CCR-Newsletter-BannerNewsletter 461  |  October 12th 2020

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Welcome to the 461st Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.

The highlights of this week's edition are randomised controlled trials on tranexamic acid for prehospital trauma; the final report of the ACTT-1 Study, investigating remdesivir for the treatment of Covid-19, and the latest two results from the RECOVERY platform trial investigating therapies for COVID-19 - hydroxychloroquine and lopinavir–ritonavir; systematic reviews and meta analyses on ECMO for severe ARDS & intravenous thiamine for septic shock; and observational studies on left ventricular unloading in cardiogenic shock treated with veno-arterial ECMO & pressure injuries in adult intensive care unit patients.

There are also guidelines on post-cardiotomy extracorporeal life support & acute kidney injury biomarkers; narrative reviews on human albumin solutions & acute kidney injury in COVID-19; and commentaries on why corticosteroid therapy reduces mortality in severe COVID-19 & why critically ill status is not a carte blanche for unlimited antibiotic use.

This week's Topic of the Week is pulmonary vascular disorders, starting with a paper on life-threatening hemoptysis in today's Paper of the Day.

If you only have time to read one article this week, this astonishing piece from the editors of the New England Journal of Medicine should be it - Dying in a Leadership Vacuum.

 

Research

Miscellaneous

CCR21 Meeting

Due to the phenomenal success of CCR20, the Critical Care Reviews Meeting 2021 has been expanded to 3 days, allowing more time for major trial results presentations, as well as understanding the best clinical trials published during 2020. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.


Until next week

Rob

Supported by the Health Research Board

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