CCR-Newsletter-BannerNewsletter 395  |  July 13th 2019

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Welcome to the 395th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature from the week of July 1st to 7th. I'm slowly catching up....

The highlights of this week's edition are randomised controlled trials on transesophageal echocardiography in critically ill patients with shock, early TIPS with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis, & aggressive versus slow rehydration in gastroenteritis; systematic reviews and meta analyses on corticosteroids in septic shock, family support interventions in the ICU, & endovascular thrombectomy in acute ischemic stroke; observational studies on trends in sepsis mortality over time in randomised trials & rehospitalization and resource use after extracorporeal life support in the USA; & the statistical and health economic analysis plan for 65, one of our big trials at CCR20 in January.

There are also guidelines on vascular catheter infections & hospital- and ventilator- associated pneumonia; narrative reviews on death by neurologic criteria, ST-elevation myocardial infarction, & chimeric antigen receptor T cell–related toxicity; editorials on intracranial hypertension, pre-hospital plasma transfusion, & sepsis; and commentaries on neurological prognostication after cardiac arrest & the vitamin C cocktail for sepsis.

With the REST trial continuing to recruit, if you only have time to read one review article from this newsletter, try this one on extracorporeal carbon dioxide removal for acute hypercapnic respiratory failure.



Review Articles









CCR20 Meeting

Now in it's 8th year, the Critical Care Reviews Meeting brings the chief investigators for the best critical care trials of the previous year to Titanic, Belfast, to discuss their studies. We aim to decide whether these trials are sufficiently robust to support their findings and if we should consider changing practice on the basis of them. To help in this endeavour we invite world leading experts to provide independent editorial overviews and have panel discussions to delve deep into the specifics of each trial. In addition, we also have detailed discussions on research methodology, to encourage critical thinking about the scientific findings which form the basis of our clinical practice. It's not just about specific trials though; for 2020, we have a distinguished panel of trialists, methodologists, statisticians and clinicians provide insight into the mysteries of clinical trial interpretation. We also have the annual honorary John Hinds Trauma Lecture, and finish the meeting with the incredibly popular "Informal Chat", where the faculty and delegates congregate in the bar and an enormous, meandering discussion about all things critical care takes place.

Based on our feedback from last year, we've reverted to keeping everyone on the same floor during breaks. In addition, we will also provide a sleeping area for those post-call to rest for a few hours as needed. As before, we are offering free childcare and a baby feeding area, where the meeting will live streamed. All dietary requirements are catered for also. Please get in touch if you have any specific needs. We sold out last year, so please don't delay if you want to attend. As usual, CPD points will be applied for in due course.

CCH Journal

Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive.  If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.

COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.

I hope you find these links useful.

Until next week


Supported by the Health Research Board

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