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NICO presentation at CCR24

Yonathan Freund (Paris) presents the NICO trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. Sheila Myatra (Mumbai) delivers an independent editorial. The session is chaired by Danny McAuley (Belfast).

The NICO trial investigated non-invasive airway management of patients comatose from acute poisoning.

NICO was previously published in JAMA.

NICO Paper

added January 17th

Critical Care Reviews Meeting 2025

The first trials for the Critical Care Reviews Meeting 2025 have started to be announced.

Join us in June to hear the best critical care trials in the world.

The Critical Care Reviews Meeting is a focused trials meeting. We host the results of the most impactful and important critical care trials in the world. In 2024, between our Belfast and Melbourne meetings, we hosted 19 major trial results, plus many accompanying systematic reviews and meta analyses.

Many of these presentations were in conjunction with simultaneous publications in the New England Journal of Medicine, JAMA and NEJM Evidence.

If you haven't been yet, check out our video - there's no other meeting like it.

Trial Announcements

TTM2 Biomarker

Biomarkers of Brain Injury after Cardiac Arrest

Trial Registration | Protocol | Biomarker SAP | Website

PROMIZING

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation

Trial Registration | Protocol

NOTACS

Nasal High-Flow Oxygen Therapy after Cardiac Surgery

Trial Registration | Protocol

FLUID

Crystalloid FLUID Choices for Resuscitation of Hospital Patients

Trial Registration | Protocol

UK-ROX

Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care

Trial Registration | Protocol | Website

GASTROSAM

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition

Trial Registration | Protocol

TARGET Protein

Augmented Administration of Enteral Protein to Critically Ill Adults

Trial Registration | Trial Protocol

updated January 17th

Paper of the Day

Friday, January 17th

De Jong. How to improve intubation in the intensive care unit. Update on knowledge and devices. Intensive Care Med 2022;48;1287-1298

Join us to read one paper per day and cover the spectrum of critical care across 2024. Previous papers of the day are available here.

Have it emailed to you!

image: Shutterstock / ChaNaWiT

Randomised Controlled Trial

Waldron. Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. Lancet Child Adolesc Health 2025;epublished January 8th

added January 14th

image: Shutterstock / Saiful52

CT scan showing a large left ischaemic stroke

Randomised Controlled Trial

Liu. Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial. JAMA 2025;epublished January 13th

added January 15th

image: Shutterstock / Yok_onepiece

HEMOTION presentation at CCR24

Alexis Turgeon and Francois Lauzier (both Quebec City) present the results of the HEMOTION trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. HEMOTION compared liberal with restrictive transfusion thresholds in critically ill patients with traumatic brain injury.

The session is chaired by Catriona Kelly (Dublin). John Myburgh (Sydney) delivers an independent editorial. Anthony Gordon (London), Marion Campbell (Aberdeen), Alistair Nichol (Dublin) and Carol Hodgson (Melbourne) contribute to a panel discussion.

HEMOTION was simultaneously published in the New England Journal of Medicine.

HEMOTION Paper

added January 14th

Randomised Controlled Trial

Yao. Sequential Versus Continuous Feeding and Its Effect on the Gut Microbiota in Critically Ill Patients: A Randomized Controlled Trial. Clin Nutr ESPEN 2025;epublished January 9th

added January 15th

image: Shutterstock / sfam_photo

Narrative Review

Brahmbhatt. From Escalate to Elevate: A New Paradigm for Comprehensive Cardiogenic Shock Management. Canadian Journal of Cardiology 2025;epublished January 9th

added January 13th

image: Shutterstock / Chaikom

PREOXI presentation at CCR24

Jonathan Casey and Kevin Gibbs present the results of the PREOXI trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast. PREOXI investigated non-invasive ventilation for preoxygenation in emergency intubation in the critically ill.

Yonathan Freund delivers an independent editorial. Catriona Kelly chairs a panel discussion with Anthony Gordon, Sheila Myatra, Victoria Cornelius and Jan Gunst.

PREOXI was simultaneously published in the New England Journal of Medicine.

PREOXI Paper

added January 9th

Narrative Review

Kamla. Kidney Injury Following Cardiac Surgery: A Review of Our Current Understanding. Am J Cardiovasc Drugs 2025;epublished January 12th

added January 13th

image: Shutterstock / Yok_onepiece

Narrative Review

Iba. Impact of hyper- and hypothermia on cellular and whole-body physiology. J Intensive Care 2025;13:4

added January 13th

image: Shutterstock / Mumemories

FAST scan with liver and kidney identified

Narrative Review

Nagesh. Management of gastrointestinal bleed in the intensive care setting, an updated literature review. World J Crit Care Med 2025;2025;14(1):101639

added January 8th

image: Shutterstock / Noppadon Seesuwan

DEFENDER presentation at CCR24

Profs Caio Tavares and Fernando Zampieri present the results of the DEFENDER trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast.

DEFENDER investigated the efficacy of dapagliflozin in the critically ill.

Danny McAuley delivers an independent editorial and Christopher Seymour chairs a panel discussion between Simon Finfer, Lennie Derde, Marion Campbell and Catherine McKenzie.

DEFENDER was simultaneously published in JAMA.

DEFENDER Paper

added January 7th

Narrative Review

Wong. Extracorporeal membrane oxygenation and pregnancy. Best Pract Res Clin Anaesthesiol 2024;38(3):293-301

added January 8th

image: Shutterstock / ChaNaWiT

Guideline

Management of Central Airway Obstruction. An American College of Chest Physicians Clinical Practice Guideline. Chest 2025;167(1):283-295

added January 8th

image: Shutterstock / Solid Design

Editorial

Newcombe. What’s new: the Glasgow Coma Scale at 50—evolution and future directions. Intensive Care Med 2025;epublished January 7th

added January 7th

image: Shutterstock / Tomatheart

REVISE presentation at CCR24

Deborah Cook and Adam Deane present the results of the REVISE trial, plus an accompanying systematic review and meta analysis, at the Critical Care Reviews Meeting 2024, in Titanic Belfast.

REVISE investigates the efficacy of stress ulcer prophylaxis with pantoprazole in critically ill mechanically ventilated patients.

Kathy Rowan delivers an editorial and Darren Taichman chairs a panel discussion between David Harrison, Martina Baiardo Redaelli, Madiha Hasmi and Danny McAuley.

REVISE was simultaneously published in the New England Journal of Medicine. The SRMA was simultaneously published in NEJM Evidence.

REVISE Paper

SRMA

added January 6th