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CCR Down Under 2025

The Edge, Melbourne

Week of December 8th, 2025

CCR Down Under Livestream

Published Trials Day 2

Arleth. Early Restrictive vs Liberal Oxygen for Trauma Patients. The TRAUMOX2 Randomized Clinical Trial. JAMA 2024;epublished December 10th
RENOVATE Investigators and the BRICNet Authors. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory FailureThe RENOVATE Randomized Clinical Trial. JAMA 2024;epublished December 11th
- Editorial: Frat. Is High-Flow Oxygen the Standard for All Patients With Acute Respiratory Failure? JAMA 2024;epublished December 11th
- Editorial: Freund. Reevaluating Respiratory Support in Acute Respiratory Failure—Insights From the RENOVATE Trial and Implications for Practice. JAMA 2024;epublished December 11th
Arabi. Electronic Sepsis Screening Among Patients Admitted to Hospital WardsA Stepped-Wedge Cluster Randomized Trial. JAMA 2024;epublished December 10th
- Editorial: Angus. Do Sepsis Alerts Help? JAMA 2024;epublished December 10th
Podcast: JAMA Research at Critical Care Reviews 2024 (CCR Down Under)

Published Trials Day 1

Latest RCTs

Updated December 17th

The SCREEN Panel Discussion at CCR Down Under

We're now on BlueSky

Latest Guidelines

Updated December 17th

Latest SRMAs

Updated December 17th

Latest Observational Studies

Updated December 17th

Propofol ampoules

Narrative Review

Boncyk. Management of pain and sedation in the intensive care unit. BMJ 2024;387:e079789

Added December 16th

Image: Shutterstock / Mongkolchon Akesin

Heart at transplantation

Narrative Review

Chapman. Type 2 myocardial infarction: challenges in diagnosis and treatment. Eur Heart J 2024;epublished December 10th

Added December 16th

Image: Shutterstock / Saiful52

Sevoflurane vapouriser

Narrative Review

Darwish. Inhaled anesthetics: beyond the operating room. J Clin Med 2024;13:7513

Added December 15th

Image: Shutterstock / KILO-LUX

Nurse changing the settings on a mechanical ventilator

Narrative Review

Giosa. Bedside assessment of the respiratory system during invasive mechanical ventilation. J Clin Med 2024;13:7456

Added December 15th

Image: Shutterstock / Gerain0812

Nurse holding a patient's hand

Narrative Review

Vail. How I do it: part 1: best practices for intensivists planning and opening hospital-based deceased organ donor care units. Chest Crit Care 2024;epublished November 8th

Added December 15th

Image: Shutterstock / PongMoji

Doctor reading on a laptop

Editorial

Spencer. What if we do, but what if we don’t? The opportunity cost of artificial intelligence hesitancy in the intensive care unit. Intensive Care Med 2024;epublished December 11th

Added December 13th

Image: Shutterstock / PeopleImages.com-Yuri-A

Three doctors reading from a tablet in the corridor

Editorial

Wernly. The role of artificial intelligence in life-sustaining treatment decisions: current state and future considerations. Intensive Care Med 2024;epublished December 11th

Added December 13th

Image: Shutterstock / WBMUL

Doctor reading data from a mobile phone

Editorial

Lijović. Leveraging the power of routinely collected ICU data. Intensive Care Med 2024;epublished December 11th

Added December 13th

Image: Shutterstock / sfam_photo

ECMO machine in the ICU

Commentary

Kon. POINT: is it ethically justifiable to withdraw extracorporeal membrane oxygenation against the wishes of a patient with decision-making capacity when cure is not possible? Yes. Chest 2024;166(6):1281-1283

Added December 13th

Image: Shutterstock / sfam_photo

ECMO machine

Commentary

Childress. COUNTERPOINT: is it ethically justifiable to withdraw extracorporeal membrane oxygenation against the wishes of a patient with decision-making capacity when cure is not possible? No. Chest 2024;166(6):1283-1285

Added December 13th

Image: Shutterstock / April stock

Unit of red cells being transfused

Commentary

Noitz. Physiologic transfusion thresholds, better than using Hb-based thresholds? Blood Transfus 2024;epublished November 22nd

Added December 13th

Image: Shutterstock / sfam_photo

The latest from Critical Care Reviews

Bruising across a patient's lower abdomen

Paper of the Day

Saturay, December 21st

Carenzo. Contemporary management of traumatic cardiac arrest and peri-arrest states: a narrative review. J Anesth Analg Crit Care 2024;4:66

Join us to read one paper per day and cover the spectrum of critical care across 2024. Previous papers of the day are available here.

Have it emailed to you!

image: Shutterstock / Jeremy Wee

Latest Podcast

Couper. A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest. N Engl J Med 2024;epublished October 31st

Added November 12th