CCR26

ACTiVE Trial

Prof Ary Serpa Neto (Melbourne) presents the results of the ACTiVE trial at CR Down Under 2025 in melbourne. ACTiVE investigates automated closed-loop ventilation in critically ill adults. Prof Danny McAuley (Belfast) delivers an independent editorial. Carol Hodgson (Melbourne) chairs a panel discussion between Anais Charles-Nelson (Melbourne), Shay McGuinness (Auckland) and Matthew Semler (Nashville).

added January 22nd

Trialists' Summary

Prof Ary Serpa Neto (Melbourne) summaries the ACTiVE trial, presnted at CCR Down Under 2025 in Melbourne

Papers

Journal Watch Latest

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Sample Issue

Guideline

Brain Trauma Foundation Guidelines for the Management of Penetrating Traumatic Brain Injury, Second Edition

added October 27th

image: Shutterstock / Tomatheart

Narrative Review

Mottale. The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications. Ann Intensive Care 2025;15:174

added October 27th

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Randomised Controlled Trial

Pettilä. Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial-The TARTARE-2S Trial. Crit Care Med 2025;epublished October 17th

added October 17th

image: Shutterstock / ivvv1975

Randomised Controlled Trial

Khan. Slow-tempo music and delirium/coma-free days among older adults undergoing mechanical ventilation: a randomized clinical trial. JAMA Intern Med 2025;epublished Oct 13th

added October 17th

image: Shutterstock / ME_Image

Systematic Review & Meta Analysis

Su. Is volatile sedation truly associated with increased mortality in mechanically ventilated critically ill adults compared to intravenous sedation? Moving beyond pairwise meta-analysis to individual agent assessment via Bayesian network meta-analysis. Crit Care 2025;29:435

added October 17th

image: Shutterstock / Zay Nyi Nyi

Peripheral intra venous callula being flushed

Systematic Review & Meta Analysis

Petros. Peripheral line for vasopressor administration: prospective multicenter observational cohort study for survival and safety. PLoS One 2025;20(10):e0333275

added October 17th

image: Shutterstock / Casa-nayafana

Narrative Reviews

Zhang. Thrombolytic therapy efficacy in cardiopulmonary resuscitation: investigating the effect of recombinant tissue plasminogen activator. Mol Med Rep 2025;32:335

added October 17th

image: Shutterstock / urbans

Narrative Review

Jain. Post-operative infection treatment in cardiac surgery: current practices and future directions. Perioper Med 2025;14:110

added October 17th

image: Shutterstock / Pitchyfoto

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR18

EOLIA Trial

Prof Niall Ferguson (Toronto) presents the EOLIA trial, investigating extracorporeal membrane oxygenation (ECMO) in severe acute respiratory distress syndrome

added January 22nd

CCR Content

Chest radiograph showing multiple rib fractures

Paper of the Day

Sarani. Contemporary management of patients with multiple rib fractures: What you need to know. J Trauma Acute Care Surg 2024;97(3):337-342

Thursday, January 22nd

Highlighted Narrative Reviews

Hydroxyethyl starch fluid hanging from a drip stand

Foundational Trials

We're putting together a collection of the trials which have formed the foundation of contemporary critical care over the past quarter of a century. The trials are critiqued and further reading provided, giving an excellent opportunity to learn about landmark trials or refresh your knowledge.

CCR26

ACTiVE Trial

Trialists' Summary

Papers

Journal Watch Latest

Would you like to receive the latest critical care literature every weekend? Get the Critical Care Reviews Newsletter - there's nothing else like it!

Guideline

Narrative Review

Randomised Controlled Trial

Randomised Controlled Trial

Systematic Review & Meta Analysis

Systematic Review & Meta Analysis

Narrative Reviews

Narrative Review

CCR Meeting Talks

After 14 meetings, we have a huge collection of superb presentations. We'll showcase them here, one at a time.

CCR18

EOLIA Trial

CCR Content

Paper of the Day

Latest Newsletter

Highlighted Narrative Reviews

Foundational Trials

Highlighted Guidelines

Privacy Settings

Functional

Preferences

Would you like to receive the latest critical care literature every weekend?
Get the Critical Care Reviews Newsletter - there's nothing else like it!