CCR Blog
Vitamin C - A Love Story
Vitamin C in critical illness has always hinted at more than scurvy’s salvation. From Lind’s lemons to Linus Pauling’s promise to an ICU cocktail that briefly looked like a cure, the arc swings between elegant biology and stubborn clinical reality. We track the enzymes and endothelium, the catecholamines and carnitine, and the redox alchemy that can both shield and scorch. Then we meet the trials—VITAMINS neutral, LOVIT unnerving—and ask why sepsis would not yield while burns, post-arrest care, and megadose strategies still tempt inquiry. This piece follows the CCR thread through Belfast to Melbourne, where VITaCCA may yet decide whether our romance with ascorbate is requited or finally unmasked.
Added October 16th
CCR Down Under 2025 Trials to Date
Join us in Melbourne, December 9th & 10th, to discuss the best critical care trials in the world
Journal Watch Latest
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Randomised Controlled Trial

Randomised Controlled Trial

Systematic Review & Meta Analysis

Systematic Review & Meta Analysis
added October 17th

Narrative Reviews
added October 17th

Narrative Review
added October 17th

Narrative Review
Monet. Preoxygenation in the ICU. J Clin Med 2025;14(20):7305
added October 16th

Narrative Reviews
Hahn. Where does the fluid go?. Ann Intensive Care 2025;15:156
added October 15th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR22
LOVIT Trial Review
Francois Lamontagne and Neill Adhikari present the results of the LOVIT trial, investigating vitamin C in patients with sepsis.
added October 17th
CCR Content

Paper of the Day
