9 Days to go
Critical Care Reviews Meeting 2025
June 11th to 13th
Titanic Belfast
Free, Full Livestream

CCR Down Under 2025
Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.


A2B Results Presentation
Tim Walsh and Christopher Weir present the results of the A2B trial at the Critical Care Reviews Meeting 2024. Yahya Shehabi (Melbourne) delivers an editorial. Chris Nutt (Belfast) chairs a panel discussion including Deborah Cook (Hamilton), Lydia Emerson (Edinburgh), Alistair Nichol (Dublin), Ranjit Lall (Warwick) and Carol Hodgson (Melbourne).
JAMA Paper
Related
Interview with the Trialists
Tim Walsh and Christopher Weir give a brief summary of the A2B trial.

Paper of the Day
Monday, June 2nd
Paul. Point-of-care Ultrasound in Cardiac Arrest. Anesthesiology 2021;135(3):508-519
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Newsletter 703
Critical Care Reviews Newsletter 703, bringing you the best critical care research and open access articles for the week May 26th to June 1st.
Subscriptions are available to individuals and departments.
added June 1st

Randomised Controlled Trial
Walsh. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients. The A2B Randomized Clinical Trial. JAMA 2025;epublished May 19th
added May 20th

Randomised Controlled Trial

Editorial
Barbar. Acute kidney injury: when and how to start renal replacement therapy. Intensive Care Med 2025;epublished May 19th
added May 19th

Narrative Review

Narrative Review
Pantet. Advances in resuscitation and deresuscitation. Curr Opin Crit Care 2025;epublished March 7th
added May 16th

Randomised Controlled Trial
Endo. Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med 2025;epublished May 13th
added May 16th

Guidelines

Commentary

Narrative Review
Scandroglio. The application of mechanical circulatory support in special conditions. Eur Heart J Suppl 2025;27(Suppl_4):iv62-iv71
added April 29th

Narrative Review

Narrative Review
Thevathasan. The Heart Team approach to cardiac arrest. Eur Heart J Suppl 2025;27(Suppl_4):iv31-iv38
added April 29th

Randomised Controlled Trial

Observational Study
Azoulay. Outcomes in immunocompromised patients with acute hypoxemic respiratory failure treated by high-flow nasal oxygen. Intensive Care Med 2025;epublished April 22nd
added April 22nd

Narrative Review
Møller. Mechanical circulatory support: when, how, and for whom. Eur Heart J 2025;46(16):1480–1492
added April 22nd

Randomised Controlled Trial

Randomised Controlled Trial
added April 7th

Narrative Review
added April 7th

Guideline
John Hinds Lecture 2025
"Ukuthola ubuhle"

Prof John Myburgh
Sydney, Australia
Dr John Hinds
Dr John Hinds was a remarkable doctor and person. He worked as a prehospital physician, providing medical cover to professional motorbike road races, as well as being an intensivist and anaesthetist at Craigavon Area Hospital in County Armagh, Northern Ireland.
Sadly, in 2015, John died whilst on duty at the Skerries 100 Road Race in Dublin. He leaves a legacy of improved trauma care, not just in Northern Ireland, but with a vision and passion that had impact worldwide through his lectures and talks. Locally, he was one of the most prominent voices campaigning for a HEMS service, which is now established and highly successful.
Every year at the Critical Care Reviews Meeting, we remember our friend and colleague with the John Hinds Lecture, delivered by a world leading critical care clinician. The 2025 edition will be delivered by Prof John Myburgh, another impressive individual with a remarkable story to tell. The lecture is titled "Ukuthola ubuhle".

Dr John Hinds
1980 - 2015
added February 21st
Check out this short video from the Critical Care Reviews Meeting 2024. If you're interested in critical care trials, this is the meeting for you.
The Critical Care Reviews Meeting is a focused trials meeting. We host the results of the most impactful and important critical care trials in the world. In 2024, between our Belfast and Melbourne meetings, we hosted 19 major trial results, plus many accompanying systematic reviews and meta analyses.
Many of these presentations were in conjunction with simultaneous publications in the New England Journal of Medicine, JAMA and NEJM Evidence.
If you haven't been yet, check out our video - there's no other meeting like it.
Trial Announcements

RESCUE 3
Trial Registration | Trial Protocol | RESCUE 2

INDex-CTP
Trial Registration | Trial Protocol

ENCOMPASS

TTM2 Biomarker

PROMIZING

FLUID

UK-ROX

GASTROSAM

TARGET Protein
updated February 4th
CCR Down Under 2025
December 9th & 10th
Due to the success of CCR Down Under, we're heading back to Melbourne in December 2025 for another 2 day event.
Join us in the Edge, Federation Square, to hear the results of the best critical care trials in the world.
Registration will open in May.
CCR Down Under is run in partnership with The Alfred Intensive Care Academic Centre.
