Critical Care Reviews Newsletter
Newsletter 477 | February 7th 2021
Welcome to the 477th Critical Care Reviews newsletter, bringing you the best critical care research and open access articles from across the medical literature for the week of January 25th to 31st.
It's been a frustrating few weeks, as I've worked day and night to restore both the website and newsletter after my now ex- web host inflicted serious damage to these, to the point of being offline, non-functional and not easily restored with a simple backup. My apologies to those of you who either haven't received the last couple of newsletters, or received it in a non-rendered fashion. Hopefully, these issues are now resolved. For those who missed the last couple of newsletters, they are available on the website.
Spring Series of Major Trial Results Presentations
Our Spring season of major trial results presentations should begin in the next few weeks. Similar to eCCR21, thee will be live-streamed and freely available to watch on the CCR website, vimeo and Twitter. We'll be bringing you the results of the REMAP-CAP IL-6 receptor antagonist domain, the multi-platform anti-coagulation in COVID-19 trial, TTM2 and BASICS.
New Look Website
The CCR website has been updated, with a new look and more streamlined interface. The old site contained over 9000 webpages, diluting attention on the major evidence in our specialty. The new site refocuses on critical care trials, with the homepage highlighting the latest major trials, studies and guidelines. It will take a while to repopulate the site, but I'll hopefully have the importation complete by the end of February. The additional pages will be added daily as they are completed. There are sections on major trials, major guidelines and hot articles to add, as well as the archive of all 473 previous newsletters.
eCCR Attendance Certificate
For those of you who registered for eCCR21 and are having difficultly accessing the attendance certificate, please reply to this email. My apologies for the trouble, but, as mentioned, I've had issues with the website over the past few weeks, which I've now mostly resolved. The unedited recording of the entire 3 days of the meeting is available to watch on the meeting webpage. This includes 5 major trial results, 14 of the best trials of 2020 presented by their chief investigators and accompanied by independent editorials, plus talks on pandemic publishing, pilot trials and the John Hinds Lecture.
Support CCR
If you watched eCCR21, or get the newsletter regularly, or use the CCR website, podcast or books, then please consider supporting the project. Over the past 11 years it has grown enormously, to the point where it far exceeds my ability to run it in my spare time. Everything within the CCR project is made freely available for the benefit of all. If you find the CCR project a valuable service, both personally and for the wider critical care community, and are in a position to be able to make a small contribution, then please consider supporting it.
Randomised Controlled Trials
- Hui. Safety and efficacy of long-term mild hypothermia for severe traumatic brain injury with refractory intracranial hypertension (LTH-1): A multicenter randomized controlled trial, EClinicalMedicine 2021;epublished January 28th
- Parke. A Multicenter, Open-Label, Randomized Controlled Trial of a Conservative Fluid Management Strategy Compared With Usual Care in Participants After Cardiac Surgery. The Fluids After Bypass Study. Crit Care Med 2021;epublished January 28th
- Eslami. A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial of High-Dose, Short-Term Vitamin D Administration in the Prevention of Acute Kidney Injury after Cardiac Surgery. Cardiorenal Med 2021;epublished January 26th
- Franco. Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial. Ann Intensive Care 2021;11(1):15
Systematic Reviews & Meta Analyses
- Wan. Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review. Biomarkers 2021;26(1):1-12
- Al Duhailib. The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. Can J Anaesth 2021;epublished January 25th
- Wang. Inhaled nitric oxide and acute kidney injury risk: a meta-analysis of randomized controlled trials. Ren Fail 2021;43(1):281-290
- Zhu. Extracorporeal membrane oxygenation versus mechanical ventilation alone in adults with severe acute respiratory distress syndrome: a systematic review and meta‐analysis. Internation Journal of Clinical Practice 2021;epublished January 24th
- Yang. Safety Assessment Criteria for Early Active Mobilization in Mechanically Ventilated ICU Subjects. Respir Care 2021;66:307-315
- Mitra. Concurrent Use of Renal Replacement Therapy during Extracorporeal Membrane Oxygenation Support: A Systematic Review and Meta-Analysis. J Clin Med 2021;10(2):241
- Song. Low- versus High-Chloride Content Intravenous Solutions for Perioperative Patients: A Systematic Review and Meta-Analysis. Biomed Res Int 2021;2021:3571397
- Deng. Early versus late tracheotomy in ICU patients: A meta-analysis of randomized controlled trials. Medicine 2021;100(3):e24329
- Pappal. Awareness With Paralysis in Mechanically Ventilated Patients in the Emergency Department and ICU. A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished January 20th
Observational Studies
- Heijnen. Biological Subphenotypes of ARDS Show Prognostic Enrichment in Mechanically Ventilated Patients Without ARDS. Am J Respir Crit Care Med 2021;epublished January 27th
- Lumlertgul. Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study). Crit Care 2021;25:39
- Friedrichson. Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs. Crit Care 2021;25:38
- Bravata. Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic. JAMA Netw Open 2021;4(1):e2034266
- Hariri. Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients. Crit Care 2021;25:33
- Hunziker. Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study. Crit Care 2021;25:32
- Combes. Global absence and targeting of protective immune states in severe COVID-19. Nature 2021;epublished January 25th
- Toporek. Balanced Crystalloids versus Saline in Critically Ill Adults with Hyperkalemia or Acute Kidney Injury: Secondary Analysis of a Clinical Trial. Am J Respir Crit Care Med 2020;epublished January 27th
- Lowery. Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation. JAMA Otolaryngol Head Neck Surg 2021;epublished January 28th
Protocols & Statistical Analysis Plans
- Liu. Acetate Ringer's solution versus 0.9% saline for septic patients: study protocol for a multi-center parallel controlled trial. Trials 2021;22(1):89
- Solanich. Pragmatic, open-label, single-center, randomized, phase II clinical trial to evaluate the efficacy and safety of methylprednisolone pulses and tacrolimus in patients with severe pneumonia secondary to COVID-19: The TACROVID trial protocol. Contemp Clin Trials Commun. 2021;21:100716
Clinical
COVID-19
Circulation
Respiratory
- Wildi. The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine? J Intensive Care 2021;9:14
- Kichloo. Utilization of extracorporeal membrane oxygenation during the COVID-19 pandemic. World J Crit Care Med 2021;10(1):1-11
Nutrition
Renal
Haematology
Sepsis
Perioperative
Miscellaneous
Non-Clinical
- Vincent. COVID-19: it is all about sepsis. Future Microbiol 2021;epublished January 25th
- Colak. Five principles for the intelligent use of AI in medical imaging. Intensive Care Med 2021;epublished January 15th
- Isgro. The Right Ventricle in COVID-19 Lung Injury: Proposed Mechanisms, Management, and Research Gaps. J Cardiothorac Vasc Anesth 2021;epublished January 15th
- Dale. Leaving a mark: pressure injury research in the intensive care unit. Intensive Care Med 2021;epublished January 27th
- Vincent. COVID-19: What we’ve done well and what we could or should have done better—the 4 Ps. Crit Care 2021;25:40
- Cook. The safety of anaesthetists and intensivists during the first COVID-19 surge supports extension of use of airborne protection PPE to ward staff. Clin Med 2021;epublished January 28th
- Bhatia. Pro: Venoarterial ECMO Should Be Considered in Patients With COVID-19. J Cardiothorac Vasc Anesth 2021;35(3):703-706
- McLean. Con: Venoarterial ECMO Should Not Be Considered in Patients With COVID-19. J Cardiothorac Vasc Anesth 2021;35(3):707-710
- Aberegg. Aspergillosis in the ICU: Hidden Enemy or Bogeyman? Am J Respir Crit Care Med 2021;epublished January 26th
- Pagel. Very Rare, but Not Unique. J Cardiothorac Vasc Anesth 2021;35(3):957
- Kim. Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19. N Engl J Med 2021;epublished January 27th
- Hu. The Anesthetic Management of the First Lung Transplant for a Patient with COVID-19 Respiratory Failure. J Cardiothorac Vasc Anesth 2021;35(3):917-920
- Lalabekyan. Torsades de Pointes in Coronavirus Disease 2019 Infection. J Cardiothorac Vasc Anesth 2021;35(3):954-955
- Kothari. The Risk of Malposition: A Tale of Two Devices. J Cardiothorac Vasc Anesth 2021;35(3):963-966
- Jounieaux. Pure SARS-CoV-2 related AVDS (Acute Vascular Distress Syndrome). BMC Infect Dis 2021;21:122
I hope you find these links useful
Until tomorrow
Rob