Foundational Trials Collection
Introducing our latest resource – Foundational Trials in Critical Care. Replacing our old Top 100 Trials, this new collection presents the trials that underpin modern intensive care practice.
All trials are fully appraised in the same systematic manner, allowing clinicians to easily follow every trial. If you are new to critical care, need a resource to guide those new to the field, or just want to refresh your knowledge, then enjoy reading our Foundational Trials Collection.
We’ll release one every few days, starting with arguably the most impactful trial of them all – ARMA. Our second trial is the landmark Kress trial on daily sedation interuptions from 2000.
Latest Randomised Trials
- Guyette. A Randomized Controlled Trial of Sublingual Sufentanil in Early Management of Pain in Trauma. Anesth Analg 2025;141(1):172-180
- Miyasaka. EEG-Guided Titration of Sevoflurane and Pediatric Anesthesia Emergence Delirium—A Randomized Clinical Trial. JAMA Pediatr 2025;179(7):704-712
- Wijk. Effects of increased cardiopulmonary bypass pump flow on renal filtration, perfusion, oxygenation and tubular injury in cardiac surgical patients - a randomized controlled trial. Anesthesiol 2025;epublished July 7th
- Tao. Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke. N Engl J Med 2025;epublished July 3rd
Last updated July 8th
Latest Meta Analyses
- Chen. Effects of different respiratory training methods on respiratory function in patients with spinal cord injury: a network meta-analysis of randomized controlled trials. Crit Care 2025;29:285
- Basmaji. The diagnostic accuracy of point-of-care ultrasound in shock: a systematic review and meta-analysis. Can J Anaesth 2025;epublished July 2nd
- Gao. Noninvasive neuromodulation for disorders of consciousness: an updated systematic review and meta-analysis. Crit Care 2025;29(1):269
- Trelles. Prevalence of invasive fungal infection in critically ill patients: a systematic review and meta-analysis. BMC Infect Dis 2025;25(1):896
Last updated July 8th
Latest Observational Studies
- Jennings. Epidemiology and Mortality of Invasive Staphylococcus aureus Infections in Hospitalized Infants. JAMA Pediatr 2025;179(7):747-755
- Paul. Prolonged Mechanical Ventilation in Critically Ill Patients. Six-Month Mortality, Care Pathways, and Quality of Life. Chest 2025;168(1):106-118
- Trenchat. Self-extubation in critically ill patients: from the French OUTCOMEREA Network. Crit Care 2025;29(1):286
- Coppola. Driving pressure vs. oxygenation-based PEEP titration strategies in ARDS patients: a physiological study. Crit Care 2025;29:28
Last updated July 6th
Latest Guidelines
- Cecconi. Implementing Artificial Intelligence in Critical Care Medicine: a consensus of 22. Crit Care 2025;29:290
- Raina. Liberation from continuous renal replacement therapy due to renal recovery in adults and children: a literature review and Delphi consensus on clinical practice. Crit Care 2025;29:287
- 2025 ESVM Guidelines on interventional treatment of venous thromboembolism. Vasa 2025;epublished June 30th
- Forero-Delgadillo. Colombian consensus on the care of critically ill patients with suspected or confirmed severe yellow fever. Lancet Reg Health Am 2025;48:101144
Last updated July 8th
Latest Narrative Reviews
- Aydın. Foundations and Advancements in Hemodynamic Monitoring: Part II - Advanced Parameters and Tools. Turk J Anaesthesiol Reanim 2025;epublished June 17th
- Woodford. Clarity in Hemodynamics and End-Organ Perfusion: Pulsatility, Patient Phenotype, and the Pressure Field as a Novel Approach. Anesth Analg 2025;141(1):113-119
- Gondode. Blockchain in Critical Care. Indian J Crit Care Med 2025; 29 (6):525-530.
- Szewczyk. Neuromuscular Blocking Agents and Reversal Agents Usage, and Neuromuscular Blockade Monitoring in the Intensive Care Unit. Int J Gen Med 2025:18 3651–3688
- Yahya. Maternal Sepsis Review and Update. Mayo Clin Proc 2025;100(7):1212-1230
Last updated July 7th
Latest Editorials
- Demiselle. Hemodynamic targets in the initial resuscitation of older patients with sepsis: time for a reappraisal?. Intensive Care Med 2025;epublished July 3rd
- Ostermann. Renal tubular epithelial cells: A revived kidney biomarker?. Intensive Care Med 2025;epublished June 30th
- Annetta. The never-ending confusion between subclavian vein and axillary vein. J Vasc Access 2025;epublished June 27th
- Malvindi. The 10 Commandments of On-Table Extubation After Cardiac Surgery: Why and How to Increase Adoption. Innovations 2025;epublished June 30th
- Ng. Re-defining ‘clinical reasoning’. Intern Med J 2025;epublished July 1st
Last updated July 4th
Latest Commentaries
- Malyszko. DEFENDER trial: dapagliflozin for critically ill patients with acute organ dysfunction—implications for clinicians. Nephrol Dial Transplant 2025;40(7):1267–1269
- Kellum. Rinaldo Bellomo, MD (1956–2025). Blood Purif 2025;epublished June 26th
- Tripathy. Green intensive care: reimplementing what LMICs have long practised. Lancet Glob Health 2025;13(7):e1166-e1167
- Alghaith. Young ERC Masterclass Journal Club Article: The TOMAHAWK trial. Resuscitation Plus 2025;epublished June 25th
Last updated July 4th
CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.
If you missed the presentations last December, the presentations of the so far published trials are available here.



CCR Content

Paper of the Day
Thursday, July 10th
Martyn. Opioid Tolerance in Critical Illness. N Engl J Med 2019;24;380(4):365-378
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Foundational Trials
We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.
added July 2nd

Newsletter 708
Critical Care Reviews Newsletter 708, bringing you the best critical care research and open access articles for the week June 30th to July 6th.
Subscriptions are available to individuals and departments.
added July 6th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR25
John Hinds Lecture
Prof John Myburgh delivers a remarkable John Hinds Lecture at the Critical Care Reviews Meeting 2025, titled Ukuthola Ubuhle