CCR26
Announcing the trials for the Critical Care Reviews Meeting 2026
Day 6 - The VICTORY Trial
CCR Down Under is barely over and we now turn our focus back to Belfast for CCR26, June 10th to 12th, 2026.
Over the rest of December we'll announce the the major trial results to be presented at Titanic Belfast.
Our sixth trial is VICTORY, a multicentre, double-blind, randomised controlled trial evaluating high-dose intravenous vitamin C in adults with severe, life-threatening burn injury. Patients with deep second- and/or third-degree burns involving at least 20% total body surface area are randomly allocated to receive vitamin C at 200 mg/kg/day for 96 hours or placebo, in addition to standard burn care. Conducted across more than 40 burn centres worldwide, the trial tests the hypothesis that vitamin C can reduce organ dysfunction and accelerate recovery after major burns. The primary outcome is time to discharge alive from hospital, with secondary outcomes including ICU and hospital length of stay, organ support, mortality, quality of life, and healthcare resource use.
Registration for CCR26 opens soon!
Added December 26th
RSI Trial
Jonathan Casey and Matthew Semler (Nashville) presents the results of the RSI trial at CCR Down Under 2025, in Melbourne. The RSI trial compared etomidate with ketamine for emergency intubation in the critically ill. Chris Nickson (Melbourne) delivers an independent editorial. Paul Young (Wellington) chairs a panel discussion between Wangari Waweru-Siika (Nairobi), Elissa Milford (Brisbane) and Liz Ryan (Melbourne). The RSI trial was simultaneous published in the New England Journal of Medicine.
Trialists' Summary
Jonathan Casey and Matthew Semler (Nashville) summarise the results of the RSI trial.
Paper
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Guideline
added October 27th
Narrative Review
Randomised Controlled Trial
Randomised Controlled Trial
Systematic Review & Meta Analysis
Systematic Review & Meta Analysis
added October 17th
Narrative Reviews
added October 17th
Narrative Review
added October 17th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR22
CLASSIC Trial Results
Dr Tine Sylvest Meyhoff (Copenhagen, Denmark) presents the results of the CLASSIC trial. Prof Katryn Maitland (Kalifi, Kenya) delivers an editorial, which is followed by a panel discussion including Prof David Harrison (London, England), Dr Lennie Derde (Utrecht, the Netherlands), Dr Jon Silversides (Belfast, Northern Ireland), and the chief investigator for CLASSIC, Prof Anders Perner (Copenhagen, Denmark). The session is chaired by Prof Bala Venkatesh from Brisbane, Australia.
added December 4th
CCR Content
Paper of the Day