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