Welcome to the 402nd Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days.
It's been a big week for the Critical Care Reviews Meeting 2020, with the announcement we are to host the results of the ANZICS Clinical Trials Group PEPTIC trial, comparing proton pump inhibitors with histamine 2 receptor blockers in mechanically ventilated ICU patients. This huge multi-centre, cluster randomised, crossover, registry trial has recruited 26,733 patients. For those who can't make it to Titanic to hear Dr Paul Young present the results, we will live stream this worldwide, although it's far better to be there in person. You can also listen to the podcast I recorded with Dr Shay McGuinness, another senior investigator, a few years ago during the recruitment phase of PEPTIC.
If that wasn't enough, we have also added VITAMINS, another great ANZICS trial, to the CCR20 programme. This phase IIb trial investigates vitamin C, thiamine and hydrocortisone in patients with septic shock. It will be presented by Dr Tomoko Fujii from Melbourne. Finally, the videos from CCR19 continue to be released, with APPROCCHSS by Prof Djillali Annane, and its editorial by Dr Manu Shankar-Hari, plus Artificial Intelligence in Sepsis by Prof Anthony Gordon, with its editorial by Prof Kathy Rowan, all available this week just past. Another two sets of trial presentations will be released this week.
Registration for CCR20 is open, so don't delay too long and miss out the opportunity to discuss the best critical care trials of 2019 with their chief investigators, and hear the results of the PEPTIC trial.
- Abstract: Metra. Effects of Serelaxin in Patients with Acute Heart Failure. N Engl J Med 2019;381:716-726
- Abstract: Panza. Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy. N Engl J Med 2019; 381:739-748
- Abstract: Yanase. A Pilot, Double-Blind, Randomized, Controlled Trial of High Dose Intravenous Vitamin C for Vasoplegia after Cardiac Surgery. J Cardiothorac Vasc Anesth 2019;epublished August 24th
- Full Text: Schroeppel. Beta-adrenergic blockade for attenuation of catecholamine surge after traumatic brain injury: a randomized pilot trial. Trauma Surgery & Acute Care Open 2019;4:e000307
- Abstract: Kluytmans-van den Bergh. Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum β-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study. Lancet Infect Dis 2019;epublished August 23rd
- Abstract: Kugler. Ketamine Infusion for Pain Control in Elderly Patients with Multiple Rib Fractures: Results of a Randomized Controlled Trial. J Trauma Acute Care Surg 2019;epublished August 14th
- Abstract: Núñez. A randomized controlled trial on carbohydrate antigen 125-guided diuretic treatment versus usual care in patients with acute heart failure and renal dysfunction. Am J Med 2019;epublished August 15th
- Abstract: Gladstone. Effect of Recombinant Activated Coagulation Factor VII on Hemorrhage Expansion Among Patients With Spot Sign-Positive Acute Intracerebral Hemorrhage: The SPOTLIGHT and STOP-IT Randomized Clinical Trials. JAMA Neurol 2019;epublished August 19th
- Full Text: Calabró. Effect of different methods of cooling for targeted temperature management on outcome after cardiac arrest: a systematic review and meta-analysis. Crit Care 2019;23:285
- Full Text: Shillan. Use of machine learning to analyse routinely collected intensive care unit data: a systematic review. Crit Care 2019;23:284
- Abstract: Tinelli. High Flow Nasal Cannula Oxygen vs. Conventional Oxygen Therapy and Noninvasive Ventilation in Emergency Department Patients: A Systematic Review and Meta-Analysis. J Emerg Med 2019;epublished August 14th
- Abstract: Antcliffe. Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial. Intensive Care Med 2019;epublished August 19th
- Full Text: Ferrando. Family satisfaction with critical care in the UK: a multicentre cohort study. BMJ Open 2019;9:e028956BMJ Open 2019;9:e028956
- Abstract: Jensen. The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia: A Prospective Cohort Study. Annals ATS 2019;epublished August 22nd
- Abstract: Yue. Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study. Lancet Neurology 2019;epublished August 23rd
- Full Text: Commereuc. Hyperchloremia is not associated with AKI or death in septic shock patients: results of a post hoc analysis of the "HYPER2S" trial. Ann Intensive Care 2019;9(1):95
- Abstract: Madsen. Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study. Intensive Care Med 2019;epublished August 22nd
- Abstract: Granholm. Time to onset of gastrointestinal bleeding in the SUP-ICU trial: a preplanned substudy. Acta Anaesthesiol Scand 2019;epublished August 23rd
- Full Text: Weng. Micronutrient and Amino Acid Losses During Renal Replacement Therapy for Acute Kidney Injury. Kidney Int Rep 2019;4(8):1094–1108
- Full Text: Ramgopal. Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a Pediatric Intensive Care Unit. JAMA Netw Open 2019;2(8):e199812
- Full Text: Raux. Analysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury. Intensive Care Med 2019;epublished August 15th
- Full Text: Jacquot. Epidemiology of post-influenza bacterial pneumonia due to Panton–Valentine leucocidin positive Staphylococcus aureus in intensive care units: a retrospective nationwide study. Intensive Care Med 2019;epublished July 2nd
- Abstract: Jeffcote. Patient characteristics, ICU-specific supports, complications, and outcomes of persistent critical illness. J Crit Care 2019;epublished August 20th
- Heyland. Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ Open 2019;9(7):e027893
- Schlapbach. NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial. BMJ Open 2019;9(8):e026664
- Disclosure of Interests and Management of Conflicts of Interest in Clinical Guidelines and Guidance Statements: Methods From the Clinical Guidelines Committee of the American College of Physicians. Ann Intern Med 2019;epublished August 20th
- Caputo. Diagnosis and treatment of acute alcohol intoxication and alcohol withdrawal syndrome: position paper of the Italian Society on Alcohol. Internal and Emergency Medicine 2019;14(1):143–160
- Maschmann. New clinical guidelines on the spinal stabilisation of adult trauma patients - consensus and evidence based. Scand J Trauma Resusc Emerg Med. 2019 Aug 19;27(1):77
- Turkish Society of Cardiology consensus report on the rational use of cardiac troponins in daily practice. Anatol J Cardiol. 2019; 21(6): 331–344
- Leichtle. High-Dose Intravenous Ascorbic Acid: Ready for Prime Time in Traumatic Brain Injury? Neurocrit Care 2019;epublished August 22nd
- Thiele. Management of cardiogenic shock complicating myocardial infarction: an update 2019. Eur Heart J 2019;40(32):2671–2683
- Mayo. Thoracic ultrasonography: a narrative review. Intensive Care Med 2019;epublished August 15th
- Spinelli. Electrical impedance tomography in perioperative medicine: careful respiratory monitoring for tailored interventions. BMC Anesthesiol 2019;19:140
- Hernández-Beeftink. Genomics and the Acute Respiratory Distress Syndrome: Current and Future Directions. Int J Mol Sci 2019;20(16)
- Murphy. Pulmonary thromboendarterectomy. Nursing Critical Care 2019;14(4):6–13
- Hümmeke-Oppers. Innovative Drugs to Target Renal Inflammation in Sepsis: Alkaline Phosphatase. Front Pharmacol 2019;epublished August 23rd
- Lazăr. Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View. J Crit Care Med 2019;5(3):90–96J Crit Care Med 2019;5(3):90–96
- Koulenti. Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms. Microorganisms. 2019;7(8)
- Yin. The Role of Autophagy in Sepsis: Protection and Injury to Organs. Front Physiol 2019;epublished August 23rd
- Andersson. Clinical reasoning in the emergency medical services: an integrative review. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2019;27:76
- Nett. Invasive candidiasis trial supports echinocandins for primary therapy. Ann Infect 2019;3:3
- Rolls. Social media for researchers – beyond cat videos, over sharing, and narcissism. Australian Critical Care 2019;32(5):351-352
- Vitin. Perioperative Care for Organ Transplant Recipient: Time for Paradigm Shift. J Crit Care Med 2019;5(3):87–89
- Zampieri. Is prophylaxis worse than treatment in the ICU? Intensive Care Med 2019;epublished July 29th
- Gibbins. Getting it right first time: time to simplify our approach to the airway by using our best tools first. Southern African Journal of Anaesthesia and Analgesia 2019; 25(3):5-9
- Patel. Venovenous Extracorporeal Membrane Oxygenation Therapy in Adults. Cureus 2019;11(8):e5365
- Patel. Applied Uses of Extracorporeal Membrane Oxygenation Therapy. Cureus 2019;11(7):e5163
- Blood pressure reduction and intravenous thrombolysis. Lancet 2019;394(10199):e24
- Surgery for intracerebral haemorrhage. Lancet 2019;394(10199):e20
- The importance of randomised vs non-randomised trials. Lancet 2019;394(10199):634-635
- Fanaroff. High-quality evidence to inform clinical practice. Lancet 2019;394(10199):633-634
- Morio. Does nasal high-flow preoxygenation really reduce intubation-related adverse events?. Intensive Care Med 2019;epublished August 19th
- Lim. Major liver surgery in a Jehovah’s Witness patient: challenges for safe surgery. Southern African Journal of Anaesthesia and Analgesia 2019;25(3):24-26
- Pikto-Pietkiewicz. The Management of a Thirteen Weeks Pregnant Woman Rendered Brain-Dead Following a Ruptured Aneurysm. J Crit Care Med 2019;5(3):111–114
Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Lecture, to be delivered by Prof Kathryn Maitland, entitled "A Higher Calling: Two Decades of Emergency Research in Africa", and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.
Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week
Supported by the Health Research Board