Critical Care Reviews Newsletter
Newsletter 503 | August 3rd 2021
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Three Major Trial Results Livestreams Coming Up
Welcome to the 503rd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on tofacitinib in patients hospitalized with Covid-19 pneumonia & the effect of systemic hydrocortisone initiated 7 to 14 days after birth in ventilated preterm infants; systematic reviews and meta analyses on high flow nasal oxygen for acute type two respiratory failure & corticosteroids in ARDS; and observational studies on Covid-19 breakthrough infections in vaccinated health care workers & electrical rhythm degeneration in adults with out-of-hospital cardiac arrest according to the no-flow and bystander low-flow time.
There are also narrative reviews on ultrasound during cardiopulmonary resuscitation & coagulopathy in COVID-19; editorials on human albumin infusion strategy in liver cirrhosis & why improved PF ratio should not be our target when treating ARDS; and commentaries on SARS-CoV-2 variants & using updated PubMed; as well as correspondence on spike-antibody waning after second dose of BNT162b2 or ChAdOx1 & diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients.
If you only have time to read one review article this week, try this one on Long COVID.
Major Trial Results Livestreams
We have 3 major trial results livestreams to bring you over the next week. Tomorrow, Wednesday August 4th, the multiplatform anticoagulation in COVID-19 trial group present their results, followed on Thursday August 5th, by the RECOVERY-RS trial comparing CPAP vs HFNO vs standard care in hypoxic COVID-19 patients. Next week, on Tuesday 10th, we have the massive 11,000 patient BASICS trial from Brazil, comparing both saline with plasmalyte, and faster with slower fluid infusion rates. All three livestreams will be freely available on the Critical Care Reviews homepage.
Research
Randomised Controlled Trials
- Guimarães. Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med 2021;385:406-415
- Saka. Comparison of arterial blood pressure and cardiac index-based hemodynamic management on cognitive function in elderly patients undergoing spinal surgery: a randomized clinical trial. Minerva Anestesiologica 2021;87(7):757-65
- Kosiborod. Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2021;epublished July 21st
- Halbmeijer. Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years’ Corrected Age. Follow-up of a Randomized Clinical Trial. JAMA 2021;326(4):355-357
- Diaper. Goal-directed hemodynamic therapy versus restrictive normovolemic therapy in major open abdominal surgery: A randomized controlled trial. Surgery 2021;169(5):1164-1174
Systematic Review & Meta Analyses
- Alnajada. High flow nasal oxygen for acute type two respiratory failure: a systematic review. F1000Research 2021;10:482
- Malekahmadi. Effect of enteral immunomodulatory nutrition formula on mortality and critical care parameters in critically ill patients: A systematic review with meta-analysis. Nurs Crit Care 2021;epublished July 29th
- Johansen. Use of hydroxyethyl starch in sepsis research: A systematic review with meta-analysis. Acta Anaesthesiol Scand 2021;epublished July 26th
- Rashid. Efficacy and Safety of Corticosteroids in Acute Respiratory Distress Syndrome: An overview of Meta-analyses. Int J Clin Pract 2021;epublished July 26th
Observational Studies
- Bergwerk. Covid-19 Breakthrough Infections in Vaccinated Health Care Workers. N Engl J Med 2021;epublished July 28th
- Boots. Temperature rhythms and ICU sleep: the TRIS study. Minerva Anestesiologica 2021;87(7):794-802
- Zufferey. Pharmacokinetics of enoxaparin in COVID-19 critically ill patients. Thromb Res 2021;205:120-127
- Citerio. Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study. Intensive Care Med 2021;epublished July 24th
- Cournoyer. Electrical rhythm degeneration in adults with out-of-hospital cardiac arrest according to the no-flow and bystander low-flow time. Resuscitation 2021;epublished July 26th
Protocols
Reviews
Clinical
COVID-19
- Mucha. Update to coagulopathy in COVID-19: Manifestations and management. Cleve Clin J Medicine 2021;epublished June 2nd
- Crook. Long covid—mechanisms, risk factors, and management. BMJ 2021;374:n1648
- Marinangeli. Chronic pain and COVID-19: pathophysiological, clinical and organizational issues. Minerva Anestesiologica 2021;87(7):828-32
Neurological
Circulatory
Respiratory
Hepatobiliary
- Matar. Extracorporeal Liver Support: A Bridge to Somewhere. Clin Liver Dis 2021;epublished July 22nd
- Acharya. Acute Liver Failure: Indian Perspective. Clin Liver Dis 2021;epublished July 22nd
Renal
Annals of Translational Medicine Series on Trauma
- Jamal. Emerging approaches to pre-hospital hemorrhage control: a narrative review. Ann Transl Med 2021;9(14):1192
- Brown. Acute traumatic injury of the aorta: presentation, diagnosis, and treatment. Ann Transl Med 2021;9(14):1193
- Cretcher. Splenic trauma: endovascular treatment approach. Ann Transl Med 2021;9(14):1194
- Roberts. Hepatic trauma. Ann Transl Med 2021;9(14):1195
- Weir. Endovascular management of pelvic trauma. Ann Transl Med 2021;9(14):1196
- Khurana. Endovascular interventions in the management of acute extremity trauma: a narrative review. Ann Transl Med 2021;9(14):1197
- Smith. Endovascular embolization in renal trauma: a narrative review. Ann Transl Med 2021;9(14):1198
- Smith. Narrative review of vascular iatrogenic trauma and endovascular treatment. Ann Transl Med 2021;9(14):1199
Editorials
- Donker. Transfusion of a disillusion? Neth J Crit Care 2021;29(4):168
- Bai. Human albumin infusion strategy in liver cirrhosis: liberal or restrictive? Ann Transl Med 2021;9(14):1114
- Spinelli. Why improved PF ratio should not be our target when treating ARDS. Minerva Anestesiologica 2021;87(7):752-4
- Pasero. Artificial intelligence and perioperative medicine. Minerva Anestesiologica 2021;87(7):755-6
- Kane. The 7th UK National Audit Project (NAP7). The challenges of defining, studying and learning from peri-operative cardiac arrest. Anaesthesia 2021;76(8):1026-1030
Commentaries
Correspondence
- Galazzi. Pain in Intensive Care Unit: Italian critical care nurses’ best practice. Minerva Anestesiologica 2021;87(7):839-40
- Liu. BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants. N Engl J Med 2021; 385:472-474
- Shrotri. Spike-antibody waning after second dose of BNT162b2 or ChAdOx1. Lancet 2021;398(10298):385-387
- de Tymowski. Ketamine-induced cholangiopathy in ARDS patients. Intensive Care Med 2021;epublished July 27th
- Kuindersma. “L’histoire se répète”, one size does not fit all. Intensive Care Med 2021;July 20th
- Prattes. Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry . Intensive Care Med 2021;epublished July 16th
Case Reports
- Pitlick. EVALI: A Mimicker of COVID-19. Mayo Clin Proc 2021;5(3):682-687
- Buijser. Extracorporeal rewarming and support in severe hypothermia with cardiac arrest: a return from death. Akin. Neth J Crit Care 2021;29(4):182-184
- Bagerman. Arytenoid swelling due to inhalation frostbite injury after the recreational use of nitrous oxide. Neth J Crit Care 2021;29(4):185-187
- Hiel. Endoscopic treatment of pharmacobezoar caused by slow-release clomipramine and quetiapine overdose. Neth J Crit Care 2021;29(4):188-190
- Vos. Fatal haemolytic shock. Neth J Crit Care 2021;29(4):181
I hope you find this newsletter useful.
Until next week
Rob
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