Critical Care Reviews Meeting 2025

The Best Critical Care Trials in the World

Paper of the Day

Thursday, February 20th

Nierhaus. Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis. Ann Intensive Care 2020;10(1):132

Join us to read one paper per day and cover the spectrum of critical care across 2024. Previous papers of the day are available here.

Have it emailed to you!

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Narrative Review

Gómez-Johnson. Point-of-care ultrasound in nephrology: beyond kidney ultrasound. Diagnostics 2025;15(3):297

added February 17th

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Guidelines

Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis 2025;epublished February 13th

added February 16th

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Guideline

Frontera. Guidelines for Seizure Prophylaxis in Patients Hospitalized with Nontraumatic Intracerebral Hemorrhage: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society. Neurocrit Care 2025;42:1–21

added February 11th

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Commentary

Rossetti. Epileptiform Electrographic Patterns After Cardiac Arrest. Give Up or Treat? JAMA Neurol 2025;82(2):119-120

added February 11th

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Narrative Review

Karunakaran. Trace elements: Clinical perspectives in the critically ill. J Intensive Care Soc 2025;epublished February 5th

added February 10th

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Guideline

Red Blood Cell Transfusion in Critically Ill Adults. An American College of Chest Physicians Clinical Practice Guideline. Chest 2025;167(2):477-489

added February 10th

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Narrative Review

Zhang. Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies. Front Immunol 2025;16:1546474

added February 10th

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Critical Care Reviews Meeting 2025

Check out this short video from the Critical Care Reviews Meeting 2024. If you're interested in critical care trials, this is the meeting for you.

The Critical Care Reviews Meeting is a focused trials meeting. We host the results of the most impactful and important critical care trials in the world. In 2024, between our Belfast and Melbourne meetings, we hosted 19 major trial results, plus many accompanying systematic reviews and meta analyses.

Many of these presentations were in conjunction with simultaneous publications in the New England Journal of Medicine, JAMA and NEJM Evidence.

If you haven't been yet, check out our video - there's no other meeting like it.

Trial Announcements

PRINCE

Ischaemic Preconditioning in Non Cardiac Surgery

Trial Registration

ANH

Acute normovolemic hemodilution in cardiac surgery patients

Trial Registration | Protocol

RESCUE 3

Temporary Transvenous Diaphragm Pacing versus Standard of Care for Weaning From Mechanical Ventilation

Trial Registration | Trial Protocol | RESCUE 2

INDex-CTP

CT Perfusion for the Neurological Determination of Death

Trial Registration | Trial Protocol

ENCOMPASS

Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship

Trial Registration | Trial Protocol

TTM2 Biomarker

Biomarkers of Brain Injury after Cardiac Arrest

Trial Registration | Protocol | Biomarker SAP | Website

PROMIZING

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation

Trial Registration | Protocol

NOTACS

Nasal High-Flow Oxygen Therapy after Cardiac Surgery

Trial Registration | Protocol

FLUID

Crystalloid FLUID Choices for Resuscitation of Hospital Patients

Trial Registration | Protocol

UK-ROX

Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care

Trial Registration | Protocol | Website

GASTROSAM

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition

Trial Registration | Protocol

TARGET Protein

Augmented Administration of Enteral Protein to Critically Ill Adults

Trial Registration | Trial Protocol

updated February 4th

Chest radiograph showing pleural space infection

Paper of the Day

Tuesday, February 11th

Abdulelah. Infective Pleural Effusions-A Comprehensive Narrative Review Article. Clin Pract 2024;14(3):870-881

Join us to read one paper per day and cover the spectrum of critical care across 2024. Previous papers of the day are available here.

Have it emailed to you!

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Narrative Review

Faggioni. A Rational Approach to the Treatment of Acute Pulmonary Embolism. Annu Rev Med 2025;76:327-337

added January 29th

image: Shutterstock / Radiological-imaging

Narrative Review

Khemichian. Update on Hepatorenal Syndrome: From Pathophysiology to Treatment. Annu Rev Med 2025;76:373-387

added January 29th

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Narrative Review

Hiser. Intensive care unit acquired weakness and physical rehabilitation in the ICU. BMJ 2025;388:e077292

added January 28th

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Narrative Review

Bezati. Major Bleeding in the Emergency Department: A Practical Guide for Optimal Management. J Clin Med 2025;14:784

added January 25th

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Narrative Review

Leng. The endovascular treatment strategies of cerebrovascular injuries in traumatic brain injury. Chin J Traumatol 2025;epublished January 22nd

added January 25th

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Glucose Control IPDMA presentation at CCR24

Simon Finfer (Sydney) and Derick Adigbli (Melbourne) present the results of an IPDMA of intensive glucose control in the critically ill at the Critical Care Reviews Meeting 2024. Lennie Derde (Utrecht) delivers an independent editorial. Danny McAuley (Belfast) chairs the session.

This IPDMA was simultaneously published in NEJM Evidence.

IPDMA Paper

added January 24th

TGC-FAST presentation at CCR24

Jan Gunst (Leuven) presents the TGC-FAST trial at the Critical Care Reviews Meeting 2024. Lennie Derde delivers an independent editorial. The session is chaired by Danny McAuley (Belfast).

TGC-FAST was published in the New England Journal of Medicine.

TGC-FAST Paper

added January 24th

CYCLE presentation at CCR24

Michelle Kho and Heather O'Grady present the results of the CYCLE trial at the Critical Care Reviews Meeting 2024. CYCLE investigates the use of in-bed ergometry in the critically ill mechanically ventilated patient.

The session is chaired by Marion Campbell. Panellists include Andrew Althouse, Carol Hodgson, Kevin Gibbs and Paul Mouncey.

CYCLE was simultaneously published in NEJM Evidence.

CYCLE Paper

Meta Analysis

added January 23rd

Narrative Review

Liu. Recent advances in the development of invasive ventilator liberation. Trends Anaesth Crit Care 2025;60:101521

added January 25th

image: Shutterstock / tungtaechit

Person typing on a laptop with AI symbols hovering above the keyboard

Editorial

McNicholas. Natural language processing in critical care: opportunities, challenges, and future directions. Intensive Care Med 2025;epublished January 20th

added January 20th

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Editorial

Young. Using AI to detect and treat delirium. Intensive Care Med 2025;epublished January 20th

added January 20th

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John Hinds Lecture 2024

Kathy Rowan delivering the John Hinds Lecture at CCR24

Professor Kathy Rowan delivers the 2024 John Hinds Lecture, entitled "ICNARC at 30 - Back to the Future".

added January 21st

NICO presentation at CCR24

Yonathan Freund (Paris) presents the NICO trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. Sheila Myatra (Mumbai) delivers an independent editorial. The session is chaired by Danny McAuley (Belfast).

The NICO trial investigated non-invasive airway management of patients comatose from acute poisoning.

NICO was previously published in JAMA.

NICO Paper

added January 17th

Editorial

Messina. How we could use critical care echocardiography in the assessment of and management of cardiovascular phenotypes in septic shock: the good, the bad, and the ugly profiles. Intensive Care Med 2025;epublished January 20th

added January 20th

image: Shutterstock / sfam_photo

Randomised Controlled Trial

Waldron. Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. Lancet Child Adolesc Health 2025;epublished January 8th

added January 14th

image: Shutterstock / Saiful52

HEMOTION presentation at CCR24

Alexis Turgeon and Francois Lauzier (both Quebec City) present the results of the HEMOTION trial at the Critical Care Reviews Meeting 2024 in Titanic Belfast. HEMOTION compared liberal with restrictive transfusion thresholds in critically ill patients with traumatic brain injury.

The session is chaired by Catriona Kelly (Dublin). John Myburgh (Sydney) delivers an independent editorial. Anthony Gordon (London), Marion Campbell (Aberdeen), Alistair Nichol (Dublin) and Carol Hodgson (Melbourne) contribute to a panel discussion.

HEMOTION was simultaneously published in the New England Journal of Medicine.

HEMOTION Paper

added January 14th

CT scan showing a large left ischaemic stroke

Randomised Controlled Trial

Liu. Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial. JAMA 2025;epublished January 13th

added January 15th

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Randomised Controlled Trial

Yao. Sequential Versus Continuous Feeding and Its Effect on the Gut Microbiota in Critically Ill Patients: A Randomized Controlled Trial. Clin Nutr ESPEN 2025;epublished January 9th

added January 15th

image: Shutterstock / sfam_photo

Narrative Review

Brahmbhatt. From Escalate to Elevate: A New Paradigm for Comprehensive Cardiogenic Shock Management. Canadian Journal of Cardiology 2025;epublished January 9th

added January 13th

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PREOXI presentation at CCR24

Jonathan Casey and Kevin Gibbs present the results of the PREOXI trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast. PREOXI investigated non-invasive ventilation for preoxygenation in emergency intubation in the critically ill.

Yonathan Freund delivers an independent editorial. Catriona Kelly chairs a panel discussion with Anthony Gordon, Sheila Myatra, Victoria Cornelius and Jan Gunst.

PREOXI was simultaneously published in the New England Journal of Medicine.

PREOXI Paper

added January 9th

Narrative Review

Kamla. Kidney Injury Following Cardiac Surgery: A Review of Our Current Understanding. Am J Cardiovasc Drugs 2025;epublished January 12th

added January 13th

image: Shutterstock / Yok_onepiece

Narrative Review

Iba. Impact of hyper- and hypothermia on cellular and whole-body physiology. J Intensive Care 2025;13:4

added January 13th

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FAST scan with liver and kidney identified

Narrative Review

Nagesh. Management of gastrointestinal bleed in the intensive care setting, an updated literature review. World J Crit Care Med 2025;2025;14(1):101639

added January 8th

image: Shutterstock / Noppadon Seesuwan

DEFENDER presentation at CCR24

Profs Caio Tavares and Fernando Zampieri present the results of the DEFENDER trial at the Critical Care Reviews Meeting 2024, in Titanic Belfast.

DEFENDER investigated the efficacy of dapagliflozin in the critically ill.

Danny McAuley delivers an independent editorial and Christopher Seymour chairs a panel discussion between Simon Finfer, Lennie Derde, Marion Campbell and Catherine McKenzie.

DEFENDER was simultaneously published in JAMA.

DEFENDER Paper

added January 7th

Narrative Review

Wong. Extracorporeal membrane oxygenation and pregnancy. Best Pract Res Clin Anaesthesiol 2024;38(3):293-301

added January 8th

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Guideline

Management of Central Airway Obstruction. An American College of Chest Physicians Clinical Practice Guideline. Chest 2025;167(1):283-295

added January 8th

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Editorial

Newcombe. What’s new: the Glasgow Coma Scale at 50—evolution and future directions. Intensive Care Med 2025;epublished January 7th

added January 7th

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REVISE presentation at CCR24

Deborah Cook and Adam Deane present the results of the REVISE trial, plus an accompanying systematic review and meta analysis, at the Critical Care Reviews Meeting 2024, in Titanic Belfast.

REVISE investigates the efficacy of stress ulcer prophylaxis with pantoprazole in critically ill mechanically ventilated patients.

Kathy Rowan delivers an editorial and Darren Taichman chairs a panel discussion between David Harrison, Martina Baiardo Redaelli, Madiha Hasmi and Danny McAuley.

REVISE was simultaneously published in the New England Journal of Medicine. The SRMA was simultaneously published in NEJM Evidence.

REVISE Paper

SRMA

added January 6th