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Latest Livestream

Pragmatic Investigation of optimaL Oxygen Targets Trial

PILOT trial

The PILOT trial compares three different oxygenation targets in critically ill mechanically ventilated patients - SpO2 90% vs 94% vs 98%

Monday, October 24th

20:00 UTC + 1

Previous Livestreams

2022

FIRST-ABC  |  RePHILL  |  PLUS  |  NITRIC

2021

BOUGIE  |  COCA  |  COVID-STEROID 2  |  VAM-IHCA  |  COVID-19 Anticoagulation  |  RECOVERY-RS  |  BaSICS  |  TTM2  |  REMAP-CAP IL-6 RA

NITRIC Trial

Schlapbach. Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery. The NITRIC Randomized Clinical Trial. JAMA 2022;328(1):38-47

NITRIC Trial Results Presentation

Prof Luregn Schlapbach (Zurich, Switzerland)

Editorial

Prof Mark Peters (London, England)

Viewer's Questions

Dr Bronwen Connolly (Belfast, Northern Ireland)

Answers from Prof Luregn Schlapbach (Zurich, Switzerland)

Panel Discussion

Rob Mac Sweeney (Belfast, Northern Ireland) hosts a panel discussion including Prof Paul Checchia (Houston, USA), Prof Wes Diddle (Washington DC, USA), Prof Ranjit Lall (Coventry, England), Prof Kathy Rowan (London, England), as well as the NITRIC trial chief investigator Luregn Schlapbach (Zurich, Switzerland) and editorialist Prof Mark Peters (London, England)

PLUS Trial and Balanced Solutions Systematic Review

Published Paper:  Finfer. Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. N Engl J Med 2022;epublished January 18th

Published Paper:  Hammond. Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis. NEJM Evidence 2022;epublished January 18th

PLUS Trial Results Presentation

Prof Simon Finfer (Sydney, Australia)

Balanced Crystalloids Systematic Review Results Presentation

Assoc Prof Naomi Hammond (Sydney, Australia)

Editorial

Prof Deborah Cook (Hamilton, Canada)

Viewer's Questions

Dr Murali Shyamsundar (Belfast, Northern Ireland)

Answers from Prof Simon Finfer & Assoc Prof Naomi Hammond (both Sydney, Australia)

Panel Discussion

Rob Mac Sweeney hosts a panel discussion on the results of the PLUS trial, including Prof John Kellum (Pittsburgh, USA), Prof Gordon Guyatt (Hamilton, Canada), Dr Tomoko Fujii (Tokyo, Japan) & Prof Jeff Drazen (Boston, USA)

BOUGIE Trial

Published Paper:  Driver. Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation. A Randomized Clinical Trial. JAMA 2021;epublished December 8th

BOUGIE Trial Results Presentation

Drs Jon Casey (Nashville, USA), Stacy Trent (Denver, USA) and Brian Driver (Minneapolis, USA)

Editorial

Prof Sheila Nainan Myatra (Mumbai, India).

Replies from Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nasville, USA), plus comments from Prof Jonathan Benger (Bristol, England).

Viewer's Questions

Dr Chris Nutt (Bellfast, Northern Ireland).

Replies from Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nasville, USA)

Panel Discussion

Prof Jonathan Benger (Bristol, England), Dr Jean-Baptiste Lascarrou (Nantes, France), George Kovacs (Halifax, Canada), Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA), Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nasville, USA). Chaired by Dr Rob Mac Sweeney (Bellfast, Northern Ireland).

COCA Trial

Published Paper:  Vallentin. Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest. A Randomized Clinical Trial. JAMA 2021;epublished November 30th

COCA Trial Results Presentation

Dr Mikael Fink Vallentin and Lars Andersen (Aarhus, Denmark)

Editorial

Prof Gavin Perkins (Coventry, England)

Viewer's Questions

Dr Chris Nutt (Belfast, Northern Ireland)

Panel Discussion

Prof Theresa Olasveengen (Oslo, Norway), Dr Victoria Cornelius (London, England), Prof Christopher Seymour (Pittsburgh, USA), Prof Gavin Perkins (Coventry, England), Dr Mikael Fink Vallentin & Prof Lars Andersen (Aarhus, Denmark)

COVID-STEROID 2 Trial

Published Paper:  The COVID STEROID 2 Trial Group. Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia. The COVID STEROID 2 Randomized Trial. JAMA 2021;epublished October 21st

COVID STEROID 2 Trial Results Presentation

Prof Sheila Nainan Myatra (Mumbai, India), Prof Bala Ventakesh (Brisbane, Australia), Prof Anders Perner (Copenhagen, Denmark)

Editorial

Prof Marion Campbell (Aberdeen, Scotland)

Viewer's Questions

Dr Chris Nutt (Belfast, Northern Ireland)

Panel Discussion

Prof Bram Rochwerg (Hamilton, Canada), Dr Paul Mouncey (London, England) & Prof Colin McArthur (Auckland, New Zealand), Prof Sheila Nainan Myatra (Mumbai, India), Prof Bala Ventakesh (Brisbane, Australia), Prof Anders Perner (Copenhagen, Denmark), Prof Marion Campbell (Aberdeen, Scotland).

The HOPE Trial
Research Challenges during a Pandemic

Dr Bharath Kumar (Chennai, India)

VAM-IHCA Trial

Published Paper:  Andersen. Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest. A Randomized Clinical Trial. JAMA 2021;epublished September 29th

VAM-IHCA Trial Results Presentation

Asger Granfeldt and Lars Wiuff Andersen (both Aarhus, Denmark)

Editorial

Prof Spyros Mentzelopoulos (Athens)

Viewer's Questions

Dr Chris Nutt (Belfast, Northern Ireland)

Panel Discussion

Katherine Berg (Boston), Bernd Böttiger (Cologne), Ranjit Lall (Coventry), Louise Morrison (Toronto), Spyros Mentzelopoulos (Athens), Lars Wiuff Andersen & Asger Granfeldt (Aarhus), Spyros Mentzelopoulos (Athens). Hosted by Rob Mac Sweeney (Belfast)

COVID-19 Anticoagulation Multi-Platform Trial

Published Paper:  The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med 2021;epublished August 4th

Published Paper:  The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med 2021;epublished August 4th

VAM-IHCA Trial Results Presentation

Drs Patrick Lawler (Toronto), Lindsay Berry (Austin) & Ewan Goligher (Toronto)

Editorial

Charlotte Summers (Cambridge)

Viewer's Questions

Dr Peter McGuigan (Belfast)

Panel Discussion

An international panel of experts discuss the robustness and implications of the COVID-19 Anticoagulation Trial at a livestreamed Critical Care Reviews Trial Results Meeting, on August 4th, 2021.The panel include Profs Judith Hochman (New York), Saskia Middledorp (Nijmegen) and James Douketis (Hamilton).

RECOVERY-RS Trial

Published Paper:  Perkins. Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19The RECOVERY-RS Randomized Clinical Trial. JAMA 2022;epublished January 24th

RECOVERY-RS Trial Results Presentation

Drs Bronwen Connolly (Belfast) and Keith Couper (Coventry)

Editorial

Prof Manu Shankar-Hari (London)

Viewer's Questions

Dr Chris Nutt (Belfast)

Panel Discussion

Dr Rob Mac Sweeney (Belfast) hosts a panel discussion on the RECOVERY-RS trial. The panelists include Profs Leticia Kawano-Dourado (Sao Paulo), Janet Diaz (San Francisco) & John Norrie (Edinburgh), plus Dr Stephen Webb (Cambridge).

BaSICS Trial

Published Paper:  Zampieri. Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill PatientsThe BaSICS Randomized Clinical Trial. JAMA 2021;epublished August 10th

Published Paper:  Zampieri. Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill PatientsThe BaSICS Randomized Clinical Trial. JAMA 2021;epublished August 10th

BaSICS Trial Results Presentation

Dr Fernando Zampieri & Alexandre Biasi Cavalcante (São Paulo)

Editorial

Prof Simon Finfer (Sydney)

Viewer's Questions

Dr Bronwen Connolly (Belfast)

Panel Discussion

Rob Mac Sweeney hosts an international panel discussion on the results of the BaSICS trial. The panelists are Prof Kathryn Maitland (Kenya), Dr Tine Sylvest Meyhoff (Denmark), Assoc Prof Christopher Seymour (USA) & Asst. Prof Andrew Althouse (USA). They are joined by the lead trialists Drs Fernando Zampieri & Alexandre Biasi Cavalcante (both Brazil), as well Simon Finfer (Australia), who delivered an editorial on the trial.

Learnings from the BaSICS Trial

Dr Fernando Zampieri (São Paulo)

TTM2 Trial

Livestreamed June 16th, 2021

Published Paper:  Dankiewicz. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. N Engl J Med 2021;384:2283-2294

TTM2 Trial Results Presentation

Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund)

Editorial

Stephen Bernard (Melbourne)

Viewer's Questions

Phil Gillen (Belfast)

Panel Discussion

Jerry Nolan (Bath), Kathy Rowan (London) and Terri Hough (Portland), join Stephen Bernard plus the TTM2 trial team of Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund). Hosted by Rob Mac Sweeney (Belfast)

REMAP-CAP IL-6 Receptor Antagonist Domain Results Livestream

Livestreamed February 26th, 2021

Published Paper:  The REMAP-CAP Investigators. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med 2021;epublished February 25th

Editorial:  Rubin. Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup. N Engl J Med 2021;epublished February 25th

Dr Lennie Derde (Utrecht, The Netherlands)

This is the REMAP-CAP IL-6 receptor antagonist domain results presentation, recorded February 25th. The presentation was accompanied by a simultaneous publication in the New England Journal of Medicine.

Prof Derek Angus (Pittsburgh, USA) & Dr Liz Lorenzi (Berry Consultants, Austin, USA), set the scene with talks on the adaptive platform design of REMAP-CAP, and its underlying Bayesian framework, respectively. Next, Dr Lennie Derde (Utrecht, The Netherlands) presents the full results of the IL-6 receptor antagonist domain, followed by an independent editorial by Prof Tim Walsh (Edinburgh, Scotland). Lennie and her co-investigators reply to the editorial and questions from viewers. The session ends with a panel discussion, including external experts Dr David Harrison (Chief Statistician, ICNARC, London), Prof Anders Perner (Copenhagen, Denmark), and Prof Anthony Gordon (London, England), the lead investigator for the IL-6 RA domain at REMAP-CAP.

Session Timings

  • 1:37 - Derek Angus - The Beauty of Adaptive Designs

  • 19:22 - Liz Lorenzi -.The Statistical Framework of REMAP-CAP

  • 42:50 - Lennie Derde - The Results

  • 1:09:05 - Tim Walsh - The Editorial

  • 1:35:40 - Lennie Derde et al - Reply to the Editorial

  • 1:43:52 - Questions va Chris Nutt

  • 1:54:10 - Panel Discussion