Welcome to the 492nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
The highlights of this week's edition are randomised controlled trials on convalescent plasma in patients admitted to hospital with COVID-19 & cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation; systematic reviews and meta analyses on early vasopressin use in patients with septic shock & factor Xa inhibitor reversal in acute major bleeding; and observational studies on nurse-to-patient ratios & changes in UK in-hospital mortality in the first wave of COVID-19.
There are also guidelines on pediatric severe traumatic brain injury & postoperative acute kidney injury in adult non-cardiac surgery; narrative reviews on the furosemide stress test & perioperative care in cardiac surgery; editorials on the unprecedented challenges facing ICUs during the COVID-19 pandemic & management of severe covid-19; and commentaries on a tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19 & reconceptualizing how to support surrogates making medical decisions for critically ill patients.
If you only have time to read one review article this week, try this one on acute myopathy and muscle wasting after sepsis.
Research
Randomised Controlled Trials
- RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet 2021;epublished May 14th
- Supady. Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial. Lancet Respir Med 2021;epublished May 14th
- Nguyen. Low Tidal Volume Mechanical Ventilation Against No Ventilation During Cardiopulmonary Bypass in Heart Surgery (MECANO). Chest 2021;159(5):1843-1853
- Lal. Oral Midodrine Administration During the First 24 Hours of Sepsis to Reduce the Need of Vasoactive Agents: Placebo-Controlled Feasibility Clinical Trial. Crit Care Explor 2021;3(5):e0382
- O'Donnell. A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19. J Clin Invest 2021;epublished May 11th
- Amaru. Effect of Recruitment Maneuvers and PEEP on Respiratory Failure After Cardiothoracic Surgery in Obese Subjects: A Randomized Controlled Trial. Respir Care 2021;epublished May 11th
Systematic Reviews & Meta Analyses
- Huang. The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis. Am J Emerg Med 2021;48:203-208
- Nederpelt. Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished May 7th
- Eckert. Association of specialized enteral nutrition with glycemic control and clinical outcomes in critically ill patients: A meta-analysis of randomized controlled trials. Clin Nut 2021;epublished May 8th
Observational Studies
- McHugh. Effects of nurse-to-patient ratio legislation on nurse staffing and patient mortality, readmissions, and length of stay: a prospective study in a panel of hospitals. Lancet 2021;epublished May11th
- Docherty. Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. Lancet Respir Med 2021;epublished May 14th
- Dubin. Functional Outcomes, Goals, and Goal Attainment Amongst Chronically Critically Ill Long-Term Acute Care Hospital Patients. Ann Am Thor Soc 2021;epublished May 12th
- Hatzl. Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study. Ann Intensive Care 2021;11(1):73
- Patel. Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom. Intensive Care Med 2021;epublished May 11th
- Fernando. Suicide and self-harm in adult survivors of critical illness: population based cohort study. BMJ 2021;373:n973
- Chen. Corticosteroid Therapy Is Associated With Improved Outcome in Critically Ill Patients With COVID-19 With Hyperinflammatory Phenotype. Chest 2021;159(5):1793-1802
- Dupont. Identification of Distinct Immunophenotypes in Critically Ill Coronavirus Disease 2019 Patients. Chest 2021;159(5):1884-1893
- Doyen. Characteristics of Cardiac Injury in Critically Ill Patients With Coronavirus Disease 2019. Chest 2021;159(5):1974-1985
- Wick. Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS. JCI Insight 2021;epublished May 11th
- Vasquez. Identification of distinct clinical subphenotypes in critically ill patients with COVID-19. Chest 2021;epublished May 5th
Guidelines
- Bussolin. The management of pediatric severe traumatic brain injury: Italian Guidelines. Minerva Anestesiologica 2021;87(5):567-79
- Prowle. Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative. Nat Rev Nephrol 2021;epublished May 11th
- Puelacher. Expert consensus on peri-operative myocardial injury screening in noncardiac surgery. A literature review. Eur J Anaesthesiol 2021;38(6):600-608
American College of Radiology Series
- ACR Appropriateness Criteria® Intensive Care Unit Patients. J Am Coll Radiol 2021;18(5S):S62-S72
- ACR Appropriateness Criteria® Head Trauma: 2021 Update. J Am Coll Radiol 2021;18(5S):S13-S36
- ACR Appropriateness Criteria® Infective Endocarditis. J Am Coll Radiol 2021;18(5S):S52-S61
- ACR Appropriateness Criteria® Myelopathy: 2021 Update. J Am Coll Radiol 2021;18(5S):S73-S82
- ACR Appropriateness Criteria® Nontraumatic Aortic Disease. J Am Coll Radiol 2021;18(5S):S106-S118
- ACR Appropriateness Criteria® Radiologic Management of Lower Gastrointestinal Tract Bleeding: 2021 Update. J Am Coll Radiol 2021;18(5S):S139-S152
- ACR Appropriateness Criteria® Radiologic Management of Portal Hypertension. J Am Coll Radiol 2021;18(5S):S153-S173
- ACR Appropriateness Criteria® Renal Failure. J Am Coll Radiol 2021;18(5S):S174-S188
- ACR Appropriateness Criteria® Seizures-Child. J Am Coll Radiol 2021;18(5S):S199-S211
Reviews
Clinical
COVID-19
- Grigonis. Long-Term Acute Care Hospitals Extend ICU Capacity for COVID-19 Response and Recovery. Chest 2021;159(5):1894-1901
- Saracoglu. COVID-19 patients in the operating room: a concise review of existing literature. Minerva Anestesiologica 2021;87(5):604-12
- Mardian. Review of Current COVID-19 Diagnostics and Opportunities for Further Development. Front Med 2021;8:615099
- Golob. SARS-CoV-2 vaccines: a triumph of science and collaboration. JCI Insight 2021;6(9):e149187
Neurological
- Lee. Succinct Approach to Delirium in the Emergency Department. Curr Emerg Hosp Med Rep 2021;9:11–18
Circulatory
- Correale. New Targets in Heart Failure Drug Therapy. Front Cardiovasc Med 2021;8:665797
- Zengin. Heart failure in adults with congenital heart disease: a narrative review. Cardiovasc Diagn Ther 2021;11(2):529-537
Airway
Nutrition
Hepatobiliary
Renal
- McMahon. The furosemide stress test: current use and future potential. Ren Fail 2021;43(1):830-839
- Katsoulis. Immunopathology of Acute Kidney Injury in Severe Malaria. Front Immunol 2021;12:651739
Sepsis
- Costantini. Type 2 diabetes mellitus and sepsis: state of the art, certainties and missing evidence. Acta Diabetol 2021;epublished May 10th
- Lee. Clostridium difficile: Diagnosis and the Consequence of Over Diagnosis. Infect Dis Ther 2021;10:687–697
- Mankowski. Pathophysiology and Treatment Strategies of Acute Myopathy and Muscle Wasting after Sepsis. J Clin Med 2021;10(9):1874
- Corcione. Novel Cephalosporins in Septic Subjects and Severe Infections: Present Findings and Future Perspective. Front Med 2021;8:617378
- Nguyen. Carbapenem Resistance in Acinetobacter baumannii, and their Importance in Hospital-acquired Infections: A Scientific Review. J Appl Microbiol 2021 May 10th
Paediatrics
- Egbuta. Current State of Analgesia and Sedation in the Pediatric Intensive Care Unit. J Clin Med 2021;10(9):1847
- Sawa. Difficult Airway Management in Neonates and Infants: Knowledge of Devices and a Device-Oriented Strategy. Front Pediatr 2021;9:654291
Perioperative
- McCarthy. Perioperative care in cardiac surgery. Minerva Anestesiologica 2021;87(5):591-603
- Sipilä. Sleep Well and Recover Faster with Less Pain—A Narrative Review on Sleep in the Perioperative Period. J Clin Med 2021;10(9):2000
Non-Clinical
Editorials
- Martin-Loeches. If not now, when? A clinical perspective on the unprecedented challenges facing ICUs during the COVID-19 pandemic. Intensive Care Med 2021;epublished May 11th
- Lee. Management of severe covid-19: progress and promise. BMJ 2021;373:n1147
- Helms. Yentl syndrome and the ICU. Intensive Care Med 2021;epublished May 5th
Commentaries
- McGonagle. A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19. Lancet respir Med 2021;epublished May 14th
- Dionne-Odom. Reconceptualizing How to Support Surrogates Making Medical Decisions for Critically Ill Patients. JAMA 2021;epublished May 14th
- Hasegawa. β1-blocker in sepsis. J Intensive Care 2021;9:39
- Jamil. Genetic Variants of SARS-CoV-2: What do we know so far? Am J Respir Crit Care Med 2021;epublished May 10th
Debate
Correspondence
- Thille. Does Prophylactic Use of High-Flow Nasal Cannula in the Immediate Postoperative Period Actually Decrease the Risk of Intubation?: Be Cautious With Findings From Meta-analyses. Chest 2021;159(5):2113-2114
- Mombrun. Questioning Tocilizumab Use in Hospitalized Patients With Coronavirus Disease 2019. Chest 2021;159(5):2115-2116
- Gubensek. Regional citrate anticoagulation for intermittent hemodialysis in the intensive care: what is the optimal setup? Ann Intensive Care 2021;11(1):67
- Trahtemberg. COVID‑19‑associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med 2021;epublished April 30th
Case Reports
- Chong. Persistent Dyspnea in a 74-Year-Old Man With Normal Spirometry and Lung Volumes. Chest 2021;159(5):e303-e307
- Burke. A 67-Year-Old Woman With Abdominal Pain and Dyspnea. Chest 2021;159(5):e309-e312
- Triantafyllidou. A Well-Defined Endobronchial Tumor in a 26-Year-Old Man. Chest 2021;159(5):e313-e317
- Hamad. Respiratory Distress and Chest Pain in an Airplane Passenger With Radiolucent Left Hemithorax. Chest 2021;159(5):e319-e323
- Harris. An 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities. Chest 2021;159(5):e325-e329
- Chopra. An Unusual Case of Chronic Hemoptysis. Chest 2021;159(5):e331-e335
- Rahman. Dyspnea With Unilateral Pulmonary Ground Glass Opacities and Cavitary Lesions. Chest 2021;159(5):e337-e342
- Nada. Pneumonia and Poorly Controlled Diabetes. Chest 2021;159(5):e343-e347
- Fried. A 66-Year-Old Woman With Hypoxia and Shock. Chest 2021;159(5):e349-e352
- Choi. A Morbidly Obese 26-Year-Old Man With Respiratory Failure and Bilateral Lower Extremity Swelling. Chest 2021;159(5):e353-e356
- Salinas. An Unusual Case of Abdominal Pain and Shock. Chest 2021;159(5):e357-e359
- Beckerman. Coronavirus disease 2019 (COVID-19)-associated constrictive pericarditis. BMJ Case Reports CP 2021;14:e242018
- Mitler. Recent use of formaldehyde-‘free’ hair straightening product and severe acute kidney injury. Clin Kid J 2021;14(5):1469–1471
I hope you find this newsletter useful.
Until next week
Rob
Supported by the Health Research Board
