Methodology & Statistics Reviews

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Narrative Reviews

Methodology & Statistics

Sections

General | Investigations & Monitoring | Therapies

General

NEJM Series on Clinical Trials

NEJM Webpage

Introduction: Woodcock. Clinical Trials Series. N Engl J Med 2016; 374:2167

Fiore. Integrating Randomized Comparative Effectiveness Research with Patient Care. N Engl J Med 2016; 374:2152-2158
Bhatt. Adaptive Designs for Clinical Trials. N Engl J Med 2016; 375:65-74
Ford. Pragmatic Trials. N Engl J Med 2016; 375:454-463
Pocock. The Primary Outcome Fails — What Next?. N Engl J Med 2016; 375:861-870
Pocock. The Primary Outcome Is Positive — Is That Good Enough? N Engl J Med 2016; 375:971-979

General

Meizoso. Advanced and alternative research methods for the acute care surgeon scientist. Trauma Surg Acute Care Open 2024;9:e001320

Trial Design

Replication

Sidebotham. The winner's curse: why large effect sizes in discovery trials always get smaller and often disappear completely. Anaesthesia 2023;79(1):86-90

Analysis

P Value

In. Alternatives to the P value: connotations of significance. Korean J Anesthesiol 2024;77(3):316-325

Intention-to-Treat

Ahn. Intention-to-treat versus as-treated versus per-protocol approaches to analysis. Korean J Anesthesiol 2023;76(6):531-539

Analysis

ROC Curves

Çorbacıoğlu. Receiver operating characteristic curve analysis in diagnostic accuracy studies: A guide to interpreting the area under the curve value. Turk J Emerg Med 2023;23(4):195–198