Foundational Trials Collection
Introducing our latest resource – Foundational Trials in Critical Care. Replacing our old Top 100 Trials, this new collection presents the trials that underpin modern intensive care practice.
All trials are fully appraised in the same systematic manner, allowing clinicians to easily follow every trial. If you are new to critical care, need a resource to guide those new to the field, or just want to refresh your knowledge, then enjoy reading our Foundational Trials Collection.
We’ll release one most days, starting with arguably the most impactful trial of them all – ARMA.
Latest Randomised Trials
- Tao. Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke. N Engl J Med 2025;epublished July 3rd
- Hyldegaard. Use of Hyperbaric Oxygen in Patients with Necrotizing Soft Tissue Infections: A Scandinavian Multicenter, Prospective, Observational Cohort. Infect Dis Ther 2025;epublished July 4th
- Mekontso Dessap. Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL). Intensive Care Med 2025;epublished July 3rd
- Jiao. Randomized Trial of Early vs Standard Renal Replacement Therapy in Patients With Acute Kidney Injury After Type A Aortic Dissection. Ann Thorac Surg 2025;120(1):17-24
Last updated July 6th
Latest Meta Analyses
- Basmaji. The diagnostic accuracy of point-of-care ultrasound in shock: a systematic review and meta-analysis. Can J Anaesth 2025;epublished July 2nd
- Gao. Noninvasive neuromodulation for disorders of consciousness: an updated systematic review and meta-analysis. Crit Care 2025;29(1):269
- Trelles. Prevalence of invasive fungal infection in critically ill patients: a systematic review and meta-analysis. BMC Infect Dis 2025;25(1):896
- Cao. Efficacy and safety of corticosteroids in critically ill patients: a systematic review and meta-analysis. BMC Anesthesiol 2025;25(1):319
Last updated July 6th
Latest Observational Studies
- Hanajima. Early Rehabilitation for Patients with Septic Shock Associated with Mobilization During Their Intensive Care Unit Stay Without Worsening Mortality: A Multicenter, Prospective, Cohort Study. J Intensive Care Med 2025;epublished July 4th
- Meyer. Does the 1:1:1 Transfusion Ratio Mortality Benefit Hold True in Ultra-massive Transfusion? A Study From the Product (Patient Related Outcomes During Ultra-massive transfusion multi-Center Trial) Consortium. Am Surg 2025;epublished July 4th
- Bianchi. Mortality of cancer patients with septic shock: A nation-based cohort analysis of 77,888 patients. Anaesth Crit Care Pain Med 2025;44(5):101557
- Serpa-Neto. Regional Practice Variation in the Management of Renal Replacement Therapy Modalities in the STARRT-AKI Trial. Blood Purif 2025;epublished July 1st
Last updated July 6th
Latest Guidelines
- 2025 ESVM Guidelines on interventional treatment of venous thromboembolism. Vasa 2025;epublished June 30th
- Forero-Delgadillo. Colombian consensus on the care of critically ill patients with suspected or confirmed severe yellow fever. Lancet Reg Health Am 2025;48:101144
- Adams. CALM ICU guidelines: Preliminary guidelines on non-pharmacological strategies for agitation in the ICU − A Delphi study. Intensive Crit Care Nurs 2025;90:104135
- Le Marechal. Detection, evaluation and management of the sequelae of infectious encephalitis in adults. Infectious Diseases Now 2025;epublished June 26th
Last updated July 2nd
Latest Narrative Reviews
- Szewczyk. Neuromuscular Blocking Agents and Reversal Agents Usage, and Neuromuscular Blockade Monitoring in the Intensive Care Unit. Int J Gen Med 2025:18 3651–3688
- Yahya. Maternal Sepsis Review and Update. Mayo Clin Proc 2025;100(7):1212-1230
- Halgas. Hemodynamic Monitoring in Burn Resuscitation: Current Status. Ann Burns Fire Disasters 2025;38(2):91–99
- Griva. The role of the tidal volume challenge test in volume responsiveness assessment: a narrative review. J Anesth Analg Crit Care 2025;5:37
- Fujishima. Current corticosteroid therapeutic strategy for community-acquired pneumonia in adults: indications, dosage, and timing. J Intensive Care 2025;13:37
Last updated July 7th
Latest Editorials
- Demiselle. Hemodynamic targets in the initial resuscitation of older patients with sepsis: time for a reappraisal?. Intensive Care Med 2025;epublished July 3rd
- Ostermann. Renal tubular epithelial cells: A revived kidney biomarker?. Intensive Care Med 2025;epublished June 30th
- Annetta. The never-ending confusion between subclavian vein and axillary vein. J Vasc Access 2025;epublished June 27th
- Malvindi. The 10 Commandments of On-Table Extubation After Cardiac Surgery: Why and How to Increase Adoption. Innovations 2025;epublished June 30th
- Ng. Re-defining ‘clinical reasoning’. Intern Med J 2025;epublished July 1st
Last updated July 4th
Latest Commentaries
- Malyszko. DEFENDER trial: dapagliflozin for critically ill patients with acute organ dysfunction—implications for clinicians. Nephrol Dial Transplant 2025;40(7):1267–1269
- Kellum. Rinaldo Bellomo, MD (1956–2025). Blood Purif 2025;epublished June 26th
- Tripathy. Green intensive care: reimplementing what LMICs have long practised. Lancet Glob Health 2025;13(7):e1166-e1167
- Alghaith. Young ERC Masterclass Journal Club Article: The TOMAHAWK trial. Resuscitation Plus 2025;epublished June 25th
Last updated July 4th
CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.
If you missed the presentations last December, the presentations of the so far published trials are available here.



CCR Content

Paper of the Day
Sunday, July 6th
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Foundational Trials
We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.
added July 2nd

Newsletter 707
Critical Care Reviews Newsletter 707, bringing you the best critical care research and open access articles for the week June 23rd to 29th.
Subscriptions are available to individuals and departments.
added June 30th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR25
John Hinds Lecture
Prof John Myburgh delivers a remarkable John Hinds Lecture at the Critical Care Reviews Meeting 2025, titled Ukuthola Ubuhle