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CCR25

CCR25 has come and gone. It was a spectacular success, with 12 superb trials presented, 9 with simultaneous publications. The videos from CCR25 are available here.  Next stop, Melbourne!

CCR Down Under 2025

Registration has opened for CCR Down Under in Melbourne, on December 9th and 10th, again at the Edge in Federation Square.

We aim to bring another set of fantastic international critical care trials to Australia. If you are interested in the science underlying clinical practice, this is the meeting for you.

We're delighted to be partnering once again with the Alfred Intensive Care Academic Centre, and this year, with Monash University.

If you missed the presentations last December, the presentations of the so far published trials are available here.

Register

Latest Literature

Regional block under untrasound guidance

Paper of the Day

Monday, June 23rd

Ott. Non-Neuraxial Chest and Abdominal Wall Regional Anesthesia for Intensive Care Physicians—A Narrative Review. J Clin Med 2024;13(4):1104

Join us to read one paper per day and cover the spectrum of critical care across 2025. Previous papers of the day are available here.

Have it emailed to you!

image: Shutterstock / PIJITRA-PHOMKHAM
CCR Newsletter icon

Newsletter 705

Critical Care Reviews Newsletter 705, bringing you the best critical care research and open access articles for the week June 9th to 15th.

Subscriptions are available to individuals and departments.

added June 16th

Bedside vial of dexmedetomidine

Randomised Controlled Trial

Walsh. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients. The A2B Randomized Clinical Trial. JAMA 2025;epublished May 19th

added May 20th

image: Shutterstock / Sora
ICU patient lying prone

Randomised Controlled Trial

Legrand. Iloprost for the Treatment of Severe Septic Shock with Persistent Hypoperfusion: A Double-Blind, Randomized Controlled Trial. Am J Respir Crit Care Med 2025;epublished May 19th

added May 19th

image: Shutterstock / sfam_photo
Nurse operating a CRRT machine in the ICU

Editorial

Barbar. Acute kidney injury: when and how to start renal replacement therapy. Intensive Care Med 2025;epublished May 19th

added May 19th

image: Shutterstock / shutter_o
CT brain showing a large left sided infarction with mass effect

Narrative Review

BMJ. Advances in treatments for acute ischemic stroke. BMJ 2025;389:e076161

added May 16th

image: Shutterstock / PeopleImages.com-Yuri A
Finger imprints in a patient with pitting oedema

Narrative Review

Pantet. Advances in resuscitation and deresuscitation. Curr Opin Crit Care 2025;epublished March 7th

added May 16th

image: Shutterstock / Gorodenkoff
Bedside ICU monitor

Randomised Controlled Trial

Endo. Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med 2025;epublished May 13th

added May 16th

image: Shutterstock / shutter_o
Patient with arm on a support during a rehab session

Guidelines

Hodgson. Australian clinical practice guideline for physical rehabilitation and mobilisation in adult intensive care units. Aus Crit Care 2025;38(4):101235

added May 2nd

image: Shutterstock / WeStudio
CCR Newsletter icon

Randomised Controlled Trial

Duan. Low versus high positive end expiratory pressure in noninvasive ventilation for hypoxemic respiratory failure: a multicenter randomized controlled trial. Intensive Care Med 2025;epublished April 30th

added May 2nd

CXR of a lobar pneumonia

Commentary

Markley. Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients With Cirrhosis: First, Do No Harm. Clin Infect Dis 2025;80(4):710-714

added May 2nd

image: Shutterstock / Zay Nyi Nyi
Infusion pump being programmed

Narrative Review

Scandroglio. The application of mechanical circulatory support in special conditions. Eur Heart J Suppl 2025;27(Suppl_4):iv62-iv71

added April 29th

image: Shutterstock / Fotosr52
12 lead ECG

Narrative Review

Haneya. Optimizing outcomes in heart transplantation: multidisciplinary Heart Teams and mechanical circulatory support for primary graft dysfunction. Eur Heart J Suppl 2025;27(Suppl_4):iv55-iv61

added April 29th

image: Shutterstock / PeopleImages.com-Yuri A
Ventilated ICU patient on dialysis

Narrative Review

Thevathasan. The Heart Team approach to cardiac arrest. Eur Heart J Suppl 2025;27(Suppl_4):iv31-iv38

added April 29th

image: Shutterstock / Gorodenkoff
CXR of a lobar pneumonia

Randomised Controlled Trial

The REMAP-CAP Investigators. Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia. Intensive Care Med 2025;epublished April 22nd

added April 22nd

image: Shutterstock / sfam_photo
Nurse working with a COVID-19 patient in an isolation room

Observational Study

Azoulay. Outcomes in immunocompromised patients with acute hypoxemic respiratory failure treated by high-flow nasal oxygen. Intensive Care Med 2025;epublished April 22nd

added April 22nd

image: Shutterstock / Patrik_Slezak
VAD battery and drive lead visible on a patients abdomen

Narrative Review

Møller. Mechanical circulatory support: when, how, and for whom. Eur Heart J 2025;46(16):1480–1492

added April 22nd

image: Shutterstock / John-Fs-Pic
Poppy field

Randomised Controlled Trial

Smyth. Paramedic analgesia comparing ketamine and morphine in trauma (PACKMaN): a randomised, double-blind, phase 3 trial. Lancet Reg Health Eur 2025;53:101265

added April 8th

image: Shutterstock / Svetlana Beleacov
Console of a mechanical ventilator

Randomised Controlled Trial

Seitz. Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial. Chest 2025;epublished April 4th

added April 7th

image: Shutterstock / sfam_photo
Nurse working with a COVID-19 patient in an isolation room

Narrative Review

Weckler. Multiorgan sequelae following non-COVID-19 respiratory infections: a review. Infection 2025;epublished April 4th

added April 7th

image: Shutterstock / shutter_o_
Intra-aortic balloon pump console

Guideline

Resuscitative Endovascular Balloon Occlusion of the Aorta in surgical and trauma patients: a systematic review, meta-analysis and practice management guideline from the Eastern Association for the Surgery of Trauma. Trauma Surg Acute Care Open 2025;10:e001730

added April 2nd

image: Shutterstock / pirke