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Would you like to receive the latest critical care literature every weekend?
Get the Critical Care Reviews Newsletter - there's nothing else like it!
Latest Randomised Trials
- Miatello. Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial. Lancet Respir Med 2025;epublished July 15th
- Voiriot. Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial. Intensive Care Med 2025;epublished July 15th
- Ke. Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial. Intensive Care Med 2025;epublished July 14th
- Lemiale. Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med 2025;epublished July 10th
Last updated July 17th
Latest Meta Analyses
- Abu‐Sultaneh. Intravenous Bronchodilators in Pediatric Critical Asthma: A Systematic Review and Network Meta‐Analysis. Pediatric Pulmonology 2025;60:e71192
- Lamarche-Fontaneto. Cardiac output monitors in septic shock: do they deliver what matters? A systematic review and meta-analysis. Crit Care 2025;29:299
- Ward. The Effect of Early Fluid Resuscitation on Mortality in Sepsis: A Systematic Review and Meta-Analysis. Crit Care Med 2025;epublished July 10th
- Mateos-Haro. Recommendations for the use of biomarkers for the management of adults with sepsis: a scoping review and critical appraisal. BMJ Open 2025;15:e090922
Last updated July 15th
Latest Observational Studies
- Tangchitthavorngul. Epidemiology and long-term outcomes of critically ill patients with severe AKI in India and Southeast Asia. Intensive Care Med 2025;epublished July 14th
- Ostadal. Cardiac index, SvO2 or pCO2 gap may determine benefit from ECMO in cardiogenic shock: post-hoc analysis of the multicenter, randomized ECMO-CS trial. Crit Care 2025;29:303
- Gross. Mortality and antibiotic timing in deep learning-derived surviving sepsis campaign risk groups: a multicenter study. Crit Care 2025;29:302
- Zampieri. Effects of dapagliflozin on urinary output, fluid balance, and biochemistry in critically ill patients: a post-hoc secondary analysis of the DEFENDER trial. Crit Care 2025;29:297
Last updated July 15th
Latest Guidelines
- Neurosurgical management of the acute phase of adult and pediatric traumatic brain injury: 2025 guidelines of the French Society of Neurosurgery. Neurochirurgie 2025 Jul;71(4):101686
- Expert consensus‑based clinical practice guidelines for nutritional support in the intensive care unit: the French Intensive Care Society (SRLF) and the French-Speaking Group of Pediatric Emergency Physicians and Intensivists (GFRUP). Ann Intensive Care 2025;15:99
- European Association for the Study of the Liver. EASL Clinical Practice Guidelines on TIPS. J Hepatol 2025;83(1):177-210
- Yan. 2024 Guidelines on Patient Blood Management for Adult Cardiac Surgery Under Cardiopulmonary Bypass in China. Rev Cardiovasc Med 2025;26(6):31384
Last updated July 18th
Latest Narrative Reviews
- Martin-Loeches. Severe community-acquired pneumonia (sCAP): advances in management and future directions. Thorax 2025;80:565-575
- Sekhon. Clinical heterogeneity and phenotyping of post cardiac arrest brain injury: one size may not fit all. Intensive Care Med 2025;epublished July 16th
- Zarbock. Preventing acute kidney injury and its longer-term impact in the critically ill. Intensive Care Med 2025;epublished July 15th
- Li. Crosstalk between lung and extrapulmonary organs in sepsis-related acute lung injury/acute respiratory distress syndrome. Ann. Intensive Care 2025;15:97
- Matsuo. The Latest Approaches to Fracture-Related Infection. Curr Infect Dis Rep 2025;27:15
- Moore. The unwell patient with advanced chronic liver disease: when to use each score?. BMC Med 2025;23:413
Last updated July 18th
Latest Editorials
- Arabi. Venous thromboprophylaxis in the ICU: navigating evidence, risk, and practice gaps. Intensive Care Med 2025;epublished July 16th
- Skrifvars. A Personal Reflection on the Late Rinaldo Bellomo, One of the Most Prolific Researchers in Intensive Care Medicine. Acta Anaesthesiol Scand 2025;69(7):e70097
- Skrifvars. Restrictive Oxygen Use Did Not Improve Outcomes in the UK ROX Study. Acta Scandanavica Anesthesiologica 2025;69(7):e70098
- Augoustides. Scoping Reviews—Understanding their Evolution, Methodology, Context, and Contributions to Systematic Reviews and Meta-Analyses. J Cardiothorac Vasc Anesth 2025;epublished June 13th
Last updated July 16th
Latest Commentaries
- Gruartmoner. Hemodynamic coherence: a metabolic perspective. Crit Care 2025;29:293
- Laurentiu. Climate Change, Emissions of Volatile Anesthetics, and Policy Making: The Case of Desflurane. Anesth Analg 2025;141(1):123-127
- Callaway. Estimating bias from withdrawal of life sustaining treatment in clinical trials. Crit Care 2025;29:288
- Song. What should be done with PEEP during weaning from mechanical ventilation? Crit Care 2025;29(1):283
- Guidet. Balancing our art with our performance. Intensive Care Med 2025;epublished July 7th
Last updated July 10th
CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.
We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.
We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.
If you missed the presentations last December, the presentations of the so far published trials are available here.



CCR Content

Paper of the Day
Friday, July 18th
Vora. Awake tracheal intubation. BJA Education 2022;22(8):298-305
Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Foundational Trials
We start a new section looking at the foundation trials in critical care and start with probably the most important trial yet in the field.
added July 15th

Newsletter 709
Critical Care Reviews Newsletter 709, bringing you the best critical care research and open access articles for the week July 7th to 13th.
Subscriptions are available to individuals and departments.
added July 13th

Highlighted Narrative Reviews
With thousands of open access narrative reviews listed across the website, CCR provides a comprehensive educational resource. We'll highlight one topic here every few days. Today, we look at Acute Kidney Injury
added July 15th

Highlighted Guidelines
Need a guideline, or just want to refresh your knowledge on the evidence-based management of a particular condition? We provide more up-to-date guidelines than any other critical care resource. have a look at our Burns guideline section
added July 13th
CCR Meeting Talks
After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.
CCR18
The ADRENAL Trial Results
Prof Bala Venkatesh presents the results of the landmark ADRENAL trial at the Critical Care Reviews Meeting 2018