Tuesday 19th

Research

Randomised Controlled Trials

• Le May. Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial. JAMA 2021;326(15):1494-1503
• Kalil. Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial. Lancet Respir Med 2021;epublished October 18th
  • Editorial:  Wilkinson. Subcutaneous interferon beta-1a in COVID-19: raking the ashes of an intervention trial. Lancet Respir Med 2021;epublished October 18th
• RECOVERY Collaborative Group. Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet Respir Med 2021;epublished October 18th
• Sancho-López. Efficacy and Safety of Sarilumab in patients with COVID19 Pneumonia: A Randomized, Phase III Clinical Trial (SARTRE Study). Infect Dis Ther 2021;epublished October 17th

Monday 18th

Narrative Reviews

Clinical

• Saini. Airway management in maxillofacial trauma. J Anaesthesiol Clin Pharm 2021;37(3):319-327
• Sameera. Human errors and their prevention in healthcare. J Anaesthesiol Clin Pharm 2021;37(3):328-335
• Unwin. The 1918 Influenza Pandemic: Back to the Future? Kidney Blood Press Res 2021;epublished October 18th

Editorials

• Zochios. Protecting the Injured Right Ventricle in COVID-19 Acute Respiratory Distress Syndrome: Can Clinicians Personalize Interventions and Reduce Mortality? J Cardiothorac Vasc Anesth 2021;35(11):3325-3330
• Weiss. Chicken or the egg? Critical illness and mental health. Intensive Care Med 2021;epublished October 18th

Commentaries

• Nesta. Implantable ventricular assistance systems (VAD) as a bridge to transplant or as ‘destination therapy’. Eur Heart J 2021;23(Suppl_E):E99–E102
• Lorini. Coagulopathy and COVID-19. Eur Heart J 2021;23(Suppl_E):E95-98

Sunday 17th

Correspondence

• Korley. Convalescent Plasma for Outpatients with Covid-19. N Engl J Med 2021;epublished October 13th
• Tone. Emergency awake fibreoptic intubation with confirmed COVID-19. Can J Anesth 2021;68:1721–1722
• Karagiannidis. High In-Hospital Mortality Rate in Patients with COVID-19 Receiving Extracorporeal Membrane Oxygenation in Germany: A Critical Analysis. Am J Respir Crit Care Med 2021;204(8):991–994
• Levy. Outcomes of Patients Denied Extracorporeal Membrane Oxygenation during the COVID-19 Pandemic in Greater Paris, France. Am J Respir Crit Care Med 2021;204(8):994–997
• Suzuki. Relevant Factors for Physical, Mental, and Cognitive Problems in ICU Survivors. Am J Respir Crit Care Med 2021;204(8):1001
  • Geense. Reply to Suzuki et al. Am J Respir Crit Care Med 2021;204(8):1001–1002
• Behringer. “Meta-analyses of targeted temperature management in adult cardiac arrest studies – the big picture is dependent on study selection”. Resuscitation 2021;epublished October 16th
  • Granfeldt. Reply to: Meta-analyses of targeted temperature management in adult cardiac arrest studies – the big picture is dependent on study selection! Resuscitation 2021;epublished October 16th
• Yip. “Cold War”: why does the debate continue? Resuscitation 2021;epublished October 12th
• Bhakta. Securing the airway in critical care scenarios: questioning the fundamentals. Intensive Care Med 2021;epublished October 5th
• Bachmann. Cardiovascular SOFA score may not reflect current practice. Intensive Care Med 2021;epublished October 1st
• Vanderbeke. Critical influenza and prophylactic antifungal therapy for aspergillosis: a nuanced approach to a pertinent infectious disease. Intensive Care Med 2021;epublished October 4th

Case Reports

• Sekhon. Spontaneous Pneumomediastinum in COVID-19: The Macklin Effect? Am J Respir Crit Care Med 2021;204(8):989–990
• Duvvuri. A 50-Year-Old Woman With Shortness of Breath. Chest 2021;160(4):e365-e368
• Arabiat. A 56-Year-Old Woman With Nonresolving Pneumonia. Chest 2021;160(4):e369-e370
• Loi. Case 1-2021: A 10-Year-Old Male With Respiratory Failure, Pleural Effusions, and Renal Failure 60 Days After Hematopoietic Stem Cell Transplant. Ped Crit Care Med 2021;22(10):e524-e531
• Zhao. Bronchus-blocked ultrasound-guided percutaneous transthoracic needle biopsy (BUS-PTNB) for intubated patients with severe lung diseases. Crit Care 2021;25:359
• Hock. Case 31-2021: A 21-Year-Old Man with Sore Throat, Epistaxis, and Oropharyngeal Petechiae. N Engl J Med 2021; 385:1511-1520

Saturday 16th

Research

Randomised Controlled Trials

• Osman. Helmet continuous positive airway pressure vs. high flow nasal cannula oxygen in acute cardiogenic pulmonary oedema: a randomized controlled trial. Eur Heart J: Acute Cardiovascular Care 2021;zuab078
• Ely. Baricitinib plus Standard of Care for Hospitalised Adults with COVID-19 on Invasive Mechanical Ventilation or Extracorporeal Membrane Oxygenation: Results of a Randomised, Placebo-Controlled Trial. MedRxiv 2021;epublished October 12th
• Casamento. Assessment of Opioid Administration to Lead to Analgesic Effects and Sedation in Intensive Care (ANALGESIC) trial centers. A Phase II Cluster-Crossover Randomized Trial of Fentanyl vs. Morphine for Analgosedation in Mechanically Ventilated Patients. Am J Respir Crit Care Med 2021;epublished September 20th
• Editorial:  Young. New Insights Into the Comparative Effectiveness of Fentanyl and Morphine Infusions in Intensive Care Unit Patients. Am J Respir Crit Care Med 2021;epublished October 14th
• Labro. Impact on antimicrobial consumption of procalcitonin-guided antibiotic therapy for pneumonia/pneumonitis associated with aspiration in comatose mechanically ventilated patients: a multicenter, randomized controlled study. Ann Intensive Care 2021;11:145
• Kwon. Regional cerebral oxygen saturation in cardiac arrest survivors undergoing targeted temperature management 36 °C versus 33 °C: A randomized clinical trial. Resuscitation 2021;167:362-371

Systematic Reviews & Meta Analyses

• Kyriakopoulos. Tocilizumab administration for the treatment of hospitalized patients with COVID-19: A systematic review and meta-analysis. Respirology 2021;epublished October 3rd
• Ortega-Paz. Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. Eur Heart J Cardiovasc Pharmacother 2021;epublished September 14th
• Belletti. Barotrauma in Coronavirus Disease 2019 Patients Undergoing Invasive Mechanical Ventilation A Systematic Literature Review. Crit Care Med 2021;epublished September 22nd
• Liu. Simultaneous Use of Hypertonic Saline and IV Furosemide for Fluid Overload: A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(11):e1163-e1175
• Duan. Predictive power of extubation failure diagnosed by cough strength: a systematic review and meta-analysis. Crit Care 2021;25:357

Observational Studies

• Bos. Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts. Lancet Respir Med 2021;epublished October 12th
• Lascarrou. COVID-19-related ARDS: one disease, two trajectories, and several unanswered questions. Lancet Respir Med 2021;epublished October 12th
• Pickens. Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia. Am J Respir Crit Care Med 2021;204(8):921–932
  • Editorial:  Kitsios. Seek and Ye Shall Find: COVID-19 and Bacterial Superinfection. Am J Respir Crit Care Med 2021;204(8):875–877
• Kienzle. The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest. Am J Respir Crit Care Med 2021;204(8):977–985
  • Editorial:  Shaffner. Epinephrine Administration Intervals: Seeing the Forest for the Trees. Am J Respir Crit Care Med 2021;204(8):885–887
• Dennis. Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021. Crit Care Med 2021;49(11):1895-1900
• Haines. Transitions of Care After Critical Illness—Challenges to Recovery and Adaptive Problem Solving. Crit Care Med 2021;49(11):1923-1931
  • Editorial:  Prescott. Temporal Trends in ICU Survival for Coronavirus Disease 2019: A Bumpy Road. Crit Care Med 2021;49(11):1986-1988
• Darvall. Routine Frailty Screening in Critical Illness. Chest 2021;160(4):1292-1303
  • Editorial:  Pugh. Frailty Screening in Critical Care at Scale. Chest 2021;160(4):1165-1166
• Qadir. Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States. The Severe ARDS: Generating Evidence Study. Chest 2021;160(4):1304-1315
  • Editorial:  Rezoagli. The Severe ARDS Generating Evidence (SAGE) Study. A Call for Action in the Daily Clinical Practice. Chest 2021;160(4):1167-1168
• Schmidt. Evolving outcomes of extracorporeal membrane oxygenation support for severe COVID-19 ARDS in Sorbonne hospitals, Paris. Crit Care 2021;25:355

Friday 15th

Narrative Reviews

Clinical

• Shankar-Hari. Reflections on Critical Care’s Past, Present, and Future. Crit Care Med 2021;49(11):1855-1865
• Finfer. Clinical Research: From Case Reports to International Multicenter Clinical Trials. Crit Care Med 2021;49(11):1866-1882
• Buchman. Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines—Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials. Crit Care Med 2021;49(11):1963-1973
• Poor. Pulmonary Thrombosis and Thromboembolism in COVID-19. Chest 2021;160(4):1471-1480
• Kanlerd. Nonoperative management for abdominal solid-organ injuries: A literature review. Chin J Traumatol 2021;epublished September 20th
• Kollef. Timing of antibiotic therapy in the ICU. Crit Care 2021;25:360
• Lee. Comfort-holding in critically ill children: a scoping review. Can J Anesth 2021;68:1695–1704

Thursday 14th

Editorials

• Garland. Medical dominos: impact of COVID-19 care on the health of the population. Intensive Care Med 2021;epublished October 6th
• Capuzzo. Assess COVID-19 prognosis ... but be aware of your instrument’s accuracy! Intensive Care Med 2021;epublished October 5th
• Tatham. The REMDACTA trial: do interleukin receptor antagonists provide additional benefit in COVID‑19? Intensive Care Med 2021;epublished October 7th

Commentaries

• Martin. The Evolution of Toolkits and Bundles to Improve the Care of Sepsis Patients. Crit Care Med 2021;49(11):1849-1850
• Kane-Gill. SCCM/ACCM Guideline and Toolkit Development Pathways. Crit Care Med 2021;49(11):1851-1854
• Burki. Circulation of influenza, RSV, and SARS-CoV-2: an uncertain season ahead. Lancet Respir Med 2021;9(10):e103
• Mema. Arts and ARDS. The Critical Importance of Medical Humanities. Chest 2021;160(4):1568-1571
• De Corte. The future of antimicrobial dosing in the ICU: an opportunity for data science. Intensive Care Med 2021;epublished October 11th

Wednesday 13th

Guidelines & Position Statements

• A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med 2021;204(8):891–901
• 2021 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19. Circulation: Cardiovascular Quality and Outcomes 2021;epublished October 13th

Tuesday 12th

Narrative Reviews

Clinical

• Powys-Lybbe. Echocardiography for patients with COVID-19 in intensive care. BJA Educ 2021;epublished October 7th
• Tait. Preoperative hypertension: perioperative implications and management. BJA Educ 2021;21(11):426-432
• Pohl. Ischemic stroke mimics: A comprehensive review. J Clin Neurosciences 2021;93:174-182
• Ziaka. Brain–lung interactions and mechanical ventilation in patients with isolated brain injury. Crit Care 2021;25:358
• Agnello. The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis. Diagnostics 2021;11:1881
• Elrobaa. COVID-19: Pulmonary and Extra Pulmonary Manifestations. Front Public Health 2021;9:711616
• Lee. Hemodynamic monitoring and management of pediatric septic shock. Biomedical Journal 2021;epublished October 12th

Monday 11th

Narrative Reviews

Clinical

• Romano. Corticosteroids in patients with COVID-19: use and misuse. Minerva Anestesiologica 2021;87(9):1042-8
• Albert. Metabolism and energy prescription in critically ill children. Minerva Anestesiologica 2021;87(9):1025-33

Sunday 10th

Research

Randomised Controlled Trials

• Boxhoorn. Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis. N Engl J Med 2021;385:1372-1381
• Neuman. Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults. N Engl J Med 2021;epublished October 9th

Editorials

• Roscoe. Echocardiography in Weaning Right Ventricular Mechanical Circulatory Support: are we measuring the right stuff? J Cardiothorac Vasc Anesth 2021;epublished September 30th
• Tatham. The REMDACTA trial: do interleukin receptor antagonists provide additional benefit in COVID-19?. Intensive Care Med 2021;epublished October 7th
• Garland. Medical dominos: impact of COVID-19 care on the health of the population. Intensive Care Med 2021;epublished October 6th
• Capuzzo. Assess COVID-19 prognosis … but be aware of your instrument’s accuracy!. Intensive Care Med 2021;epublished October 5th
• Disma. Neonatal tracheal intubation: From art to evidence. Eur J Anaesthesiol 2021;38(11):1109-1110
• Honore. What should clinicians know about the renal effect and the mechanism of action of levosimendan? Expert Opin Drug Saf 2021;epublished October 6th
• George. COVID-19 pneumonia and the pulmonary vasculature: a marriage made in hell. Eur Respir J 2021;58:2100811

Commentaries

• Argulian. Spectrum of Pericardial Tamponade: A New Look at an Old Problem. J Am Coll Cardiol Case Rep 2021;3(13):1557–1559
• Panda. Aftermath of COVID-19 and Critical Care in India. Indian J Crit Care Med 2021; 25(10):1171-1173
• Morrison. What’s Wrong With Advance Care Planning? JAMA 2021;epublished October 8th
• The ISARIC Clinical Characterisation Group. The value of open-source clinical science in pandemic response: lessons from ISARIC. Lancet Infect Dis 2021;epublished October 4th

Guidelines & Position Statements

• Research Needs for Inpatient Management of Severe Alcohol Withdrawal Syndrome: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med 2021;204(7):e61-e87

Study Critique

• Greer. Does hypothermia versus normothermia after out-of-hospital cardiac arrest improve patient-oriented outcomes?. Can J Emerg Med 2021;epublished October 5th

Audio

• Rubin. Audio Interview: Are Covid-19 Vaccine Boosters Necessary? N Engl J Med 2021;385(15):e63

Saturday 9th

Narrative Reviews

Clinical

• Huang. Basic research and clinical progress of sepsis-associated encephalopathy. J Intensive Med 2021;epublished September 24th
• Phua. The story of critical care in Asia: a narrative review. J Intensive Care 2021;9:60
• Elzo Kraemer. POCUS series: right ventricular assessment with emphasis on TAPSE, apical and subcostal variants. Neth J Crit Care 2021;29(5):209-216
• Beadman. Key elements of an evidence-based clinical psychology service within adult critical care. JICS 2021;epublished September 24th
• Gandhi. Role of proning and positive end-expiratory pressure in COVID-19. World J Crit Care Med 2021;10(5):183-193
• Deshwal. Point-of-care ultrasound in a pandemic: Practical guidance on point of care ultrasound in COVID-19 units. World J Crit Care Med 2021;10(5):204-219
• Gkoufa. Elderly adults with COVID-19 admitted to intensive care unit: A narrative review. World J Crit Care Med 10(5):278-289
• Chaney. A Review for the Practicing Clinician: Hepatorenal Syndrome, a Form of Acute Kidney Injury, in Patients with Cirrhosis. linical and Experimental Gastroenterology 2021;14:385–39
• Villela. Systems of Care in Cardiogenic Shock. Front Cardiovasc Med. 2021;8:712594

Friday 8th

Research

Randomised Controlled Trials

• Dale. Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial. Intensive Care Med 2021;epublished October 5th
• Duyu. Chlorhexidine-impregnated dressing RCT for central-line associated bloodstream infection in critically-ill pediatric patients. Pediatr Int 2021;epublished October 5th
• Jeong. Pressure Support versus Spontaneous Ventilation during Anesthetic Emergence-Effect on Postoperative Atelectasis: A Randomized Controlled Trial. Anesthesiology 2021;epublished October 5th
• Spyropoulos. Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19The HEP-COVID Randomized Clinical Trial. JAMA Intern Med 2021;epublished October 7th
  
  • Editorial:  Wahid. Anticoagulant Therapy in Patients Hospitalized With COVID-19. JAMA Intern Med 2021;epublished October 7th
  • Audio:  Author Interview. Efficacy of Therapeutic-Dose Heparin for Thromboprophylaxis in Hospitalized Patients With COVID-19. JAMA Intern Med 2021;epublished October 7th
• Garbero. High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial. Intensive Care Med 2021;epublished October 3rd
• Schweitzer. Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial. Lancet Infect Dis 2021;epublished October 7th

Systematic Reviews & Meta Analyses

• Prasitlumkum. Acute kidney injury and cardiac arrest in the modern era: an updated systematic review and meta-analysis. Hosp Pract (1995) 2021;49(4):280-291
• Wongtanasarasin. Clinical benefits of corticosteroid administration during adult cardiopulmonary resuscitation: A systemic review and meta-analysis. World J Crit Care Med 2021;10(5):290-300
• Fang. Effect of earplugs and eye masks on the sleep quality of intensive care unit patients: A systematic review and meta-analysis. J Adv Nurs 2021;77(11):4321-4331
• Nederpelt. Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(10):e1025-e1036

Observational Studies

• Amoah. Administration of a β-lactam Prior to Vancomycin as the First Dose of Antibiotic Therapy Improves Survival in Patients with Bloodstream Infections. Clin Infect Dis 2021;ciab865
• Ray. Brain herniation on computed tomography is a poor predictor of whether patients with a devastating brain injury can be confirmed dead using neurological criteria. JICS 2021;eublished September 28th
• Xu. Pulse oximetry waveform: a non-invasive physiological predictor for the return of spontaneous circulation in cardiac arrest patients ---- A multicenter, prospective observational study. Resuscitation 2021;epublished October 5th
• Plečko. Rapid evaluation of Coronavirus Illness Severity (RECOILS) in intensive care: Development and validation of a prognostic tool for in-hospital mortality. Acta Anaesthesiol Scand 2021;epublished October 8th
• Tanaka. Predictors of post-extubation stridor in patients on mechanical ventilation: a prospective observational study. Sci Rep 2021;11(1):19993
• Evans. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. Lancet Respir Med 2021;epublished October 7th
  • Commentary:  Denehy. Surviving COVID-19: a familiar road to recovery? Lancet Respir Med 2021;epublished October 7th
• Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce. Crit Care Med 2021;epublished October 6th

Thursday 7th

Narrative Reviews

Clinical

• Jacobi. The pathophysiology of sepsis—2021 update: Part 1, immunology and coagulopathy leading to endothelial injury. Am J Health Syst Pharm 2021;epublished October 4th
• Malek. Clinical drug therapies and biologicals currently used or in clinical trial to treat COVID-19. Biomed Pharmacother 2021;144:112276
• Shimabukuro-Vornhagen. Critical care management of chimeric antigen receptor T-cell therapy recipients. CA Cancer J Clin 2021;epublished October 6th
• Notarianni. Mechanical Cardiac Circulatory Support: an Overview of the Challenges for the Anesthetist. Curr Anesthesiol Rep 2021;epublished October 1st
• Zhang. Narrative Review of Neurologic Complications in Adults on ECMO: Prevalence, Risks, Outcomes, and Prevention Strategies. Front Med 2021;8:713333
• Estime. Diversity, equity, and inclusion in anesthesiology. International Anesthesiology Clinics 2021;59(4):81-85
• Pinna. Monoclonal antibodies for the treatment of COVID-19 patients: An umbrella to overcome the storm? Int Immunopharmacol 2021;101:108200
• Kalra. Risk Prediction in Cardiogenic Shock: Current State of Knowledge, Challenges and Opportunities. J Card Failure 2021;10:1099-1110
• Arora. Current Status of Cardiac Transplantation in the 21st Century. Indian J Clin Cardiol 2021;epublished October 3rd

Wednesday 6th

Correspondence

• Tobin. The Dethroning of 6 ml/kg as the “Go-To” Setting in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;204(7):868–869
  • Goligher. Reply to Tobin. Am J Respir Crit Care Med 2021;204(7):869–870
• Yu. Critical care ultrasound goal-directed versus early goal-directed therapy in septic shock. Intensive Care Med 2021;epublished October 7th

Case Reports

• Grandbois van Ravenhorst. Tentamen suicidii, examen neurologiae: Attempted suicide with neurological symptoms. A case report. Neth J Crit Care 2021;29(5):217-219
• Blom. Diffuse alveolar haemorrhage in ANCA-associated vasculitis following cocaine use. Neth J Crit Care 2021;29(5):220-221
• van den Hoven. Remission of catatonia after intravenous propofol infusion for unrelated reasons. Neth J Crit Care 2021;29(5):222-225
• Escudero-Acha. Age as a limiting factor of admission to an intensive care unit. Medicina Intensiva 2021;epublished September 2nd
• Peiro Chamarro. Histolo-radiological dissociation in pulmonary fibrosis secondary to SARS-CoV-2 infection. Medicina Intensiva 2021;epublished August 26th
• Cuddihy. Near-fatal Panton-Valentine leukocidin-positive Staphylococcus aureus pneumonia, shock and complicated extracorporeal membrane oxygenation cannulation: A case report. World J Crit Care Med 2021;10(5):301-309
• Bing. In Vivo Thrombosis Imaging in Patients Recovering from COVID-19 and Pulmonary Embolism. Am J Respir Crit Care Med 2021;204(7):855–856
• Paramythiotou. Phlegmonous Gastritis and Streptoccocal Toxic Shock Syndrome: An Almost Lethal Combination. Indian J Crit Care Med 2021;25(10):1195-1198
• Henry. Challenge in acute care surgery: sudden cardiac arrest in the surgical intensive care unit. Trauma Surg Acute Care Open 2021;6:e000814

Tuesday 5th

Research

Randomised Controlled Trials

• Ramanan. Sodium chloride or Plasmalyte-148 evaluation in severe diabetic ketoacidosis (SCOPE-DKA): a cluster, crossover, randomized, controlled trial. Intensive Care Med 2021;epublished October 5th
  • Editorial:  Besen. Fluid management in diabetic ketoacidosis: new tricks for old dogs?. Intensive Care Med 2021;epublished October 5th
• Dale. Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial. Intensive Care Med 2021;epublished October 5th
• van Esch. Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of LifeThe SILENCE Randomized Clinical Trial. JAMA 2021;326(13):1268-1276
  • Audio:  van Esch. Scopolamine Butylbromide for Preventing End-of-Life Death Rattle. JAMA 2021;epublished October 5th
  • Editorial:  Lowe. Preventing Death Rattle With Prophylactic Subcutaneous Scopolamine Butylbromide. JAMA 2021;326(13):1263-1265
• Taylor. Effect of a Multicomponent Sepsis Transition and Recovery Program on Mortality and Readmissions After Sepsis: The Improving Morbidity During Post-Acute Care Transitions for Sepsis Randomized Clinical Trial. Crit Care Med 2021;epublished September 16th
• Rosas. Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial. Intensive Care Med 2021;epublished October 5th

Monday 4th

Research

Randomised Controlled Trial

• Writing Committee for the REMAP-CAP Investigators. Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19A Randomized Clinical Trial. JAMA 2021;epublished October 4th
• Laterre. Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial. Intensive Care Med 2021;epublished October 4th

Narrative Reviews

Clinical

• Notarianni. Mechanical Cardiac Circulatory Support: an Overview of the Challenges for the Anesthetist. Curr Anesthesiol Rep 2021;epublished October 1st
• Winning. Oral health care for the critically ill: a narrative review. Crit Care 2021;25:353
• Poulsen. Delirium in Intensive Care. Curr Anesthesiol Rep 2021;epublished September 3rd
• Toledano. What’s New in Neuraxial Labor Analgesia. Curr Anesthesiol Rep 2021;11:340–347
• Geen. Optimizing care for critically ill older adults. CMAJ 2021;193(39):E1525-E1533

Sunday October 3rd

Research

Randomised Controlled Trials

• NICUSeq Study Group. Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial. JAMA Pediatr 2021;epublished September 27th
• Garbero. High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial. Intensive Care Med 2021;epublished October 3rd
• Ibarra-Estrada. Use of Airway Pressure Release Ventilation in Patients With Acute Respiratory Failure Due to Coronavirus Disease 2019: Results of a Single-Center Randomized Controlled Trial. Crit Care Med 2021;epublished September 29th
• Kristen. Standard versus Accelerated Speaking Valve Placement after Percutaneous Tracheostomy: A Randomized Controlled Feasibility Study. Ann Am Thorac Soc 2021;18(10): 1693–1701
• Barrett. Study of Alteplase for Respiratory failure in SARS-Cov2 COVID-19 (STARS): A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized, Controlled Trial. Chest 2021;epublished September 27th
• Lapergue. Effect of Thrombectomy With Combined Contact Aspiration and Stent Retriever vs Stent Retriever Alone on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion. The ASTER2 Randomized Clinical Trial. JAMA 2021;326(12):1158-1169

Systematic Reviews & Meta Analyses

• Ponnapa Reddy. Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019-A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(10):e1001-e1014
• Karve. The impact of selection criteria and study design on reported survival outcomes in extracorporeal oxygenation cardiopulmonary resuscitation (ECPR): a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med 2021;29(1):142

Observational Studies

• Rose. Communication and Virtual Visiting for Families of Patients in Intensive Care during the COVID-19 Pandemic: A UK National Survey. Ann Am Thorac Soc 2021;18(10):685–1692
• Hrebinko. Evaluating the Cost-effectiveness of Prehospital Plasma Transfusion in Unstable Trauma Patients. A Secondary Analysis of the PAMPer Trial. JAMA Surg 2021;epublished September 22nd
• Cottereau. Handgrip strength to predict extubation outcome: a prospective multicenter trial. Ann Intensive Care 2021;11:144

Press Release

• Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate COVID-19 in Positive Interim Analysis of Phase 3 Study

Saturday October 2nd

Guidelines & Position Statements

• Evans. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 2021;epublished October 2nd
• Prevention of venous thromboembolism and haemostasis monitoring in patients with COVID-19: Updated proposals (April 2021): From the French working group on perioperative haemostasis (GIHP) and the French study group on thrombosis and haemostasis (GFHT), in collaboration with the French society of anaesthesia and intensive care (SFAR). Anaesth Crit Care Pain Med 2021;40(4):100919
• Acute abdomen in the immunocompromised patient: WSES, SIS-E, WSIS, AAST, and GAIS guidelines. World J Emerg Surg 2021;16:40
• Schell. Essential Emergency and Critical Care: a consensus among global clinical experts. BMJ Global Health 2021;6:e006585
• Swiss Academy of Medical Sciences. Intensive care triage under exceptional resource scarcity. Swiss Med Wkly 2021;151:w30077

Correspondence

• Various. SARS-CoV-2 Human Challenge Studies. Reply. N Engl J Med 2021;epublished September 29th
• Nguyen. Using the lung ultrasound score to monitor disease progression for COVID-19-associated ARDS. Intensive Care Med 2021;epublished September 30th
• Jamale. The AKIKI 2 trial: a case for strategy of initiation instead of timing. Lancet 2021;398(10307):1215
  • Gaudry. The AKIKI 2 trial: a case for strategy of initiation instead of timing – Authors' reply. Lancet 2021;398(10307):1215-1216
• Ohbe. Immortal time bias in an observational study on enteral nutrition. Resuscitation 2021;166:144-145
• Verma. Myocarditis after Covid-19 mRNA Vaccination. N Engl J Med 2021; 385:1332-1334
• Keehner. Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce. N Engl J Med 2021; 385:1330-1332

Case Reports

• Murphy. Rapid cognitive decline and myoclonus in a 52-year-old woman. Cleve Clin J Med 2021;88(10):572-583
• Jansen van Rensburg. Chest pain: The importance of serial ECGs. Cleve Clin J Med 2021;88(10):538-540

Friday October 1st

Editorials

• Carmona. Comprehensive perioperative eye protection. Braz J Anesthesiol 2021;epublished September 30th
• Hofmeyr. On strife, natural selection and success in airway management during the COVID-19 pandemic: Shifting from best guess to best practice. Trends Anaesth Crit Care 2021;40:1-3

Commentaries

• Busana. The knowns and unknowns of perfusion disturbances in COVID-19 pneumonia. Crit Care 2021;25:352
• McFadyen. The known knowns and known unknowns of vaccine-induced thrombotic thrombocytopaenia. Cardiovascular Research 2021;117(11):e147–e150
• Meurer. Interim Analyses During Group Sequential Clinical Trials. JAMA 2021;epublished October 1st
• El-Baba. Is Aspergillus isolated from respiratory cultures clinically significant? Cleve Clin J Med 2021;88(10):543-546
• Mossad. Fungus among us: A poster child for diagnostic stewardship. Cleve Clin J Med 2021;88(10):541-542
• Woodcock. Integrating Research into Community Practice — Toward Increased Diversity in Clinical Trials. N Engl J Med 2021;epublished October 2nd

Thursday 30th

Narrative Reviews

Clinical

• Kim. Focused Management of Patients With Severe Acute Brain Injury and ARDS. Chest 2021;epublished September 7th
• Tandon. Artificial liver support systems. J Gastroenterol Hepatol 2021;36(5):1164-1179
• Kaddoura. Current evidence in the diagnosis and management of cardiogenic shock complicating acute coronary syndrome. Rev Cardiovasc Med 2021;22(3):691-715
• Bline. Immune Function in Critically Ill Septic Children. Pathogens 2021;10(10):1239
• Sussman. VAPIng into ARDS: Acute respiratory distress syndrome and cardiopulmonary failure. Pharmacol Ther 2021;epublished September 25th
• Gierhardt. Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome. Eur Respir Rev 2021 30:210059
• Raghu. Cryptogenic organising pneumonia: current understanding of an enigmatic lung disease. Eur Respir Rev 2021 30:210094
• Villa. Hemodynamic Instability during Acute Kidney Injury and Acute Renal Replacement Therapy: Pathophysiology and Clinical Implications. Blood Purif 2021;50:729–739
• Redant. Rationale of Blood Purification in the Post-Resuscitation Syndrome following Out-of-Hospital Cardiac Arrest: A Narrative Review. Blood Purif 2021;50:750–757
• Simpson. Pre-hospital management of penetrating neck injuries: a scoping review of current evidence and guidance. Scand J Trauma Resusc Emerg Med 2021;29:137
• Tesoro. Anesthesiological approach to the floppy child. Minerva Anestesiologica 2021;87(8):940-9
• Shanafelt. Physician Well-being 2.0: Where Are We and Where Are We Going? Mayo Clin Proc 2021;96(10):2682-2693
• Song. Strategies for successful implementation and permanent maintenance of a rapid response system. Korean J Intern Med 2021;36(5):1031-1039

Wednesday 29th

Research

Randomised Controlled Trials

• Andersen. Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest. A Randomized Clinical Trial. JAMA 2021;epublished September 29th
  • Editorial:  Haukoos. Vasopressin and Steroids as Adjunctive Treatment for In-Hospital Cardiac Arrest. JAMA 2021;epublished September 29th
• Weinreich. REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19. N Engl J Med 2021;epublished September 29th

Observational Studies

• Barbaro. Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the international Extracorporeal Life Support Organization Registry. Lancet 2021;epublished September 29th
  • Commentary:  Vuylsteke. ECMO in COVID-19: do not blame the tool. Lancet 2021;epublished September 29th
• Perry. Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study. Lancet 2021;398(10306):1147-1156
• Lee. Cerebral venous sinus thrombosis after vaccination: the UK experience. Lancet 2021;398(10306):1107-1109

Tuesday 28th

Research

Randomised Controlled Trials

• Bohé. Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial. Intensive Care Med 2021;epublished September 29th
  • Editorial:   Krinsley. The goal of personalized glucose control in the critically ill remains elusive. Intensive Care Med 2021;epublished September 17th
• McGuinness. A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet-New Zealand pilot trial. Vox Sang 2021;epublished September 28th
• Belenguer-Muncharaz. Noninvasive ventilation versus conventional oxygen therapy after extubation failure in high-risk patients in an intensive care unit: a pragmatic clinical trial. Rev Bras Ter Intensiva 2021 ;epublished September 24th

Meta Analyses & Systematic Reviews

• Vahedian-Azimi. Comparison of the clinical features in open and closed format intensive care units: A systematic review and meta-analysis. Anaesth Crit Care Pain Med 2021;epublished September 20th
• Castellini. Resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with major trauma and uncontrolled haemorrhagic shock: a systematic review with meta-analysis. World J Emerg Surg 2021;16(1):41
• Wang. Efficacy of volume-based feeding (VBF) protocol on critically ill patients: A meta-analysis and systematic review. Asia Pac J Clin Nutr 2021;30(3):392-400
• Areia. The impact of wearable continuous vital sign monitoring on deterioration detection and clinical outcomes in hospitalised patients: a systematic review and meta-analysis. Crit Care 2021;25:351
• Modra. Sex differences in illness severity and mortality among adult intensive care patients: A systematic review and meta-analysis. J Crit Care 2021;65:116-123
• Assouline. Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. Crit Care Med 2021;epublished September 27th

Observational Studies

• van Kammen. Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia. JAMA Neurol 2021;epublished September 28th
• Laurikkala. Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial. Crit Care 2021;25:350
• Camporota. Prone Position in Coronavirus Disease 2019 and Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome: An International Multicenter Observational Comparative Study. Crit Care Med 2021;epublished September 24th
• Shein. Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med. 2021 September 27th
• Zaaqoq. Beneficial Effect of Prone Positioning During Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019.
  Crit Care Med 2021;epublished September 27th

Monday 27th

Research

Randomised Controlled Trials

• Yu. Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial. Crit Care 2021;25:349

Narrative Reviews

Clinical

• Feng. Blood purification in sepsis and systemic inflammation. Curr Opin Crit Care 2021;epublished September 27th
• Kapp. Renal Considerations in COVID-19: Biology, Pathology, and Pathophysiology. ASAIO Journal 2021;67(10):1087-1096
• Aziz. An Extracorporeal Membrane Oxygenation First Strategy in COVID-19 Acute Respiratory Distress Syndrome. ASAIO Journal 2021;67(10):1097-1099
• Lu. Imaging Acute Stroke: From One-Size-Fit-All to Biomarkers. Front Neurol 2021;12:697779
• Alayash. The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective. Front Physiol 2021;12:711976
• Khalid. Cardiac manifestations of the coronavirus disease-19: a review of pathogenesis, clinical manifestations, diagnosis, and treatment. Pan Afr Med J 2021;39:173
• Depta. Programmed Multi-Level Ventilation: A Strategy for Ventilating Non-Homogenous Lungs. Med Devices 2021;14:277-285

Sunday 26th

Guidelines & Position Statements

• Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: An Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists—Part I, Technical Aspects of Extracorporeal Membrane Oxygenation Anesth Analg 2021;eoublished September 24th
• Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: An Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists—Part II, Intraoperative Management and Troubleshooting. Anesth Analg 2021;epublished September 24th

Narrative Reviews

Clinical

• Hellas. Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization. Neurocrit Care 2021;epublished SEptember 8th
• Gergi. Viscoelastic hemostasis assays (VHA) in septic, critically ill COVID-19 patients: A practical guide for clinicians. Blood Coagul Fibrinolysis 2021;32(3):225–228
• Baratella. Chest X-ray in intensive care unit patients: what there is to know about thoracic devices. Diagn Interv Radiol 2021;27:633–638
• Hellman. Renal Replacement Techniques in Septic Shock. Int J Mol Sci 2021;22(19):10238
• Jones. Sepsis and Cognitive Assessment. J Clin Med 2021;10(18):4269
• Mangini. New Therapies of Liver Diseases: Hepatic Encephalopathy. J Clin Med 2021;10(18);4050
• McGrowder. Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis. Diseases 2021;9(3):50
• Zazzeron. Comparison of Published Guidelines for the Diagnosis and the Management of Vaccine-Induced Immune Thrombotic Thrombocytopenia. Crit Care Explor 2021;3(9):e0519

Saturday 25th

Research

Randomised Controlled Trials

• Kumar. Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized controlled double blind study. Braz J Anesthesiol 2021;epublished September 21st
• Nascimento. Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial. Braz J Anesthesiol 2021;epublished September 23rd

Systematic Reviews & Meta Analyses

• Zhu. Balanced crystalloids versus saline in critically ill patients: The PRISMA study of a meta-analysis. Medicine 2021;100(38):e27203
• Yang. Comparison between remifentanil and other opioids in adult critically ill patients: A systematic review and meta-analysis. Medicine 2021;100(38):e27275
• Haug. Long-term sequelae of critical illness in sepsis, trauma and burns: A systematic review and meta-analysis. J Trauma Acute Care Surg 2021;91(4):736-747
• Siemieniuk. Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis. BMJ 2021;374:n2231

Observational Studies

• Papolos. Management and Outcomes of Cardiogenic Shock in Cardiac ICUs With Versus Without Shock Teams. J Am Coll Cardiol 2021;78(13):1309–1317
• Haas. Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs. Age Ageing 2021;50(5):1719-1727
• Dewitte. High mean arterial pressure target to improve sepsis-associated acute kidney injury in patients with prior hypertension: a feasibility study. Ann Intensive Care 2021;11:139

Protocols

• Monti. Continuous infusion versus intermittent administration of meropenem in critically ill patients (MERCY): A multicenter randomized double-blind trial. Rationale and design. Contemp Clin Trials 2021;104:106346
• Sanchez. Reduced-dose intravenous thrombolysis for acute intermediate high-risk pulmonary embolism: Rationale and design of the PEITHO-3 trial. Thromb Haemost 2021;epublished September 24th

Friday 24th

Editorials

• Barreras-Espinoza . Communication in the ICU during the COVID-19 pandemic. Eur J Anaesthesiol 2021;38(10):1009-1011
• Huang. 2021 Clinical Practice Guidelines on Patient Blood Management in Cardiac Surgery for Anesthesiologists. J Cardiothor Vasc Anesth 2021;epublished September 23rd

Commentaries

• Kerlin. It Is What It Is. JAMA 2021;326(11):1007-1008
• Wijdicks. Predicting Coma Trajectories: The Impact of Bias and Noise on Shared Decisions. Neurocrit Care 2021;epublished August 23rd

Thursday 23rd

Correspondence

• Vacheron. Quiet scandal: variable selection in three major intensive care medicine journals. Intensive Care Med 2021;epublished September 21st
• Palanidurai. Is it time to revisit the PaO2/FiO2 ratio to define the severity of oxygenation in ARDS?. Ann Intensive Care 2021;11:138
• El-Khatib. Incorporating ventilatory support parameters into the PaO2/FiO2 ratio in ARDS patients. Ann Intensive Care 2021;11:137

Case Reports

• Dorsey. More Than Meets the Eye? Clin Liv Dis 2021;epublished September 8th
• Sessums. 37-Year-Old Woman With Shortness of Breath. Mayo Clin Proc 2021;96(9):2480-2485
• Trickett. 21-Year-Old Man With Fever, Night Sweats, Productive Cough, and Diarrhea. Mayo Clin Proc 2021;96(9):2486-2491
• Pasha. Heparin Skin Necrosis in Heparin-Induced Thrombocytopenia. Mayo Clin Proc 2021;96(9):2492
• Hayano. Dermatomyositis-related interstitial lung disease mimicking COVID-19 pneumonia. Cleve Clin J Med 2021;88(9):484-486

Wednesday 22nd

Narrative Reviews

Clinical

• Chris-Olaiya. Therapeutic plasma exchange in liver failure. World J Hepatol 2021;13(8):904-915
• Hossain. Post-traumatic thrombotic microangiopathy: What trauma surgeons need to know? Chin J Traumatol 2021;24(2):69-74
• Lim. Extracorporeal life support in adult patients with out-of-hospital cardiac arrest. Singapore Med J 2021;62(8):433-437
• Chia. Beyond return of spontaneous circulation: update on post-cardiac arrest management in the intensive care unit. Singapore Med J 2021;62(8):444-451
• Bromley. Life-threatening skin conditions presenting to critical care. Br J Anaesth 2021;21(10):376-383
• Ladzinski. Rational Fluid Resuscitation in Sepsis for the Hospitalist. A Narrative Review. Mayo Clin Proc 2021;96(9):2464-2473
• Wiesen. Medical, ethical, and legal aspects of end-of-life dilemmas in the intensive care unit. Cleve Clin J Med 2021;88(9):516-527

Tuesday 21st

Research

Randomised Controlled Trials

• Johnstone. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients. A Randomized Clinical Trial. JAMA 2021;326(11):1024-1033
• de Waal. Perioperative goal-directed therapy in high-risk abdominal surgery. A multicenter randomized controlled superiority trial. J Clin Anesth 2012;75:110506

Guidelines & Position Statements

• Meert. Critically ill cancer patient’s resuscitation: a Belgian/French societies’ consensus conference. Intensive Care Med 2021;epublished September 20th
• A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies. The AGReMA Statement. JAMA 2021;326(11):1045-1056
  • Yadav. A Reporting Guideline for Mediation Analyses. JAMA 2021;326(11):1011-1012
  • Fontanarosa. Reporting Findings From Mediation Analyses. JAMA 2021;326(11):1057

Monday 20th

Narrative Reviews

Critical Care Clinics series on ARDS

• Hendrickson. The Epidemiology of Acute Respiratory Distress Syndrome Before and After Coronavirus Disease 2019. Crit Care Clin 2021;37(4):703-716
• Kotas. Toward Optimal Acute Respiratory Distress Syndrome Outcomes. Recognizing the Syndrome and Identifying Its Causes. Crit Care Clin 2021;37(4):733-748
• Swenson. Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury. Crit Care Clin 2021;37(4):749-776
• Middleton. COVID-19–Associated Acute Respiratory Distress Syndrome. Lessons from Tissues and Cells. Crit Care Clin 2021;37(4):777-793
• Sinha. Pathophysiology of the Acute Respiratory Distress Syndrome. Insights from Clinical Studies. Crit Care Clin 2021;37(4):795-815
• Park. Acute Kidney Injury and Acute Respiratory Distress Syndrome. Crit Care Clin 2021;37(4):835-849
• Coleman. Acute Respiratory Distress Syndrome. Ventilator Management and Rescue Therapies. Crit Care Clin 2021;37(4):851-866
• Lee. Fluid Therapy and Acute Respiratory Distress Syndrome. Crit Care Clin 2021;37(4):867-875
• Qadir. Pharmacologic Treatments for Acute Respiratory Distress Syndrome. Crit Care Clin 2021;37(4):877-893
• Palakshappa. Long-Term Outcomes in Acute Respiratory Distress Syndrome. Epidemiology, Mechanisms, and Patient Evaluation. Crit Care Clin 2021;37(4):895-911

Sunday 19th

Narrative Reviews

Clinical

• Lumb. International Critical Care—From an Indulgence of the Best-Funded Healthcare Systems to a Core Need for the Provision of Equitable Care. Crit Care Med 2021;49(10):1589-1605
• Dellinger. 50 Years of Sepsis Investigation/Enlightenment Among Adults—The Long and Winding Road. Crit Care Med 2021;49(10):1606-1625
• Aslakson. Palliative and End-of-Life Care: Prioritizing Compassion Within the ICU and Beyond. Crit Care Med 2021;49(10):1626-1637
• Vincent. Hemodynamic Monitoring and Support. Crit Care Med 2021;49(10):1638-1650
• Sridhar. Antimicrobial-resistant bacteria in international travelers. Curr Opin Infect Dis 2021;34(5):423-431
• Sharp. Policy and planning for large epidemics and pandemics – challenges and lessons learned from COVID-19. Curr Opin Infect Dis 2021;34(5):393-400
• Imazio. Anti-interleukin-1 agents for pericarditis: a primer for cardiologists. Eur Heart J 2021;epublished September 16th
• Clarke. Management of the brain-dead organ donor. Indian J Thorac Cardiovasc Surg. 2021;epublished September 17th
• Sarkar. COVID-19 and coagulopathy. Clin Respir J 2021;epublished August 16th
• Michalski. From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic? Translational Research 2021;epublished September 18th

Saturday 18th

Guidelines & Position Statements

• Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA). Cardiovascular Research 2021;epublished September 16th
• Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III. Crit Care Med 2021;49(10):1684-1693
• Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney International 2021;100(4):S1-S276

Correspondence

• Various. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med 2021;385:1147-1149
• Liebchen. No clinically relevant removal of meropenem by cytokine adsorber CytoSorb® in critically ill patients with sepsis or septic shock. Intensive Care Med 2021;epublished September 14th
• Stahl. The Janus Face of Coronavirus Disease 2019–Associated Coagulopathy. Crit Care Med 2021;49(10):e1049-e1050
• Doyle. The authors reply. Crit Care Med 2021;49(10):e1050-e1051
• Liebchen. No clinically relevant removal of meropenem by cytokine adsorber CytoSorb® in critically ill patients with sepsis or septic shock. Intensive Care Med 2021;epublished September 14th
• Teijeiro-Paradis. Standardized liberation trials in patients with COVID-19 ARDS treated with venovenous extracorporeal membrane oxygenation: when ready, let them breathe!. Intensive Care Med 2021;epublished September 16th
• Gravesteijn. Targeted temperature management after out-of-hospital cardiac arrest, no de-implementation required based on network meta analysis. Intensive Care Med 2021;epublished September 18th
• Riera. Increased mortality in patients with COVID‑19 receiving extracorporeal respiratory support during the second wave of the pandemic. Intensive Care Med 2021;epublished September 9th
• Rivera‑Lara. Sweeping TTM conclusion may deprive many post-arrest patients of effective therapy. Intensive Care Med 2021;epublished September 14th
• Briassoulis. The lonely glutamine tree in the middle of the infinite critically ill forest. Crit Care 2021;25:342
• Jaber. Use of stylet and airway management procedure in critically ill patients. Intensive Care Med 2021;epublished September 14th
• Garot. Mechanically ventilated COVID-19 patients failed to meet the criteria for the Berlin definition of ARDS. Infection 2021;epublished September 14th

Case Reports

• Ma. Paradoxical carbon dioxide embolism during laparoscopic nephrectomy. Intensive Care Med 2021;epublished September 14th
• Morales-Ortega. Bedside ultrasonography for the diagnosis of pneumonia. CMAJ 2021;193(37):E1463-E1464

News

• Abbasi. SARS-CoV-2 Variant Antibodies Wane 6 Months After Vaccination. JAMA 2021;326(10):901
• Abbasi. Point-of-Care SARS-CoV-2 Variant Diagnostic in Development. JAMA 2021;326(10):901

Audio

• Ely. Rebounding From COVID-19’s Reversal of Recent Progress in the ICU. JAMA 2021;epublished September 15th
• Rubin. Audio Interview: New Evidence on SARS-CoV-2 Vaccine Boosters. N Engl J Med 2021; 385:e48

Friday 17th

Research

Randomised Controlled Trials

• Jorro-Barón. Handoff improvement and adverse event reduction programme implementation in paediatric intensive care units in Argentina: a stepped-wedge trial. BMJ Quality & Safety 2021;30:782-791
• Ader. Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial. Lancet Infect Disease 2021;epublished September 14th
• Tongyoo. High-flow nasal oxygen cannula vs. noninvasive mechanical ventilation to prevent reintubation in sepsis: a randomized controlled trial. Ann Intensive Care 2021;11:135
• Liu. Hydration for prevention of kidney injury after primary coronary intervention for acute myocardial infarction: a randomised clinical trial. Heart 2021;epublished September 11th
• Tavernier. Inhaled amikacin versus placebo to prevent ventilator-associated pneumonia: the AMIKINHAL double-blind multicentre randomised controlled trial protocol. BMJ Open 2021;11(9):e048591
• Mahr. Postoperative Neurocognitive Disorders After Closed-Loop Versus Manual Target Controlled-Infusion of Propofol and Remifentanil in Patients Undergoing Elective Major Noncardiac Surgery: The Randomized Controlled Postoperative Cognitive Dysfunction-Electroencephalographic-Guided Anesthetic Administration Trial. Anesth Analg 2021;133(4):837-847
• Hergenroeder. Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial. Neurocrit Care 2021;epublished September 13th

Systematic Reviews & Meta Analyses

• Wang. Neuroprognostic Accuracy of Quantitative Versus Standard Pupillary Light Reflex for Adult Postcardiac Arrest Patients: A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(10):1790-1799
• Martin. Association Between Lack of Blinding and Mortality Results in Critical Care Randomized Controlled Trials: A Meta-Epidemiological Study. Crit Care Med 2021;49(10):1800-1811
• Martin. Association Between Lack of Blinding and Mortality Results in Critical Care Randomized Controlled Trials: A Meta-Epidemiological Study. CCrit Care Med 2021;49(10):1800-1811
• Reddy. Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(10):e1001-e1014
• Prakash. ROX index as a good predictor of high flow nasal cannula failure in COVID-19 patients with acute hypoxemic respiratory failure: A systematic review and meta-analysis. J Crit Care 2021;66:102-108
• Liu. Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials. J Cardiothorac Surg 2021;16(1):261
• Navas-Blanco. Intraoperative Focused Cardiac Ultrasound for Assessment of Hypotension: A Systematic Review. Anesth Analg 2021;133(4):852-859
• Simonassi. Hemodynamic Monitoring in Patients With Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. J Neurosurg Anesth 2021;33(4):285-292
• Tsujimoto. Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2021;9:CD013330

Observational Studies

• Zampieri. The association of the COVID-19 pandemic and short-term outcomes of non-COVID-19 critically ill patients: an observational cohort study in Brazilian ICUs. Intensive Care Med 2021;epublished September 13th
• Tsalik. Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test. Crit Care Med 2021;49(10):1651-1663
  • Editorial:  Vlasschaert. A Host of Host Assays: The Clinical Accuracy of Two Host Gene Expression Assays in Acute Infection. Crit Care Med 2021;49(10):1812-1814
• Bauer. A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study. Crit Care Med 2021;49(10):1664-1673
  • Editorial:  Dahmer. Whole Genome Sequencing as a First-Line Clinical Test: Almost Ready for Prime Time. Crit Care Med 2021;49(10):1815-1817
• Bhalla. Adherence to Lung-Protective Ventilation Principles in Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med 2021;49(10):1779-1789
• Duff. Urinary biomarkers predict progression and adverse outcomes of acute kidney injury in critical illness. Neph Dial Transplant 2021;epublished September 7th
• Ferreyro. Critical illness in patients with hematologic malignancy: a population-based cohort study. Intensive Care Med 2021;epublished September 14th
  • Editorial:  Azoulay. Preempting critical care services for patients with hematological malignancies. Intensive Care Med 2021;epublished September 14th
• Coppola. Role of total lung stress on the progression of early COVID-19 pneumonia. Intensive Care Med 2021;epublished September 16th
• Guirgis. A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes. Crit Care 2021;25:341
• Smit. Lung ultrasound in a tertiary intensive care unit population: a diagnostic accuracy study. Crit Care 2021;25:339
• Imaeda. Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group-. Crit Care 2021;25:338
• Prats-Uribe. Timing of elective tracheotomy and duration of mechanical ventilation among patients admitted to intensive care with severe COVID-19: A multicenter prospective cohort study. Head Neck 2021;epublished September 15th

Protocols

• Kanjo. Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS): protocol of a prospective, randomised, adaptive, multicentre clinical trial. BMJ Open 2021;11(8):e050464
• Bouzat. Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a randomized multicenter double-blind superiority study. Trials 2021;22:634

Thursday 16th

Editorials

• Contreras-Barbeta. Convalescent plasma for SARS-CoV-2 infection: Win or Learn. Eur Respir J 2021;epublished September 16th
• Lorello. Authorship of Women in Neuroanesthesia and Neurocritical Care: Publish or Perish?. J Neurosurg Anesth 2021;33(4):283-284

Commentaries

• Cameron. Critical care archetypes. Can J Anesth 2021;68:1471–1473
• Rosenberg. Holding Hope for Patients With Serious Illness. JAMA 2021;epublished September 16th
• Rubin. How COVID-19 Made It Even Tougher to Know ICU Patients as Individuals. JAMA 2021;epublished September 15th
• Coffey. Interpreting SARS-CoV-2 Test Results. JAMA 2021;epublished September 17th
• Gostin. An International Agreement on Pandemic Prevention and Preparedness. JAMA 2021;epublished September 15th
• Wilensky. Seeking the Origins of SARS-CoV-2—and More Cooperative Global Responses to New Viral Threats. JAMA Health Forum 2021;2(9):e213547
• Gattinoni. Standardised PaO 2/FiO 2 ratio in COVID-19: Added value or risky assumptions? Eur J Intern Med 2021;epublished September 9th
• Beil. The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?. Crit Care 2021;25:330

Wednesday 15th

Narrative Reviews

Clinical

• Pleșoianu. Extracorporeal membrane oxygenation in the management of critically ill patients with coronavirus disease 2019: A narrative review. Exp Ther Med 2021;22:1296
• Gougol. Alcoholic Hepatitis. Clin Liver Dis 2021;18(2):90-95
• Wolfisberg. Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19. Crit Rev Clin Lab Sci 2021;epublished September 13th
• Bowman. Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression. Crit Care 2021;25(1):334
• Varughese. Environmental and Occupational Considerations of Anesthesia: A Narrative Review and Update. Anesth Analg 2021;133(4):826-835
• Montrucchio. Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elements. Ann Intensive Care 2021;11(1):136
• Ma. Albumin Use in Brain-injured and Neurosurgical Patients: Concepts, Indications, and Controversies. J Neurosurg Anesth 2021;33(4):293-299
• Slavin. When to change treatment of acute invasive aspergillosis: an expert viewpoint. J Antimicrob Chemotherapy 2021;epublished September 11th
• Nawijn. Necrotizing Soft Tissue Infections, the Challenge Remains. Front Surg 2021;8:721214
• Martin-Loeches. Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies. Crit Care Explor 2021;3(9):e0511
• Agarwal. Advances in Hemostatic Wound Dressings. Clinical Implications and Insight. Adv Skin Wound Care 2021;epublished September 7th
• Lee. Airway management in the adult patient with COVID-19: High flow nasal oxygen or not? A summary of evidence and local expert opinion. Anaesth Intensive Care 2021;49(4):268–274
• Kinno. Takotsubo Syndrome: Optimizing Care with a Multidisciplinary Approach. Journal of Multidisciplinary Healthcare 2021:14 2487–2499

Tuesday 14th

Guidelines & Position Statements

• Gai. Guidance on the management of left ventricular assist device (LVAD) supported patients for the non-LVAD specialist healthcare provider: executive summary. Eur J Heart Fail 2021;epublished August 18th
• Difficult Airway Management in Adult Coronavirus Disease 2019 Patients: Statement by the Society of Airway Management. Anesth Analg 2021;133(4):876-890
• Ko. Consensus statement and recommendations on the treatment of COVID-19: 2021 update. J Chin Med Assoc 2021;epublished September 3rd

Monday 13th

Narrative Reviews

Clinical

• Patolia. Bronchoscopy in intubated and non-intubated intensive care unit patients with respiratory failure. J Thorac Dis 2021;13(8):5125-5134
• Benn. Therapeutic bronchoscopy facilitates liberation from mechanical ventilation and improves quality of life for critically ill patients with central airway obstruction. J Thorac Dis 2021;13(8):5135-5138
• Charya. Management of life-threatening hemoptysis in the ICU. J Thorac Dis 2021;13(8):5139-5158
• Bajaj. Foreign body aspiration. J Thorac Dis 2021;13(8):5159-5175
• Lin. The intersection of bronchoscopy and extracorporeal membrane oxygenation. J Thorac Dis 2021;13(8):5176-5182
• Kalchiem-Dekel. An evolving role for endobronchial ultrasonography in the intensive care unit. J Thorac Dis 2021;13(8):5183-5194
• Thachuthara-George. Pneumothorax in patients with respiratory failure in ICU. J Thorac Dis 2021;13(8):5195-5204
• Hu. Management of complex pleural disease in the critically ill patient. J Thorac Dis 2021;13(8):5205-5222
• Kurman. Persistent air leak management in critically ill patients. J Thorac Dis 2021;13(8):5223-5231
• Thakore. Medical thoracoscopy in intensive care unit. J Thorac Dis 2021;13(8):5232-5241
• Williams. Managing complications of pleural procedures. J Thorac Dis 2021;13(8):5242-5250
• Barash. Patient selection and preoperative evaluation of percutaneous dilation tracheostomy in the intensive care unit. J Thorac Dis 2021;13(8):5251-5260
• Ghattas. State of the art: percutaneous tracheostomy in the intensive care unit. J Thorac Dis 2021;13(8):5261-5276
• Wei. An overview of percutaneous endoscopic gastrostomy tube placement in the intensive care unit. J Thorac Dis 2021;13(8):5277-5296
• Alsunaid. Wound care management: tracheostomy and gastrostomy. J Thorac Dis 2021;13(8):5297-5313
• Zouk. Managing complications of percutaneous tracheostomy and gastrostomy. J Thorac Dis 2021;13(8):5314-5330
• Ray. Equipment and procedural setup for interventional pulmonology procedures in the intensive care unit. J Thorac Dis 2021;13(8):5331-5342
• Milojevic. Ultrasound use in the ICU for interventional pulmonology procedures. J Thorac Dis 2021;13(8):5343-5361

Sunday 12th

Narrative Reviews

Clinical

• Abrams. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Med 2021;epublished September 10th
• Beane. What intensive care registries can teach us about outcomes. Curr Opin Crit Care 2021;27(5):537-543
• Coppadoro. The use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings. Crit Care 2021;25:327
• Peng. Blood Pressure Management After Endovascular Thrombectomy. Front Neurol 2021;12:723461
• Rubiano. Management of severe traumatic brain injury in regions with limited resources. Brain Inj 2021;epublished September 7th
• Washington. Acute Ischemic Stroke. Am J Nurs 2021;121(9):26-33
• Beasley. Acute lung injury-from cannabis to COVID. Mod Pathol 2021;epublished September 9th
• Li. Targeting Mitochondria and Metabolism in Acute Kidney Injury. J Clin Med 2021;10(17):3991
• Ergin. Kidney Microcirculation as a Target for Innovative Therapies in AKI. J Clin Med 2021;10(17):4041
• Menè. Acute Kidney Injury in Monoclonal Gammopathies. J Clin Med 2021;10(17):3871
• Ow. Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice. J Clin Med 2021;10(17):3798
• Mangini. New Therapies of Liver Diseases: Hepatic Encephalopathy. J Clin Med 2021;10(17):4050
• Liew-Spilger. Viscoelastic Hemostatic Assays for Postpartum Hemorrhage. J Clin Med 2021;10(17):3946
• Varrias. The Use of Point-of-Care Ultrasound (POCUS) in the Diagnosis of Deep Vein Thrombosis. J Clin Med 2021;10(17):3903
• Nakanishi. Post-Intensive Care Syndrome and Its New Challenges in Coronavirus Disease 2019 (COVID-19) Pandemic: A Review of Recent Advances and Perspectives. J Clin Med 2021;10(17):3870
• Zanetto. Recent Advances in the Management of Acute Variceal Hemorrhage. J Clin Med 2021;10(17):3818
• Veldscholte. Intermittent fasting in paediatric critical illness: The properties and potential beneficial effects of an overnight fast in the PICU. Clin Nutrition 2021;40(9):5122-5132
• Hwang. Trauma Surgery and War: A Historical Perspective. J Trauma Inj 2021;epublished September 7th
• Lampejo. Acute myocarditis: aetiology, diagnosis and management. Clin Med 2021;21(5):e505-e510
• Mohan. Metabolic emergencies in pregnancy. Clin Med 2021;21(5):e438-e440
• Lim. Liver diseases in pregnancy. Clin Med 2021;21(5):e441-e445
• Nana. COVID-19 in pregnancy. Clin Med 2021;21(5):e446-e450
• Wiles. Severe hypertension in pregnancy. Clin Med 2021;21(5):e451-e456
• Mung. Interplay between endocrinology, metabolism and COVID-19 infection. Clin Med 2021;21(5):e499-e504
• Giacalone. Multisystem inflammatory syndrome in children (MIS-C): a mini-review. Int J Emerg Med 2021;14:50
• Livingstone. Coagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypes. Front Med 2021;8:723217

Saturday 11th

Commentaries

• Gattinoni. Isn’t it time to abandon ARDS? The COVID-19 lesson. Crit Care 2021;25:326
• Beil. The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?. Crit Care 2021;25:330
• Siddiqui. Pathological disease in the lung periphery after acute COVID-19. Lancet Respir Med 2021;epublished September 7th
• Alam. The dominant left ventricular assist device: lessons from an era. ESC Heart Fail 2021;epublished September 10th
• Zaidi. Family Calls and Visitation in the COVID-19 Era. 1147-1148
• Ely. Medicine at Its Finest. 1149-1150
• Montrucchio. When Words Are Not Enough (First Anniversary of Pandemic in the Words of a Doctor to a Patient). 1145-1146
• Rapeport. SARS-CoV-2 Human Challenge Studies — Establishing the Model during an Evolving Pandemic. N Engl J Med 2021; 385:961-964

Correspondence

• Shah. Effect of Vaccination on Transmission of SARS-CoV-2. N Engl J Med 2021;epublished September 8th
• Schönborn. Decline in Pathogenic Antibodies over Time in VITT. N Engl J Med 2021;epublished September 8th
• Normark. Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination. N Engl J Med 2021;385:1049-1051
• Murray. Opioids for Sedation: Has the Pendulum Swung Too Far? Am J Respir Crit Care Med 2021;204(5):611
  • Duprey. Reply to Murray and Newsome. Am J Respir Crit Care Med 2021;204(5):612
• Yasuma. No Strong Evidence for Ruling Out the Role of Coagulation in Long-Term Disability after Critical Illness. Am J Respir Crit Care Med 2021;204(5):613
  • Brummel. Reply to Yasuma et al. Am J Respir Crit Care Med 2021;204(5):613–614
• Dugar. Defining Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome. J Cardiothorac Vasc Anesth 2021;epublished September 7th
• Perez-Vizcaino. Interleukin-6 and intrapulmonary shunt. Eur Respir J 2021;58:2101292
• Riera. Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic. Intensive Care Med 2021;epublished September 9th
• Rouzé,. High Incidence of Nosocomial Infections in COVID-19 Patients. Chest 2021;160(3):e315
  • Grasselli. Response. Chest 2021;160(3):e316
• Zuin. Right Ventricular Dysfunction in Early Sepsis and Septic Shock. Chest 2021;160(3):e318-e319
  • Lanspa. Response. Chest 2021;160(3):e319-e320
• Xiao. The Linkage Between Intraabdominal Hypertension and Acute Kidney Injury Remains To Be Confirmed. Chest 2021;160(3):e320-e321
  • Dupont. Response. Chest 2021;160(3):e321-e322

Editorials

• Naeije. Phenotyping long COVID. Eur Respir J 2021;58:2101763

Audio

• Rubin. Audio Interview: Protecting against Severe Disease and Transmission. N Engl J Med 2021;385:e44

Friday 10th

Research

Randomised Controlled Trials

• Bégin. Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. Nat Med 2021;epublished September 9th
• Jacquier. Effect of a Musical Intervention During the Implantation of a Central Venous Catheter or a Dialysis Catheter in the Intensive Care Unit: A Prospective Randomized Pilot Study. Anesth Analg 2021;epublished September 9th
• Page. Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome: : A Randomized Pilot Study. Ann Am Thorac Soc 2021;epublished September 7th

Systematic Reviews & Meta Analyses

• Sato. Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med 2021;epublished Septemebr 8th
• Foran. Timing of tracheostomy in acute traumatic spinal cord injury: a systematic review and meta-analysis. J Trauma Acute Care Surg 2021;epublished September 9th

Observational Studies

• Rasmussen. Oxygenation targets in ICU patients with COVID-19: a post-hoc sub-group analysis of the HOT-ICU trial. Acta Anaesthesiol Scand 2021;;epublished August 23rd
• Ergün. Aspergillus test profiles and mortality in critically-ill COVID-19 patients. J Clin Microbiol 2021;epublished September 8th
• Riera. Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic. Intensive Care Med 2021;epublished September 8th
• Nadig. Psychological Outcomes in Family Members of Patients With Acute Respiratory Failure. Does Inter-ICU Transfer Play a Role? Chest 2021;160(3):890-898
  • Editorial:  de Moraes. Family Members of Transferred Critically Ill Patients Also Need Care. Chest 2021;160(3):793-794
• Han. Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults. Chest 2021;160(3):909-918
• Hirshberg. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial. Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). Chest 2021;160(3):919-928
• Vasquez. Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19. Chest 2021;160(3):929-943
  • Editorial:  Pham. Clinical Subphenotypes in Critically Ill Patients With COVID-19. Now Looking for Different Treatment Responses! Chest 2021;160(3):795-796
• Azoulay. Symptoms of Mental Health Disorders in Critical Care Physicians Facing the Second COVID-19 Wave. A Cross-Sectional Study. Chest 2021;160(3):944-955
  • Editorial:  England. Psychological Distress Persists Among COVID-19 Health Care Providers, Suggesting New Challenges and Missed Opportunities for Support. Chest 2021;160(3):797-798
• Schwager. Utilizing machine learning to improve clinical trial design for acute respiratory distress syndrome. NPJ Digit Med 2021;4(1):133
• Garcia. Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications. Am J Respir Crit Care Med 2021;204(5):557–565
  • Editorial:  Mayr. Identifying Survivors of Sepsis at Risk for Adverse Cardiovascular Outcomes. Am J Respir Crit Care Med 2021;204(5):500-501
• Rouzé. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial. Am J Respir Crit Care Med 2021;204(5):546–556
  • Editorial:  Musher. Bacterial Coinfection in COVID-19 and Influenza Pneumonia. Am J Respir Crit Care Med 2021;204(5):498–500
• Duprey. Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain. Am J Respir Crit Care Med 2021;204(5):566–572
  • Editorial:  Hayhurst. The Conundrum of Pain, Opiate Use, and Delirium: Analgosedation or Analgesia-First Approach? Am J Respir Crit Care Med 2021;204(5):502–503
• Östlund. Neuron-Specific Enolase and long-term neurological outcome after OHCA - a validation study. Resuscitation 2021;epublished September 8th
• Boyle. Hyperoxaemia and hypoxaemia are associated with harm in patients with ARDS. BMC Pulm Med 2021;21:285
• Weiner-Lastinger. The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: A summary of data reported to the National Healthcare Safety Network. Infection Control & Hospital Epidemiology 2021;epublished September 3rd
• Thompson. Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings. N Engl J Med 2021;epublished September 8th
  • Editorial:  Dean. Covid-19 Vaccine Effectiveness and the Test-Negative Design. N Engl J Med 2021;epublished September 8th

Thursday 9th

Guidelines & Position Statements

• Clinical practice guideline on the management of septic shock and sepsis-associated organ dysfunction in children: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine.
  Acta Anaesthesiol Scand 2021;epublished July 26th
• Clinician Well-Being—addressing global needs for improvements in the health care field: a joint opinion from the American College of Cardiology, American Heart Association, European Society of Cardiology, World Heart Federation. Eur Heart J 2021;42(33):3122–3126
• Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults. Clin Infect Dis 2021;73(5):755–757
• Mass Critical Care Surge Response during COVID-19: Implementation of Contingency Strategies A Preliminary Report of findings from the Task Force for Mass Critical Care. Chest 2021;epublished September 6th
• Wang. Expert consensus of perioperative intensive care and management of critically ill cancer patients (2021). Ann Palliat Med 2021;epublished September 4th
• Circulating Heart Failure Biomarkers beyond Natriuretic Peptides: updated review from the Biomarker Study Group of the Heart Failure Association (HFA), European Society of Cardiology (ESC). Eur J Heart Fail 2021;epublished September 8th

Wednesday 8th

Case Reports

• Chakraborty. The Tricky Trachea. Chest 2021;160(3):e255-e258
• Manoukian. A 70-Year-Old Woman With Refractory Hypoxemia. Chest 2021;160(3):e265-e268
• Alnabulsi. A 60-Year-Old Man With Acute Chest Pain. A Common Presentation, But Unusual Diagnosis. Chest 2021;160(3):e269-e272
• Karime. A 49-Year-Old Woman With Persistent Bilateral Pleural Effusions.Chest 2021;160(3):273-e278
• Winston. A 24-Year-Old Woman Presenting With Altered Mental Status and Multiorgan Failure. Chest 2021;160(3):e279-e283
• Tzilas. A 58-Year-Old Woman With Lung Nodules and Chronic Cough. Chest 2021;160(3):e285-e288
• Gable. A 24-Year-Old Man With Hemoptysis Found to Have a Chest Mass and Contralateral Axillary Lymphadenopathy. Chest 2021;160(3):e289-e293
• Qureshi. Dyspnea, Elevated Jugular Venous Pulse, and Lower Extremity Edema in the Setting of Interstitial Lung Disease in a Patient Who Has Undergone Liver and Kidney Transplantation. Chest 2021;160(3):e295-e298
• Fanget. Intestinal Air in the Mediastinum. Chest 2021;160(3):e299-e303
• Kourouni. A Hydropneumothorax That Never Was! Chest 2021;160(3):e305-e309
• Haloot. 60-Year-Old Man With Liver Lesions and a Subcutaneous Nodule. Chest 2021;160(3):e311-e313
• Newman. Images of the month 1: ‘Soy sauce’ pleural effusion: what causes black pleural fluid? Clin Med 2021;21(5):e531-e532

Tuesday 7th

Research

Randomised Controlled Trials

• Naccache. Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med 2021;epublished September 7th
• The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial. Anaesthesia 2021;76(10):1342-1351

Observational Studies

• Falvey. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Intern Med 2021;epublished online September 7th
• Pugh. Long-term trends in critical care admissions in Wales. Anaesthesia 2021;76(10):1316–25
  • Editorial:  Lone. Critical care in an ageing world: too much of a good thing, or a rising challenge? Anaesthesia 2021;76(10):1291-1295

Guidelines & Position Statements

• Fire safety and emergency evacuation guidelines for intensive care units and operating theatres: for use in the event of fire, flood, power cut, oxygen supply failure, noxious gas, structural collapse or other critical incidents. Guidelines from the Association of Anaesthetists and the Intensive Care Society. Anaesthesia 2021;76(10):1377-1391

Monday 6th

Narrative Reviews

Clinical

• Young. Oxygen therapy for critically Ill and post-operative patients. J Anesth 2021;epublished September 6th
• Giorni. Pediatric Mechanical Circulatory Support: Pathophysiology of Pediatric Hemostasis and Available Options. Front Cardiovasc Med 2021;8:671241
• Laho. Invasive Group A Streptococcal Infections: Benefit of Clindamycin, Intravenous Immunoglobulins and Secondary Prophylaxis. Front Pediatr 2021;9:697938
• Takla. General anaesthesia in end-of-life care: extending the indications for anaesthesia beyond surgery. Anaesthesia 2021;76(10):1308-1315

Non-Clinical

• Tleyjeh. Overlooked Shortcomings of Observational Studies of Interventions in Coronavirus Disease 2019: An Illustrated Review for the Clinician. Open Forum Infectious Diseases 2021;8(8):ofab317

Sunday 5th

Commentaries

• Hoskote. What’s new in mechanical support strategies for the intensivist in children with severe cardiac failure. Intensive Care Med 2021;epublished August 19th
• Velu. Post-mortem dissection of COVID-19: a pathogenic role for macrophages?. Intensive Care Med 2021;epublished September 1st
• Hurley. Selective digestive decontamination, a seemingly effective regimen with individual benefit or a flawed concept with population harm? Crit Care 2021;25:323

Editorials

• Atwoli. Call for Emergency Action to Limit Global Temperature Increases, Restore Biodiversity, and Protect Health. N Engl J Med 2021;epublished September 5th
• Hodgson. Ten strategies to optimize early mobilization and rehabilitation in intensive care. Crit Care 2021;25(1):324

Correspondence

• Keehner. Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce. N Engl J Med 2021;epublished September 1st
• Avdeev. Can We Reliably Predict the Failure of Noninvasive Ventilation in COVID-19–associated Acute Hypoxemic Respiratory Failure? Ann Am Thor Soc 2021;18(9):1594-1595
• Bellani. Reply: Can We Reliably Predict the Failure of Noninvasive Ventilation in COVID-19–associated Acute Hypoxemic Respiratory Failure? Ann Am Thor Soc 2021;18(9):1595-1596
• Wendel Garcia. Cytokine adsorption in severe, refractory septic shock. Intensive Care Med 2021;epublished September 1st
• Prattes. COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges. Intensive Care Med 2021;epublished September 1st
• de Metz. Behavioural artificial intelligence technology for COVID-19 intensivist triage decisions: making the implicit explicit. Intensive Care Med 2021;epublished August 25th

Case Reports

• Fiorentino. Intermittent Abdominal Pressure Ventilation: An Alternative for Respiratory Support. Can Respir J 2021;2021:5554765
• Singh. Paranephric air in COVID-ARDS patient: an extension of pneumothorax. Intensive Care Med 2021;August 30th
• Bajwa. Argyria: a cause of pseudocyanosis. QJM 2021;114(5):341
• Banerjee. Intraosseus route for thrombolysing acute stroke is safe and successful. QJM 2021;114(5):324–325

Multimedia

Audio

• Lewis. Using Prior Information to Interpret the Results of Clinical Trials. JAMA 2021;epublished September 2nd
• Rubin. Audio Interview: A New Round of Rising Covid-19 Numbers. N Engl J Med 2021;385(10):e41

Saturday 4th

Guidelines and Position Statements

• 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA). Eur Heart J 2021;epublished August 29th
• 2021 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)
  Eur Heart J 2021;epublished August 28th
• Coloretti. Rationale for Polyclonal Intravenous Immunoglobulin Adjunctive Therapy in COVID-19 Patients: Report of a Structured Multidisciplinary Consensus. J Clin Med 2021;10(16):3500
• Woods-Hill. Consensus Recommendations for Blood Culture Use in Critically Ill Children Using a Modified Delphi Approach. Ped Crit Care Med 2021;22(9):774-784
• American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate intensity anticoagulation in critically ill patients. Blood Adv 2021;epublished September 22nd

Narrative Reviews

Clinical

• Li. Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine. Mol Cell Biochem 2021;epublished September 3rd
• Colliou. Kidney Failure after Liver Transplantation. Transplantology 2021;2:315–335
• Pruvost-Robieux. Evoked- and Event-Related Potentials as Biomarkers of Consciousness State and Recovery. J Clin Neurophysiol 2021;epublished August 30th
• Sethi. Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist's perspective. Clin Kidney J 2021;14(9):2000-2011

Non-Clinical

• Perneger. How to use likelihood ratios to interpret evidence from randomized trials. J Clin Epi 2021;136:235-242
  • Commentary:  Knottnerus. The RCT-based and the prognostic likelihood ratio. J Clin Epi 2021;136:133-135

Friday 3rd

Research

Randomised Controlled Trials

• Metoprolol in Critically Ill Patients With COVID-19. J Am Coll Cardiol 2021,78(10):1001–1011
• Seidelman. Impact of Antibiotic Stewardship Rounds in the Intensive Care Setting: a prospective cluster-randomized crossover study. Clin Infect Dis 2021;epublished August 30th

Systematic Reviews & Meta Analyses

• Holmberg. Targeted Temperature Management in Adult Cardiac Arrest: Systematic Review and Meta-Analysis. Resuscitation 2021;epublished August 30th
• Chorath. Association of Early vs Late Tracheostomy Placement With Pneumonia and Ventilator Days in Critically Ill Patients: A Meta-analysis. JAMA Otolaryngol Head Neck Surg 2021;147(5):450-459
• Boucher. The cost of the Acute Respiratory Distress Syndrome: A systematic review. Chest 2021;epublished August 31st
• Ivermectin for preventing and treating COVID‐19. Cochrane Database Syst Rev 2021;2021(7):CD015017
• Liu. Gastric-tube versus post-pyloric feeding in critical patients: a systematic review and meta-analysis of pulmonary aspiration- and nutrition-related outcomes. Eur J Clin Nutrition 2021;75:1337–1348
• Kreuzberger. SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19. Cochrane Database Syst Rev 2021;epublished September 2nd

Observational Studies

• Adelman. Secondary Bacterial Pneumonias and Bloodstream Infections in Patients Hospitalized with COVID-19. Ann Am Thorac Soc 2021;189(9):1584-1587
• Davies. One-Year Outcomes of Critical Care Patients Post–COVID-19 Multisystem Inflammatory Syndrome in Children. JAMA Pediatr 2021;epublished August 30th
• Wallenburg. High unbound flucloxacillin fraction in critically ill patients. J Antimicrob Chemother 2021;epublished August 31st
• Mehta. Utilization and effect of neuromuscular blockade in a randomized trial of high-frequency oscillation. J Crit Care 2021;66:86-92

Protocols

• Garcia. Rationale and Design of the Awake Prone Position for Early Hypoxemia in COVID-19 Study Protocol: A Clinical Trial. Ann Am Thorac Soc 2021;189(9):1560-1566

Thursday 2nd

Narrative Reviews

Clinical

• Matava. Pediatric Airway Management in Times of COVID-19—a Review of the Evidence and Controversies. Curr Anesthesiol Rep 2021;11:243–247
• Uhlig. Volatile Versus Intravenous Anesthetics in Cardiac Anesthesia: a Narrative Review. Curr Anesthesiol Rep 2021;11:275–283
• Perchermeier. The Use of Corticosteroids for Cardiopulmonary Bypass in Adults. Curr Anesthesiol Rep 2021;11:292–297
• Labus. Role of Echocardiography for the Perioperative Assessment of the Right Ventricle. Curr Anesthesiol Rep 2021;11:306–317
• Koechlin. Aortic Valve Neocuspidization Using Autologous Pericardium (Ozaki Procedure): an Alternative to Aortic Valve Replacement in Adult Cardiac Surgery?. Curr Anesthesiol Rep 2021;11:318–325
• Kalagara. Ultrasound Imaging of the Spine for Central Neuraxial Blockade: a Technical Description and Evidence Update. Curr Anesthesiol Rep 2021;11:326–339
• Richardson. Pain Management in Children During the COVID-19 Pandemic. Curr Anesthesiol Rep 2021;11:214–222
• Alqudimat. State of the Art: Immersive Technologies for Perioperative Anxiety, Acute, and Chronic Pain Management in Pediatric Patients. Curr Anesthesiol Rep 2021;11:265–274

Wednesday 1st

Research

Randomised Controlled Trial

• Marconi. Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial. Lancet Respir Med 2021;epublished September 1st
  • Commentary:  Kalil. Baricitinib: the first immunomodulatory treatment to reduce COVID-19 mortality in a placebo-controlled trial. Lancet Respir Med 2021;epublished September 1st
• Thanapongsatorn. Comprehensive versus standard care in post-severe acute kidney injury survivors, a randomized controlled trial. Crit Care 2021;25:322

Narrative Reviews

Annual Update in Intensive Care and Emergency Medicine 2021

• Heringlake. Still a place for aortic counterpulsation in cardiac surgery and patients with cardiogenic shock?. Crit Care 2021;25:309
• Rozemeijer. Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?. Crit Care 2021;25:310
• Weinstein. Advanced management of intermediate-high risk pulmonary embolism. Crit Care 2021;25:311
• Skrifvars. Monitoring and modifying brain oxygenation in patients at risk of hypoxic ischaemic brain injury after cardiac arrest. Crit Care 2021;25:312
• Ostermann. Acute kidney injury in ECMO patients. Crit Care 2021;25:313
• Yagi. Management of acute metabolic acidosis in the ICU: sodium bicarbonate and renal replacement therapy. Crit Care 2021;25:314
• Roca. To prone or not to prone ARDS patients on ECMO. Crit Care 2021;25:315
• Williams. Tracheostomy for COVID-19: evolving best practice. Crit Care 2021;25:316
• Grasselli. Secondary infections in critically ill patients with COVID-19. Crit Care 2021;25:317
• Ltaief. Pathophysiology and clinical implications of the veno-arterial PCO2 gap. Crit Care 2021;25:318

Tuesday 31st

Research

Randomised Controlled Trial

• McNamee. Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure. The REST Randomized Clinical Trial. JAMA 2021;epublished August 31st
• Gelissen. Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients. A Randomized Clinical Trial. JAMA 2021;epublished August 31st
  • Editorial:  Urner. Titrating Oxygen Therapy in Critically Ill Patients. JAMA 2021;epublished August 31st

Protocols

• Voiriot. Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units. BMJ Open 2021;11(8):e048187

Monday 30th

Research

Randomised Controlled Trial

• Evered. Anaesthetic depth and delirium after major surgery: a randomised clinical trial. Br J Anaesth 2021;epublished August 28th

Systematic Reviews & Meta Analyses

• Granfeldt. Targeted Temperature Management in Adult Cardiac Arrest: Systematic Review and Meta-Analysis. Resuscitation 2021;epublished August 29th
• Snow. Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regression. Br J Anaesth 2021;epublished August 29th

Observational Studies

• Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients- a multinational observational study by the European Confederation of Medical Mycology. Clin Microbiol Infect 2021;epublished August 25th

Sunday 29th

Research

Randomised Controlled Trials

• Desch. Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation. N Engl J Med 2021;epublished August 29th
• Meiser. Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial. Lancet Respir Med 2021;epublished August 26th
• Valgimigli. Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. N Engl J Med 2021;epublished August 28th
• Supinski. A randomized controlled trial to determine whether beta-hydroxy-beta-methylbutyrate and/or eicosapentaenoic acid improves diaphragm and quadriceps strength in critically Ill mechanically ventilated patients. Crit Care 2021;25:308
• Amado-Rodríguez. Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial. Ann. Intensive Care 2021;11:132
• Rahat-Dahmardeh. Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated Patients in Intensive Care Unit: A Double-Blind Randomized. Biomed Res Int 2021:5550653
• Devos. Early high antibody-titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma. Eur Respir J 2021;epublished August 26th

Systematic Reviews & Meta Analyses

• Kyo. Patient–ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis. J Intensive Care 2021;9:50
• Chilkoti. Awake Prone Positioning in the Management of COVID-19 Pneumonia: A Systematic Review. Indian J Crit Care Med 2021;25(8):896-905
• Somagutta. The Efficacy of vitamin C, thiamine, and corticosteroid therapy in adult sepsis patients: a systematic review and meta-analysis. Acute Crit Care 2021;epublished June 30th
• Cheng. Acute Cardiac Injury in Coronavirus Disease 2019 and Other Viral Infections—A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(9):1558-1566
• Gustafson. Musculoskeletal complications following critical illness: A scoping review. J Crit Care 2021;66:60-66
• Harnisch. Contraindications to the Initiation of Veno-Venous ECMO for Severe Acute Respiratory Failure in Adults: A Systematic Review and Practical Approach Based on the Current Literature. Membranes 2021;11(8):584
• The Blood Pressure Lowering Treatment Trialists' Collaboration. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis. Lancet 2021;epublished August 26th

Observational Studies

• Sud. A comparison of gastric gas volumes measured by computed tomography after high-flow nasal oxygen therapy or conventional facemask ventilation. Anaesthesia 2021;76(9):1184-1189
• Dogani. The application of an oxygen mask, without supplemental oxygen, improved oxygenation in patients with severe COVID-19 already treated with high-flow nasal cannula. Crit Care 2021;25:319
• Cammarota. Effect of awake prone position on diaphragmatic thickening fraction in patients assisted by noninvasive ventilation for hypoxemic acute respiratory failure related to novel coronavirus disease. Crit Care 2021;25:305
• Hippisley-Cox. Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. BMJ 2021;374:n1931
  • Editorial:  Klungel. Strengthening international surveillance of vaccine safety. BMJ 2021;374:n1994
• Likhvantsev. Six-Month Quality of Life in COVID-19 Intensive Care Unit Survivors. J Cardiothorac Vasc Anesth 2021;epublished August 28th

Protocols

• Arabi. Helmet Non-Invasive Ventilation for COVID-19 Patients (Helmet-COVID): study protocol for a multicentre randomised controlled trial. BMJ Open 2021;11(8):e052169

Narrative Reviews

Clinical

• Navas-Blanco. Expert Consensus Decision Pathway of the American College of Cardiology on Management of Bleeding in Patients With Oral Anticoagulants: A Review of the 2020 Update for Perioperative Physicians. J Cardiothorac Vasc Anesth 2021;35(8):2471-2479
• Luan. Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections. Front Immunol 2021;12:720363

Commentaries

• Little. Estimands, Estimators, and Estimates. JAMA 2021;epublished August 23rd

Correspondence

• de Metz. Behavioural artificial intelligence technology for COVID-19 intensivist triage decisions: making the implicit explicit. Intensive Care Med 2021;epublished August 25th
• Murali. A RUSH to SALVATION? Practical and Tested Ultrasound-Guided Evaluations of Critically ill Patients Already Exist. J Cardiothorac Vasc Anesth 2021;epublished August 27th
  • Reply:  Matyal. Salvation through Evolution. J Cardiothorac Vasc Anesth 2021;epublished August 28th

Audio

• Rubin. Audio Interview: Assessing Vaccine Safety. N Engl J Med 2021;385:e37

News

• Kuehn. Post–COVID-19 Symptoms Were Worse Than Cancer’s Effects. JAMA.2021;326(8):692
• Rubin. Influenza’s Unprecedented Low Profile During COVID-19 Pandemic Leaves Experts Wondering What This Flu Season Has in Store. JAMA 2021;epublished August 25th
• Feinmann. How the world is (not) handling surplus doses and expiring vaccines. BMJ 2021;374:n2062

Saturday 28th

Guidelines & Position Statements

• McDonagh. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 2021;epublished August 27th
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020). J Intensive Care 2021;9:53
• Recommendations for standards of monitoring during anaesthesia and recovery 2021: Guideline from the Association of Anaesthetists. Anaesthesia 2021;76(9):1212-1223

Friday 27th

Narrative Reviews

Clinical

• Perkins. Brain injury after cardiac arrest. Lancet 2021;epublished August 26th
• Saor. Cardiopulmonary resuscitation in special circumstances. Lancet 2021;epublished August 26th
• Niederman. Initial antimicrobial management of sepsis. Crit Care 2021;25(1):307
• Imran. Acute Reperfusion Therapies for Acute Ischemic Stroke. J Clin Med 2021;10(16):3677
• Singh. Acute Kidney Injury in Cardiogenic Shock: An Updated Narrative Review. J Cardiovasc Dev Dis 2021;8(8):88
• Donovan. Adjunctive treatments for the management of septic shock – a narrative review of the current evidence. Anaesthesia 2021;76(9):1245-1258
• Kang. Bacteria and Sepsis: Microbiome to the Rescue? J Clin Med 2021;10(16):3578
• Massoth. Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury. J Clin Med 2021;10(16):3664
• Afonso. Combination Therapy for Neuropathic Pain: A Review of Recent Evidence. J Clin Med 2021;10(16):3533
• Cadamuro. Rise of the Machines: The Inevitable Evolution of Medicine and Medical Laboratories Intertwining with Artificial Intelligence—A Narrative Review. Diagnostics 2021;11(8):1399
• Lavalle. Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives. J Clin Med 2021;10(16):3696
• Sousa. Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials. Antibiotics 2021;10(8):942
• Yoon. MALDI-TOF Mass Spectrometry Technology as a Tool for the Rapid Diagnosis of Antimicrobial Resistance in Bacteria. Antibiotics 2021;10(8):982
• Jorgensen. Tocilizumab for COVID-19 in pregnancy and lactation: a narrative review. Clin Microbiol Infect 2021;epublished August 23rd
• Lara-Prado. Acute Kidney Injury and Organ Dysfunction: What Is the Role of Uremic Toxins? Toxins 2021;13(8):551

Thursday 26th

Case Reports

• Camargo-Martinez. Giant Inverse T-wave in a Patient with COVID-19. J Transl Crit Care Med 2021;3:3
• Colbenson. 61-Year-Old Man With Shortness of Breath and Cough. Mayo Clin Proc 2021;96(8):2243-2247
• Mohan. 45-Year-Old Woman With Fever and Malaise. Mayo Clin Proc 2021;96(8):2248-2253
• Warczytowa. 80-Year-Old Man With Orthopnea, Dyspnea, and Hemoptysis. Mayo Clin Proc 2021;96(8):2254-2259
• Tsukui. Multiple Renal Microaneurysms in Polyarteritis Nodosa. Mayo Clin Proc 2021;96(8):2277-2278
• Durer. Adult-onset ornithine transcarbamylase deficiency as a rare cause of fatal hyperammonaemia. Lancet 2021;398(10302):e11

Correspondence

• Smith. Pre-oxygenation using high-flow nasal oxygen vs. tight facemask during rapid sequence induction. Anaesthesia 2021;76(9):1274-1274
  • Reply:  Sjöblom. Pre-oxygenation using high-flow nasal oxygen vs. tight facemask during rapid sequence induction: a reply. Anaesthesia 2021;76(9):1275-1275
• Loo. Pre-oxygenation using high-flow nasal oxygen vs. tight facemask during rapid sequence induction: What is really being compared? Anaesthesia 2021;76(9):1276-1277
  • Reply:  Sjöblom. Pre-oxygenation using high-flow nasal oxygen vs. tight facemask during rapid sequence induction: a reply. Anaesthesia 2021;76(9):1277-1278

Wednesday 25th

Commentaries

• Barracca. Evolution of Clinical Medicine: From Expert Opinion to Artificial Intelligence. J Transl Crit Care Med 2020;2:78-82
• Barbash. Fostering Hospital Resilience—Lessons From COVID-19. JAMA 2021;326(8):693-694
• Kapłon-Cieślicka. Do we need a definition of acute heart failure with preserved ejection fraction? Ann Med 2021;53(1):1470-1475
• Anonymous. Understanding long COVID: a modern medical challenge. Lancet 2021;398(10302):275
• Barbash. Fostering Hospital Resilience—Lessons From COVID-19. JAMA 2021;326(8):693-694
• Detsky. COVID-19 in Canada. Experience and Response to Waves 2 and 3. JAMA 2021;epublished August 23rd
• Pan. It is time to update the ARDS definition: It starts with COVID-19-induced respiratory failure. J Intensive Med 2021;epublished August 23rd

Tuesday 24th

Narrative Reviews

Clinical

• Chen. Autoimmune Encephalitis–Related Seizures and Epilepsy: Diagnostic and Therapeutic Approaches. Mayo Clin Proc 2021;96(8):2029-2039
• Khanna. My Treatment Approach to Clostridioides difficile Infection. Mayo Clin Proc 2021;96(8):2192-2204
• Dobler. Users’ Guide to Medical Decision Analysis. Mayo Clin Proc 2021;96(8):2205-2217
• Ganesh. Perioperative Cardiac Risk Reduction in Noncardiac Surgery. Mayo Clin Proc 2021;96(8):2260-2276

Monday 23rd

Narrative Reviews

Clinical

• Wang. Peptide-Based Enteral Nutrition for Critically Ill Patients. J Transl Crit Care Med 2021;3:2
• Hu. The Doctors in ICU Need to Know the Basics of Coagulopathy. J Transl Crit Care Med 2020;2:69-77
• Lu. Recent Advances of MicroRNA in Sepsis-associated Acute Lung Injury. J Transl Crit Care Med 2021;3:1
• Dalton. Cardiopulmonary Resuscitation and Rescue Therapies. Crit Care Med 2021;49(9):1375-1388
• Misak. Patient and Family Engagement in Critical Illness. Crit Care Med 2021;49(9):1389-1401
• Marshall. The Multiple Organ Dysfunction Syndrome: Syndrome, Metaphor, and Unsolved Clinical Challenge. Crit Care Med 2021;49(9):1402-1413

Sunday 22nd

Research

Randomised Controlled Trials

• Dat. Effectiveness of continuous endotracheal cuff pressure control for the prevention of ventilator associated respiratory infections: an open-label randomised, controlled trial. Clin Infect Dis 2021;epublished August 22nd
• Datta. Effectiveness of enteral ivabradine for heart rate control in septic shock: A randomised controlled trial. Anaesth Intensive Care 2021;epublished August 18th

Systematic Reviews & Meta Analyses

• Kyo. Patient–ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis. J Intensive Care 2021;9:50
• Chilkoti. Awake Prone Positioning in the Management of COVID-19 Pneumonia: A Systematic Review. Indian J Crit Care Med 2021; 25 (8):896-905
• Somagutta. The Efficacy of vitamin C, thiamine, and corticosteroid therapy in adult sepsis patients: a systematic review and meta-analysis. Acute Crit Care 2021;epublished June 30th

Protocols

• Rozemeijer. Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial. Trials 2021;22:546
• Hodgson. The SHINE trial (a multicentre, randomised trial of stabilisation with nasal high flow during neonatal endotracheal intubation): statistical analysis plan. Trials 2021;22:565
• Balachandran. Postoperative 20% albumin vs standard care and acute kidney injury after high-risk cardiac surgery (ALBICS): study protocol for a randomised trial. Trials 2021;22:558 
• Brede. REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical multicentre trial. Trials 2021;22:511

Narrative Reviews

Clinical

• Krakowski. Persistent Pain After Cardiac Surgery: Prevention and Management. SDem Cardiothor Vasc Anesth 2021;epublished August 20th
• Prins. What is the optimal timing to perform surgical stabilization of rib fractures? J Thorac Dis 2021;13(Suppl 1):S13-S25
• Saha. Pleural abnormalities in COVID-19: a narrative review. J Thorac Dis 2021;13(7):4484-4499
• Pauley. Resilience in survivors of critical illness: A scoping review of the published literature in relation to definitions, prevalence, and relationship to clinical outcomes. JICS 2021;epublished July 27th
• Khanna. Tracheostomy in Patients with Coronavirus Disease 2019: An Overview. Turk J Anaesthesiol Reanim 2021;49:273-277

Saturday 21st

Commentaries

• Moran. Persistent SARS-CoV-2 infection: the urgent need for access to treatment and trials. Lancet Infect Dis 2021;epublished August 16th
• del Rio. Confronting the Delta Variant of SARS-CoV-2, Summer 2021. JAMA 2021;epublished August 18th
• Papineni. A Pink Salwar. N Engl J Med 2021;epublished August 21st
• Scales. The Covid-19 Infodemic — Applying the Epidemiologic Model to Counter Misinformation. N Engl J Med 2021; 385:678-681
• Zuger. Preventing a Pandemic's Toll—We've Been Here Before. JAMA 2021;epublished August 19th

Editorial

• D'Silva. Oxygenation Indices in Noninvasive Ventilation: Could They Predict Mortality in COVID-19? Indian J Crit Care Med 2021;25(8):841–842
• Willows. CONFIRMing Hepatorenal Syndrome Management: #NephJC Editorial. Kid Med 2021;epublished August 19th

Correspondence

• Lange. Breakthrough Infections in BNT162b2-Vaccinated Health Care Workers. N Engl J Med 2021;epublished August 18th
• Various. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med 2021;epublished August 18th
• Verma. Myocarditis after Covid-19 mRNA Vaccination. N Engl J Med 2021;epublished August 18th
• Various. Health Care Worker Strikes and the Covid Pandemic. N Engl J Med 2021;epublished August 18th

Case Reports

• Quitadamo. Black oesophagus in an adolescent with type 2 diabetes. Lancet Diabetes Endocrinol 2021;9:638
• Vadi.  Perioperative  Implication  of  Sodium-glucose  Cotransporter-2  Inhibitor  in  a  Patient  Following Major Surgery. Indian J Crit Care Med 2021;25(8):958–959
• Elkhatib. The Use of an Interleukin-6 Inhibitor in Vasoplegic Shock from Severe Systemic Inflammatory Response Syndrome: A Case Report. Indian J Crit Care Med 2021;25(8):939–941
• Long. Postoperative Hemidiaphragmatic Paralysis and Platypnea–Orthodeoxia Syndrome. Indian J Crit Care Med 2021; 25 (8):951-953
• Mahale. Intravenous Methylene Blue as a Rescue Therapy in the Management of Refractory Hypoxia in COVID-19 ARDS Patients: A Case Series. Indian J Crit Care Med 2021; 25 (8):934-938

Friday 20th

Research

Randomised Controlled Trials

• Ehrmann. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med 2021;epublished August 20th
  • Editorial:  Weatherald. Awake prone positioning in COVID-19: is tummy time ready for prime time? Lancet Respir Med 2021;epublished August 20th
  • Audio:  Audio Interview: Bairbre McNicholas and Jie Li on awake prone positioning and COVID-19. Lancet Respir Med 2021;epublished August 20th

Guidelines & Position Statements

• Ventilatory support at home for children: A joint position paper from the Thoracic Society of Australia and New Zealand/Australasian Sleep Association. Respirology 2021;epublished August 13th
  • Editorial:  Piper. Long-term ventilatory support for children: there's no place like home. Respirology 2021;epublished August 18th
• Zhang. Adsorptive hemofiltration for sepsis management. Expert recommendations based on the Asia Pacific experience. Chinese Medical Journal 2021;epublished August 16th

Thursday 19th

Research

Systematic Reviews & Meta Analysis

• Chow. Pulmonary artery catheterization in patients with cardiogenic shock: a systematic review and meta-analysis. Can J Anesth 2021;epublished August 17th
  • Editorial:  Thiara. The pulmonary artery catheter: a solution still looking for a problem. Can J Anaesth 2021;epublished August 17th

Observational Studies

• Korley. Early Convalescent Plasma for High-Risk Outpatients with Covid-19. N Engl J Med 2021;epublished August 18th
• Tan. Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors. N Engl J Med 2021;epublished August 18th
• Brunin. Lung Recruiting Effect of Prone Positioning in Spontaneously Breathing Patients with COVID-19 Assessed by Electrical Impedance Tomography. Am J Respir Crit Care Med 2021;204(4):
• Fiest. Long-Term Outcomes in ICU Patients with Delirium: A Population-based Cohort Study. Am J Respir Crit Care Med 2021;204(4):412–420
  • Editorial:  Devlin. Long-Term Outcomes after Delirium in the ICU: Addressing Gaps in Our Knowledge. Am J Respir Crit Care Med 2021;204(4):383–385
• Churpek. Hospital-Level Variation in Death for Critically Ill Patients with COVID-19. Am J Respir Crit Care Med 2021;204(4):403–411
  
  • Editorial:  Teja. Pinpointing the Cause of Variation in Mortality in COVID-19. Am J Respir Crit Care Med 2021;204(4):381–382
• Morell. Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU. Am J Respir Crit Care Med 2021;204(4):454–461
  
  • Editorial:  Coleman. Under Pressure: The Pulmonary Vasculature and Its Role in the Pediatric Cardiac ICU. Am J Respir Crit Care Med 2021;204(4): 391–392
• Moseby-Knappe. Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest. Intensive Care Med 2021;epublished August 21st
• Wiegers. Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study. Lancet Neurol 2021;20(8):627-638
• Pickens. Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia. Am J Respir Crit Care Med 2021;epublished August 19th

Wednesday 18th

Narrative Reviews

Non-Clinical

• Hoogland. A tutorial on individualized treatment effect prediction from randomized trials with a binary endpoint. Statistics in Medicine 2021;epublished August 16th
• Iglesias. A primer on deep learning and convolutional neural networks for clinicians. Insights Imaging 2021;12:117

Pre-Clinical

• Fathizadeh. SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review. International Journal of Biological Macromolecules 2021;188:740-750
• Farooqi. An overview of SARS-COV-2 epidemiology, mutant variants, vaccines, and management strategies. Journal of Infection and Public Health 2021;epublished August 16th
• Holmes. The Origins of SARS-CoV-2: A Critical Review. Cell 2021;epublished August 18th

Tuesday 17th

Narrative Reviews

Clinical

• Stollings. Delirium in critical illness: clinical manifestations, outcomes, and management. Intensive Care Med 2021;epublished August 16th
• Suverein. Ethics of ECPR Research. Resuscitation 2021;epublished August 16th
• Adlam. Spontaneous Coronary Artery Dissection: Pitfalls of Angiographic Diagnosis and an Approach to Ambiguous Cases. J Am Coll Cardiol Intv 2021;14(16):1743–1756
• Gogry. Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in Bacteria. Front Med 2021;8:677720
• Rattay. Drug-Induced Idiosyncratic Agranulocytosis - Infrequent but Dangerous. Front. Pharmacol 2021;12:727717
• Nagarajan. Artificial intelligence in the diagnosis and management of arrhythmias. Eur Heart J 2021;ehab544
• Takia. Updated Management Protocol for Multisystem Inflammatory Syndrome in Children (MIS-C). J Trop Pediatr 2021;67(3):fmab071
• Dishong. The rebirth of the cool: a narrative review of the clinical outcomes of cold stored low titer group O whole blood recipients compared to conventional component recipients in trauma. Hematology 2021;26(1):601-611

Monday 16th

Correspondence

• Tsolaki. Driving Pressure in COVID-19 Acute Respiratory Distress Syndrome Is Associated with Respiratory Distress Duration before Intubation. Am J Respir Crit Care Med 2021;204(4):478–481
• Tandjaoui-Lambiotte. Viral Dispersion in the ICU: The Wind Effect. Am J Respir Crit Care Med 2021;204(4):488
• Hiebert. Reply to Tandjaoui-Lambiotte et al.: Viral Dispersion in the ICU: The Wind Effect. Am J Respir Crit Care Med 2021;204(4): 489
• Arina. Severe Covid-19 disease: sepsis but rarely septic shock. Br J Anaesth 2021;epublished August 16th

Sunday 15th

Guidelines & Position Statements

• Hawk. Consensus Recommendations on the Treatment of Opioid Use Disorder in the Emergency Department. Ann Emerg Med 2021;78(3):434-442
• Thoracic Anesthesia during the 2019 Novel Coronavirus Infection Pandemic: 2021 Updated Recommendations for Airway Management by the EACTAIC Thoracic Subspecialty Committee. J Cardiothorac Vasc Anesth 2021;epublished July 26th

Narrative Reviews

Clinical

• Hart. Family Presence for Critically Ill Patients During a Pandemic. Chest 2021;160(2):549-557
• Machnicki. The Usefulness of Chest CT Imaging in Patients With Suspected or Diagnosed COVID-19. A Review of Literature. Chest 2021;160(2):652-670
• Santhosh. Rapid Design and Implementation of Post-COVID-19 Clinics. Chest 2021;160(2):671-677
• Tzimenatos. Managing Diabetic Ketoacidosis in Children. Ann Emerg Med 2021;78(3):340-345
• Foti. Acute Kidney Injury and Extracorporeal Membrane Oxygenation: Review on Multiple Organ Support Options, Int J Nephrol Renovasc Dis 2021;14:321-329
• Tsonas. Ventilation management in acute respiratory failure related to COVID-19 versus ARDS from another origin - a descriptive narrative review. Expert Rev Respir Med 2021;15(8):1013-1023
• Hrdlicka. Neurological Complications of Cardiac Procedures. Semin Neurol 2021; 41(04): 398-410
• Kunkel. 2021 Update for the Diagnosis and Management of Acute Coronary Syndromes for the Perioperative Clinician. J Cardiothorac Vasc Anesth 2021;epublished July 22nd
• Milne. Neuromonitoring and Neurocognitive Outcomes in Cardiac Surgery: A Narrative Review. J Cardiothorac Vasc Anesth 2021;epublished July 20th

Editorials

• Kalagara. Point-of-Care Ultrasound (POCUS) Training for Anesthesiologists: Is it Time to Embrace and Attain Competency? J Cardiovasc Vasc Anesth 2021;epublished August 13th
• Geeraerts. Moderate hypocapnia for intracranial pressure control after traumatic brain injury: a common practice requiring further investigations. Intensive Care Med 2021;epublished August 14th
• de Boer. Enhanced recovery after surgery: The road to improve peri-operative care globally. Eur J Anaesthesiol 2021;38(9):905-907
• Kalagara. Point-of-Care Ultrasound (POCUS) Training for Anesthesiologists: Is it Time to Embrace and Attain Competency? J Cardiothorac Vasc Anesth 2021;epublished August 13th
• Kiefer. Acute Myocardial Infarction With Cardiogenic Shock: - Navigating the Invasive Options in Clinical Management. J Cardiothorac Vasc Anesth 2021;epublished July 13th

Commentaries

• Arabi. How COVID-19 will change the management of other respiratory viral infections. Intensive Care Med 2021;epublished August 11th
• Varekojis. Introducing the Advanced Practice Respiratory Therapist. Chest 2021;160(2):e157-e159
• García. Receiver operating characteristic analysis: an ally in the pandemic. J Bras Pneumol.2021;47(2):e20210139

Multimedia

Audio

• Charles Sprung and authors on end-of-life practices in ICUs globally. Lancet Respir Med 2021;epublished August 5th
• Rubin. Audio Interview: Looking Back and Looking Forward — Part 1. N Engl J Med 2021;385:e24
• Rubin. Audio Interview: Looking Back and Looking Forward — Part 2. N Engl J Med 2021; 385:e25
• Rubin. Audio Interview: Monoclonal Antibodies and Booster Shots. N Engl J Med 2021;385:e29
• Rubin. Audio Interview: Aspects of Covid-19 Immunity. N Engl J Med 2021;385:e31

Saturday 14th

Research

Randomised Controlled Trials

• Marjanovic. Continuous Pneumatic Regulation of Tracheal Cuff Pressure to Decrease Ventilator-associated Pneumonia in Trauma Patients Who Were Mechanically Ventilated. The AGATE Multicenter Randomized Controlled Study. Chest 2021;160(2):499-508
  • Editorial:  Nseir. Continuous Control of Tracheal Cuff Pressure and Ventilator-Associated Pneumonia. Beyond Agate and Feng Shui. Chest 2021;160(2):393-395
• Trepatchayakorn. Balanced Salt Solution Versus Normal Saline in Resuscitation of Pediatric Sepsis: A Randomized, Controlled Trial. Indian J Pediatr 2021;88(9):921-924

Systematic Reviews & Meta Analyses

• Fernando. Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets. Intensive Care Med 2021;epublished August 13th
• Gottlieb. Effect of Ultrashort-Acting Beta Blocker Administration on Mortality for Patients With Sepsis and Persistent Tachycardia Despite Initial Resuscitation. Ann Emerg Med 2021;78(3):381-383
• Burry. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Med 2021;epublished August 11th
• Mitaka. Incidence and mortality of COVID-19-associated pulmonary aspergillosis: A systematic review and meta-analysis. Mycoses 2021;64(9):993-1001
• Buckley. Dexmedetomidine for Facilitating Mechanical Ventilation Extubation in Difficult-to-Wean ICU Patients: Systematic Review and Meta-Analysis of Clinical Trials. J Intensive Care Med 2021;36(8):925-936

Observational Sudies

• Flannery. Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study. Crit Care 2021;25:294
• Appavu. Implementation of Multimodality Neurologic Monitoring Reporting in Pediatric Traumatic Brain Injury Management. Neurocrit Care 2021;35:3–15
  • Editorial:  Figaji, A. Complex Approaches for a Complex Organ. Neurocrit Care 2021;35:1–2
• Citerio. Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER‑TBI study. Intensive Care Med 2021;epublished July 24th
• van Veen. Occurrence and timing of withdrawal of life‑sustaining measures in traumatic brain injury patients: a CENTER‑TBI study. Intensive Care Med 2021;epublished August 5th
• Perry. Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study. Lancet 2021;epublished August 6th

Friday 13th

Correspondence

• Fazzini. Time outside for a long-term ventilated ICU patient. Intensive Care Med 2021;epublished August 10th
• Kuindersma. “L’histoire se répète”, one size does not fit all. Intensive Care Med 2021;epublished July 20th
  • Reply:  Snow. “L’histoire se répète”, one size does not fit all. Author’s reply. Intensive Care Med 2021;epublished August 6th
• Rouzé. COVID‑19‑associated invasive pulmonary aspergillosis: high incidence or difficult diagnosis? Intensive Care Med 2021;epublished August 3rd
• Various. Therapy for Multisystem Inflammatory Syndrome in Children. N Engl J Med 2021;epublished August 11th
• Confalonieri. Caution When Comparing the Impact of Corticosteroids in COVID-19. Chest 2021;160(2):e243-e244
  
  • Cano. Response. Chest 2021;160(2):e244
• Lakhal. Regulation of Tracheal Cuff Pressure. Get Connected, Stay Connected. Chest 2021;160(2):e245
  • Marjanovic. Response. Chest 2021;160(2):245-e247
• Vargas. COVID-19 in the Critically Ill. Too Risky for High-Dose Anticoagulation? Chest 2021;160(2):e249
  
  • Tacquard. Response. Chest 2021;160(2):e250

Case Reports

• Tateby. Harlequin syndrome after surgery for aortic dissection. Intensive Care Med 2021;epublished July 20th
• Chauhan. Mucormycosis after COVID-19 in a patient with diabetes. Lancet 2021;398(10301):e10
• Krieger. A 57-Year-Old Man With COVID-19 Pneumonia Who Required Venovenous Extracorporeal Life Support With a Rapidly Escalating WBC Count. Chest 2021;160(2):e189-e193
• Omballi. A 29-Year-Old Woman With Cough, Dry Eyes, Pulmonary Cysts, and Nodules. Chest 2021;160(2):195-e198
• Avdeev. A 61-Year-Old Woman With Insidious Dyspnea and Diffuse Cystic Lung Disease. Chest 2021;160(2):e199-e203
• Laurenzo. A 48-Year-Old Amateur Bodybuilder With History of Provoked DVT With Subacute Progressive Shortness of Breath. Chest 2021;160(2):e205-e208
• Homer. Progressive Dyspnea With Recurrent Pneumothoraces. Chest 2021;160(2):e209-e215
• Matyjek. Giant Intrathoracic Mass in a Young Woman With Acute Kidney Injury. Chest 2021;160(2):e217-e223
• Rogers. A 60-Year-Old Man With Dyspnea, Proximal Muscle Weakness, and Pulmonary Arterial Hypertension. Chest 2021;160(2):e225-e231
• Stassen. Ultrasound Diagnosis of Cardiac Arrest in an 81-Year-Old Postoperative Patient. Chest 2021;160(2):e233-e236
• Gao. A 51-Year-Old Man With Right Atrial Neoplasm Presenting With Syncope and Shock. Chest 2021;160(2):e237-e241
• Marsters. A 58-Year-Old Man With Episodic Hypercapnic Respiratory Failure. Chest 2021;160(2):e185-e188
• Yu. A 66-Year-Old Woman With Progressive Dyspnea and Obstructive Pneumonia. Chest 2021;160(2):e177-e180
• Saha. A 61-Year-Old Man With Influenza Pneumonia and New Onset Hemoptysis. Chest 2021;160(2):e181-e184
• Wang. Benzene poisoning presenting as status epilepticus: a case report and literature review. Ann Transl Med 2021;9(15):1263
• Kuo. Early cytomegalovirus reactivation after heart transplantation: A case report and literature review. Transplantation Reports 2021;epublished August 15th

Thursday 12th

Research

Randomised Controlled Trials

• Nakamura. High protein versus medium protein delivery under equal total energy delivery in critical care: A randomized controlled trial. Clin Nutr 2021;40(3):796-803

Systematic Reviews & Meta Analyses

• Perera. EEG Patterns and Outcomes After Hypoxic Brain Injury: A Systematic Review and Meta-analysis. Neurocrit Care 2021;August 11th
• Poon. Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care 2021;25:292
• Burry. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Med 2021;epublished August 11th

Observational Studies

• Pavord. Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis. N Engl J Med 2021;epublished August 11th
• Timsit. Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial. Crit Care 2021;25:290

Wednesday 11th

Editorials

• Sweeney. Transcriptional markers in response to hydrocortisone in sepsis in ADRENAL: a step toward precision medicine. Intensive Care Med 2021;epublished August 10th

Commentaries

• Shemies. Renal replacement therapy for critically ill patients with COVID-19-associated Acute Kidney Injury: a review of current knowledge. Ther Apher Dial 2021;epublished August 11th

Correspondence

• Jouffroy. Comparison of culture‑negative and culture‑positive sepsis or septic shock: outcomes are more influenced by the nature of the infectious agent itself than by the samples’ positivity. Crit Care 2021;25:293
• Hoechter. Letter to the editor regarding Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Crit Care 2021;25(1):285
• Fazzini. Time outside for a long-term ventilated ICU patient. Intensive Care Med 2021;epublished August 10th
• Bing. In vivo Thrombosis Imaging in Patients Recovering from COVID-19 and Pulmonary Embolism. Am J Respir Crit Care Med 2021;epublished August 10th

Tuesday 10th

Research

Randomised Controlled Trials

• Zampieri. Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill PatientsThe BaSICS Randomized Clinical Trial. JAMA 2021;epublished August 10th
• Zampieri. Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill PatientsThe BaSICS Randomized Clinical Trial. JAMA 2021;epublished August 10th
  • Editorial:  Connor. Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU? JAMA 2021;epublished August 10th

Observational Studies

• Levy. Outcomes of Patients Denied ECMO During the COVID-19 Pandemic in Greater Paris, France. Am J Respir Crit Care Med 2021;epublished August 10th
• Schuijt. Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study. Crit Care 2021;25:283
• Anstey. Intensive care doctors and nurses personal preferences for Intensive Care, as compared to the general population: a discrete choice experiment. Crit Care 2021;25:287
• Di Santo. Impact of baseline beta-blocker use on inotrope response and clinical outcomes in cardiogenic shock: a subgroup analysis of the DOREMI trial. Crit Care 2021;25:289

Monday 9th

Narrative Reviews

Clinical

• Randhawa. A Pragmatic Approach to Weaning Temporary Mechanical Circulatory Support: A State-of-the-Art Review. JACC Heart Fail 2021;epublished August 5th
• Uppal. Local anesthetics for the Nephrologist. Clin Kid J 2021;epublished July 2nd
• Schading. Improving Diagnostic Workup Following Traumatic Spinal Cord Injury: Advances in Biomarkers. Curr Neurol Neurosci Rep 2021;21:49

Sunday 8th

Research

Randomised Controlled Trial

• Taylor. Awake Prone Positioning Strategy for Nonintubated Hypoxic Patients with COVID-19: A Pilot Trial with Embedded Implementation Evaluation. Ann Am Thorac Soc 2021;18(8):1360–1368
• Lewis. Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients: A Pilot Randomised Controlled Trial. Ann Am Thorac Soc 2021;epublished July 9th

Systematic Reviews & Meta Analyses

• Santacruz. Association of cerebrospinal fluid protein biomarkers with outcomes in patients with traumatic and non-traumatic acute brain injury: systematic review of the literature. Crit Care 2021;25:278

Observational Studies

• Avidan. Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study. Lancet Respir Med 2021;epublished August 5th
• van Veen. Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study. Intensive Care Med 2021;epublished August 5th
• Costa. Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;204(3):303–311
  • Editorial:  Beitler. The Staying Power of Pressure- and Volume-limited Ventilation in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;204(3):247–249
• Monteiro. Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial. Crit Care 2021;25:271
• Kooistra. Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients. Crit Care 2021;25:281
• Boscolo. Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDS. Crit Care 2021;25:263
• Gamberini. Resuscitative endovascular occlusion of the aorta (REBOA) for refractory out of hospital cardiac arrest. An Utstein-based case series. Resuscitation 2021;165, 161-169

Saturday 7th

Narrative Reviews

Clinical

• Hsu. Hemodynamics for the Heart Failure Clinician: A State-of-the-Art Review. J Card Fail 2021;epublished August 10th
• Lara-Prado. Acute Kidney Injury and Organ Dysfunction: What Is the Role of Uremic Toxins? Toxins 2021;13:551
• van den Bosch. Breathing variability—implications for anaesthesiology and intensive care. Crit Care 2021;25:280
• Marini. Improving lung compliance by external compression of the chest wall. Crit Care 2021;25:264
• Bouajram. A Clinician’s Guide to Dosing Analgesics, Anticonvulsants, and Psychotropic Medications in Continuous Renal Replacement Therapy. Kidney Int Rep 2021;6(8):2033-2048
• Rea. Out of hospital cardiac arrest: Past, present, and future. Resuscitation 2021;165:101-109
• The Society of Critical Care Medicine at 50 Years. Interprofessional Practice in Critical Care - Looking Back and Forging Ahead. Crit Care Med 2021;epublished August 14th
• Dimopoulos. COVID-19-associated pulmonary aspergillosis (CAPA). J Intensive Med 2021;epublished August 7th
• Allen. Multi-Organ Dysfunction in Cerebral Palsy. Front Pediatr 2021;9:668544
• Kaushal. Tips and Pearls for Tracheostomy during the Covid-19 Pandemic. Int Arch Otorhinolaryngol 2021;25(3):e459-e462
• Conti. Evidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap. Drug Des Devel Ther 2021;15:3391-3409

Commentaries

• Taccone. Targeted temperature management and cardiac arrest after the TTM-2 study. Crit Care 2021;25:275
• Lynch. Ignoring Nurses: Media Coverage during the COVID-19 Pandemic. Ann Am Thorac Soc 2021;18(8):1278–1282
• Oxman. The Crisis in Crisis Standards of Care. Ann Am Thorac Soc 2021;18(8):1283–1284
• Brown. What Does "ARDS" Mean during the COVID-19 Pandemic? Ann Am Thorac Soc 2021;epublished July 21st

Friday 6th

Correspondence

• Rouzé. COVID-19-associated invasive pulmonary aspergillosis: high incidence or difficult diagnosis?. Intensive Care Med 2021;epublished August 3rd
• Johnson. Patient-directed Prone Positioning in Awake Patients with COVID-19 Requiring Hospitalization (PAPR). Ann Am Thorac Soc 2021;18(8):1423-1426
• Rosén. Letter to the Editor in response to “Find the real responders and improve the outcome of awake prone positioning”. Crit Care 2021;25:273
• Hofmaenner. What every intensivist should know about Tocilizumab. Crit Care 2021;25: 262
• Orlob. Never quite there? — Hyperventilation in cardiopulmonary resuscitation. Resuscitation 2021;165:138-139
• Vieillard-Baron. The difficulty in defining right ventricular failure at the bedside and its clinical significance. Ann Intensive Care 2021;11:122

Thursday 5th

Research

Randomised Controlled Trial

• Preprint:  Perkins. An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19. medRxiv 2021;epublished August 5th

Editorial

• Grigorescu. Hypothalamic-pituitary axis disorder – “the puppet master” of multiple organ dysfunction in brain-dead patients. JCCM 2021;epublished July 24th
• Guideline Production Group of the European Academy of Neurology. Guidelines should be guidelines: Time to leave the terms "consensus" and "position" for other purposes. Eur J Neurol 2021;28(8):2461-2466

Wednesday 4th

Research

Randomised Controlled Trials

• The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med 2021;epublished August 4th
• The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med 2021;epublished August 4th
  • Editorial:  Cate. Surviving Covid-19 with Heparin? N Engl J Med 2021;epublished August 4th
• Mathew. Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock. N Engl J Med 2021;385:516-525

Guidelines & Position Statements

• Chalkias. Clinical practice recommendations on the management of perioperative cardiac arrest: A report from the PERIOPCA Consortium. Crit Care 2021;25:265
• Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report – Executive Summary. Chest 2021;epublished August 2nd
• Enhancing Recruitment and Retention of Minority Populations for Clinical Research in Pulmonary, Critical Care, and Sleep Medicine: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med 2021;204(3):e26–e50

Tuesday 3rd

Research

Randomised Controlled Trials

• Blackwood. Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial (SANDWICH). JAMA 2021;326(5):401-410

Systematic Reviews & Meta Analyses

• Cammarota. Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis. Crit Care 2021;25:268

Observational Studies

• Kienzle. The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest. Am J Respir Crit Care Med 2021;epublished July 15th

Monday 2nd

Narrative Reviews

Clinical

• Shilston. Initial management of blunt and penetrating neck trauma. BJA Education 2021;21(9):329-335
• Luo. Tailoring glucocorticoids in patients with severe COVID-19: a narrative review. Ann Transl Med 2021;9(15):1261
• Tilea. Critical Care Management of Decompensated Right Heart Failure in Pulmonary Arterial Hypertension Patients – An Ongoing Approach. The Journal of Critical Care Medicine 2020;7(3):170-183
• Tilinca. The Pathophysiology and Management of Diabetic Ketoacidosis in COVID-19 Patients: A Literature Review. The Journal of Critical Care Medicine 2021;epublished July 21st
• Santini. Accuracy of Diagnostic Tests. The Journal of Critical Care Medicine 2020;7(3):241-248

Sunday 1st

Research

Randomised Controlled Trials

• Guimarães. Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med 2021;385:406-415
  • Editorial:  Stebbing. JAK Inhibitors — More Than Just Glucocorticoids. N Engl J Med 2021;385:463-465

Systematic Reviews & Meta Analyses

• Alnajada. High flow nasal oxygen for acute type two respiratory failure: a systematic review. F1000Research 2021;10:482

Observational Studies

• Bergwerk. Covid-19 Breakthrough Infections in Vaccinated Health Care Workers. N Engl J Med 2021;epublished July 28th

Case Reports

• Pitlick. EVALI: A Mimicker of COVID-19. Mayo Clin Proc 2021;5(3):682-687
• Buijser. Extracorporeal rewarming and support in severe hypothermia with cardiac arrest: a return from death. Akin. Neth J Crit Care 2021;29(4):182-184
• Bagerman. Arytenoid swelling due to inhalation frostbite injury after the recreational use of nitrous oxide. Neth J Crit Care 2021;29(4):185-187
• Hiel. Endoscopic treatment of pharmacobezoar caused by slow-release clomipramine and quetiapine overdose. Neth J Crit Care 2021;29(4):188-190
• Vos. Fatal haemolytic shock. Neth J Crit Care 2021;29(4):181
  • Answer:  Vos. Fatal haemolytic shock - Answer. Neth J Crit Care 2021;29(4):191

Audio

• Rubin. Audio Interview: Looking Back and Looking Forward — Part 1. N Engl J Med 2021;385:e24

Saturday 31st

Editorials

• Donker. Transfusion of a disillusion? Neth J Crit Care 2021;29(4):168
• Bai. Human albumin infusion strategy in liver cirrhosis: liberal or restrictive? Ann Transl Med 2021;9(14):1114

Commentaries

• Becker. Identifying and Tracking SARS-CoV-2 Variants — A Challenge and an Opportunity. N Engl J Med 2021;385:389-391

Correspondence

• Galazzi. Pain in Intensive Care Unit: Italian critical care nurses’ best practice. Minerva Anestesiologica 2021;87(7):839-40
• Liu. BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants. N Engl J Med 2021; 385:472-474
• Shrotri. Spike-antibody waning after second dose of BNT162b2 or ChAdOx1. Lancet 2021;398(10298):385-387

Friday 30th

Narrative Reviews

Clinical

• Mucha. Update to coagulopathy in COVID-19: Manifestations and management. Cleve Clin J Medicine 2021;epublished June 2nd
• Crook. Long covid—mechanisms, risk factors, and management. BMJ 2021;374:n1648
• Gijtenbeek. POCUS series: ultrasound during cardiopulmonary resuscitation. Neth J Crit Care 2021;29(4):170-175

Annals of Translational Medicine Series on Trauma

• Jamal. Emerging approaches to pre-hospital hemorrhage control: a narrative review. Ann Transl Med 2021;9(14):1192
• Brown. Acute traumatic injury of the aorta: presentation, diagnosis, and treatment. Ann Transl Med 2021;9(14):1193
• Cretcher. Splenic trauma: endovascular treatment approach. Ann Transl Med 2021;9(14):1194
• Roberts. Hepatic trauma. Ann Transl Med 2021;9(14):1195
• Weir. Endovascular management of pelvic trauma. Ann Transl Med 2021;9(14):1196
• Khurana. Endovascular interventions in the management of acute extremity trauma: a narrative review. Ann Transl Med 2021;9(14):1197
• Smith. Endovascular embolization in renal trauma: a narrative review. Ann Transl Med 2021;9(14):1198
• Smith. Narrative review of vascular iatrogenic trauma and endovascular treatment. Ann Transl Med 2021;9(14):1199

Thursday 29th

Research

Randomised Controlled Trials

• Saka. Comparison of arterial blood pressure and cardiac index-based hemodynamic management on cognitive function in elderly patients undergoing spinal surgery: a randomized clinical trial. Minerva Anestesiologica 2021;87(7):757-65
  • Editorial:  Kletecka. Improving postoperative neurocognitive recovery: is flow the key? Minerva Anestesiologica 2021;87(7):747-9

Systematic Reviews & Meta Analyses

• Malekahmadi. Effect of enteral immunomodulatory nutrition formula on mortality and critical care parameters in critically ill patients: A systematic review with meta-analysis. Nurs Crit Care 2021;epublished July 29th

Observational Study

• Boots. Temperature rhythms and ICU sleep: the TRIS study. Minerva Anestesiologica 2021;87(7):794-802
  • Editorial:  Rasulo. Alterations of circadian rhythms in critically ill patients: can we sleep on it? Minerva Anestesiologica 2021;87(7):750-1

Narrative Reviews

Clinical

• Pesonen. Acute kidney injury after brain injury: does it exist? Minerva Anestesiologica 2021;87(7):823-7
• Marinangeli. Chronic pain and COVID-19: pathophysiological, clinical and organizational issues. Minerva Anestesiologica 2021;87(7):828-32

Editorials

• Spinelli. Why improved PF ratio should not be our target when treating ARDS. Minerva Anestesiologica 2021;87(7):752-4
• Pasero. Artificial intelligence and perioperative medicine. Minerva Anestesiologica 2021;87(7):755-6

Wednesday 28th

Editorial

• Kane. The 7th UK National Audit Project (NAP7). The challenges of defining, studying and learning from peri-operative cardiac arrest. Anaesthesia 2021;76(8):1026-1030

Commentaries

• Kang. Using Updated PubMed: New Features and Functions to Enhance Literature Searches. JAMA 2021;eublished July 26th

Correspondence

• de Tymowski. Ketamine-induced cholangiopathy in ARDS patients. Intensive Care Med 2021;epublished July 27th
• Kuindersma. “L’histoire se répète”, one size does not fit all. Intensive Care Med 2021;July 20th
• Prattes. Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry . Intensive Care Med 2021;epublished July 16th

Tuesday 27th

Research

Randomised Controlled Trials

• Kosiborod. Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2021;epublished July 21st
• Halbmeijer. Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years’ Corrected AgeFollow-up of a Randomized Clinical Trial. JAMA 2021;326(4):355-357
• Diaper. Goal-directed hemodynamic therapy versus restrictive normovolemic therapy in major open abdominal surgery: A randomized controlled trial. Surgery 2021;169(5):1164-1174

Systematic Reviews & Meta Analyses

• Johansen. Use of hydroxyethyl starch in sepsis research: A systematic review with meta-analysis. Acta Anaesthesiol Scand 2021;epublished July 26th
• Rashid. Efficacy and Safety of Corticosteroids in Acute Respiratory Distress Syndrome: An overview of Meta-analyses. Int J Clin Pract 2021;epublished July 26th

Observational Studies

• Zufferey. Pharmacokinetics of enoxaparin in COVID-19 critically ill patients. Thromb Res 2021;205:120-127
• Citerio. Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study. Intensive Care Med 2021;epublished July 24th
• Cournoyer. Electrical rhythm degeneration in adults with out-of-hospital cardiac arrest according to the no-flow and bystander low-flow time. Resuscitation 2021;epublished July 26th

Protocol

• Mølgaard Nielsen. Handling oxygenation targets in ICU patients with COVID-19 - protocol and statistical analysis plan in the HOT-COVID trial. Acta Anaesthesiol Scand 2021;epublished July 26th

Monday 26th

Narrative Reviews

Clinical

• Lidington. Cerebral Autoregulation in Subarachnoid Hemorrhage. Front Neurol 2021;12:688362
• Huang. Advances in medical imaging to evaluate acute respiratory distress syndrome. Chin J Acad Radiol 2021;epublished July 17th
• Matar. Extracorporeal Liver Support: A Bridge to Somewhere. Clin Liver Dis 2021;epublished July 22nd
• Acharya. Acute Liver Failure: Indian Perspective. Clin Liver Dis 2021;epublished July 22nd

Sunday 25th

Research

Randomised Controlled Trials

• Preprint:  The COVID STEROID 2 trial investigators. Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial. MedRxiv 2021;epublished July 24th
• Dadam. The Effect of Reconnection to Mechanical Ventilation for 1 Hour After Spontaneous Breathing Trial on Reintubation Among Patients Ventilated for More Than 12 Hours. A Randomized Clinical Trial. Chest 2021;160(1):148-156
  • Editorial:  Fernandez. Opening New Paths Toward Successful Weaning. Chest 2021;160(1):11-12
• Fuest. Comparison of volume-controlled, pressure-controlled, and chest compression-induced ventilation during cardiopulmonary resuscitation with an automated mechanical chest compression device: a randomized clinical pilot study. Resuscitation 2021;epublished July 21st

Systematic Reviews & Meta Analyses

• Honarmand. Clinical Trials in COVID-19 Management & Prevention: A Meta-epidemiological Study examining. J Clin Epi 2021;epublished July 14th
• Jawaid. Efficacy and safety of N-acetylcysteine for the treatment of non-acetaminophen-induced acute liver failure: an updated systematic review and meta-analysis. Clin Exp Hepatol 2021;7(2):156-164

Observational Studies

• Warner. Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis. Anesthesiology 2021;135:284–291
• Wong. Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study. Anesthesiology 2021;135:292–303
• Tsareva. Inhaled iloprost improves gas exchange in patients with COVID-19 and acute respiratory distress syndrome. Crit Care 2021;25:258
• Bernal. Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant. N Engl J Med 2021;epublished July 21st
  • Editorial:  Evans. Vaccine Effectiveness Studies in the Field. N Engl J Med 2021;epublished July 21st
• Madelaine. Prediction of Brain Death After Out-of-Hospital Cardiac Arrest. Development and Validation of the Brain Death After Cardiac Arrest Score. Chest 2021;160(1):139-147
  • Editorial:  Strobos. Predicting Death Following Out-of-Hospital Cardiac Arrest. Have We Found the Crystal Ball? Chest 2021;160(1):17-18
• Teixeira. The Burden of Mental Illness Among Survivors of Critical Care—Risk Factors and Impact on Quality of Life. A Multicenter Prospective Cohort Study. Chest 2021;160(1):157-164
  • Editorial:  Bienvenu. Prediction of Emotional Distress After Critical Illness Is Vital For Prevention. Chest 2021;160(1):9-10
• González-Gutiérrez. Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19. A 3-Month Prospective Cohort. Chest 2021;160(1):187-198
  • Editorial:  Ramani. Surviving COVID-19. A Burden Yet to Come? Chest 2021;160(1):15-16
• Prest. Current Trends in Sepsis-Related Mortality in the United States. Crit Care Med 2021;49(8):1276-1284
  • Editorial:  Plopper. Disparities in Sepsis Outcomes May Be Attributable to Access to Care. Crit Care Med 2021;49(8):1358-1360
• Lawler. The Range of Cardiogenic Shock Survival by Clinical Stage: Data From the Critical Care Cardiology Trials Network Registry. Crit Care Med 2021;49(8):1293-1302

Guidelines & Position Statements

• Beitler. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med 2021;epublished July 23rd
• French. Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence. J Clin Epi 2021;epublished July 3rd
• Multimodality imaging of myocardial viability: an expert consensus document from the European Association of Cardiovascular Imaging (EACVI). Eur Heart J - Cardiovasc Imaging 2021;22(8):e97–e125

Case Reports

• Zink. Cerebral air embolism after flushing a radial arterial line: a case report. J Emerg Crit Care Med 2021;5:28
• Chong. Dyspnea in a 57-Year-Old Man With Recent Viral Illness. Chest 2021;160(1):e19-e24
• Ghalib. A Young Woman With Recurrent Episodes of Fever and Cough. Chest 2021;160(1):e25-e28
• Hyde. A 67-Year-Old Woman With Abdominal Pain, Paresthesia, and Rapidly Expanding Lung Nodule. Chest 2021;160(1):e29-e34
• Manion. A 34-Year-Old Man With HIV/AIDS and a Cavitary Pulmonary Lesion. Chest 2021;160(1):e35-e38
• Pasula. Spontaneous Hemoptysis in a Patient With COVID-19. Chest 2021;160(1):e39-e44
• Qin. A 12-Year-Old Girl Presenting With Recurrent Dyspnea and Pulmonary Ground-Glass Opacities. Chest 2021;160(1):e45-e50
• Saha. A 75-Year-Old Woman With Pulmonary Nodules and Dyspnea. Chest 2021;160(1):e51-e56
• Perlepe. A 72-Year-Old Woman With Multiple Pulmonary Nodules and a History of Malignancy. Chest 2021;160(1):e57-e61
• Watabe. Rare Diagnosis of a Multilobular Pulmonary Mass. Chest 2021;160(1):e63-e67
• Kattih. Intermittent Cough and Hemoptysis With Tree-in-Bud Opacities on Imaging. Chest 2021;160(1):e69-e75
• McDill. Can You Catch a Break? Thoracic Ultrasound Images for the Identification of Pleural Effusion Cause After a Fall. Chest 2021;160(1):e77-e79
• Prats. A Vaporizing Revelation. Unexplained Hemoptysis. Chest 2021;160(1):e81-e84

Audio

• Rubin. Audio Interview: The Impact of Covid-19 on Trainees and Junior Faculty. N Engl J Med 2021;385:e21

News

• Kuehn. FDA: Stop Using Medtronic’s Heartware Ventricular Assist Device. JAMA 2021;326(3):215
• Kuehn. Antibiotic Use in UK’s COVID-19 Patients Often Unnecessary. JAMA 2021;326(3):214

Saturday 24th

Editorials

• Maslove. Two Key Takeaways From a Year of Pandemic Research. Crit Care Med 2021;49(8):1223-1226

Commentaries

• Newcombe. The future of acute and emergency care. Future Healthc J 2021;8(2):e230–6
• Einav. Continuous positive airway pressure after major abdominal surgery: an independent discussion of the Prevention of Respiratory Insufficiency after Surgical Management trial. Br J Anaesth 2021;127(2):310-315
• Kavanagh. Sharing Technology and Vaccine Doses to Address Global Vaccine Inequity and End the COVID-19 Pandemic. JAMA 2021;326(3):219-220
• Krakower. To Err Is Human, to Apologize Is Hard. JAMA 2021;326(3):223-224
• Armstrong. COVID-19 and the Future of Clinical Epidemiology. J Clin Epi 2021;epublished July 17th

Correspondence

• Hick. Social Factors and Critical Care Triage: Right Intentions, Wrong Tools. Am J Respir Crit Care Med 2021;204(2):237–238
  • White. Reply to Hick and Hanfling: Social Factors and Critical Care Triage: Right Intentions, Wrong Tools. Am J Respir Crit Care Med 2021;204(2):238–239
• Honore. Higher incidence of arrhythmia in COVID-19 than in other community-acquired pneumonia: possible role of concurrent therapies. Crit Care 2021;25:259
• Sjöberg. Letter to the editor. Crit Care 2021;25:255
• Nadeem. High-Dose Prophylactic Anticoagulation in Severe COVID-19 Pneumonia. Chest 2021;160(1):e94-e95
  • Tacquard. Response. Chest 2021;160(1):e95-e96
• Myo. Oral, in place of intravenous, paracetamol as the new normal for elective cases. Anaesthesia 2021;76(8):1143-1144
• Leucht. Let us not rush back to odds ratios without a recommendation to convert them to interpretable measures. J Clin Epi 2021;134:172-173

Friday 23rd

Narrative Reviews

Clinical

• Thille. Oxygenation strategies after extubation of critically ill and postoperative patients. J Intensive Med 2021;epublished June 29th
• Drikite. Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review. Crit Care 2021;25:257
• Schou. Ethics in extracorporeal life support: a narrative review. Crit Care 2021;25:256
• Chen. Potential Adverse Effects of Dexamethasone Therapy on COVID-19 Patients: Review and Recommendations. Infect Dis Ther 2021;epublished July 22nd
• Lee. Preoperative laboratory testing in elderly patients. Curr Opin Anaesth 2021;34(4):409-414
• Kanmaniraja. Review of COVID-19, part 1: Abdominal manifestations in adults and multisystem inflammatory syndrome in children. Clin Imaging 2021;80:88-110
• Huang. Pathophysiology of Brain Injury and Neurological Outcome in Acute Respiratory Distress Syndrome: A Scoping Review of Preclinical to Clinical Studies. Neurocrit Care 2021;epublished July 23rd
• Hawchar. The Potential Role of Extracorporeal Cytokine Removal in Hemodynamic Stabilization in Hyperinflammatory Shock. Biomedicines 2021;9(7):768
• Kallet. 2020 Year in Review: Mechanical Ventilation During the First Year of the COVID-19 Pandemic. Respir Care 2021;66(8):1341-1362
• Musiał. Current Concepts of Pediatric Acute Kidney Injury-Are We Ready to Translate Them into Everyday Practice? J Clin Med 2021;10(14):3113
• Guinot. Vasopressor-Sparing Strategies in Patients with Shock: A Scoping-Review and an Evidence-Based Strategy Proposition. J Clin Med 2021;10(14):3164
• Marcucci. Vaccine-induced thrombotic thrombocytopenia: the elusive link between thrombosis and adenovirus-based SARS-CoV-2 vaccines. Intern Emerg Med 2021;16:1113–1119
• Mele. Myocarditis in COVID-19 patients: current problems. Intern Emerg Med 2021;16:1123–1129
• Al-Tawfiq. COVID-19 and mucormycosis superinfection: the perfect storm. Infection 2021;epublished July 24th
• Mart. ICU Survivorship—The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness. Crit Care Med 2021;49(8):1227-1240

Non-Clinical

• Bion. Society of Critical Care Medicine 50th Anniversary Review Series: Critical Care Education. Crit Care Med 2021;49(8):1241-1253
• Barr. The Coming of Age of Implementation Science and Research in Critical Care Medicine. Crit Care Med 2021;49(8):1254-1275
• Christensen. Effect Modifiers and Statistical Tests for Interaction in Randomized Trials. J Clin Epi 2021;134:174-177
• Bours. Tutorial: A nontechnical explanation of the counterfactual definition of effect modification and interaction. J Clin Epi 2021;134:113-124

Thursday 22nd

Research

Randomised Controlled Trials

• Caricchio. Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19. A Randomized Clinical Trial. JAMA 2021;326(3):230-239
• Li. Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial. Anesthesiology 2021;135:218–232
• Joosten. Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial. Anesthesiology 2021;135:258–272
• Ledowski. Reversal of residual neuromuscular block with neostigmine or sugammadex and postoperative pulmonary complications: a prospective, randomised, double-blind trial in high-risk older patients. Br J Anaesth 2021;127(2):316-323
• Lipcsey. Endotoxin Removal in Septic Shock with the Alteco LPS Adsorber Was Safe But Showed no Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial—the Asset Study. Shock 2020;54(2):224-231

Systematic Reviews & Meta Analyses

• Chen. Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials. J Intensive Care 2021;9:47
• Dumas. Survival in Immunocompromised Patients Ultimately Requiring Invasive Mechanical Ventilation: A Pooled Individual Patient Data Analysis. Am J Respir Crit Care Med 2021;204(2):187–196
  • Editorial:  Pikkers. Immunocompromised Patients with Acute Respiratory Failure: “Don’t Wait to Intubate”? Am J Respir Crit Care Med 2021;204(2):121–123
• Lee. The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials. Crit Care 2021;25:260

Wednesday 21st

Narrative Reviews

Clinical

• Thille. Oxygenation strategies after extubation of critically ill and postoperative patients. J Intensive Med 2021;epublished June 29th
• Drikite. Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review. Crit Care 2021;25:257
• Schou. Ethics in extracorporeal life support: a narrative review. Crit Care 2021;25:256
• Chen. Potential Adverse Effects of Dexamethasone Therapy on COVID-19 Patients: Review and Recommendations. Infect Dis Ther 2021;epublished July 22nd
• Lee. Preoperative laboratory testing in elderly patients. Curr Opin Anaesth 2021;34(4):409-414
• Kanmaniraja. Review of COVID-19, part 1: Abdominal manifestations in adults and multisystem inflammatory syndrome in children. Clin Imaging 2021;80:88-110

Tuesday 20th

Case Reports

• Edwards. Pregnancy-induced atypical haemolytic uraemic syndrome. Clin Med 2021;21(4):e403-e404
• Badu-Boateng. Artery of Percheron infarct: hiding in plain sight. Clin Med 2021;21(4):e405-e407
• Singh. Images of the month 2: A target sign in COVID-19 pneumonia. Clin Med 2021;21(4):e410-e411
• Patil. Lessons of the month 1: Cardiac tamponade: don't forget the pancreas. Clin Med 2021;21(4):e414-e416

Monday 19th

Guidelines & Position Statements

• Recommendations for Statistical Reporting in Cardiovascular Medicine. A Special Report From the American Heart Association. Circulation 2021;epublished May 25th
• Teixeira-Pinto. Of Scandals and Statistics: Improving Analytical Methods in Clinical and Health Services Research. Circulation 2021;epublished May 25th

Narrative Reviews

Clinical

• Mauri. Personalized Positive End-Expiratory Pressure and Tidal Volume in Acute Respiratory Distress Syndrome: Bedside Physiology-Based Approach. Crit Care Explor 2021;3(7):e0486
• Stefanova. Insulin therapy for the non-specialist physician. Clin Med 2021;21(4):e323-e326
• Hussain. Managing hyperglycaemia in inpatients. Clin Med 2021;21(4):e332-e336
• Yu. Awake Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: Which Clinical Issues Should Be Taken Into Consideration. Front Med 2021;8:682526

Sunday 18th

Research

Randomised Controlled Trials

• Adi. Randomized clinical trial comparing helmet continuous positive airway pressure (hCPAP) to facemask continuous positive airway pressure (fCPAP) for the treatment of acute respiratory failure in the emergency department. Am J Emerg Med 2021;49:385-392
• Rood. The Impact of Nursing Delirium Preventive Interventions in the Intensive Care Unit: A Multicenter Cluster Randomized Controlled Trial (UNDERPIN-ICU). Am J Resp Crit Care Med 2021;epublished June 25th
  • Editorial:  Slooter. Non-pharmacological Interventions in Delirium: The Law of the Handicap of a Head Start. Am J Resp Crit Care Med 2021;epublished July 7th
• Zarbock. Prevention of Cardiac Surgery–Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial. Anesth Analg 2021;133(2):292-302
• Dougan. Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19. N Engl J Med 2021;epublished July 14th
• Preprint:  Sholzberg. Heparin for Moderately Ill Patients with Covid-19 (RAPID Trial). MedRxiv 2021;epublished July 12th

Systematic Reviews & Meta Analyses

• Kleinveld. Platelet-to-red blood cell ratio and mortality in bleeding trauma patients: A systematic review and meta-analysis Transfusion 2021;61 Suppl 1:S243-S251
• Pettenuzzo. Higher versus lower positive end-expiratory pressure in patients without acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. Crit Care 2021;25:247
• Ling. Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis. Crit Care 2021;25:246
• Gracie. The Association of Preoperative Frailty and Postoperative Delirium: A Meta-analysis. Anesth Analg 2021;133(2):314-32
• Haug. Long-term sequelae of critical illness in sepsis, trauma and burns. a systematic review and meta-analysis. J Trauma Acute Care Surg 2021;epublished July 9th

Audio

• Rubin. Audio Interview: Monoclonal Antibodies and Vaccine Boosts. N Engl J Med 2021;385:e18

Saturday 17th

Narrative Reviews

Clinical

• Pelosi. Personalized mechanical ventilation in acute respiratory distress syndrome. Crit Care 2021;25:250
• Kellum. Acute kidney injury. Nat Rev Dis Primers 2021;7:52
• Chong. Comparing Central Venous Blood Gas to Arterial Blood Gas and Determining Its Utility in Critically Ill Patients: Narrative Review. Anesth Analg 2021;133(2):374-378
• van de Veerdonk. COVID-19-associated Aspergillus tracheobronchitis: the interplay between viral tropism, host defence, and fungal invasion. Lancet Respir Med 2021;9(7):795-802
• Nunes. Use of medicines for covid-19 treatment in patients with loss of kidney function: a narrative review. J Bras Nefrol 2021;43(2):254–262
• Puntillo. The Routes of Administration for Acute Postoperative Pain Medication. Pain Ther 2021;epublished July 17th
• Peres. Prediction of intensive care units length of stay: a concise review. Rev Bras Ter Intensiva 2021;33(2):183-187
• da Silva Moura. Extubation in the pediatric intensive care unit: predictive methods. An integrative literature review. Rev Bras Ter Intensiva 2021;33(2):304-311
• Batte. Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges. Int J Nephrol Renovasc Dis 2021 Jul 8;14:235-253

Non-Clinical

• Teixeira. What outcomes should be evaluated in critically ill patients? Rev Bras Ter Intensiva 2021;33(2):312–319

Editorials

• Chaney. So You Want to Write a Narrative Review Article? J Cardiothorac Vasc Anesth 2021;epublished June 18th
• Kiefer. Acute Myocardial Infarction with Cardiogenic Shock – navigating the invasive options in clinical management. J Cardiothorac Vasc Anesth 2021;epublished July 13th
• Pospishil. Contemporary Practice of Echocardiography in Transcatheter Aortic Valve Replacement. J Cardiothorac Vasc Anesth 2021;epublished July 14th

Friday 16th

Research

Observational Studies

• Diaz. Extracorporeal Membrane Oxygenation for COVID-19–associated Severe Acute Respiratory Distress Syndrome in Chile: A Nationwide Incidence and Cohort Study. Am J Respir Crit Care Med 2021;204(1):34–43
  • Editorial:  de Chambrun. Appraising the Real-Life Need for Extracorporeal Membrane Oxygenation during the COVID-19 Pandemic. Am J Respir Crit Care Med 2021;204(1):2–4
• Ray. Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. Lancet Child Adolesc Health 2021;epublished July 14th
  • Editorial:   Dale. Neuroinflammation triggered by SARS-CoV-2 infection: syndromes and therapies. Lancet Child Adolesc Health 2021;epublished July 14th
• Ma. Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen. Crit Care 2021;25:243
• Wu. 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study. Lancet Respir Med 2021;9(7):747-754
• de Freitas. Resuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS. Rev Bras Ter Intensiva 2021;33(2):206-218
• Wang. Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection. Nature 2021;595:426–431

Guidelines & Position Statements

• Holcomb. Civilian walking blood bank emergency preparedness plan. Transfusion 2021;61 Suppl 1:S313-S325
• Shackelford. Joint Trauma System, Defense Committee on Trauma, and Armed Services Blood Program consensus statement on whole blood. Transfusion 2021;61 Suppl 1:S333-S335

Thursday 15th

Correspondence

• Horn. Prognostication in postanoxic coma: not too early, not too late. Resuscitation 2021;epublished July 13th
  • Nolan. Reply to: Prognostication in postanoxic coma: Not too early, not too late. Resuscitation 2021;epublished July 13th
• Amin-Chowdhury. Causation or confounding: why controls are critical for characterizing long COVID. Nat Med 2021;27:1129–1130

Case Reports

• Moses. Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria. N Engl J Med 2021; 385:217-227
• Garg. Triple whammy! Steroids, strongyloidiasis and septic meningitis. Ann Indian Acad Neurol 2021;24:461-3
• Alves da Silva, Neurological dysfunction associated with COVID-19. Rev Bras Ter Intensiva 2021;33(2):325-325
• Guedri. A rare cause of cyanosis: Congenital methemoglobinemia. Clin Case Rep 2021;9(7):e04422
• Bae. Coombs-negative hemolytic anemia in a male with COVID-19. Clin Case Rep 2021;9(7):e04503

Wednesday 14th

Commentaries

• Parotto. Recovery after prolonged ICU treatment in patients with COVID-19. Lancet Respir Med 2021;epublished July 14th
• Venkatesan. Repurposing drugs for treatment of COVID-19. Lancet Respir Med 2021;9(7):e63

Tuesday 13th

Narrative Reviews

Clinical

• Khateeb. Emerging SARS-CoV-2 variants of concern and potential intervention approaches. Crit Care 2021;25:244
• Chandarana. Myoclonus- A review. Ann Indian Acad Neurol 2021;24:327-38
• Khan. Precision Medicine and Heterogeneity of Treatment Effect in Therapies for Acute Respiratory Distress Syndrome. Chest 2021;epublished July 13th
• Pati. Treating the endotheliopathy of SARS-CoV-2 infection with plasma: Lessons learned from optimized trauma resuscitation with blood products.  Transfusion 2021;61 Suppl 1:S336-S347
• Wang. The Role of Pulmonary Surfactants in the Treatment of Acute Respiratory Distress Syndrome in COVID-19. Front Pharmacol 2021;12:698905

Monday 12th

Research

Randomised Controlled Trials

• Arabi. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med 2021;epublished July 12th

Systematic Reviews & Meta Analyses

• Gomez. Transcranial Doppler Based Cerebrovascular Reactivity Indices in Adult Traumatic Brain Injury: A Scoping Review of Associations With Patient Oriented Outcomes. Front Pharmacol 2021;epublished July 6th

Observational Studies

• Wozniak. Mental health outcomes of ICU and non-ICU healthcare workers during the COVID-19 outbreak: a cross-sectional study. Ann Intensive Care 2021;11:106

Sunday 11th

Research

Randomised Controlled Trials

• Chapple. Use of a High-Protein Enteral Nutrition Formula to Increase Protein Delivery to Critically Ill Patients: A Randomized, Blinded, Parallel-Group, Feasibility Trial. JPEN J Parenter Enteral Nutr 2021;45(4):699-709

Systematic Reviews & Meta Analyses

• Shenoy. SARS-CoV-2 (COVID-19), viral load and clinical outcomes; lessons learned one year into the pandemic: A systematic review. World J Crit Care Med 2021;10(4):132-150

Observational Studies

• Schmidt. Tracheostomy management in patients with severe acute respiratory distress syndrome receiving extracorporeal membrane oxygenation: an International Multicenter Retrospective Study. Crit Care 2021;25:238
• Chapple. Effects of Standard vs Energy-Dense Formulae on Gastric Retention, Energy Delivery, and Glycemia in Critically Ill Patients. JPEN J Parenter Enteral Nutr 2021;45(4):710-719

Protocols

• Francois. Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trialBMJ Open 2021;11:e042921

Guidelines

• Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1-Preoperative: Diagnosis, Rapid Assessment and Optimization. World J Surg 2021;45(5):1272-1290
• Yoshiji. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol 2021;epublished July 7th

Narrative Reviews

Clinical

• Edlow. Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions. Neurocrit Care 2021;35(Suppl 1):68-85
• Claassen. Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocrit Care 2021;35(Suppl 1):4–23
• Luppi. Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science. Neurocrit Care 2021;35:37–54
• Cavka. Diaphragm Pacing and a Model for Respiratory Rehabilitation After Spinal Cord Injury. J Neurol Phys Ther 2021;45(3):235-242
• Chen. Heparin beyond anti-coagulation. Curr Res Transl Med 2021;69(4):103300
• Mahalaxmi. Mucormycosis: An opportunistic pathogen during COVID-19. Environ Res 2021;epublished July 6th
• Farshidfar. Cardiovascular complications of COVID-19. JCI Insight 2021;6(13):e148980

Pre-Clinical

• Yang. The signal pathways and treatment of cytokine storm in COVID-19. Sig Transduct Target Ther 2021;6:255

Commentaries

• Kofman. Potential COVID-19 Endgame Scenarios. Eradication, Elimination, Cohabitation, or Conflagration? JAMA 2021;epublished July 8th
• Hays Shapshak, A. Religious Perspectives on Death by Neurological Criteria: The Role of the Hospital Chaplain. Neurocrit Care 2021;epublished June 30th

Correspondence

• Pramesh. Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians. Nat Med 2021;epublished July 5th
• Calisher. Science, not speculation, is essential to determine how SARS-CoV-2 reached humans. Lancet 2021;epublished July 5th
• Rochwerg. WHO COVID-19 therapeutic guidelines. Lancet 2021;398(10295):117
  • White. WHO COVID-19 therapeutic guidelines – Authors' reply. Lancet 2021;398(10295):117-118
• Patriquin. Therapeutic Plasma Exchange in Vaccine-Induced Immune Thrombotic Thrombocytopenia. N Engl J Med 2021;epublished July 7th

Saturday 10th

Guidelines & Position Statements

• Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 2021;18(7):1087–1097
• Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association. Circulation 2021;epublished July 7th
• Arslan. 2020 ESC Guidelines on acute coronary syndrome without ST-segment elevation. Recommendations and critical appraisal from the Dutch ACS and Interventional Cardiology working groups. Netherlands Heart Journal 2021;epublished July 7th

Commentaries

• Diehl. When could airway plateau pressure above 30 cmH2O be acceptable in ARDS patients?. Intensive Care Med 2021;epublished July 8th
• Reintam Blaser. The gut in COVID-19. Intensive Care Med 2021;epublished July 8th

Editorials

• Hauw-Berlemont. Gender imbalance in intensive care: High time for action and evaluation!. Crit Care 2021;25:239

Correspondence

• Kurtz. SAPS-3 performance for hospital mortality prediction in 30,571 patients with COVID-19 admitted to ICUs in Brazil. Intensive Care Med 2021;epublished July 10th
• Levy. Not All Breaths That Follow a Ventilator Cycle Are Reverse Triggering. Ann Am Thorac Soc 2021;18(7):1263-1264
• Shimatani. Reply: Not All Breaths That Follow a Ventilator Cycle Are Reverse Triggering. Ann Am Thorac Soc 2021;18(7):1264

Case Reports

• Hayon. Skin-to-skin care with sedated and ventilated mother. Intensive Care Med 2021;epublished July 5th
• Oulego-Erroz. Diagnosis of spontaneous intestinal perforation using point of care ultrasound. Intensive Care Med 2021;epublished July 9th
• Viskin. Long QT Syndrome and Torsade de Pointes Ultimately Treated With Quinidine: Introducing the Concept of Pseudo–Torsade de Pointes. Circulation 2021;144(1):85–89

Friday 9th

Narrative Reviews

Clinical

• Barbosa-Silva. Infectious disease-associated encephalopathies. Crit Care 2021;25:236
• Swenson. The Pathophysiology and Dangers of Silent Hypoxemia in COVID-19 Lung Injury. Ann Am Thorac Soc 2021;18(7):1098–1105
• Vassiliou. Glucocorticoid and mineralocorticoid receptor expression in critical illness: A narrative review. World J Crit Care Med 2021;10(4):102-111
• Pravda. Sepsis: Evidence-based pathogenesis and treatment. World J Crit Care Med 2021;10(4):66-80
• Nitesh. What we learned in the past year in managing our COVID-19 patients in intensive care units?  World J Crit Care Med 2021;10(4):81-101
• Dang. Predictive modeling in neurocritical care using causal artificial intelligence. World J Crit Care Med 2021;10(4):112-119
• Chiurlo. Invasive fungal infections in patients with COVID-19: a review on pathogenesis, epidemiology, clinical features, treatment, and outcomes. New Microbiol 2021;44(2):71-83
• Shang. Contemporary narrative review of treatment options for COVID-19. Respirology 2021;epublished July 8th
• Sridhar. Pathophysiology of infection with SARS-CoV-2—What is known and what remains a mystery. Respirology 2021;epublished May 26th
• Raine. Management of Acinetobacter baumannii infection in intensive care units. Afr J Thorac Crit Care Med 2021;27(1):
• Shields. Top 10 Pearls for the Recognition, Evaluation, and Management of Maternal Sepsis. Obstet Gynecol 2021;epublished July 8th
• Leung. Therapeutics for paediatric oncological emergencies. Drugs Context 2021;10:2020-11-5

Thursday 8th

Correspondence

• Rybalko. Cytokine adsorption and ECMO in patients with COVID-19. Lancet Respir Med 2021;epublished July 6th
• Nardelli. Lancet Respir Med 2021;epublished July 6th
  • Supady. Cytokine adsorption and ECMO in patients with COVID-19 – Author's reply. Lancet Respir Med 2021;epublished July 6th
• Wang. Find the real responders and improve the outcome of awake prone positioning. Crit Care 2021;25:242

Editorial

• Hauw-Berlemont. Gender imbalance in intensive care: High time for action and evaluation!. Crit Care 2021;25:239

Wednesday 7th

Research

Randomised Controlled Trials

• Bihari. Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study. ICMx 2021;9:33
•  Pang. Lung Ultrasound–Guided Emergency Department Management of Acute Heart Failure (BLUSHED-AHF): A Randomized Controlled Pilot Trial. J Am Coll Cardiol HF 2021;epublished July 7th

Systematic Reviews & Meta Analyses

• Pavlov. Awake prone positioning in non-intubated patients with acute hypoxemic respiratory failure due to COVID-19: A systematic review of proportional outcomes comparing observational studies with and without awake prone positioning in the setting of COVID-19. Respir Care 2021;epublished July 7th

Guidelines & Position Statements

• 2021 Korean Society of Myocardial Infarction Expert Consensus Document on Revascularization for Acute Myocardial Infarction. Korean Circ J 2021;51(4):289-307
• Malin. Key summary of German national treatment guidance for hospitalized COVID-19 patients Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021). Infection 2021;epublished July 6th

Narrative Reviews

Clinical

• Grieco. Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS. Intensive Care Med 2021;epublished July 7th
• Lim. Pathophysiology of Cardiorenal Syndrome and Use of Diuretics and Ultrafiltration as Volume Control. Korean Circ J 2021;epublished May 27th
• Legrand. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol 2021;epublished July 5th
• Tsangaris. Overview of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support for the Management of Cardiogenic Shock. Front Cardiovasc Med 2021;8:686558

Editorials

• Singer. Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions. Intensive Care Med 2021;epublished July 5th
• Tognoni. Why and how do we need comprehensive international clinical epidemiology of ARDS?. Intensive Care Med 2021;epublished July 3rd

Tuesday 6th

Research

Sysematic Reviews & Meta Analyses

• The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group. Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19A Meta-analysis. JAMA 2021;epublished July 6th
  • Editorial:  Matthay. IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19. Who, When, and How? JAMA 2021;epublished July 6th

Guideline & Position Statements

• Siemieniuk. A living WHO guideline on drugs for covid-19 [Update 3]. BMJ 2020;370:m3379

Monday 5th

Narrative Reviews

Clinical

• Meyer. Acute respiratory distress syndrome. Lancet 2021;epublished July 1st
• Wang. Respiratory care for the critical patients with 2019 novel coronavirus. Respir Med 2021;186:106516
• Battaglini. Noninvasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review. Br J Anaesth 2021;epublished June 3rd
• Aoki. Computed tomography imaging of resuscitative endovascular balloon occlusion of the aorta (REBOA): pearls and pitfalls. Jpn J Radiol 2021;epublished July 3rd
• Preau. Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care 2021;11(1):104

Sunday July 4th

Research

Randomised Controlled Trials

• He. Early individualized positive end-expiratory pressure guided by electrical impedance tomography in acute respiratory distress syndrome: a randomized controlled clinical trial. Crit Care 2021;25(1):230
• Luckraz. Reduction in acute kidney injury post cardiac surgery using balanced forced diuresis: a randomized, controlled trial. Eur J Cardiothorac Surg 2021;59(3):562-569

Systematic Reviews & Meta Analyses

• Chan. Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care: A Systematic Review and Meta-Analysis of Observational Studies. Crit Care Med 2021;49(7):1159-1168
• Wang. Effect of dexmedetomidine on delirium during sedation in adult patients in intensive care units: A systematic review and meta-analysis. J Clin Anesth 2021;69:110157
• Shao. Effect of different levels of PEEP on mortality in ICU patients without acute respiratory distress syndrome: systematic review and meta-analysis with trial sequential analysis. J Crit Care 2021;epublished July 3rd
• Tang. Effectiveness and safety of adjunctive inhaled antibiotics for ventilator-associated pneumonia: A systematic review and meta-analysis of randomized controlled trials. J Crit Care 2021;65:133-139
• Yuan. Neurally adjusted ventilatory assist as a weaning mode for adults with invasive mechanical ventilation: a systematic review and meta-analysis. Crit Care 2021;25:222
• Kula. Invasive mould disease in fatal COVID-19: a systematic review of autopsies. Lancet Microbe 2021;epublished June 23rd

Observational Studies

• Rabie. Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India. Intensive Care Med 2021;epublished June 22nd
• Cohen. The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock. Intensive Care Med 2021;epublished June 29th
• Guinchard. Informed consent in critically ill adults participating to a randomized trial. Brain Behav 2021;11(2):e01965
• Mathews. Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure. Crit Care Med 2021;49(7):1026-1037
• Vera. Intubation timing as determinant of outcome in patients with acute respiratory distress syndrome by SARS-CoV-2 infection. J Crit Care 2021;65:164-169
• van Kammen. Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic. JAMA 2021;epublished July 2nd
• Fronczek. Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study. Crit Care 2021;25:231
• Pham. Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study. Eur Respir J 2021;57:2003317
• Chary. Gender disparity in critical care publications: a novel Female First Author Index. Ann Intensive Care 2021;11(1):103

Saturday July 3rd

Narrative Reviews

Clinical

• Pickkers. Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Intensive Care Med 2021;epublished July 2nd
• Schober. Neurologic Manifestations of COVID-19 in Children: Emerging Pathophysiologic Insights. Ped Crit Care Med 2021;22(7):655-661
• da Silva. Renal and cardiovascular repercussions in preeclampsia and their impact on fluid management: a literature review. Braz J Anesthesiol 2021;71(4):421-428
• Galhardo Jr. Clinical protocols for oral anticoagulant reversal during high risk of bleeding for emergency surgical and nonsurgical settings: a narrative review. Braz J Anesthesiol 2021;71(4):429-442
• Andersen. Upper Airway Assessment and Responses During Mechanically Assisted Cough. Respir Care 2021;66:1196-1213
• Saunders. 2020 Year in Review: Pharmacologic Treatments for COVID-19. Respir Care 2021;66(7):1167-1172
• Zhang. The pathogenesis and diagnosis of sepsis post burn injury. Burns Trauma 2021;9:tkaa047
• Song. Extracorporeal membrane oxygenation combined with continuous renal replacement therapy for the treatment of severe burns: current status and challenges. Burns Trauma 2021;9:tkab017

Correspondence

• Lepper. Lung transplantation for COVID-19-associated ARDS. Lancet Respir Med 2021;epublished July 2nd
• Messika. Lung transplantation for COVID-19-associated ARDS. Lancet Respir Med 2021;epublished July 2nd
  • Bharat. Lung transplantation for COVID-19-associated ARDS – Authors' reply. Lancet Respir Med 2021;epublished July 2nd
• Hutin. Refractory cardiac arrest: when timing is crucial. Lancet 2021;398(10294):22-23
  • Bartos. Refractory cardiac arrest: when timing is crucial – Authors' reply. Lancet 2021;398(10294):23-24
• Jimenez. Tranexamic acid for subarachnoid haemorrhage. Lancet 2021;398(10294):25
  • Post. Tranexamic acid for subarachnoid haemorrhage – Authors' reply. Lancet 2021;398(10294):25

Friday July 2nd

Guidelines & Position Statements

• AARC Clinical Practice Guideline: Management of Pediatric Patients With Oxygen in the Acute Care Setting. Respir Care 2021;66:1214-1223
• Verweij. Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis. Intensive Care Med 2021;epublished June 23rd
• Nunnally. The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis. Intensive Care Med Exp 2021;9(1):34
• Emergent Truncal Hemorrhage Control Study Group. Determination of optimal deployment strategy for REBOA in patients with non-compressible hemorrhage below the diaphragm. Trauma Surgery & Acute Care Open 2021;6:e000660

Commentaries

• Wilcox. Delirium in COVID-19: can we make the unknowns knowns?. Intensive Care Med 2021;epublished June 30th
• Xie. Critical care after the COVID-19 outbreak in China: lessons and renaissance. Intensive Care Med 2021;epublished June 22nd
• Bose. Placing the results of the SOLIDARITY trial with regards to remdesivir in perspective. Lung India 2021;38:382-6
• Kirby. Elisa Estenssoro: a career devoted to critical care. Lancet Respir Med 2021;epublished July 2nd

Case Reports

• Pai. Oxygen delivery failure due to improper installation of carbon dioxide absorbent canister: a case report. Braz J Anesthesiol 2021;71(4):443-446
• Veiga. Omega-shaped epiglottis: a challenge. Braz J Anesthesiol 2021;71(4):464-465
• Ramos Perkis. Challenges in acute care surgery: penetrating vertebral artery injury in ‘extremis’ patient. Trauma Surgery & Acute Care Open 2021;6:e000684

Thursday July 1st

Correspondence

• Heldeweg. Determining the optimal number of lung ultrasound zones to monitor COVID-19 patients: can we keep it ultra-short and ultra-simple?. Intensive Care Med 2021;epublished June 26th
• Meersseman. Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients. Intensive Care Med 2021;epublished June 29th
• Cour. Differential effects of prone position in COVID-19-related ARDS in low and high recruiters. Intensive Care Med 2021;epublished June 28th
• Sanfilippo. COVID-19, pneumomediastinum and echocardiography: friends or foes? Minerva Anestesiologica 2021;87(6):739-40
• Honore. Success rate of naso-jejunal tube placement influenced by CRRT: possible removal of metoclopramide. Crit Care 2021;25:228
• Jouffroy. The impact of frailty on survival in elderly intensive care patients with COVID‑19: do not dismiss intensive care unit overcrowding. Crit Care 2021;25:225

Audio

• Misleading Presentations of Clinical Trial Results with Dr Victor Montori. JAMA 2021;epublished July 1st

Wednesday 30th

Narrative Reviews

Clinical

• Smarz-Widelska. Pathophysiology and Clinical Manifestations of COVID-19-Related Acute Kidney Injury-The Current State of Knowledge and Future Perspectives. Int J Mol Sci 2021;22(13):7082
• Carteaux. Patient-Self Inflicted Lung Injury: A Practical Review. J Clin Med 2021;10(12):2738
• Brito. Prehospital resuscitation. Trauma Surgery & Acute Care Open 2021;6:e000729
• Feldhaus. The Evolution of the Use of Extracorporeal Membrane Oxygenation in Respiratory Failure. Membranes 2021;11(7):491
• Ceravolo. Update on the Classification and Pathophysiological Mechanisms of Pediatric Cardiorenal Syndromes. Children 2021;8(7):528
• Carretta. Cardiac Involvement in COVID-19 Patients: A Contemporary Review. Infect Dis Rep 2021;13(2):494-517
• Bonnemain. The Right Ventricle in COVID-19. J Clin Med 2021;10(12):2535

Tuesday 29th

Editorials

• Clohisey. Genome-wide association studies in ARDS: SNPing the tangled web of heterogeneity. Intensive Care Med 2021;epublished June 26th
• McNally. Preoperative assessment and optimisation: the key to good outcomes after the pandemic. Br J Hosp Med 2021;82(6):1-6
• Credland. Humanizing critical care. Nurs Crit Care 2021;26(4):222-223

Monday 28th

Narrative Reviews

Clinical

• Khazanova. A matter of timing: EEG monitoring for neurological prognostication after cardiac arrest in the era of targeted temperature management. Minerva Anestesiologica 2021;87(6):704-13
• Chun. Updates on neurologic complications in pediatric regional anesthesia. Minerva Anestesiologica 2021;87(6):695-703
• Pivard. Staphylococcus aureus Arsenal To Conquer the Lower Respiratory Tract. mSphere 2021;6:e00059-21

Sunday 27th

Correspondence

• Verdonk. A multifaceted approach to intensive care unit capacity. Lancet Public Health 2021;6(7):e448
• Marini. Conceptual simplicity in pursuit of precision. Intensive Care Med 2021;epublished June 16th

Case Reports

• Santos. Extrapyramidal Symptoms Induced by Treatment for Delirium: A Case Report. Crit Care Nurse 2021;41(3):50–54
• Schmidt. Extracorporeal Membrane Oxygenation instead of Invasive Mechanical Ventilation in a Patient with Severe COVID-19–associated Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;203(12):1571–1573
• Jacob. Malignant middle cerebral artery syndrome with thrombotic thrombocytopenia following vaccination against SARS-CoV-2. JICS 2021;epublished June 24th
• Brunin. Lung Recruiting Effect of Prone Positioning in Spontaneously Breathing COVID-19 Patients Assessed by Electrical Impedance Tomography. Am J Respir Crit Care Med 2021;epublished June 25th
• Barral. Thromboaspiration and fibrinolysis infusion for portomesenteric thrombosis after AstraZeneca COVID‑19 vaccine administration. Intensive Care Med 2021;epublished June 16th

Multimedia

Video

• Fauci. COVID-19 in 2021: Lessons Learned and Remaining Challenges. 131st Annual Shattuck Lecture. N Engl J Med 2021

Podcast

• Verweij. COVID-19 associated aspergillosis. Lancet Respiratory Med 2021
• Rubio. COVID-19: Pathophysiology and phenotypes. Lancet Respiratory Med 2021
• Shekar. Cytokine adsorption and severe COVID-19 pneumonia. Lancet Respiratory Med 2021

Saturday 26th

Narrative Reviews

Clinical

• Cook. Assessment and management of cardiovascular disease in the intensive care unit. Heart 2021;epublished June 24th
• Levey. Defining AKD: The Spectrum of AKI, AKD, and CKD. Nephron 2021;epublished June 24th
• Lupuşoru. Renal replacement therapy in cancer patients with acute kidney injury. Exp Ther Med 2021;22(2):864
• Paramitha. The role of continuous renal replacement therapy (Crrt) in Coronavirus disease 2019 (Covid-19) patients. Trends Anaesth Crit Care 2021;epublished June 6th

Commentaries

• Fischer. Rapid Response Teams as a Patient Safety Practice for Failure to Rescue. JAMA 2021;epublished June 24th
• Barracca. Evolution of Clinical Medicine: From Expert Opinion to Artificial Intelligence. J Transl Crit Care Med 2020;2:78-82
• Fuchs. Translation and application of guidelines into clinical practice: a colour-coded difficult airway trolley. Trends Anaesth Crit Care 2021;epublished June 27th

Friday 25th

Editorials

• Bourgault. Embrace Teamwork to Create and Maintain a Positive Workplace Culture. Crit Care Nurse 2021;41(3):8–10
• Winck. Non Invasive Respiratory Support Therapies in COVID-19 Related Acute Respiratory Failure: Looking at the Neglected Issues. Arch Bronconeumol 2021;57(Suppl 2):9-10
• Lefrant. ICU bed capacity during COVID-19 pandemic in France: From ephemeral beds to continuous and permanent adaptation. Anaesth Crit Care Pain Med 2021;40(3):100873
• Lessells. SARS-CoV-2 variants of concern: the knowns and unknowns. Anaesth Crit Care Pain Med 2021;40(3):100868
• Sofonea. Two waves and a high tide: the COVID-19 epidemic in France. Anaesth Crit Care Pain Med 2021;40(3):100881
• Rello. Post-acute COVID-19 Syndrome (PACS): A public health emergency. Anaesth Crit Care Pain Med 2021;40(3):100882

Thursday 24th

Guidelines & Position Statements

• Recommendations From the Professional Advisory Committee on Nursing Practice in the Care of ECMO–Supported Patients. Crit Care Nurse 2021;41(3):e1–e8
• South African guidelines on the determination of death. South Afr J Crit Care 2021;37(1b):41-54
• Orkin. Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating CircumstancesThe CONSERVE 2021 Statement. JAMA 2021;epublished June 21st
• Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults. Clin Infect Dis 2021;epublished June 24th
• Goodloe. Interim Guidance for Emergency Medical Services Management of Out-of-Hospital Cardiac Arrest During the COVID-19 Pandemic. Circ Cardiovasc Qual Outcomes 2021;epublished June 23rd

Wednesday 23rd

Research

Randomised Controlled Trials

• Rood. The Impact of Nursing Delirium Preventive Interventions in the Intensive Care Unit: A Multicenter Cluster Randomized Controlled Trial. Am J Respir Crit Care Med 2021;epublished June 17th
• The REMAP-CAP Investigators. Effectiveness of Tocilizumab, Sarilumab, and Anakinra for critically ill patients with COVID-19 The REMAP-CAP COVID-19 Immune Modulation Therapy Domain Randomized Clinical Trial. MedRxiv 2021.06.18.21259133
• The REMAP-CAP Investigators. Convalescent Plasma in Critically ill Patients with Covid-19. MedRxiv 2021.06.11.21258760
• Horby. Casirivimab and imdevimab in patients admitted to hospital with covid-19 (RECOVERY): a randomised, controlled, open-label, platform trial. MedRxiv 2021.06.15.21258542v1
• RECOVERY Collaborative Group. Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. MedRxiv 2021.06.08.21258132

Systematic Reviews & Meta Analyses

• Mowbray. Prognostic Association of Frailty with Post-Arrest Outcomes Following Cardiac Arrest: A Systematic Review and Meta-Analysis. Resuscitation 2021;epublished June 21st
• Feng. The Relationship Between Perioperative Regional Cerebral Oxygen Saturation and Postoperative Cognitive Dysfunction: A Systematic Review and Meta-Analysis. J Transl Crit Care Med 2020;2:83-9
• Richards. Clinical benefits of prone positioning in the treatment of non-intubated patients with acute hypoxic respiratory failure: a rapid systematic review. Emerg Med J 2021;epublished June 23rd

Observational Studies

• Zachary. Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study. J Trauma Acute Care Surg 2021;91(1):24-33
• Heijnen. Biological Subphenotypes of Acute Respiratory Distress Syndrome Show Prognostic Enrichment in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2021;203(12):1503–1511
  • Editorial:  Reddy. Acute Respiratory Distress Syndrome Subphenotypes beyond the Syndrome: A Step toward Treatable Traits?. Am J Respir Crit Care Med 2021;203(12):1449–1451
• Geense. New Physical, Mental, and Cognitive Problems 1 Year after ICU Admission: A Prospective Multicenter Study. Am J Respir Crit Care Med 2021;203(12):1512–1521
  • Editorial:  Maley. The Intersection of Health and Critical Illness: Preservation and Restoration. Am J Respir Crit Care Med 2021;203(12):1451-1453

Tuesday 22nd

Narrative Reviews

Clinical

• Hu. The Doctors in ICU Need to Know the Basics of Coagulopathy. J Transl Crit Care Med 2020;2:69-77
• Chotirmall. Update in COVID-19 2020. Am J Respir Crit Care Med 2021;203(12):1462–1471
• Page. Sedation in the Intensive Care Unit. Curr Anesthesiol Rep 2021;11:92–100

Monday 21st

Narrative Reviews

Clinical

• Kirov. Volumetric Monitoring and Extravascular Lung Water in Perioperative Setting and Critically Ill. Turk J Anaesthesiol Reanim 2021;49:201-210
• Bierle. Integrating Palliative Care Into Heart Failure Management. Crit Care Nurse 2021;41(3):e9–e18

Debate

• POINT: Is It Ethically Permissible to Unilaterally Withdraw Life-Sustaining Treatments During Crisis Standards of Care? CHEST 2021;159(6):2165–2170
  • Bishop - Yes  |  Sulmasy - No  |  Bishop - Rebuttal  |  Sulmasy - Rebuttal

Sunday 20th

Narrative Reviews

Clinical

• Ogawa. Non-invasive oxygenation strategies for respiratory failure with COVID-19: A concise narrative review of literature in pre and mid-COVID-19 era. Anaesth Crit Care Pain Med 2021;40(4):100897
• Battaglini. The Role of Dysbiosis in Critically Ill Patients With COVID-19 and Acute Respiratory Distress Syndrome. Front Med 2021;8:671714
• Nekoukar. Methanol poisoning as a new world challenge: A review. Ann Med Surg 2021;66:102445
• Sankaran. Non-invasive carbon dioxide monitoring in neonates: methods, benefits, and pitfalls. J Perinatol 2021;epublished June 19th
• Yoshikawa. Brain death and management of the potential donor. Neurol Sci 2021;epublished June 17th
• Duque-Rodríguez. The Therapeutic Use of Plasma from Covid-19 Convalescent Patients. Plasmatology 2021;epublished June 17th
• Poimenidi. Haemolysis, elevated liver enzymes and low platelets: Diagnosis and management in critical care. JICS 2021;epublished June 17th
• Hensley. Pro-Con Debate: Fibrinogen Concentrate or Cryoprecipitate for Treatment of Acquired Hypofibrinogenemia in Cardiac Surgical Patients. Anesth Analg 2021;133(1):19-28
• Peri. New Microbiological Techniques for the Diagnosis of Bacterial Infections and Sepsis in ICU Including Point of Care. Curr Infect Dis Rep 2021;23:12
• Fang. Immunothrombosis in Acute Respiratory Dysfunction of COVID-19. Front Immunol 2021;12:651545
• Perret. Emergent Pneumonia in Children. Front Pediatr 2021;9:676296
• Piani. Acute Kidney Injury in Pediatric Diabetic Kidney Disease. Front Pediatr 2021;9:668033

Editorials

• Frat. What is the most adequate non-invasive oxygen support for acute hypoxaemic respiratory failure due to COVID-19? Anaesth Crit Care Pain Med 2021;epublished June 19th

Commentaries

• Bein. What’s new in intensive care: environmental sustainability. Intensive Care Med 2021;epublished June 19th
• Proulx. Chrysalis. Intensive Care Med 2021;epublished June 16th
• The European Society of Intensive Care Medicine. Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?. Intensive Care Med 2021;epublished June 16th
• Betello. Oesophageal balloon positioning by echocardiography to guide positive pressure ventilation. J Clin Monit Comput 2021;epublished June 20th
• Leentjens. COVID-19-associated coagulopathy and antithrombotic agents—lessons after 1 year. Lancet Haematology 2021;8(7):e524-e533

Correspondence

• Broman. Extracorporeal membrane oxygenation for COVID-19 during first and second waves. Lancet Respir Med 2021;epublished June 16th
• Proulx. Provision of critical care in austere conditions: staff, supplies and space. Intensive Care Med 2021;epublished June 18th
• Redant. Anti-Xa activity and hemorrhagic event: isn’t it time to consider time ?. Crit Care 2021;25:210
• Teja. Pinpointing the Cause of Variation in Mortality in COVID-19. Am J Respir Crit Care Med 2021;epublished June 17th
• Thrombotic Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021;epublished June 16th
• Sklar. Always Say Never: Why Studies of Timing of Invasive Ventilation Should Compare “Early versus Late/Never” as Opposed to “Early versus Late”. Am J Respir Crit Care Med 2021;epublished June 17th
  • Dumas. Reply to: Sklar and Yarnell, and Stahl et al. Am J Respir Crit Care Med 2021;epublished June 17th
• Stahl. Staying Awake in Severe ARDS – A Perspective on Immunocompromised Patients. Am J Respir Crit Care Med 2021;epublished June 17th

Case Reports

• Leuzinger-Dias. Prone Positioning Covid-19 Patients: A Double-Edged Sword—A Case Report of a Devastating Ocular Complication. Ophthalmol Ther 2021;epublished June 19th
• Rola. Clinical applications of the venous excess ultrasound (VExUS) score: conceptual review and case series. Ultrasound J 2021;13:32
• Barral. Thromboaspiration and fibrinolysis infusion for portomesenteric thrombosis after AstraZeneca COVID-19 vaccine administration. Intensive Care Med 2021;epublished June 16th
• Hibbert. Case 18-2021: An 81-Year-Old Man with Cough, Fever, and Shortness of Breath. N Engl J Med 2021;384:2332-2340
• Zhang. Case Report: Pink Urine Syndrome Following Exposure to Propofol: A Rare, Impressive but Benign Complication. Front Pharmacol 2021;12:686619

News

• Walter. Lung Transplants for COVID-19—The Option of Last Resort. JAMA 2021;epublished June 17th

Saturday 19th

Research

Randomised Controlled Trials

• Arabi. Replacing protein via enteral nutrition in a stepwise approach in critically ill patients: A pilot randomized controlled trial (REPLENISH pilot trial). Clinical Nutrition ESPEN 2021;epublished June 2nd
• Rosén. Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial. Crit Care 2021;25:209
• Aman. Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial. Lancet Respir Med 2021;epublished June 17th
  • Commentary:  Bernal-Bello. Imatinib in COVID-19: hope and caution. Lancet Respir Med 2021;epublished June 17th
• Guimarães. Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia. N Engl J med 2021;epublished June 16th

Systematic Reviews & Meta Analyses

• Ramanathan. Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Crit Care 2021;25:211

Observational Studies

• Fukuda. Association between time to advanced airway management and neurologically favourable survival during out-of-hospital cardiac arrest. Anaesth Crit Care Pain Med 2021;epublished June 17th
• Beaubien-Souligny. Intra-dialytic hypotension following the transition from continuous to intermittent renal replacement therapy. Ann Intensive Care 2021;11(1):96
• Ye. A systemic ultrasound positioning protocol for nasointestinal tube in critically ill patients. Crit Care 2021;25:213
• Tsolaki. Driving Pressure in COVID-19 ARDS is Associated with Respiratory Distress Duration Before Intubation. Am J Respir Crit Care Med 2021;epublished June 15th

Friday 18th

Research

Randomised Controlled Trial

• PRISM trial group. Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial. Lancet Respir Med 2021;epublished June 18th

Guidelines & Position Statements

• European Society of Radiology. The role of lung ultrasound in COVID-19 disease. Insights Imaging 2021;12(1):81
• Standardizing nomenclature in regional anesthesia: an ASRA-ESRA Delphi consensus study of abdominal wall, paraspinal, and chest wall blocks. Reg Anesth Pain Med 2021;46(7):571-580
• Law. Canadian Airway Focus Group updated consensus-based recommendations for management of the difficult airway: part 1. Difficult airway management encountered in an unconscious patient. Can J Anaesth 2021;epublished June 18th
• Malhotra. Second wave of COVID-19 pandemic and the surge of mucormycosis: Lessons learnt and future preparedness: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement. Indian J Anaesth 2021;65:427-33

Thursday 17th

Narrative Reviews

Clinical

Saudi Journal of Anaesthesia Series

• Licker. The hypoxic pulmonary vasoconstriction: From physiology to clinical application in thoracic surgery. Saudi J Anaesth 2021;15:250-63
• Ellenberger. How can we minimize the risks by optimizing patient's condition shortly before thoracic surgery?. Saudi J Anaesth 2021;15:264-71
• Huybrechts. Lung separation in adult thoracic anesthesia. Saudi J Anaesth 2021;15:272-9
• Eldawlatly. Double lumen tube: Size and insertion depth. Saudi J Anaesth 2021;15:280-2
• Murray-Torres. Anesthesia for thoracic surgery in infants and children. Saudi J Anaesth 2021;15:283-99
• Khidr. Difficult lung separation. An insight into the challenges faced during COVID-19 pandemic. Saudi J Anaesth 2021;15:300-11
• Parab. Inhalational versus intravenous anesthetics during one lung ventilation in elective thoracic surgeries: A narrative review. Saudi J Anaesth 2021;15:312-23
• Licker. Restricted, optimized or liberal fluid strategy in thoracic surgery: A narrative review. Saudi J Anaesth 2021;15:324-34
• Khidr. Impact of regional analgesia techniques on the long-term clinical outcomes following thoracic surgery. Saudi J Anaesth 2021;15:335-40
• Mijatovic. Post-thoracotomy analgesia. Saudi J Anaesth 2021;15:341-7
• Senturk. Enhanced recovery after thoracic anesthesia. Saudi J Anaesth 2021;15:348-55
• Gonsette. Anesthesia for robotic thoracic surgery. Saudi J Anaesth 2021;15:356-61
• Aymerich. Non intubated video-assisted thoracoscopic lung resections (NI-VATS) in COVID times. Saudi J Anaesth 2021;15:362-7
• Khidr. Education in thoracic anesthesia. Lessons learned from the European Association of Cardiothoracic Anaesthesiology (EACTA) programs. Saudi J Anaesth 2021;15:368-74

Wednesday 16th

Research

Randomised Controlled Trials

• Dankiewicz. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2 Trial). N Engl J Med 2021;384:2283-2294

Observational Studies

• Robba. Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study. Lancet Neurology 2021;20(7):548-558
• Son. Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes. N Engl J Med 2021;epublished June 16th
• McArdle. Treatment of Multisystem Inflammatory Syndrome in Children. N Engl J Med 2021;epublished June 16th

Tuesday 15th

Guidelines & Position Statements

• Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association. Circulation 2021;epublished June 15th

Monday 14th

Research

Randomised Controlled Trials

• Rosén. Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial. Crit Care 2021;25:209
• Arabi. Replacing protein via enteral nutrition in a stepwise approach in critically ill patients: A pilot randomized controlled trial (REPLENISH pilot trial). Clinical Nutrition ESPEN 2021;epublished June 2nd

Narrative Reviews

Clinical

• Wong. Pediatric sepsis biomarkers for prognostic and predictive enrichment. Pediatr Res 2021;epublished June 14th

Sunday 13th

Narrative Reviews

Clinical

• Mitaka. Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock. Acute Crit Care 2021;36(2):85-91
• Walpot. Comprehensive assessment of the aortic valve in critically ill patients for the non-cardiologist. Part I: Aortic stenosis of the native valve. Anaesthesiol Intensive Ther 2021;53(1):37–54
• Walpot. Comprehensive assessment of the aortic valve in critically ill patients for the non-cardiologist. Part II: Chronic aortic regurgitation of the native valve. Anaesthesiol Intensive Ther 2021;53(1):55–68
• Vyas. Infrared vein visualization devices for ease of intravenous access in children: hope versus hype. Anaesthesiol Intensive Ther 2021;53(1):69–78
• Husna. Systematic review of the stability and compatibility of propofol injection. Muftihatul Anaesthesiol Intensive Ther 2021;53(1):79–88

Editorials

• Putzu. Hemoadsorption in critically ill patients with or without COVID-19: A word of caution. J Crit Care 2021;epublished June 12th
• Girnius. Cardio-Obstetrics: A Review for the Cardiac Anesthesiologist. J Cardiothorac Vasc Anesth 2021;epublished June 12th

Commentaries

• Becker. Identifying and Tracking SARS-CoV-2 Variants — A Challenge and an Opportunity. N Engl J Med 2021;epublished June 9th
• Sarkar. Humanism Before Heroism in Medicine. JAMA 2021;epublished June 10th
• Talbot. COVID-19 Vaccination of Health Care Personnel as a Condition of Employment. A Logical Addition to Institutional Safety Programs. JAMA 2021;epublished June 7th
• Squara. The Ockham’s razor for estimating the needs of ICU beds during a pandemic. Ann Intensive Care 2021;11:94

Correspondence

• Ceulemans. Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19. Lancet Respir Med 2021;epublished June 9th
• Heininger. Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. N Engl J Med 2021;epublished June 9th

Case Reports

• Guetl. SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia treated with immunoglobulin and argatroban. Lancet 2021;epublished June 11th
• Deshpande. Tension pericardial abscess in a patient with tuberculosis: a rare cause of cardiac tamponade. Lancet 2021;397(10291):e15

Multimedia

Audio

• Rubin. Audio Interview: Treating Complications of Covid Vaccination. N Engl J Med 2021;384:e107
• Schaller. ESICM Talk, episode 8: What happened to mechanically ventilated COVID-19 patients in the UK? ESICM 2021;epublished June 9th
• Myatra. Effect of the use of an endotracheal tube and stylet versus an endotracheal tube alone on first-attempt intubation success. ESICM 2021;epublished June 1st
• Halacli. Ethical Issues in the ICU. ESICM 2021;epublished May 28th
• Peters. Randomised controlled trial of oxygen therapy and high‑flow nasal therapy in African children with pneumonia. ESICM 2021;epublished May 26th

Saturday 12th

Research

Randomised Controlled Trials

• RECOVERY Collaborative Group. Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. MedRxiv 2021;epublished June 8th
• Aydın. A Novel Method for Ultrasound Guided Central Catheter Placement Supraclavicular Brachiocephalic Vein Catheterization vs Jugular Catheterization – Prospective Randomized Study. J Cardiothorac Vasc Anesth 2021;epublished June 11th
• Tholén. Effects of levosimendan on renal blood flow and glomerular filtration in patients with acute kidney injury after cardiac surgery: a double blind, randomized placebo-controlled study. Crit Care 2021;25:207
• Asehnoune. Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial. BMJ 2021;373:n1162

Systematic Reviews & Meta Analyses

• Messina. Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery. Crit Care 2021;25:205
• Brandao Barreto. Exploring family members’ and health care professionals’ perceptions on ICU diaries: a systematic review and qualitative data synthesis. Intensive Care Med 2021;epublished June 12th
• Sedhai. Effect of thiamine supplementation in critically ill patients: A systematic review and meta-analysis. J Crit Care 2021;65:104-115
• Radovanovic. Mortality and clinical outcomes in patients with COVID-19 pneumonia treated with non-invasive respiratory support: A rapid review. J Crit Care 2021;65:1-8
• Dong. Mortality of right ventricular dysfunction in patients with acute respiratory distress syndrome subjected to lung protective ventilation: A systematic review and meta-analysis. Heart Lung 2021;50(5):730-735

Observational Studies

• Bourguignon. Adjunct Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia. N Engl J Med 2021;epublished June 9th
• Scully. Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021;384:2202-2211
  • Editorial:   Cines. SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia. N Engl J Med 2021;384:2254-2256
• Dzierba. Discordance Between Respiratory Drive and Sedation Depth in Critically Ill Patients Receiving Mechanical Ventilation. Crit Care Med 2021;epublished June 9th
• Borgel. Endothelial Dysfunction as a Component of Severe Acute Respiratory Syndrome Coronavirus 2–Related Multisystem Inflammatory Syndrome in Children With Shock. Crit Care Med 2021;epublished June 1st
• Singer. Feasibility of achieving different protein targets using a hypocaloric high-protein enteral formula in critically ill patients. Crit Care 2021;25:204
• Taccone. Effect of intra-arrest trans-nasal evaporative cooling in out-of-hospital cardiac arrest: a pooled individual participant data analysis. Crit Care 2021;25:198
• Miura. Clinical impact of implementing humidified high-flow nasal cannula on interhospital transport among children admitted to a PICU with respiratory distress: a cohort study. Crit Care 2021;25:194
• Ferreira. Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study. Ann. Intensive Care 2021;11:92
• Gnesin. Rapid dispatch for out-of-hospital cardiac arrest is associated with improved survival. Resuscitation 2021;163:176-183
• Paratz. The economic impact of sudden cardiac arrest. Resuscitation 2021;163:49-56
• Stokes. Cost-effectiveness of the i-gel Supraglottic Airway Device compared to Tracheal Intubation During Out-of-Hospital Cardiac Arrest: Findings from the AIRWAYS-2 Randomised Controlled Trial. Resuscitation 2021;epublished June 10th
• Merdji. Histopathological features in fatal COVID-19 acute respiratory distress syndrome. Medicina Intensiva 2021;45(5):261-270

Friday 11th

Guidelines & Position Statements

• Bouchard. Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup. Crit Care 2021;25:201
• Schlapbach. Best Practice Recommendations for the Diagnosis and Management of Children With Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 (PIMS-TS; Multisystem Inflammatory Syndrome in Children, MIS-C) in Switzerland. Front Pediatr 2021;9:667507

Thursday 10th

Narrative Reviews

Clinical

• Goswami. A Review of Pathophysiology, Clinical Features, and Management Options of COVID-19 Associated Coagulopathy. Shock 2021;55(6):700-716
• Zeineddin. Role of Von Willebrand Factor after Injury: It May Do More Than We Think. Shock 2021;55(6):717-722
• Otto. Utstein Style for emergency care — the first 30 years. Resuscitation 2021;163:16-25
• Dodd. Evidence update for the treatment of anaphylaxis. Resuscitation 2021;163:86-96
• Valdenebro. Renal replacement therapy in critically ill patients with acute kidney injury: 2020 nephrologist's perspective. Nefrologia 2021;epublished June 8th
• François. COVID-19-Associated Pneumonia: Radiobiological Insights. Front Pharmacol 2021 May 25;12:640040
• Soetanto. Early postoperative complications in lung transplant recipients. Indian J Thorac Cardiovasc Surg. 2021;epublished June 9th
• Yu. Liver injury in COVID-19: clinical features and treatment management. Virol J 2021;18(1):121
• Wallace. Laryngeal complications after tracheal intubation and tracheostomy. BJA Education 2021;21(7):250-257

Wednesday 9th

Case Reports

• De Villiers. Intracerebral Aspergillus fumigatus abscess and SARS-CoV-2. Intensive Care Med 2021;epublished June 8th
• Ahmad. Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection. Int. J. Infect. Dis 2021;108:209-211
• Lin. Idiopathic paroxysmal atrioventricular block. Intensive Care Med 2021;epublished May 28th
• Brandao Barreto. Caring for COVID-19 patients and their relatives with the ICU diary. Intensive Care Med 2021;epublisjed May 27th

Tuesday 8th

Editorials

• Suffredini. The Long Road to Normalcy Following Survival From COVID-19–Associated Acute Respiratory Distress Syndrome. Crit Care Med 2021;epublished June 1st
• Robert. Palliative, palliative or palliative?. Crit Care 2021;25:203

Correspondence

• Stahl. The Janus Face of Coronavirus Disease 2019–Associated Coagulopathy. Crit Care Med 2021;epublished May 26th
• Xiao. Reasons for the Overuse of Sedatives and Deep Sedation for Mechanically Ventilated Coronavirus Disease 2019 Patients. Crit care Med 2021;epublished June 2nd
• Pantazopoulos. Proportional assist ventilation versus pressure support ventilation for weaning from mechanical ventilation in adults: weaning success and mortality. Crit Care 2021;25:200
• van Wessem. Letter to the editor regarding Latent class analysis to predict intensive care outcomes in Acute Respiratory Distress Syndrome: a proposal of two pulmonary phenotypes. Crit Care 2021;25:195
• Yasuma. No Strong Evidence for Ruling out the Role of Coagulation in Long-Term Disability after Critical Illness. Am J Respir Crit Care Med 2021;epublished June 2nd
  • Brummel . Reply to: No Strong Evidence for Ruling out the Role of Coagulation in Long-Term Disability after Critical Illness. Am J Respir Crit Care Med 2021;epublished June 2nd
• Murray. Opioids for Sedation: Has the Pendulum Swung Too Far? Am J Respir Crit Care Med 2021;epublished June 2nd
  • Duprey. Reply to: Opioids for Sedation: Has the Pendulum Swung Too Far? Am J Respir Crit Care Med 2021;epublished June 2nd

Monday 7th

Commentaries

• Newcombe. Neurological complications of COVID-19. Intensive Care Med 2021;epublished June 7th
• O’Donnell. Pulmonary immuno‑thrombosis in COVID‑19 ARDS pathogenesis. Intensive Care Med 2021;epublished May 30th
• Berger. Anticoagulation in COVID-19: reaction to the ACTION trial. Lancet 2021;397(10291):2226-2228
• Su. Mean airway pressure has the potential to become the core pressure indicator of mechanical ventilation: Raising to the front from behind the clinical scenes. J Intensive Med 2021;epublished May 28th
• Wendler. A Call for a Patient Preference Predictor. Crit Care Med 2021;49(6):877-880

Sunday 6th

Narrative Reviews

Clinical

• Rroku. Update on myocarditis – what we know so far and where we may be heading. Eur Heart J Acute Cardiovasc Care 2021;10(4):455–467
• O’Donnell. Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis. Intensive Care Med 2021;epublished May 30th
• Demiselle. Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients. Ann Intensive Care 2021;11:88
• Choi. Interpretation of volume kinetics in terms of pharmacokinetic principles. Korean J Anesthesiol 2021;74(3):204-217
• Battaglini. Non-invasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review. Br J Anaesth 2021;epublished June 3rd

Saturday 5th

Research

Randomised Controlled Trials

• Cohen. BLAZE-2 Investigators. Effect of bamlanivimab vs placebo on incidence of COVID-19 among residents and staff of skilled nursing and assisted living facilities: a randomized clinical trial. JAMA 2021;epublished June 3rd
  • Editorial:  Kuritzkes. Bamlanivimab for Prevention of COVID-19. JAMA 2021;epublished June 3rd
• Lopes. Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet 2021;epublished June 4th
• Robin. Information Pamphlet Given to Relatives During the End-of-Life Decision in the ICU. An Assessor-Blinded, Randomized Controlled Trial. Chest 2021;159(6):2301-2308
• Vanderbeke. Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial. Intensive Care Med 2021;epublished May 29th
• Jayakumar. Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID-19 Infection—A Multicenter Feasibility Randomized Controlled Trial. J Intensive Care Med 2021;epublished May 5th

Systematic Reviews & Meta Analyses

• Vaschetto. Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials. Crit Care 2021;25:189
• Azadian. Mortality Benefit From the Passive Leg Raise Maneuver in Guiding Resuscitation of Septic Shock Patients: A Systematic Review and Meta-Analysis of Randomized Trials. J Intensive Care Med 2021;epublished June 2nd
• Elsayed. Variation in outcome of invasive mechanical ventilation between different countries for patients with severe COVID-19: A systematic review and meta-analysis. PLoS One 2021;16(6):e0252760
• Lewis. Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation. A Systematic Review and Meta-analysis of Randomized Trials. 2274-2288
• Vallabhajosyula. Impact of Right Ventricular Dysfunction on Short-term and Long-term Mortality in Sepsis. A Meta-analysis of 1,373 Patients. Chest 2021;159(6):2254-2263
• Hasegawa. Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation. A Systematic Review and Meta-analysis of Randomized Controlled Trials. Chest 2021;159(6):2289-2300
  • Editorial:  Morelli. Ultrashort-Acting β-Blockers. Are We on the Right Path? Chest 2021;159(6):2139-2140
• van de Sande. Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit. Intensive Care Med 2021;epublished June 5th
• Sud. Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe Acute Respiratory Distress Syndrome. A Network Meta-Analysis. Am J Respir Crit Care Med 2021;203(11):1366–1377
  • Editorial:  Guérin. Lower Vt and Prone Position: Quo Vadis? Am J Respir Crit Care Med 2021;203(11):1333–1334
• Moran. Multivariate Meta-Analysis of the Mortality Effect of Prone Positioning in the Acute Respiratory Distress Syndrome. J Intensive Care Med 2021;epublished May 4th

Observational Studies

• Goligher. Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance. Am J Respir Crit Care Med 2021;203(11):1378–1385
  • Editorial:  Bihari. Do More Injured Lungs Need More Protection? Let’s Test It. Am J Respir Crit Care Med 2021;203(11):1334–1336
• Spinelli. Unmatched ventilation and perfusion measured by electrical impedance tomography predicts the outcome of ARDS. Crit Care 2021;25:192
• Shi. COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study. Crit Care 2021;25:186
• Wang. Phenotypes and Subphenotypes of Patients With COVID-19. A Latent Class Modeling Analysis. Chest 2021;159(6):2191-2204
• Shashikumar. Development and Prospective Validation of a Deep Learning Algorithm for Predicting Need for Mechanical Ventilation. Chest 2021;159(6):2264-2273
• Nseir. Relationship Between Obesity and Ventilator-Associated Pneumonia. A Post Hoc Analysis of the NUTRIREA2 Trial. Chest 2021;159(6):2309-2317
  • Editorial:   Aretha. Obesity and the Incidence of Ventilator-Associated Pneumonia in Critically Ill Patients With Shock. The Paradox Persists. Chest 2021;159(6):2135-2136
• Mumoli. Bedside Abdominal Ultrasound in Evaluating Nasogastric Tube Placement. A Multicenter, Prospective, Cohort Study. Chest 2021;159(6):2366-2372
  • Editorial:  Tsujimoto. For Better Patient Safety. The Role of Ultrasonography in Gastric Tube Placement. Chest 2021;159(6):2147-2148
• Tacquard. Impact of High-Dose Prophylactic Anticoagulation in Critically Ill Patients With COVID-19 Pneumonia. Chest 2021;159(6):2417-2427
  • Editorial:  Bull. Clotting and COVID-19. Chest 2021;159(6):2151-2152
• Qadir. Variation in Early Management Practices in Moderate-to-Severe Acute Respiratory Distress Syndrome in the United States. Chest 2021;epublished June 2nd
• Carenzo. Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19. Ann Intensive Care 2021;11:91
• Laurent. Mental health and stress among ICU healthcare professionals in France according to intensity of the COVID-19 epidemic. Ann Intensive Care 2021;11:90

Friday 4th

Guidelines & Position Statements

• Joint EAPCI/ACVC expert consensus document on percutaneous ventricular assist devices. Eur Heart J Acute Cardiovasc Care 2021;epublished May 31st
• Srivastava. Surgery and opioids: evidence-based expert consensus guidelines on the perioperative use of opioids in the United Kingdom. Br J Anaesth 2021;126(6):1208-1216

Editorials

• Butler. Time for tocilizumab in COVID-19?. Intensive Care Med 2021;epublished May 31st
• Fontanarosa. To Howard Bauchner, MD, Visionary Editor in Chief of JAMA—A Sincere Thank You and a Fond Farewell. JAMA 2021;epublished June 1st

Thursday 3rd

Commentaries

• Mistraletti. Why and how to open intensive care units to family visits during the pandemic. Crit Care 2021;25:191
• Cove. Optimising the timing of renal replacement therapy in acute kidney injury. Crit Care 2021;25:184
• Wood. When Vaccine Apathy, Not Hesitancy, Drives Vaccine Disinterest. JAMA 2021;epublished June 2nd
• Brown. Famous and not-so-famous physical findings in infectious endocarditis: A look back. Cleve Clin J Med 2021;88)6):316-318
• Debate:  Is It Ethically Permissible to Unilaterally Withdraw Life-Sustaining Treatments During Crisis Standards of Care? Chest 2021;159(6):2165-2170
  • Bishop - Yes | Sulmasy - No | Bishop - Rebuttal | Sulmasy - Rebuttal
  • Editorial:  Frush. COVID-19 and Unilateral Withdrawal of Life-Sustaining Treatments. Tragedy in Crisis, and Lessons for Everyday Medicine. Chest 2021;159(6):2161-2162

Wednesday 2nd

Correspondence

• Carteaux. Potential protective effects of continuous anterior chest compression in the acute respiratory distress syndrome: physiology of an illustrative case. Crit Care 2021;25:187
• Gunst. Targeted treatment of iron deficiency in prolonged critical illness: an opportunity to improve survival or not?. Crit Care 2021;25:188
• Thomson. Timing of intubation in COVID-19: Not just location, location, location?. Crit Care 2021;25:193
• Various. Vaccine Breakthrough Infections with SARS-CoV-2 Variants. N Engl J Med 2021;epublished June 2nd
• Takuva. Thromboembolic Events in the South African Ad26.COV2.S Vaccine Study. N Engl J Med 2021;epublished June 2nd
• Solomon. Changes in Patterns of Hospital Visits for Acute Myocardial Infarction or Ischemic Stroke During COVID-19 Surges. JAMA 2021;epublished June 2nd
• Wall. Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination. Lancet 2021;epublished June 3rd
• Mitchell. Awake Proning or Trapping. Chest 2021;159(6):2505
  • Raoof. Response. Chest 2021;159(6):2505-2506
• Fiorentino. Insights About Prone and Lateral Positioning in Spontaneously Breathing Patients With COVID-19 Pneumonia Undergoing Noninvasive Helmet CPAP Treatment. Chest 2021;159(6):2506-2507
  • Retucci. Response. Chest 2021;159(6):2507-2508

Tuesday June 1st

Case Reports

• Goddard. Pulmonary Vein Thrombosis in COVID-19. Chest 2021;159(6):e361-e364
• Avci. A 19-Year-Old Pregnant Woman With Pulmonary Hypertension With Progressive Dyspnea. Chest 2021;159(6):e371-e375
• Hawes. An 80-Year-Old Man With Persistent Enterococcus faecalis Bacteremia. Chest 2021;159(6):e377-e380
• Moguillansky. A 44-Year-Old Woman With Multiple Neoplasms and Cystic Lung Disease. Chest 2021;159(6):e381-e384
• Alzghoul. A 57-Year-Old Man With Stridor and Critical Tracheal Narrowing. Chest 2021;159(6):e385-e388
• Kinoshita. A 63-Year-Old Woman With an Acute Exacerbation of Interstitial Pneumonia. Chest 2021;159(6):e389-e394
• Chieng. A 67-Year-Old Woman With Progressive Dyspnea and Innumerous Pulmonary Nodules. Chest 2021;159(6):e395-e401
• Gheyath. A 70-Year-Old Man With Conspicuous Thigh Pain and ST-Segment Elevations. Chest 2021;159(6):e403-e407
• Subramaniam. Three Variants of an Ultrasonographic Sign. Chest 2021;159(6):e409-e411
• Weber. A 31-Year-Old Man With Respiratory Failure. Chest 2021;159(6):e413-e415
• Shamil. A 25-Year-Old Man With Dengue Fever and Hypoxemic Respiratory Failure. Chest 2021;159(6):e417-e419
• Schultz. A 69-Year-Old Man With Syncope. Chest 2021;159(6):e421-e423
• Cheung. A Woman With Neck Swelling and Cardiac Arrest. Chest 2021;159(6):e425-e427
• Vaithilingam. An Intruder in the Heart. Chest 2021;159(6):e429-e431
• Sigakis. Lung Ultrasound Scans During Whole Lung Lavage. Chest 2021;159(6):433-e436
• Cui. Spontaneous Echo Contrast Mimicking Left Ventricular Thrombus in a Patient on Extracorporeal Membrane Oxygenation Support. Chest 2021;159(6):e437-e439
• Tsolaki. A Middle-Aged Woman With Viral ARDS and Acute Establishment of Shock on Invasive Mechanical Ventilation. Chest 2021;159(6):e441-e445
• Raymond. Mycoplasma pneumoniae–Induced Rash and Mucositis. Mayo Clin Proc 2021;96(6):1520-1521
• Zackary. Evolving distal signs. Cleve Clin J Med 2021;88(6):310-312

Monday May 31st

Narrative Reviews

Clinical

• O’Carroll. Intracerebral Hemorrhage. A Common yet Disproportionately Deadly Stroke Subtype. Mayo Clin Proc 2021;96(6):1639-1654
• Chesak. Challenges and Solutions for Physician Mothers: A Critical Review of the Literature. Mayo Clin Proc 2021;96(6):1578-1591
• Mucha. Update to coagulopathy in COVID-19: Manifestations and management. Cleve Clin J Med 2021;epublished June 2nd
• Howard. Dual antiplatelet therapy after percutaneous coronary intervention: Personalize the duration. Cleve Clin J Med 2021;88(6):325-332
• Thind. Point-of-care ultrasonography for the hospitalist. Cleve Clin J Med 2021;88(6):345-359
• Nitsch. Medical complications of bulimia nervosa. Cleve Clin J Med 2021;88(6):333-343
• Kreuter. The Diagnosis and Treatment of Pulmonary Fibrosis. Dtsch Arztebl Int 2021;118:152-62

Sunday 30th

Research

Randomised Controlled Trials

• Philips. Comparison of 5% human albumin and normal saline for fluid resuscitation in sepsis induced hypotension among patients with cirrhosis (FRISC study): a randomized controlled trial. Hepatol Int 2021;epublished May 25th
• Azeli. Clinical outcomes and safety of passive leg raising in out-of-hospital cardiac arrest: a randomized controlled trial. Crit Care 2021;25:176

Systematic Reviews & Meta Analyses

• Abraham. Systematic Review of Intraoperative Anesthesia Handoffs and Handoff Tools. Anesth Analg 2021;132(6):1563-1575
• Madsen. Bioimpedance as a measure of fluid status in critically ill patients: a systematic review. Acta Anaesthesiol Scand 2021;epublished May 26th
• Bunin. The burden they bear: A scoping review of physician empathy in the intensive care unit. J Crit Care 2021;epublished May 29th
• Prazak. Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis. Crit Care 2021;25:182
• Messina. COVID-19-related echocardiographic patterns of cardiovascular dysfunction in critically ill patients: A systematic review of the current literature. J Crit Care 2021;65:26-35
• Ye. Comparing Renal Replacement Therapy Modalities in Critically Ill Patients With Acute Kidney Injury: A Systematic Review and Network Meta-Analysis. Crit Care Explor 2021;3(5):e0399
• Curran. Comparison of Balanced Crystalloid Solutions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Explor 2021;3(5):e0398

Observational Studies

• Rouze. Early Bacterial Identification Among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Cohort Study. Am J Respir Crit Care Med 2021;epublished May 26th
• Garcia. Association Between Troponin I Levels During Sepsis and Post-Sepsis Cardiovascular Complications. Am J Respir Crit Care Med 2021;epublished May 26th
• Nseir. Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort. Crit Care 2021;25:177
• Mørk. Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study. Crit Care 2021;25:174
• Padar. Deepening of sedation with propofol has limited effect on intra-abdominal pressure – An interventional study in mechanically ventilated adult patients with intra-abdominal hypertension. J Crit Care 2021;epublished May 28th
• Geense. Reduced quality of life in ICU survivors - the story behind the numbers: A mixed methods study. J Crit Care 2021;65:36-41
• Caroyer. Assessment of a standardized EEG reactivity protocol after cardiac arrest. Clin Neurophysiol 2021;132(7):1687-1693

Saturday 29th

Narrative Reviews

Clinical

• Corp. The cardiovascular effects of positive pressure ventilation. BJA Education 2021;21(6):202-209
• Wang. Promising gas therapies for severe COVID-19. JIM 2021;epublished May 27th
• Chugh. Role of continuous hypertonic saline in acute ischemic infarcts: a systematic literature review. J Neurocrit Care 2021;epublished May 17th
• Rajagopalan. Hiccups in neurocritical care. J Neurocrit Care 2021;epublished March 5th

Friday 28th

Editorials

• Smit. Slicing and dicing ARDS: we almost forgot the lungs. Crit Care 2021;25:180
• Skoczyński. Lung ultrasound may improve COVID-19 safety protocols. J Thorac Dis 2021;13(5):2698-2704

Commentaries

• Bagshaw. When should we start renal-replacement therapy in critically ill patients with acute kidney injury: do we finally have the answer?. Crit Care 2021;25:179
• Kuindersma. Tailored modulation of the inflammatory balance in COVID-19 patients admitted to the ICU?—a viewpoint. Crit Care 2021;25:178

Correspondence

• Jouffroy. Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: do not confound access route and specific drug complications!. Crit Care 2021;25:183
• Madhi. Factors associated with death in children with purpura fulminans: a French national prospective cohort study. Crit Care 2021;25:181
• Tsolaki. Timing of Intubation in Covid-19 ARDS: What “time” really matters?. Crit Care 2021;25:173

Case Reports

• Ahn. Refractory brainstem encephalitis mimicking progressive cerebral infarction: infliximab and methotrexate as a salvage immunotherapy. J Neurocrit Care 2021;epublished March 10th
• Arora. ‘The photographic negative of pulmonary oedema’ in COVID-19 pneumonia. Postgraduate Medical Journal 2021;97:401
• Peters. Adult-Onset Still’s Disease Presenting as Macrophage-Activation Syndrome With Critical Illness in the Third Trimester of Pregnancy: A Case Report. Crit Care Explor 2021;3(5):e0440

Thursday 27th

Guidelines & Position Statements

• Temesgen. Adult sedation and analgesia in a resource limited intensive care unit - A Systematic Review and evidence based guideline. Ann Med Surg 2021;66:102356
• Agizew. Evidence-Based Guideline on Critical Patient Transport and Handover to ICU. Anesthesiol Res Pract 2021:6618709
• Griffiths. RAND appropriateness panel to determine the applicability of UK guidelines on the management of acute respiratory distress syndrome (ARDS) and other strategies in the context of the COVID-19 pandemic. Thorax 2021;epublished May 27th

Wednesday 26th

Research

Randomised Controlled Trials

• Jaber. Effect of the use of an endotracheal tube and stylet versus an endotracheal tube alone on first-attempt intubation success: a multicentre, randomised clinical trial in 999 patients. Intensive Care Med 2021;epublished May 25th

Narrative Reviews

Clinical

• Snyder. Cerebral Hypoxia: Its Role in Age-Related Chronic and Acute Cognitive Dysfunction. Anesth Analg 2021;132(6):1502-1513
• Tasbihgou. The role of dexmedetomidine in neurosurgery. Best Practice & Research Clinical Anaesthesiology 2021;35(2):221-229

Commentaries

• Dallmeier. COVID-19 and the intensive care unit: vaccines to the rescue. Intensive Care Med 2021;epublished May 25th
• Schober. Linear Mixed-Effects Models in Medical Research. Anesth Analg 2021;132(6):1592-1593

Tuesday 25th

Research

Randomised Controlled Trials

• Roquilly. Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury. The COBI Randomized Clinical Trial. JAMA 2021;325(20):2056-2066

Observational Studies

• Yan. Preliminary Investigation of In situ Thrombus Within Patent Foramen Ovale in Patients With and Without Stroke. JAMA 2021;325(20):2116-2118

Guidelines & Position Statements

• Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH. Hamostaseologie 2021;epublished April 1st

Narrative Reviews

Clinical

• Fernando. Sepsis: Diagnosis and management of acute respiratory distress syndrome. CMAJ 2021;193(21):E761-E768
• Choudhary. Pharmacological Approach for Neuroprotection After Cardiac Arrest—A Narrative Review of Current Therapies and Future Neuroprotective Cocktail. Front Med 2021;8:636651
• Spronk. Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation. Front Neurol 2021;12:661955

Monday 24th

Narrative Reviews

Clinical

• Elzo Kraemer. POCUS series: Focused transoesophageal echocardiography, a view from the inside. Neth J Crit Care May 2021;29(3):130-139
• Tataranno. Precision Medicine in Neonates: A Tailored Approach to Neonatal Brain Injury. Front Pediatr 2021;9:634092
• Fredenburgh. Factor XI as a Target for New Anticoagulants. Hamostaseologie 2021; 41(02): 104-110
• Zaninetti. Anticoagulation in Patients with Platelet Disorders. Hamostaseologie 2021;41(02):112-119
• Cate. Management of Disseminated Intravascular Coagulation in Acute Leukemias. Hamostaseologie 2021; 41(02): 120-126
• Cognasse. Effects and Side Effects of Platelet Transfusion. Hamostaseologie 2021; 41(02): 128-135

Case Reports

• de Lange. Unusual complication after cardiac surgery: iatrogenic Ortner’s syndrome. Neth J Crit Care May 2021;29(3):148-150
• Epskamp. Facial train-of-four monitoring as an evaluation of neuromuscular blockade in a patient with ICU-acquired weakness. Neth J Crit Care May 2021;29(3):151-153
• Kant. Arterial embolism as a first sign of pulmonary embolism: a case report. Neth J Crit Care May 2021;29(3):154-156

Sunday 23rd

Research

Randomised Controlled Trials

• Langezaal. Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion. N Engl J Med 2021;384:1910-1920
• Puymirat. Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction. N Engl J Med 2021;epublished May 16th
• Whitlock. Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. N Engl J Med 2021;epublished May 15th

Systematic Reviews & Meta Analyses

• Snow. Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials. Intensive Care Med 2021;epublished May 21st
• Avni. Tocilizumab in the treatment of COVID-19 - a meta-analysis. QJM 2021;epublished May 19th
• Pannone. Lung histopathological findings in COVID-19 disease - a systematic review. Infect Agent Cancer 2021;16(1):34
• Kursumovic. The impact of COVID-19 on anaesthesia and critical care services in the UK: a serial service evaluation. Anaesthesia 2021;epublished May 18th
• Lim. A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients With Coronavirus Disease 2019. Crit Care Med 2021;49(6):901-911
  • Editorial:  Sprung. Reassessing Cardiopulmonary Resuscitation in Hospitalized Patients With Coronavirus Disease 2019. Crit Care Med 2021;49(6):988-993
• Shah. Use of Corticosteroids in Cardiac Arrest—A Systematic Review and Meta-Analysis. Crit Care Med 2021;49(6):e642-e650
• Sato. The impact of right ventricular injury on the mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care 2021;25:172

Observational Studies

• The African COVID-19 Critical Care Outcomes Study (ACCCOS) Investigators. Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study. Lancet 2021;397(10288):1885-1894
  • Commentary:  Kirenga. Excess COVID-19 mortality among critically ill patients in Africa. Lancet 2021;397(10288):1860-1861
• Alladina. Plasma Soluble Suppression of Tumorigenicity-2 Associates with Ventilator Liberation in Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med 2021;203(10):1257–1265
  • Editorial:  Raventós. Biomarkers to Guide Ventilation Management and Readiness for Extubation. Am J Respir Crit Care Med 2021;203(10):1211–1212

Narrative Reviews

Clinical

• Chang. Neurological Critical Care: The Evolution of Cerebrovascular Critical Care. Crit Care Med 2021;49(6):881-900
• Osuchowski. COVID-19 and earlier pandemics, sepsis, and vaccines: A historical perspective. Journal of Intensive Medicine 2021;epublished May 18th

Guidelines & Position Statements

• Recommendations for standards of monitoring during anaesthesia and recovery 2021. Guideline from the Association of Anaesthetists. Anaesthesia 2021;epublished May 20th
• Fire safety and emergency evacuation guidelines for intensive care units and operating theatres: for use in the event of fire, flood, power cut, oxygen supply failure, noxious gas, structural collapse or other critical incidents. Guidelines from the Association of Anaesthetists and the Intensive Care Society. Anaesthesia 2021;epublished May 13th
• Guideline on the peri-operative management of patientswith sickle cell diseaseGuideline from the Association of Anaesthetists. Anaesthesia 2021;76:805–817

Saturday 22nd

Editorials

• Neuzil. Interplay between Emerging SARS-CoV-2 Variants and Pandemic Control. N Engl J Med 2021;384:1952-1954
• Ista. Delirium in adult and paediatric ICU patients: what is the way forward? Nurs Crit Care 2021;26(3):147-149
• Rose. Core outcome sets in intensive care–what are they and why do we need them? An example for delirium. Nurs Crit Care 2021;26(3):144-146

Correspondence

• Vayne. PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia. N Engl J Med 2021;epublished May 19th
• Metnitz. Evaluation and calibration of SAPS 3 in patients with COVID-19 admitted to intensive care units. Intensive Care Med 2021;epublished May 19th
• Hicter. Is airway regional resistances array a neglected component of ventilation?. Intensive Care Med 2021;epublished May 18th
• Guillon. Inter-regional transfers for pandemic surges were associated with reduced mortality rates. Intensive Care Med (2021;epublished May 15th

Case Reports

• Cottin. Interstitial Lung Disease after COVID-19. Am J Respir Crit Care Med 2021;203(10):1314–1315
• Jamme. Fatal cerebral venous sinus thrombosis after COVID-19 vaccination. Intensive Care Med 2021;epublished May 13th
• Ohashi. Cavernous sinus thrombosis related to sphenoid sinusitis in a child. CMAJ 2021;193(20):E737
• Jones. Limb ischemia and pulmonary artery thrombosis afer the ChAdOx1 nCoV-19 (Oxford–AstraZeneca) vaccine: a case of vaccine-induced immune thrombotic thrombocytopenia. CMAJ 2021;epublished May 14th

Multimedia

Audio

• Rubin. Audio Interview: Vaccination in Nursing Homes and New Pulmonary/Critical Care Research. N Engl J Med 2021;384(20):e89

Friday 21st

Commentaries

• Taran. Falsifiability in medicine: what clinicians can learn from Karl Popper. Intensive Care Med 2021;epublished May 22nd
• Felix. COVID-19 and difficult conversations in critical units: A practical guide for nurses. Nurs Crit Care 2021;26(3):209-211
• Takvorian. A Hidden Opportunity — Medicaid’s Role in Supporting Equitable Access to Clinical Trials. N Engl J Med 2021;epublished May 22nd
• Burris. The “Legal Epidemiology” of Pandemic Control. N Engl J Med 2021;epublished May 22nd
• Komaroff. Does Sleep Flush Wastes From the Brain? JAMA 2021;epublished May 17th

Lancet Series on the Future of the NHS

• Anderson. LSE–Lancet Commission on the future of the NHS: re-laying the foundations for an equitable and efficient health and care service after COVID-19. Lancet 2021;397(10288):1915-1978
• McKee. The changing health needs of the UK population. Lancet 2021;397(10288):1979-1991
• Anderson. Securing a sustainable and fit-for-purpose UK health and care workforce. Lancet 2021;397(10288):1992-2011
• Charlesworth. What is the right level of spending needed for health and care in the UK? Lancet 2021;397(10288):2012-2022

Thursday 20th

Narrative Reviews

Clinical

• Shang. Intensive Care and Treatment of Severe Guillain-Barré Syndrome. Front Pharmacol 2021;12:608130
• Jarczak. Sepsis—Pathophysiology and Therapeutic Concepts. Front Med 2021;8:628302
• Elhence . Coronavirus Disease-2019 (COVID-19) and the Liver. J Clin Transl Hepatol 2021;9(2):247-255
• Sahawneh. Non-pharmacologic interventions for the prevention of delirium in the intensive care unit: An integrative review. Nurs Crit Care 2021;26(3):166-175
• Staben. Development of an Anesthesiology Disaster Response Plan. Anesthesiology Clin 2021;39(2):245-253
• Wu. The Initial Response to a Pandemic: Anesthesiology Experiences from China at the Onset of COVID-19. Anesthesiology Clin 2021;39(2):255-264
• Rezoagli. Development of a Critical Care Response - Experiences from Italy During the Coronavirus Disease 2019 Pandemic. Anesthesiology Clin 2021;39(2):265-284
• Shrestha. Anesthesiology and Critical Care Response to COVID-19 in Resource-Limited Settings. Experiences from Nepal. Anesthesiology Clin 2021;39(2):285-292

Wednesday 19th

Narrative Reviews

Clinical

• Henry. AGA Clinical Practice Update on Management of Bleeding Gastric Varices: Expert Review. Clin Gastroenterol Hepatol 2021;19(6):1098-1107
• Sivakorn. How to monitor cardiovascular function in critical illness in resource-limited settings. Curr Opin Crit Care 2021;27(3):274-281
• McCredie. How do we identify the crashing traumatic brain injury patient – the intensivist's view. Curr Opin Crit Care 2021;27(3):320-327
• Koukoubanis. Role of Critical Care Units in the management of obstetric patients (Review). Biomed Rep 2021;15(1):58
• Wu. Artificial Intelligence for Clinical Decision Support in Sepsis. Front Med 2021;8:665464
• Murphy. Chronic Illness in Pediatric Critical Care. Front Pediatr 2021;9:686206
• Nasa. Euglycemic diabetic ketoacidosis: A missed diagnosis. World J Diabetes 2021;12(5):514-523
• Chen. Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration. Front Immunol 2021;12:589095
• Soumya. Impact of COVID-19 on the Cardiovascular System: A Review of Available Reports. Cardiovasc Drugs Ther 2021;35(3):411-425

Tuesday 18th

Narrative Reviews

Clinical

• Van Regenmortel. Fluid-induced harm in the hospital: look beyond volume and start considering sodium. From physiology towards recommendations for daily practice in hospitalized adults. Ann Intensive Care 2021;11:79
• Avery. Rapid sequence induction: where did the consensus go?. Scand J Trauma Resusc Emerg Med 2021;29:64
• Lopes. Chronic postoperative pain: ubiquitous and scarcely appraised – narrative review. Br J Anesthesiol 2021;epublished February 18th
• Pesce. Glomerulonephritis in AKI: From Pathogenesis to Therapeutic Intervention. Front Med 2021;7:582272

Monday 17th

Commentaries

• Levi. Vascular mechanisms and manifestations of COVID-19. Lancet Respir Med 2021;epublished May 17th
• Sinha. Immunotherapy in COVID-19: why, who, and when? Lancet Respir Med 2021;epublished May 17th
• Danica Quickfall. Angiotensin-converting-enzyme inhibitor–induced angioedema. CMAJ 2021;193(20):E735
• Sholzberg. Recognizing, managing and reporting vaccine-induced immune thrombotic thrombocytopenia. CMAJ 2021;epublished May 14th

Sunday 16th

Research

Randomised Controlled Trials

• Amaru. Effect of Recruitment Maneuvers and PEEP on Respiratory Failure After Cardiothoracic Surgery in Obese Subjects: A Randomized Controlled Trial. Respir Care 2021;epublished May 11th

Systematic Reviews & Meta Analysis

• Nederpelt. Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished May 7th
• Eckert. Association of specialized enteral nutrition with glycemic control and clinical outcomes in critically ill patients: A meta-analysis of randomized controlled trials. Clin Nut 2021;epublished May 8th

Observational Studies

• Wick. Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS. JCI Insight 2021;epublished May 11th
• Vasquez. Identification of distinct clinical subphenotypes in critically ill patients with COVID-19. Chest 2021;epublished May 5th

Guidelines & Position Statements

• ACR Appropriateness Criteria® Intensive Care Unit Patients. J Am Coll Radiol 2021;18(5S):S62-S72
• ACR Appropriateness Criteria® Head Trauma: 2021 Update. J Am Coll Radiol 2021;18(5S):S13-S36
• ACR Appropriateness Criteria® Infective Endocarditis. J Am Coll Radiol 2021;18(5S):S52-S61
• ACR Appropriateness Criteria® Myelopathy: 2021 Update. J Am Coll Radiol 2021;18(5S):S73-S82
• ACR Appropriateness Criteria® Nontraumatic Aortic Disease. J Am Coll Radiol 2021;18(5S):S106-S118
• ACR Appropriateness Criteria® Radiologic Management of Lower Gastrointestinal Tract Bleeding: 2021 Update. J Am Coll Radiol 2021;18(5S):S139-S152
• ACR Appropriateness Criteria® Radiologic Management of Portal Hypertension. J Am Coll Radiol 2021;18(5S):S153-S173
• ACR Appropriateness Criteria® Renal Failure. J Am Coll Radiol 2021;18(5S):S174-S188
• ACR Appropriateness Criteria® Seizures-Child. J Am Coll Radiol 2021;18(5S):S199-S211

Narrative Reviews

Clinical

• Egbuta. Current State of Analgesia and Sedation in the Pediatric Intensive Care Unit. J Clin Med 2021;10(9):1847
• Sipilä. Sleep Well and Recover Faster with Less Pain—A Narrative Review on Sleep in the Perioperative Period. J Clin Med 2021;10(9):2000
• Mankowski. Pathophysiology and Treatment Strategies of Acute Myopathy and Muscle Wasting after Sepsis. J Clin Med 2021;10(9):1874
• Corcione. Novel Cephalosporins in Septic Subjects and Severe Infections: Present Findings and Future Perspective. Front Med 2021;8:617378
• Sawa. Difficult Airway Management in Neonates and Infants: Knowledge of Devices and a Device-Oriented Strategy. Front Pediatr 2021;9:654291
• Correale. New Targets in Heart Failure Drug Therapy. Front Cardiovasc Med 2021;8:665797
• Mardian. Review of Current COVID-19 Diagnostics and Opportunities for Further Development. Front Med 2021;8:615099
• Nguyen. Carbapenem Resistance in Acinetobacter baumannii, and their Importance in Hospital-acquired Infections: A Scientific Review. J Appl Microbiol 2021 May 10th
• Zengin. Heart failure in adults with congenital heart disease: a narrative review. Cardiovasc Diagn Ther 2021;11(2):529-537
• Katsoulis. Immunopathology of Acute Kidney Injury in Severe Malaria. Front Immunol 2021;12:651739
• Golob. SARS-CoV-2 vaccines: a triumph of science and collaboration. JCI Insight 2021;6(9):e149187
• Krstic. Abnormal liver blood tests: Hepatologist approach. Dig Dis 2021;epublished May 10th

Non-Clinical

• Sarkar. Adaptive designs in clinical trials. J Pharmacol Pharmacother 2020;11:129-33

Editorials

• Lee. Management of severe covid-19: progress and promise. BMJ 2021;373:n1147
• Helms. Yentl syndrome and the ICU. Intensive Care Med 2021;epublishedMay 5th

Commentaries

• Dionne-Odom. Reconceptualizing How to Support Surrogates Making Medical Decisions for Critically Ill Patients. JAMA 2021;epublished May 14th
• Hasegawa. β1-blocker in sepsis. J Intensive Care 2021;9:39
• Jamil. Genetic Variants of SARS-CoV-2: What do we know so far? Am J Respir Crit Care Med 2021;epublished May 10th

Correspondence

• Trahtemberg. COVID‑19‑associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med 2021;epublished April 30th

Case Reports

• Beckerman. Coronavirus disease 2019 (COVID-19)-associated constrictive pericarditis. BMJ Case Reports CP 2021;14:e242018
• Mitler. Recent use of formaldehyde-‘free’ hair straightening product and severe acute kidney injury. Clin Kid J 2021;14(5):1469–1471

News

• Ledford. International COVID-19 trial to restart with focus on immune responses. Nature 2021;epublished May 7th

Saturday 15th

Research

Randomised Controlled Trials

• RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet 2021;epublished May 14th
  • Commentary:  Liu. Convalescent plasma in patients hospitalised with COVID-19. Lancet 2021;epublished May 14th
• Supady. Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial. Lancet Respir Med 2021;epublished May 14th
  
  • Commentary:  Shekar. Cytokine adsorption during ECMO for COVID-19-related ARDS. Lancet Respir Med 2021;epublished May 14th

Observational Studies

• McHugh. Effects of nurse-to-patient ratio legislation on nurse staffing and patient mortality, readmissions, and length of stay: a prospective study in a panel of hospitals. Lancet 2021;epublished May11th
• Docherty. Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. Lancet Respir Med 2021;epublished May 14th
• Dubin. Functional Outcomes, Goals, and Goal Attainment Amongst Chronically Critically Ill Long-Term Acute Care Hospital Patients. Ann Am Thor Soc 2021;epublished May 12th

Commentary

• McGonagle. A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19. Lancet respir Med 2021;epublished May 14th

Friday 14th

Editorials

• Martin-Loeches. If not now, when? A clinical perspective on the unprecedented challenges facing ICUs during the COVID-19 pandemic. Intensive Care Med 2021;epublished May 11th

Commentaries

• Dionne-Odom. Reconceptualizing How to Support Surrogates Making Medical Decisions for Critically Ill Patients. JAMA 2021;epublished May 14th
•  Hasegawa. β1-blocker in sepsis. J Intensive Care 2021;9:39

Correspondence

• Thille. Does Prophylactic Use of High-Flow Nasal Cannula in the Immediate Postoperative Period Actually Decrease the Risk of Intubation?: Be Cautious With Findings From Meta-analyses. Chest 2021;159(5):2113-2114
  • Chaudhuri. Response. Chest 2021;159(5):2115
• Mombrun. Questioning Tocilizumab Use in Hospitalized Patients With Coronavirus Disease 2019. Chest 2021;159(5):2115-2116
  • Price. Response. Chest 2021;159(5):2116-2117
• Gubensek. Regional citrate anticoagulation for intermittent hemodialysis in the intensive care: what is the optimal setup? Ann Intensive Care 2021;11(1):67

Thursday 13th

Research

Randomised Controlled Trials

• Lal. Oral Midodrine Administration During the First 24 Hours of Sepsis to Reduce the Need of Vasoactive Agents: Placebo-Controlled Feasibility Clinical Trial. Crit Care Explor 2021;3(5):e0382
• O'Donnell. A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19. J Clin Invest 2021;epublished May 11th

Systematic Reviews & Meta Analyses

• Huang. The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis. Am J Emerg Med 2021;48:203-208

Observational Studies

• Hatzl. Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study. Ann Intensive Care 2021;11(1):73
• Patel. Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom. Intensive Care Med 2021;epublished May 11th

Narrative Reviews

Clinical

• Lee. Succinct Approach to Delirium in the Emergency Department. Curr Emerg Hosp Med Rep 2021;9:11–18
• Moonen. Bioelectric impedance analysis for body composition measurement and other potential clinical applications in critical illness. Curr Opin Crit Care 2021;epublished May 6th
• Lee. Clostridium difficile: Diagnosis and the Consequence of Over Diagnosis. Infect Dis Ther 2021;10:687–697

Wednesday 12th

Guidelines & Position Statements

• Bussolin. The management of pediatric severe traumatic brain injury: Italian Guidelines. Minerva Anestesiologica 2021;87(5):567-79
  • Editorial:  Piastra. Traumatic brain injury: shared national guidelines are still required. Minerva Anestesiol 2021;87(5):508-509
• Prowle. Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative. Nat Rev Nephrol 2021;epublished May 11th
• Puelacher. Expert consensus on peri-operative myocardial injury screening in noncardiac surgery. A literature review. Eur J Anaesthesiol 2021;38(6):600-608
  • Commentary:  Humble. Expert consensus on peri-operative myocardial injury screening in noncardiac surgery. Eur J Anaesthesiol 2021;38(6):569-570

Narrative Reviews

Clinical

• Grigonis. Long-Term Acute Care Hospitals Extend ICU Capacity for COVID-19 Response and Recovery. Chest 2021;159(5):1894-1901
• Hinkelbein. Performance of the laryngeal tube for airway management during cardiopulmonary resuscitation. Minerva Anestesiologica 2021;87(5):580-90
• McCarthy. Perioperative care in cardiac surgery. Minerva Anestesiologica 2021;87(5):591-603
• Saracoglu. COVID-19 patients in the operating room: a concise review of existing literature. Minerva Anestesiologica 2021;87(5):604-12
• Costantini. Type 2 diabetes mellitus and sepsis: state of the art, certainties and missing evidence. Acta Diabetol 2021;epublished May 10th
• McMahon. The furosemide stress test: current use and future potential. Ren Fail 2021;43(1):830-839

Non-Clinical

• Kaul. Medical Education During the COVID-19 Pandemic. Chest 2021;159(5):1949-1960

Tuesday 11th

Case Reports

• Chong. Persistent Dyspnea in a 74-Year-Old Man With Normal Spirometry and Lung Volumes. Chest 2021;159(5):e303-e307
• Burke. A 67-Year-Old Woman With Abdominal Pain and Dyspnea. Chest 2021;159(5):e309-e312
• Triantafyllidou. A Well-Defined Endobronchial Tumor in a 26-Year-Old Man. Chest 2021;159(5):e313-e317
• Hamad. Respiratory Distress and Chest Pain in an Airplane Passenger With Radiolucent Left Hemithorax. Chest 2021;159(5):e319-e323
• Harris. An 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities. Chest 2021;159(5):e325-e329
• Chopra. An Unusual Case of Chronic Hemoptysis. Chest 2021;159(5):e331-e335
• Rahman. Dyspnea With Unilateral Pulmonary Ground Glass Opacities and Cavitary Lesions. Chest 2021;159(5):e337-e342
• Nada. Pneumonia and Poorly Controlled Diabetes. Chest 2021;159(5):e343-e347
• Fried. A 66-Year-Old Woman With Hypoxia and Shock. Chest 2021;159(5):e349-e352
• Choi. A Morbidly Obese 26-Year-Old Man With Respiratory Failure and Bilateral Lower Extremity Swelling. Chest 2021;159(5):e353-e356
• Salinas. An Unusual Case of Abdominal Pain and Shock. Chest 2021;159(5):e357-e359

Monday 10th

Research

Randomised Controlled Trials

• Nguyen. Low Tidal Volume Mechanical Ventilation Against No Ventilation During Cardiopulmonary Bypass in Heart Surgery (MECANO). Chest 2021;159(5):1843-1853
  • Editorial:  Schultz. Ventilation During Cardiopulmonary Bypass: Can We, Must We, Should We Individualize It? Chest 2021;159(5):1703-1705

Observational Studies

• Fernando. Suicide and self-harm in adult survivors of critical illness: population based cohort study. BMJ 2021;373:n973
• Chen. Corticosteroid Therapy Is Associated With Improved Outcome in Critically Ill Patients With COVID-19 With Hyperinflammatory Phenotype. Chest 2021;159(5):1793-1802
  • Editorial:  Amati. One Size Does Not Fit All: Moving Towards a Personalized Approach for Steroids in COVID-19. Chest 2021;159(5):1693-1695
• Dupont. Identification of Distinct Immunophenotypes in Critically Ill Coronavirus Disease 2019 Patients. Chest 2021;159(5):1884-1893
  • Editorial:  Wilson. Immunological Subpopulations Within Critically Ill COVID-19 Patients. Chest 2021;159(5):1706-1708
• Doyen. Characteristics of Cardiac Injury in Critically Ill Patients With Coronavirus Disease 2019. Chest 2021;159(5):1974-1985
  • Editorial:  Lanspa. What We Might Find If We Only Looked. Chest 2021;159(5):1715-1716

Debate

• Brenner. POINT: Tracheostomy in Patients With COVID-19: Should We Do It Before 14 Days? Yes. Chest 2021;159(5):1723-1727
• Pandian. COUNTERPOINT: Tracheostomy in Patients With COVID-19. Chest 2021;159(5):1727-1729
• Brenner. Rebuttal From Drs Brenner, Feller-Kopman, and De Cardenas. Chest 2021;159(5):1729-1731
• Pandian. Rebuttal From Drs Pandian, Murgu, and Lamb. Chest 2021;159(5):1731-1733

Sunday 9th

Research

Randomised Controlled Trials

• Bennett-Guerrero. Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York. Crit Care Med 2021;epublished April 16th
  • Editorial:  Sweeney. Convalescent Plasma and Coronavirus Disease 2019. Cri Care Med 2021;epublished April 16th
• van Groenendael. Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study. Crit Care Med 2021;49(5):790-803

Systematic Reviews & Meta Analyses

• Gregor. Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis. An Update Systematic Review of Comparative Efficacy and Safety. Crit Care Med 2021;epublished May 3rd
• Neuroprognostic Accuracy of Quantitative Versus Standard Pupillary Light Reflex for Adult Postcardiac Arrest Patients. A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished April 26th
• Cheng. Acute Cardiac Injury in Coronavirus Disease 2019 and Other Viral Infections—A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished April 19th
• Reddy. Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis. Crit Care Med 2021;epublished April 30th
• Li. Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis. Crit Care 2021;25:167

Observational Studies

• Martin. Association Between Lack of Blinding and Mortality Results in Critical Care Randomized Controlled Trials. A Meta-Epidemiological Study. Crit Care Med 2021;epublished April 30th
• Wu. Application of Full-Spectrum Rapid Clinical Genome Sequencing Improves Diagnostic Rate and Clinical Outcomes in Critically Ill Infants in the China Neonatal Genomes Project. Crit Care Med 2021;epublished May 3rd
• Brands. Plasma Ferritin as Marker of Macrophage Activation-Like Syndrome in Critically Ill Patients With Community-Acquired Pneumonia. Crit Care Med 2021;epublished May 3rd
• Bhalla. Adherence to Lung-Protective Ventilation Principles in Pediatric Acute Respiratory Distress Syndrome. A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med 2021;epublished April 26th
• Tsalik. Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test. Crit Care Med 2021;epublished April 28th
• Kopp. The Impact of Preintubation Noninvasive Ventilation on Outcomes in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 2021;49(5):816-827

Guidelines & Position Statements

• DeMerle. Sepsis Subclasses: A Framework for Development and Interpretation. Crit Care Med 2021;49(5):748-759
  • Editorial:  Abraham. Moving Forward With Refinement of Definitions for Sepsis. Crit Care Med 2021;49(5):861-863

Narrative Reviews

Clinical

• Kramer. Severity of Illness and Predictive Models in Society of Critical Care Medicine’s First 50 Years: A Tale of Concord and Conflict. Crit Care Med 2021;49(5):728-740
• Redant. Severe Acute Respiratory Syndrome Coronavirus-2-Associated Acute Kidney Injury: A Narrative Review Focused Upon Pathophysiology. Crit Care Med 2021;49(5):e533-e540

Saturday 8th

Guidelines & position Statements

• Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III. Crit Care Med 2021;epublished April 28th

Editorials

• Plourde. Flow is not perfusion, and perfusion is not function: ancillary testing for the diagnosis of brain death. Can J Anaesth 2021;epublished May 4th
• Helms. Yentl syndrome and the ICU. Intensive Care Med 2021;epublished May 5th

Friday 7th

Research

Randomised Controlled Trials

• Vaara. Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial. Intensive Care Med 2021;epublished May 7th
• Jayakumar. Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID-19 Infection-A Multicenter Feasibility Randomized Controlled Trial. J Intensive Care Med 2021;epublished May 5th

Systematic Reviews & Meta Analysis

• Gigliotti. A systematic review and meta-analysis of antiepileptic prophylaxis in spontaneous intracerebral hemorrhage. World Neurosurg 2021;epublished April 30th

Observational Studies

• Eskioglou. Electroencephalography of mechanically ventilated patients at high risk of delirium. Acta Neurol Scand 2021;epublished May 5th

Commentaries

• Osuchowski. The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respir Med 2021;epublished May 6th
• DeMerle. Precision Medicine for COVID-19. Phenotype Anarchy or Promise Realized? JAMA 2021;epublished May 7th
• Godoy. Hyperventilation in Severe Traumatic Brain Injury Has Something Changed in the Last Decade or Uncertainty Continues? A Brief Review. Front Neurol 2021;12:573237

Thursday 6th

Narrative Reviews

Clinical

• Musick. Neurologic Assessment of the Neurocritical Care Patient. Front Neurol 2021;12:588989
• Billings. The incidence, risk, presentation, pathophysiology, treatment, and effects of perioperative acute kidney injury. Can J Anaesth 2021;68(3):409–422
• Morens. A Centenary Tale of Two Pandemics: The 1918 Influenza Pandemic and COVID-19, Part I. Am J Public Health 2021;111(6):1086-1094
• Elalamy. SARS-CoV-2 vaccine and thrombosis: Expert opinions. Thromb Haemost 2021;epublished May 4th
• Ren. Neurological update: COVID-19. J Neurol 2021;epublished April 30th
• Vajari. COVID-19-related coagulopathy: a review of pathophysiology and pharmaceutical management. Cell Biol Int 2021;epublished May 4th
• Trevisan. Pharmacoepidemiology for nephrologists (part 1): concept, applications and considerations for study design. Clin Kid J 2021;14(5):1307–1316
• Fu. Pharmacoepidemiology for nephrologists (part 2): potential biases and how to overcome them. Clin Kid J 2021;14(5):1317–1326
• Nauth. Polytrauma: update on basic science and clinical evidence. OTA Int 2021;4(1):e116

Wednesday 5th

Research

Randomised Controlled Trials

• Maitland. Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia. Intensive Care Med 2021;epublished May 5th
• Nydahl. Mobilization in the evening to prevent delirium: A pilot randomized trial. Nurs Crit Care 2021;epublished May 4th

Observational Study

• Zorbas. Airway pressure release ventilation in mechanically ventilated patients with COVID-19: a multicenter observational study. Acute Crit Care 2021;epublished May 4th

Protocol

• Schlapbach. Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation–A Pilot Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan. Front Pediatr 2021;9:663435

Correspondence

• Muthu. Is high-dose glucocorticoid beneficial in COVID-19? Eur Respir J 2021;57:2100065
  • Edalatifard. Reply: Is high-dose glucocorticoid beneficial in COVID-19? Eur Respir J 2021;57:2100324
• Gogali. Corticosteroids in COVID-19: one size does not fit all. Eur Respir J 2021;57:2100224
• Kalbhenn. “Do no further harm” – Why shall we sedate unresponsive patients?. Intensive Care Med 2021;epublished May 5th
• Tanios. Fentanyl- and midazolam-induced coma each influence days of mechanical ventilation and 28-day mortality. Intensive Care Med 2021;epublished May 5th
• Volpicelli. A simple, reproducible and accurate lung ultrasound technique for COVID-19: when less is more. Intensive Care Med 2021;epublished May 3rd

Tuesday 4th

Guidelines & Position Statements

• Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients for Initial or Postextubation Management of Acute Respiratory Failure: A Clinical Guideline From the American College of Physicians. Ann Intern Med 2021;epublished April 27th
• Chalmers. Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline. Eur Respir J 2021;57:2100048
  • Commentary:  Kolb. Guideline-directed management of COVID-19: Do's and Don'ts. Eur Respir J 2021;57:2100753

Narrative Reviews

Clinical

• Prkachin. The Reign of the Ventilator: Acute Respiratory Distress Syndrome, COVID-19, and Technological Imperatives in Intensive Care. Ann Intern Med 2021;epublished May 4th

Editorials

• Boros. Microcirculation Guided/Targeted Resuscitation. Front Med 2021;8:649828
• Pikkers. Immunocompromised Patients with Acute Respiratory Failure: “Don’t Wait to Intubate?”. Am J Respir Crit Care Med 2021;epublished May 4th

Monday 3rd

Narrative Reviews

Clinical

• Odum. A Precision Medicine Approach to Biomarker Utilization in Pediatric Sepsis-Associated Acute Kidney Injury. Front Pediatr 2021;9:632248
• Leghrouz. Impact of Acute Kidney Injury on Critically Ill Children and Neonates. Front Pediatr 2021;9:635631
• Rutledge. Fluid Balance in the Critically Ill Child Section: “How Bad Is Fluid in Neonates?” Front Pediatr 2021;9:651458
• Samprathi. Biomarkers in COVID-19: An Up-To-Date Review. Front Pediatr 2021;8:607647
• Davenport. Hemostatic Challenges in Neonates. Front Pediatr 2021;9:627715
• Huisman. Pediatric Fibrinogen PART I—Pitfalls in Fibrinogen Evaluation and Use of Fibrinogen Replacement Products in Children. Front Pediatr 2021;9:617500
• Crighton. Pediatric Fibrinogen PART II—Overview of Indications for Fibrinogen Use in Critically Ill Children. Front Pediatr 2021;9:647680
• Gillespie. Red Blood Cell Contribution to Hemostasis. Front Pediatr 2021;9:629824